检索结果-南通市图书馆

电针“足三里”引起的肌梭传入对大鼠脊髓背角广动力型神经元伤害性反应的影响

在线全文

学校读者我要写书评

暂无评论

针刺研究 1999年第4期24卷 278-281页

作者：吴志新宋新爱张红梅李强吴苏娣樊小力西安医科大学生理教研室西安710061

以大鼠脊髓背角广动力型（ｗｉｄｅ－ｄｙｎａｍｉｃ－ｒａｎｇｅ，ＷＤＲ）神经元伤害性诱发反应为痛指标，观察了电针“足三里”穴引起肌梭传入对其的影响。结果如下：在２２只大鼠上记录到６２例ＷＤＲ神经元，“足三里”穴电针刺激... 详细信息

以大鼠脊髓背角广动力型（ｗｉｄｅ－ｄｙｎａｍｉｃ－ｒａｎｇｅ，ＷＤＲ）神经元伤害性诱发反应为痛指标，观察了电针“足三里”穴引起肌梭传入对其的影响。结果如下：在２２只大鼠上记录到６２例ＷＤＲ神经元，“足三里”穴电针刺激组２１例，其中有明显抑制作用的１５例，占７１．４３％；同样实验条件下，穴区分开０．５ｃｍ处给电针刺激组１４例，结果有明显抑制作用的仅为５例，占３５．７１％；穴区注射布比卡因破坏肌梭［８］后，施以同样参数的电针刺激组１６例，有明显抑制作用的也仅为５例，占３１．２５％。结果表明，电针“足三里”穴区引起的抑制效应是由于电针刺激引起穴位处的肌梭兴奋，后者的传入信息引起了ＷＤＲ神经元伤害性反应的抑制效应，从而进一步证实了肌梭的传入具有镇痛作用。

关键词： WDR神经元肌梭足三里镇痛电针

Recent advances in visible-light-driven organic reactions

在线全文

学校读者我要写书评

暂无评论

National Science Review 2017年第3期4卷 359-380页

作者： qiang liu li-Zhu wu State Key Laboratory of Applied Organic Chemistry Lanzhou University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences

In recent years, visible-light-driven organic reactions have been experiencing a significant renaissance in response to topical interest in environmentally friendly green chemical synthesis. The transformations using inexpensive, readily available visible-light sources have come to the forefront in organic chemistry as a powerful strategy for the activation of small molecules. In this review, we focus on recent advances in the development of visible-light-driven organic reactions, including aerobic oxidation, hydrogen-evolution reactions, energy-transfer reactions and asymmetric reactions. These key research topics represent a promising strategy towards the development of practical, scalable industrial processes with great environmental benefits.

关键词： visible light catalysis synthesis photocatalyst aerobic oxidation hydrogen evolution energy transfer asymmetric photoreaction

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing wu Wei wu Ying Wang Yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui li Nai-Kui liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting li Wei Zhang Jian wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Research and development of nanocrystalline W/W-based materials: novel preparation approaches, formation mechanisms, and unprecedented excellent properties

在线全文

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2023年第1期17卷 87-110页

作者： Zaoming wu qiang li Xiaofeng Yang Institute of Materials China Academy of Engineering PhysicsMianyang 621907China

Tungsten(W)has become the most promising plasma-facing material(PFM)in fusion reactor,and W still faces performance degradation caused by low-temperature brittleness,low recrystallization temperature,neutron irradiation effects,and plasma irradiation *** modification of wW-based materials in terms of microstructure manipulation is needed,and such techniques to improve the performance of materials are the topics of hot *** have found that refining the grain can significantly improve the strength and the irradiation resistance of Ww-based *** this paper,novel approaches and technique routes,including the"bottom-up"powder metallurgy method and"top-down"severe plastic deformation method,are introduced to the fabrication of nanocrystalline WW-based *** formation mechanisms of nanocrystalline WW-based materials were revealed,and the nanostructure stabilization mechanisms were *** mechanical properties of nanocrystalline WW-based materials were tested,and the irradiation behaviors and performances were *** mechanisms of their high mechanical properties and excellent irradiation-damage resistance were *** article may provide an experimental and theoretical basis for the design and development of high-performance novel nanocrystallineW/W-based materials.

关键词： nanocrystalline tungsten grain boundary secondary phase doping mechanicalproperty irradiation behavior

Radical and(photo)electron transfer induced mechanisms for lignin photo-and electro-catalytic depolymerization

在线全文

学校读者我要写书评

暂无评论

Green Energy & Environment 2023年第2期8卷 383-405页

作者： Kejia wu Minglong Cao qiang Zeng Xuehui li School of Chemistry and Chemical Engineering State Key Laboratory of Pulp&Paper EngineeringSouth China University of TechnologyGuangzhou510640China

As one of the three major components of woody biomass,lignin is a kind of natural organic polymer and the only abundant natural renewable resource with aromatic *** catalysis induced depolymerization is an important and effective approach for lignin *** particular,photocatalysis and electrocatalysis show great potential in accurately activating C-O/C-C bonds,which is a critical point of selective cleavage of *** this contribution,we focus on radical and(photo)electron transfer induced reaction mechanisms of the photo(electro)catalytic depolymerization of ***,the general situation of Carbon-centered radicals and active oxygen species mediated lignin conversion has been *** the mechanisms for(photo)electron transfer mediated lignin depolymerization have been *** the end of this review,the challenges and opportunities of photo(electro)catalysis in the applications of lignin valorization have been forecasted.

关键词： lignin Photocatalysis Electrocatalysis Depolymerization Reaction mechanism

Designing a New Lattice Model to Simulate Low-molecular-weight Block Copolymers for Nanolithographic Applications

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2022年第4期40卷 413-420页

作者： Jia-Ping wu Bao-Hui li qiang Wang School of Physics Nankai UniversityTianjin 300071China Department of Chemical and Biological Engineering Colorado State UniversityFort Collins CO 80523-1370USA

A new lattice model is designed to be suitable for simulating low-molecular-weight block copolymer(BCP)melts currently used in experiments to achieve sub-10 nm domain sizes(i.e.,having an invariant degree of polymerization between 10^(2) and 10^(3)).It gives an isothermal compressibility comparable to real polymers such as polystyrene and poly(methyl methacrylate),high Monte Carlo simulation efficiency,and the fluctuation effects important for the low-molecular-weight *** its high lattice coordination number,the model can also be readily used for branched chains such as star BCPs.

关键词： Lattice model Block copolymers Fluctuations

能量色散X射线荧光光谱法测定大米中镉元素的不确定度评定

在线全文

学校读者我要写书评

暂无评论

中国稻米 2018年第2期24卷 64-66,69页

作者：李强欧飞吴敏黄万燕江苏天瑞仪器股份有限公司江苏昆山215300

分析了能量色散X荧光光谱法测定大米中镉含量不确定度的各分量,分析了测量不确定度的来源。测量不确定度主要来源于标准物质和工作曲线拟合。对不确定度分量进行评定,经计算得出合成标准不确定度和扩展不确定度。当大米中镉元素的含量为... 详细信息

分析了能量色散X荧光光谱法测定大米中镉含量不确定度的各分量,分析了测量不确定度的来源。测量不确定度主要来源于标准物质和工作曲线拟合。对不确定度分量进行评定,经计算得出合成标准不确定度和扩展不确定度。当大米中镉元素的含量为0.268 mg/kg时,扩展不确定度为0.029 mg/kg(k=2)。

关键词：能量色散X荧光光谱法大米镉不确定度

A Critical Review of Real Gas Effects on the Regenerative Refrigerators

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2021年第3期30卷 782-806页

作者： CAO qiang LUAN Mingkai li Peng WEI li wu Yan Institute of Refrigeration and Cryogenics School of Mechanical EngineeringTongji UniversityShanghai 201804China Shanghai Key Laboratory of Vehicle Aerodynamics and Vehicle Thermal Management Systems Tongji UniversityShanghai 201804China Department of Electrical Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201804China

The regenerative refrigeration is an important reverse work-heat conversion cycle with a theoretical coefficient of performance(COP)identical to the Carnot *** regenerative refrigerators are capable of working down to 4 K and largely fulfill the refrigeration requirement of modern technologies in many fields,especially for space ***,the enthalpy flow associated with the pressure dependence,abbreviated as pressure-induced enthalpy flow,brought about by real gas effects degrades the theoretical COP of the refrigerator to below about 30% of the Carnot efficiency at the temperatures of below the critical *** paper reviews the long history of exploring the real gas effects which dates back to the 1970 s and continues to *** explorations of uncovering the loss mechanism and reducing such losses are *** theories that are in accordance with experimental results and simulation results are *** further carry out analyses on the expansion components,including the pulse tube and the clearance *** inferences are made in order to explore the long-lasting puzzles about real gas *** is emphasized that the underlying cause of the loss in the regenerator is an indirect effect of the real gas *** study about carrying out a direct verification of the theory is proposed.

关键词： real gas effects regenerative refrigerators loss mechanism reduction methods