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Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng Han li-Yun He Zi-Yi li Yu-Cheng Yang Fan Ping ling-ling Xu wei li Hua-Bing Zhang Yu-Xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(Plinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang Yuan-Ming Pan wei li Rui-Qiong Ma Jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

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VIBRATION AND SOUND RADIATION OF AN ASYMMETRIC LAMINATED PLATE IN THERMAL ENVIRONMENTS

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Acta Mechanica Solida Sinica 2015年第1期28卷 11-22页

作者： wei li Yueming li State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University

Analytical studies on the vibration and sound radiation characteristics of an asymmetric laminated rectangular plate are carried out in this paper. Theoretical formulations, in which the effects of thermal environments are taken into account, are derived for the vibration and sound radiation based on both first-order shear deformation plate theory and Rayleigh integral. It is found that the natural frequencies, the resonant amplitudes of vibration response and the sound pressure level decrease with the temperature rising. The natural frequencies of asym- metric plates are smaller than those of symmetric plates and the velocity responses of asymmetric plates are larger than those of symmetric plates.

关键词： asymmetric laminated plate thermal environments FSDPT vibration sound radiation

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Synthesis, UV-curing Behavior and Surface Properties of Fluorinecontaining Vinyl Ether Polymers

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Chinese Journal of Polymer Science 2014年第8期32卷 1032-1039页

作者： wei li 邹应全 College of Chemistry Beijing Normal University

Five fluorine-containing vinyl ether monomers were prepared by the reaction between 2-vinyloxy ethanol, a fluorinated alcohol and hexafluorobenzene in the presence of sodium hydride in dimethylformamide. Two representative properties of these monomers, UV-curing behavior initiated by a cationic photo-initiator PAG 201 and surface free energy of coating films, were investigated. Photo-polymerization proceeded both rapidly and completely with a high double-bond conversion （〉 90%） and a fast curing rate （maximum curing time 〈 21 s） for three monomers. The surface energies of the monomers and the resulting polymer films were then investigated. The minimum surface free energy of the UV-cured homopolymer films reaches 7.1 mJ/m2. X-ray photoelectron spectroscopy data show that the low surthce tension is influenced by fluorine content in the soft segments and fluorinated chains＇ migration to the surface. The five monomers exhibit low viscosity, low surface energy, good thermal stability and good photo-polymerization properties, which make them great candidates for UV coating and photoresist applications.

关键词： Fluorine-containing vinyl ether Photo-initiated polymerization Hydrophobic films Low surface energy.

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Multiple target localization in wireless visual sensor networks

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Frontiers of Computer Science 2013年第4期7卷 496-504页

作者： wei li weiZHANG Research Institute of Electronic Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China

Target localization is an important service in wireless visual sensor networks （WVSN）. Although the problem of single target localization has been intensively studied, few consider the problem of multiple target localization without prior target information in WVSN. In this paper, we first investigate the architecture of WVSN where data transmission is reduced to only target positions. Since target matching is a key issue in the multiple target localization, we propose a statistical method to match corresponding targets to located targets in world coordinates. In addition, we also consider scenarios where occlusion or limited field of view （FOV） occurs. The proposed method utilizes target images to the greatest extent. Our experimental results show that the proposed method obtains a more accurate result in targets localization compared with the camera discard scheme, and saves significant amounts of energy compared with other feature matching schemes.

关键词： target localization statistics wireless visualsensor networks occlusion limited field of view

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Generation methodology of isolines of earthquake ground motion

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Earthquake Engineering and Engineering Vibration 2010年第4期9卷 473-480页

作者： li wei liShanyou Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China

Due to limited financial resources and challenging geographical conditions, the number of seismic observation networks in China is still very small and they are not widely distributed. Therefore, the available earthquake records obtained after an earthquake have been limited. In this paper, auto-generation methods to obtain strong motion isolines under different conditions are proposed. To verify the accuracy of these methods, some examples, including application to the 2008 Wenchuan earthquake, are given.

关键词： isolines interpolation method attenuation law strong motion observation networks

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Clinical feature and waveform in infantile nystagmus syndrome in children with FRMD7 gene mutations

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Science China(life Sciences) 2017年第7期60卷 707-713页

作者： Dayong Bai wei Shi Zhan Qi wei li Aihua wei Yanhui Cui Cheng li li li Department of Ophthalmology Beijing Children's Hospital Capital Medical UniversityNational Center for Children's Health Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical UniversityNational Center for Children's Health Department of Dermatology Beijing Tongren Hospital Capital Medical University

Infant nystagmus sydrome presents as involuntary eye movement disorder and can affect seriously ocular function. We performed a retrospective study of clinical data and FRMD7 genetic test results in 12 cases of infantile nystagmus syndrome to correlate waveform, stereopsis, and visual acuity. The patients(age 6.40±2.67 years) had FRMD7 mutations as follows: missense in eight cases, shear in two cases, frameshift in one case, and non-frameshift in one case. Horizontal jerk waveform was observed in six cases, versus horizontal pendulum in five cases and dual jerk in one case. The uncorrected visual acuity(24 eyes) was 0.21±0.12,compared with a corrected visual acuity(24 eyes) of 0.32±0.14. All patients had simultaneous perception, versus fusion function in 10 cases(83.33%) and stereoscopic vision in seven cases(58.33%) using the synoptophore. Eleven cases(91.67%) detected the stereo fly, compared with five cases(41.67%) for stereoscopic circles and seven cases(58.33%) for stereoscopic animals by Titmus test. Stereoscopic vision using the synoptophore did not correlate with the frequency, amplitude, or intensity of nystagmus or with corrected binocular visual acuity. The infantile nystagmus syndrome with FRMD7 mutations in our cases was caused primarily de novo and missense mutations. Visual acuity and binocular visual function were significant impaired, and the waveform was generally horizontal jerk. Also, an infrared videonystagmogram can record the frequency, amplitude, and intensity of nystagmus accurately.

关键词： infantile nystagmus FRMD7 gene mutation waveform vision stereopsis

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Variant quantifiers in L_(3)-valued first-order logic

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Frontiers of Computer Science 2021年第5期15卷 151-159页

作者： wei li Yuefei SUI State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100083China Key Laboratory of Intelligent Information Processing Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China School of Computer Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Traditional first-order logic has four definitions for quantifiers,which are defined by universal and existential *** L_(3)-valued(three-valued)first-order logic,there are eight kinds of definitions for quantifiers;and corresponding Gentzen deduction systems will be given and their soundness and completeness theorems will be proved.

关键词： L_(3)-valued(three-valued)first-order logic sequent quantifier soundness theorem completeness theorem

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Dynamic Analysis of A 5-MW Tripod Offshore Wind Turbine by Considering Fluid–Structure Interaction

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China Ocean Engineering 2017年第5期31卷 559-566页

作者： ZHANG li-wei li Xin State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology

Fixed offshore wind turbines usually have large underwater supporting structures. The fluid influences the dynamic characteristics of the structure system. The dynamic model of a 5-MW tripod offshore wind turbine considering the pile-soil system and fluid structure interaction （FSI） is established, and the structural modes in air and in water are obtained by use of ANSYS. By comparing low-order natural frequencies and mode shapes, the influence of sea water on the free vibration characteristics of offshore wind turbine is analyzed. On basis of the above work, seismic responses under excitation by E1-Centro waves are calculated by the time-history analysis method. The results reveal that the dynamic responses such as the lateral displacement of the foundation and the section bending moment of the tubular piles increase substantially under the influence of the added-mass and hydrodynamic pressure of sea water. The method and conclusions presented in this paper can provide a theoretical reference for structure design and analysis of offshore wind turbines fixed in deep seawater.

关键词： 5-MW tripod offshore wind turbine fluid-structure interaction natural frequency seismic analysis,hydrodynamic pressure

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