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Exploring Mechanism of Electroacupuncture in Modulating Neuroinflammation Based on Intestinal Flora and Its Metabolites

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Chinese Journal of Integrative Medicine 2025年第2期31卷 183-192页

作者： YE Hai-min li Zhuo-yan ZHANG Peng KANG Zhen zhou De-sheng School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha(410208)China Neurology Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Acupuncture and Moxibustion Massage Rehabilitation Department The Second Affiliated Hospital of Hunan University of Chinese MedicineChangsha(410005)China Neurology Department The First Hospital of Hunan University of Chinese MedicineChangsha(410011)China

Neuroinflammatory responses play an important role in the pathogenesis of various diseases,particularly those affecting the central nervous *** of neuroinflammation is a crucial therapeutic strategy for the management of central nervous system *** intestinal microbial-gut-brain axis serves as a key regulatory pathway that modulates neuroinflammatory *** flora metabolites such as short-chain fatty acids,indoles and their derivatives,lipopolysaccharides,trimethylamine oxide,and secondary bile acids exert direct or indirect effects on *** have shown that electroacupuncture(EA)modulates the composition of the intestinal microbiota and its metabolites,while also suppressing neuroinflammation by targeting the TLR4/NF-κB,NLRP3/caspase-1,and microglial cell M2-type transformation *** review discusses the mechanisms by which EA regulates neuroinflammation via intestinal microbiota and its metabolites,providing information and a foundation for further investigation of the precise therapeutic mechanisms of EA in neurological disorders.

关键词： electroacupuncture intestinal flora metabolites of intestinal flora neuroinflammation nervous system disease review

Revisit the Gibbs-Thomson Equation Fitting of Poly(butylene succinate)Based on Oligomer Extended-Chain Crystals

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Chinese Journal of Polymer Science 2025年第2期43卷 392-398页

作者： Na li Yu-Pei Tian Tian-Yu Wu Qiong zhou Hai-Mu Ye College of New Energy and Materials China University of PetroleumBejing 102249China

The equilibrium melting point(T_(m)^(0))is a crucial thermodynamic parameter for characterizing the crystallization and melting behavior of semi-crystalline ***,the direct measurement of T_(m)^(0) poses a significant challenge because of the difficulty in physically fabricating fully-extended chain crystals of high-molecular-weight ***,various extrapolation equations for T_(m)^(0) have been proposed that utilize the thermal properties of ordinary folded-chain *** these,the Gibbs-Thomson equation is one of the most commonly employed for *** its widespread use,there are notable variations in the T_(m)^(0) values obtained by different research groups,even when based on similar *** raises questions about the validity and accuracy of using the Gibbs-Thomson equation to linearly extrapolate T_(m)^(0).In this study,we prepared a series of oligomer extended-chain crystals(ECCs)of poly(butylene succinate)(PBS)and used their properties for Gibbs-Thomson *** results reveal a perfect linear relationship,with an extrapolated T_(m)^(0) value of 136.08℃.The basal surface free energy of the oligomer ECCs was calculated as 0.084 J/m^(2),which is approximately twice that of folded-chain *** difference is attributed to the aggregation of highly mobile free tails on the crystal *** two structural features of oligomer ECCs—large thickness and fixed surface—better fulfill the conditions for applying the Gibbs-Thomson equation,ensuring its validity and ***,we believe that the Gibbs-Thomson fit can produce reliable results when sufficient high-quality data are used.

关键词： Equilibrium melting point Extended-chain crystal Gibbs-Thomson equation Inclusion complex

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： Tongyue li Ziliang Xie Wenjiao zhou Huan Tong Dawen Yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Enhanced oxygen reduction reaction on La-Fe bimetal in porous N-doped carbon dodecahedra with CNTs wrapping

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Chinese Chemical Letters 2025年第1期36卷 618-622页

作者： Yi zhou Yanzhen liu Yani Yan Zonglin Yi Yongfeng li Cheng-Meng Chen College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030024China CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China College of Materials Sciences and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

The oxygen reduction reaction(ORR)is a crucial process in Zn-air systems,and the catalyst plays a significant role in this ***,reported catalysts often suffer from poor durability and stability during the ORR ***,we synthesized La-Fe bimetallic nanoparticles encapsulated in a N-doped porous carbon dodecahedron(La-Fe/NC)originated from ZIF-8 by a simple direct *** La-Fe/NC catalyst had a numerous mesopores and dendritic outer layer generated by carbon nanotubes(CNTs),forming a high conductivity network that helped to optimize electron transfer and mass transport in the ORR *** effect of different doping transition metals and metal ratios on the ORR activity of Zn-air batteries was *** alkaline media,the La-Fe/NC showed the highest ORR catalytic activity,with a half-wave potential(E_(1/2))of 0.879 V(***,Pt/C 0.845 V).After 5000 cycles,the E_(1/2)of the La-Fe/NC catalyst only decreased by 7 m V,and its performance in stability tests and methanol tolerance tests was superior to Pt/*** used as the air electrode in a Zn-air battery,the La-Fe/NC catalyst demonstrated an excellent specific capacity of 755 m Ah/g and a peak power density of179.8 m W/cm~*** results provide important insights for the development of high-performance Zn-air batteries and new directions for the design of ORR catalysts.

关键词： Electrocatalyst ORR Bimetallic nanoparticle Dendritic CNTs Zn-air battery

Promotional effect of stannum on Pd/CeO2 catalysts for CO and C3H6 co-oxidation

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Journal of Rare Earths 2025年第03期 508-515页

作者： Congwei liu Jie li Meng Wang Jieying Cai Miaomiao liu Yulong shan Yan Zhang Wenpo shan Center for Excellence in Regional Atmospheric Environment and Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of Sciences Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control Ningbo Urban Environment Observation and Research StationInstitute of Urban EnvironmentChinese Academy of Sciences University of Chinese Academy of Sciences State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of Sciences

The successful control of hydrocarbon and CO emissions from low-temperature diesel exhausts requires the use of highly active co-oxidation *** this study,Sn was used to enhance the catalytic performance of Pd/CeO2in CO and C3H6co-oxidation ***2with added stannum（Sn） was prepared as a support using the co-precipitation method,and Pd was loaded onto the support using the impregnation *** Sn addition（the optimal Ce/Sn ratio is 0.75:0.25）,the T50values of CO and C3H6are reduced by 20 and 32℃,respectively.A series of characterization methods indicates that the addition of Sn to the support greatly enhances its lattice oxygen mobility and increases the proportion of *** the co-oxidation process,stronger lattice oxygen mobility allows CO to react faster through the Mars-van Krevelen mechanism,weakening the competition with C3H6for O2.A higher PdO content enhances the C3H6oxidation ***,CO can more readily reduce PdO than Pd2+in solid solution with the support,which consequently further enhances co-oxidation ***,the addition of Sn is a simple and effective strategy for enhancing the performance of Pd/CeO2catalysts in CO and C3H6co-oxidation ***,the promotional effect of CO achieved in this study contributes to a deeper understanding of the interactions that occur during the co-oxidation of C3H6and CO.

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Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC

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Chinese Chemical Letters 2025年第1期36卷 392-396页

作者： Wenbin zhou Yafei Gao Xinyu Feng Yanqing Zhang Cong Yang Lanxi He Fenghe Zhang Xiaoguang li Qing li School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJi’nan 250012China China&shandong Key Laboratory of Oral Tissue Regeneration Ji’nan 250012China China&shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Ji’nan 250012China Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJi’nan 250021China

Immunotherapy offers significant potential but is often hampered by the immunosuppressive environment in oral squamous cell carcinoma(OSCC).To address this,we propose an enhanced immunotherapeutic strategy that revitalizes the tumor immune microenvironment(TIME)in OSCC by integrating upconversion-based photodynamic therapy(PDT)with *** a red blood cell membraneinspired biomimetic nanoplatform,our approach concurrently delivers chlorin e6@upconversion nanoparticles(Ce6@UCNP)and doxorubicin(DOX).By leveraging fluorescence resonance energy transfer(FRET)for 980 nm to 660 nm upconversion excitation,we address challenges such as limited tissue penetration and tissue damage,as well as nanoplatform issues including immunogenicity and targeting inaccuracy Our integrated approach enhances PDT and chemotherapy with the goal of transforming immunologically“cold”tumors into“hot”ones through a cascaded therapy,thereby revitalizing the tumor immune microenvironment in OSCC.

关键词： Biomimetic nanoplatform UCNP-PDT Chemotherapy TIME OSCC

Enhanced oral drug delivery by mimicking natural amino acid and oligopeptide absorption route

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Nano Research 2025年第2期18卷 525-540页

作者： Ruinan Wu Xiaoxing Fan licheng Wu liyun Xing Jinxia Kong zhou zhou Jingyuan Wen lian li Yuan Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Faculty of Medical and Health SciencesUniversity of AucklandAuckland 1023New Zealand

Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal(Gl)tract and low efficiency of transepithelial ***,inspired by efficient absorption of protein-based nutrients,we constructed several kinds of oral drug delivery systems by mimicking natural amino acid and oligopeptide absorption *** kinds of amino acids and two kinds of oligopeptides were chosen as targeting ligands to mediate transportation of orally administered nanoparticles(NPs).liraglutide(lira),a kind of glucagon like peptide-1(GLP-1)receptor agonist,was used as model *** functionalized NPs could protect lira from enzymatic degradation in Gl ***,compared with amino acid-modified NPs,oligopeptide-modified NPs exhibited greater transepithelial transport efficiency and were primarily absorbed in the proximal small intestine due to the high expression and transportation mediated by proton coupled oligopeptide transporter 1(PEPT1).These lira-loaded NPs could effectively control the blood glucose level,reduce plasma lipid level,and repair tissue damage on type 2 diabetic mice and even showed comparable hypoglycemic effects of subcutaneous injection(s.c.)free *** study demonstrates the potential of mimicking natural oligopeptide absorption route to enhance oral delivery of protein and peptide drugs.

关键词： oral drug delivery amino acid absorption route oligopeptide absorption route liraglutide

Fabrication of Ni-Zn spinel ferrite with superior magnetic performance from electric arc furnace dust and iron scale

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Journal of Iron and Steel Research International 2025年第1期32卷 105-114页

作者： Yang li Wei-zhe Jie Chang Chen Yi Su Wu zhou Hua Zhang Hong-wei Ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina The Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina

The Ni-ZnFe_(2)O_(4)(NixZn_(1-x)Fe_(2)O_(4),x=0.4-0.7)spinel was synthesized using Zn2+extracted from electric arc furnace dust(EAFD),nickel chloride hexahydrate,and Fe^(3+)extracted from iron scale as raw *** zinc was selectively extracted from EAFD using CaO roasting followed by NH_(4)Cl solution *** ferric ion was leached from iron scale using HCl solution as acid *** experimental results demonstrate a high level of efficiency in the extraction of zinc,with a rate of 97.5%,and the leaching rate of ferric ion is 96.89%.The composition of the leaching solution is primary zinc and iron with low calcium,which is beneficial to the preparation of spinel *** influence of Ni content(x)and calcination temperature on the synthesis and magnetic properties of NixZn_(1-x)Fe_(2)O_(4)compounds was investigated by X-ray diffraction,scanning electron microscopy,and vibrating sample *** results revealed that both Ni content and calcination temperature significantly affect the synthesis and magnetic properties of spinel NixZn_(1-x)Fe_(2)O_(4).Under the conditions of Ni content set at x=0.6,calcination temperature of 1100℃,and a duration of 2 h,a spinel NixZn_(1-x)Fe_(2)O_(4)with high saturation magnetization(Ms=65.7 A m2 kg-1)and low coercivity(Hc=0.056 A m^(-1))was obtained.

关键词： Electric furnace arc dust Iron scale Spinel ferrite Magnetic performance Calcination temperature

Multi-wavelength plasmonic optoelectronic memristor for reconfigurable logic operations and mixed-color pattern recognition

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Science China(Information Sciences) 2025年第2期68卷 5-14页

作者： Jiaqi HAN Zhuangzhuang li Tao ZENG Xuanyu shan Riya SU Ya liN Zhongqiang WANG Xiaoning ZHAO Shencheng FU Haiyang XU Yichun liU Key Laboratory for UV light-Emitting Materials and Technology (Northeast Normal University) Ministry of Education Department of Materials Science and Engineering National University of Singapore

Optoelectronic memristors have emerged as promising hardware platforms for highly efficient image perception owing to their low crosstalk, fast response, and low power consumption. However, the development of optoelectronic memristors with multi-wavelength recognition capabilities remains constrained by the limitations of their inherent bandgap. In this work, a multi-wavelength-modulated optoelectronic memristor that operates based on the localized surface plasmon resonance effect is developed using silver（Ag）-titanium dioxide（TiO2）/polymethyl methacrylate（PMMA） nanocomposites. The SET voltage can be gradually reduced by modulating the optical wavelength of visible irradiation. On this basis, reconfigurable IMP and False logic operations have been implemented in the memristive logic circuit. The neuromorphic visual preprocessing and recognition function for mixed-color patterns is demonstrated based on wavelength-dependent resistive switching behaviors. The proposed optoelectronic memristor enables high-density storage and in-memory computing.

关键词： optoelectronic memristor localized surface plasmon resonance multi-wavelength resistive switching color pattern recognition

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