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Chinese Chemical Letters 2012年第3期23卷 265-268页

作者： li Min Yang Zhi Kui Yin li qiang wu School of Pharmacy Xinxiang Medical UniversityXinxiang 453003China

Novel spiro[dibenzo[a,i]xanthene-14,3＇-indoline]-2＇,8,13-triones were prepared by the three-component reaction ofβ-naphthol, isatins,and 2-hydroxy-1,4-naphoquinone in the presence of a catalytic amount of H_4SiW_（12）O_（40）.This protocol provides a simple one-step procedure with the advantages of easy work-up,mild reaction conditions and environmentally benign.

关键词： Spiro[dibenzo[a i]xanthene-14 3'-indoline] β-Naphthol 2-Hydroxy-1 4-naphoquinone H_4SiW_(12)O_(40) Solvent-free

Epstein–Barr-virus-associated hepatitis with aplastic anemia: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8242-8248页

作者： Wan-Jun Zhang li-qiang wu Jun Wang Sheng-Yun lin Bo Wang Department of Hematology The First Affiliated HospitalZhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Hepatitis-associated aplastic anemia(HAAA) is a rare condition. Patients with HAAA usually present with acute hepatitis, jaundice and significantly increased transaminase. After 1–2 mo, hepatitis gradually improves, but progressive hemocytopenia, bone marrow hematopoietic failure, and severe or extremely severe aplastic anemia are manifest. Most cases of HAAA are fulminant and usually lethal if left untreated. The literature on Epstein–Barr virus(EBV)-associated HAAA is *** SUMMARY We report a 30-year-old man who was admitted to our hospital because of pale yellow urine and skin with a simultaneous decrease in peripheral blood ternary cells. We made a diagnosis of EBV-associated HAAA. The treatment strategy for this patient included eltrombopag, an immunosuppressive regimen of rabbit antihuman thymocyte immunoglobulin, cyclosporine, and supportive care. The patient was discharged in normal physical condition after five months. A hemogram performed on follow-up revealed that he had achieved a complete *** Eltrombopag plus anti-thymocyte globubin and cyclosporine may be a therapeutic option for EBV-associated *** studies are warranted to confirm.

关键词： Epstein-Barr virus Hepatitis-associated aplastic anemia Immunosuppressive therapy Eltrombopag Case report

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by High-LET Radiation

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 149-150页

作者： Jin Xiaodong li qiang li Ping wu Qingfeng liu Xinguo Dai Zhongying

3 - 61 Test of a Ridge Filter with 4 cm SOBP in Heavy Ion Therapy Terminal at HIRFL-CSR

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IMP & HIRFL Annual Report 2010年第1期 159-160页

作者： liu Xinguo li qiang Jin Xiaodong wu Qingfeng Dai Zhongying

Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第7期16卷 580-585页

作者： Bo WANG Sheng-yun liN Ying-ying SHEN li-qiang wu Zhen-zhen CHEN Jing li Zhi CHEN Wen-bin QIAN Jian-ping JIANG Department of Hematology the First Affiliated Hospital Zhejiang Chinese Medical University Department of Hematology the First Affiliated Hospital School of Medicine Zhejiang University

To investigate the potential effects of pure total flavonoid compounds（PTFCs） from Citrus paradisi Macfadyen separately or combined with arsenic trioxide on the proliferation of human myeloid leukemia cells and the mechanisms underlying the action of PTFCs. The effects of PTFCs separately or combined with arsenic trioxide on the proliferation and apoptosis of leukemia cells were determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT）, fluorescence microscopy, and flow cytometry. Their effects on the expression levels of apoptosisrelated regulators were determined by Western blot assay. PTFCs combined with arsenic trioxide significantly inhibited the growth of Kasumi-1 cells, and apoptosis was confirmed by flow cytometry analysis. Hoechst 33258 staining showed more significant morphological changes and more apoptosis following the combined treatment. Western blots showed changes in the expression of genes for poly ADP-ribose polymerase（PARP）, caspase 3/9, and P65. The results indicated that PTFCs separately or combined with arsenic trioxide inhibited proliferation of leukemia cells in vitro and induced their apoptosis by modulating the expression of apoptosis-related regulator genes.

关键词： Pure total flavonoid compounds Human myeloid leukemia cells Growth inhibition Synergistic effect Apoptosis

集料几何学特性对PRMC抗压强度和损伤过程的影响

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工程力学 2024年第3期41卷 222-231页

作者：尹海鹏李有堂李武强黄华兰州理工大学机电工程学院甘肃兰州730050

集料几何学特性是影响颗粒复合材料力学性能的重要因素,也是实现复合材料性能精确设计的理论基础。以颗粒增强树脂基复合材料(particle-reinforced resin matrix composite,PRMC)为研究对象,采用PFC和3D MAX联合创建了精细的数字集料,... 详细信息

集料几何学特性是影响颗粒复合材料力学性能的重要因素,也是实现复合材料性能精确设计的理论基础。以颗粒增强树脂基复合材料(particle-reinforced resin matrix composite,PRMC)为研究对象,采用PFC和3D MAX联合创建了精细的数字集料,分析集料综合几何学特性对PRMC动态损伤特性的影响,进一步细化并分离出集料单一几何学特征,通过分级替换不同粒径的圆形集料研究集料单一几何学特性对PRMC力学特性的影响。研究结果表明:集料几何学特性影响原始微损伤的分布,引导裂纹的扩展并最终决定PRMC的压缩破坏模式,并且压缩破坏过程存在典型的随机损伤特性;集料的形状、棱角和纹理通过降低集料间的流动性提高PRMC的抗压强度,而集料骨架系统需要在分形维数、级配级数、最大粒径和最大最小粒径比之间寻求最佳参数组合来提高PRMC的抗压强度。

关键词：集料几何学特性复合材料力学特性损伤抗压强度

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基于在线算法的季节性产品降价策略

系统工程理论与实践 2011年第11期31卷 2070-2076页

作者：李武强刘树林倪冠群西安交通大学管理学院西安710049

针对季节性产品销售时间有限,需求难以预测的特性,从在线策略与竞争分析的角度,为销售商设计了不同情形下的降价策略,并证明了所给策略具有最优竞争比;针对允许多次降价情形分析了降价次数与竞争比的关系,为制定可行降价次数提供了依据... 详细信息

针对季节性产品销售时间有限,需求难以预测的特性,从在线策略与竞争分析的角度,为销售商设计了不同情形下的降价策略,并证明了所给策略具有最优竞争比;针对允许多次降价情形分析了降价次数与竞争比的关系,为制定可行降价次数提供了依据.通过数值算例,验证了所给策略的可行性与有效性.

关键词：季节性产品在线算法竞争分析降价策略

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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基于等待成本差异的顾客密集型服务策略研究

管理工程学报 2019年第1期33卷 197-204页

作者：李武强倪冠群许晓晴长安大学经济与管理学院陕西西安710064 福建农林大学管理学院福建福州350002

在顾客密集型服务中,服务效果同服务速度成反比,服务效率的提高受到限制,等待难以避免。而等待成本往往是顾客考虑是否选择服务的重要因素,且因人而异,因此当服务商面对单位时间等待成本不同的顾客时,该如何制定服务速度与价格才能使得... 详细信息

在顾客密集型服务中,服务效果同服务速度成反比,服务效率的提高受到限制,等待难以避免。而等待成本往往是顾客考虑是否选择服务的重要因素,且因人而异,因此当服务商面对单位时间等待成本不同的顾客时,该如何制定服务速度与价格才能使得收益最大化?基于M/M/1排队系统针对服务商面对单位时间等待成本不同的两类顾客情景进行研究,根据队列均衡状态下顾客对于服务的选择情况提出了四种有效策略,通过对比分析发现:当顾客潜在到达速率较小时,以单位时间等待成本较高的顾客(H顾客)为基准制定服务策略最优;而当潜在到达速率较大时,则应该以单位时间等待成本较低的顾客为基准制定策略;且随着两类顾客等待成本差距的缩小,以H顾客为基准所制定策略的适用范围也相对扩大。

关键词：顾客密集型服务 M/M/1排队模型异质性顾客服务时间定价