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Chinese Chemical Letters 2015年第10期26卷 1303-1306页

作者： Hui Wang Jun-Qiu li li-shan zhou Jun liu Juan li Hong-Mei Qu Key Laboratory of Systems Bioengineering Ministry of Education Tianjin Key Laboratory of Biological and Pharmaceutical Engineering Department of Pharmaceutical Engineering School of Chemical Engineering and Technology Tianjin University CNOOC Tianjin Chemical Research and Design Institute

A novel method for the synthesis of 1,2,3,4-tetraalkyl-1,4-diarylbutadienes was developed via palladiumcatalyzed cross-coupling of zirconacyclopentadienes with aryl iodides. Equivalent of Cu Cl was introduced to promote the reaction. The desired products were obtained in good to excellent yields and several of them were reported for the first time.

关键词： Zirconacyclopentadiene Cross-coupling reaction Palladium-catalyzed CuCl 1 2 3 4-Tetraalkyl-1 4-diarylbutadienes

Synthesis and structure determination of novel hexasubstituted cyclohexadienes

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Chinese Chemical Letters 2012年第10期23卷 1137-1140页

作者： Hong Mei Qu Xin Hui Niu Juan li Jun liu li li Jiang Jian Ke Tang li shan zhou Key Laboratory of Systems Bioengineering Ministry of EducationTianjin Key Laboratory of Biological and Pharmaceutical EngineeringDepartment of Pharmaceutical EngineeringSchool of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Tianjin Research and Design Institute of Chemical Industry Tianjin 300131China

The linear trienes were obtained in high yields by copper-mediated cycloaddition of 2,5-bis（trimethylsilyl）zirconacyclo- pentadienes with dimethyl acetylenedicarboxylate （DMAD） which can be quantitatively converted to novel asymmetric hex- asubstituted cyclohexadienes with high （E）-stereoselectivity. The structure of cyclohexadienes was determined via X-ray analysis.

关键词： 2,5-Bis(trimethylsilyl)zirconacyclopentadiene linear triene Hexasubstituted cyclohexadiene Cycloaddition

Berberine Inhibits Gluconeogenesis in Skeletal Muscles and Adipose Tissues in Streptozotocin-induced Diabetic Rats via LKB1-AMPK-TORC2 Signaling Pathway

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Current Medical Science 2020年第3期40卷 530-538页

作者： Xiao-hu XU Qian HU li-shan zhou li-jun XU Xin ZOU Fu-er LU Ping YI Department of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Institute of Integrated Traditional Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Integrated Traditional Chinese and Western Medicine Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430016China

The effect and potential molecular mechanisms of berberine on gluconeogenesis in skeletal muscles and adipose tissues were *** adaptive feeding for one week,8 rats were randomly selected as the normal group and fed on a standard *** remaining 32 rats were fed on a high-fat diet and given an intravenous injection of streptozotocin(STZ)for 2 weeks to induce the diabetic *** diabetic rat models were confirmed by oral glucose tolerance test(OGTT)and randomly divided into 4 groups(n=8 each),which were all fed on a high-fat ***(3 g/kg per day)or metformin(183 mg/kg per day)was intragastrically administered to the diabetic rats for 12 weeks,serving as berberine group and metformin group respectively.5-aminoimidazole-4-carboxamide1-β-D-ribofuranoside[AICAR,an agonist of AMP-activated protein kinase(AMPK),0.5 mg/kg per day]was subcutaneously injected to the diabetic rats for 12 weeks,serving as AICAR *** remaining 8 diabetic rats served as the model group,which was given a 0.5%carboxyl methylcellulose solution by oral *** serum insulin(FINS),OGTT as well as lipid parameters were tested by commercial *** protein levels of liver kinase B1(LKB1),AMPK,phosphorylated AMP-activated protein kinase(p-AMPK),transducer of regulated CREB activity 2(TORC2),phosphorylated transducer of regulated CREB activity 2(p-TORC2),phosphoenolpyruvate carboxykinase(PEPCK),and glucose-6-phosphatase(G6Pase)in skeletal muscles and adipose tissues were examined by Western *** results showed that berberine significantly decreased the body weight,plasma glucose,insulin levels,and homeostatic model assessment for insulin resistance(HOMA-IR)of diabetic rats compared with those in the model ***,the serum total triglyceride(TG),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)levels were markedly decreased and high-density lipoprotein cholesterol(HDL-C)level was significantly increased after the treatment with b

关键词： berberine gluconeogenesis skeletal muscle adipose tissue LKB1-AMPK-TORC2

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways

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Neural Regeneration Research 2025年第9期20卷 2706-2726页

作者： Biao Xiao Chaoyang Chu Zhicheng lin Tianyuan Fang Yuyu zhou Chuxia Zhang Jianghui shan Shiyu Chen liping li Department of Physiology and Pharmacology Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Ningbo Key Laboratory of Behavioral Neuroscience Health Science CenterNingbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Addiction Research of Zhejiang Province NingboZhejiang ProvinceChina

A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's ***,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating disease symptoms and ***,nonpharmacological interventions aimed at inducing adult neurogenesis are currently *** individual non-pharmacological interventions,such as aerobic exercise,acousto-optic stimulation,and olfactory stimulation,have shown limited capacity to improve neurogenesis and cognitive function in patients with Alzheimer's disease,the therapeutic effect of a strategy that combines these interventions has not been fully *** this study,we observed an age-dependent decrease in adult neurogenesis and a concurrent increase in amyloid-beta accumulation in the hippocampus of amyloid precursor protein/presenilin 1 mice aged 2-8 *** deposition became evident at 4 months,while neurogenesis declined by 6 months,further deteriorating as the disease ***,following a 4-week multifactor stimulation protocol,which encompassed treadmill running(46 min/d,10 m/min,6 days per week),40 Hz acousto-optic stimulation(1 hour/day,6 days/week),and olfactory stimulation(1 hour/day,6 days/week),we found a significant increase in the number of newborn cells(5'-bromo-2'-deoxyuridine-positive cells),immature neurons(doublecortin-positive cells),newborn immature neurons(5'-bromo-2'-deoxyuridine-positive/doublecortin-positive cells),and newborn astrocytes(5'-bromo-2'-deoxyuridine-positive/glial fibrillary acidic protein-positive cells).Additionally,the amyloid-beta load in the hippocampus *** findings suggest that multifactor stimulation can enhance adult hippocampal neurogenesis and mitigate amyloid-beta neuropathology in amyloid precursor protein/presenilin 1 ***,cognitive abilities were improved,and depressive symptoms were alleviated in amyloid precursor protein/presenilin 1 mice

关键词： acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

Two-Phase Genetic Algorithm Applied in the Optimization of Multi-Modal Function

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Wuhan University Journal of Natural Sciences 2003年第S1期8卷 259-264页

作者： Huang Yu-zhen, Kang li-shan,zhou Ai-minState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei,China Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

This paper presents a two-phase genetic algorithm (TPGA) based on the multi- parent genetic algorithm (MPGA). Through analysis we find MPGA will lead the population' s evol vement to diversity or convergence according to the population size and the crossover size, so we make it run in different forms during the global and local optimization phases and then forms TPGA. The experiment results show that TPGA is very efficient for the optimization of low-dimension multi-modal functions, usually we can obtain all the global optimal solutions.

关键词： optimization of multi-modal function genetic algorithm global optimization local optimization

First-Principles Prediction of Ductility in β-type Ti-Mo Binary Alloys

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Journal of shanghai Jiaotong university(Science) 2011年第2期16卷 227-230页

作者：赖敏杰薛祥义周中波唐斌李金山周廉 State Key Laboratory of Solidification Processing Northwestern Polytechnical University

Recent studies suggest that the ratio of the shear modulus (G) to the bulk modulus (B) and the Poisson's ratio (ν) are good indicators of *** the method of supercell and the first-principles pseudopotential plane-wave method,the G/B and ν of the β-type Ti-Mo binary alloys with Mo molar fraction (xMo) ranging from 6.25% to 37.5% are *** results show that the ductility of β-type Ti-Mo binary alloys first increases with increasing x Mo and reaches the maximum when x Mo is about 25%,and then reduces with more increasing x *** charge density difference calculations suggest that the x Mo dependence of the ductility can be ascribed to the change of bonding characteristics between Ti and Mo atoms in the [111] direction.

关键词： Ti-Mo alloys first-principles ductility charge density difference

Genome-wide gene expressional analysis of two indica rice varieties RH and TN1 under brown planthopper infestation

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Genome-wide gene expressional analysis of two indica rice va...

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

第十三届全国植物基因组学大会

作者： Changyan li,shan Jiang,zhou Fei,Yongjun lin,Hao Chen~* Huazhong Agricultural University,Wuhan 430070,China

RH(Rathu Heenati) is a rice cultivar with high resistance to several biotypes of brown planthopper(Nilaparvata lugens Stal,BPH);while another rice cultivar TN1 (Taichung Native 1) is highly susceptible to all biotypes of *** reveal molecular mechanism of resistant difference between RH and TN1,genome-wide gene expressional profiling of these two rice varieties at 6 h and 24 h after BPH infestation

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po li Zi-shan Wang Hong-Xia Yu shan-shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

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基于句法信息的微博情绪识别方法研究

计算机科学 2017年第2期44卷 244-249页

作者：黄磊李寿山周国栋苏州大学计算机科学与技术学院苏州215006

情绪识别旨在自动识别文本是否含有情绪。情绪识别是情感分析研究中的一项基本任务。针对该任务,提出了一种基于句法信息的微博文本情绪识别方法。该方法的特色在于充分考虑了微博文本的句法信息。具体实现中,首先利用词性标注(POS)序... 详细信息

情绪识别旨在自动识别文本是否含有情绪。情绪识别是情感分析研究中的一项基本任务。针对该任务,提出了一种基于句法信息的微博文本情绪识别方法。该方法的特色在于充分考虑了微博文本的句法信息。具体实现中,首先利用词性标注(POS)序列和结构句法树来表示句法信息,以分别提取POS序列模式、重写规则和二元句法标签作为特征进行文本表示;然后利用最大熵分类算法对微博文本进行情绪识别。实验结果表明,所提方法能够获得较好的识别效果。

关键词：自然语言处理微博情绪识别 POS序列模式句法树

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关键短语抽取研究现状

现代计算机（中旬刊） 2017年第1期 39-41页

作者：李珊珊周耘立四川大学计算机学院成都620065

在这个信息爆炸的社会,如何从大量的文本快速浏览读取重要信息,已经变得越来重要。关键短语抽取就是从文本中自动抽取文本中重要的并且能够代表文章主题的短语。关键短语可以帮助读者快速并且准确地了解文本信息内容。关键短语抽取方法... 详细信息

在这个信息爆炸的社会,如何从大量的文本快速浏览读取重要信息,已经变得越来重要。关键短语抽取就是从文本中自动抽取文本中重要的并且能够代表文章主题的短语。关键短语可以帮助读者快速并且准确地了解文本信息内容。关键短语抽取方法可以分为无监督方法和有监督方法两种,下面分别对关键短语抽取的两种方法进行介绍。

关键词：关键短语抽取候选关键短语有监督方法无监督方法