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Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?

Biomedical and Environmental Sciences 2020年第12期33卷 916-924页

作者： DOU Hai Wei TIAN Xiu Jun XIN De li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao ping GE li Xia SHI Da Wei Beijing Tropical Medicine Research Institute Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Disease Capital Medical UniversityBeijing 100050China Qingdao Women and Children`s Hospital Qingdao 266000ShandongChina Department of Pediatrics Peking University Third HospitalBeijing 100191China Department of Pediatrics Civil Aviation General HospitalBeijing 100123China Department of Pediatrics Beijing Chao-yang HospitalCapital Medical UniversityBeijing 100043China Department of Pediatrics Emergency General Hospital(China Meitan General Hospital)Beijing 100028China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Department of Pediatrics Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric *** Real-time quantitative polymerase chain reaction(PCR)was used to identify ***,and MLVA was *** domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point *** also investigated the activities of antibiotics against *** isolates in *** The PCR detection rate of *** in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type *** other types were *** strains were resistant to levofloxacin or *** In 2016,a specific decrease in the macrolide resistance rate occurred in *** detection rate and macrolide resistance rate of outpatients are lower than those of *** A2063 G mutants *** have high levels of resistance to erythromycin and *** primary MLVA type is 4-5-7-2,followed by *** other MLVA types were *** strains resistant to tetracycline or levofloxacin were found in vitro.

关键词： Culture Macrolide resistance MLVA type Mycoplasma pneumoniae

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Defocus spot detection of astronomical optical system

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Research in Astronomy and Astrophysics 2020年第3期20卷 162-169页

作者： Tian-Zhu Hu Yong Zhang Xiang-Qun Cui Ye-ping li Hua Bai Xiu-Shan Pan National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Tech no logy.Chinese Academy of Science Nanjing 210042China Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyChinese Academy of SciencesNanjing 210042China University of the Chinese Academy of Sciences Beijing 100049China

Defocusing spot size detection is especially essential for aberration analysis and correction of optical systems. In the case of far defocusing, the celestial forms a pupil image on the detector, and the size of the image is linearly changed with the defocusing distance, and can be used to correct the optical system and analyze the image quality. Based on the focal plane attitude detection of Large Sky Area MultiObject Fiber Spectroscopy Telescope(LAMOST), this paper uses a variety of methods to detect the size of the defocusing spot of LAMOST telescope. For the particularity of the spot, the average value spacing algorithm, the peak value spacing algorithm, the ellipse fitting algorithm, and the multi-peak Gaussian fitting algorithm are used to detect the spot size. This paper will introduce these four methods, in which the average value spacing algorithm is proposed by the author of this paper. The advantages and disadvantages of the four methods are compared. The experimental results show that the average value spacing algorithm can achieve better accuracy of spot size detection in the four algorithms.

关键词： methods data analysis-techniques image processing-telescopes

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Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients

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World Journal of Gastroenterology 2017年第34期23卷 6321-6329页

作者： An-Jiang Wang A-ping Peng Bi-Min li Na Gan li Pei Xue-lian Zheng Jun-Bo Hong Hai-Ying Xiao Jia-Wei Zhong Xuan Zhu Department of Gastroenterology and Hepatology The First Affiliated Hospital of Nanchang University Department of Radiology The First Affiliated Hospital of Nanchang University Department of Pharmacy The First Affiliated Hospital of Nanchang University

AIM To explore the natural history of covert hepatic encephalopathy(CHE) in absence of medication *** Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and evaluated for CHE diagnosis. They were followed up for a mean of 11.2 ± 1.3 mo. Time to the first cirrhosis-related complications requiring hospitalization, including overt HE(OHE), resolution of CHE and death/transplantation, were compared between CHE and no-CHE patients. Predictors for complication(s) and death/transplantation were also *** A total of 366 patients(age: 47.2 ± 8.6 years, male: 73.0%) were enrolled. CHE was identified in 131 patients(35.8%). CHE patients had higher rates of death and incidence of complications requiring hospitalization, including OHE, compared to unimpaired patients. Moreover, 17.6% of CHE patients developed OHE, 42.0% suffered persistent CHE, and 19.8% of CHE spontaneously resolved. In CHE patients, serum albumin ping OHE, and blood creatinine > 133 μmol/L(HR = 4.75, P = 0.036) predicted mortality. Child-Pugh B/C(HR = 0.084, P linically stable cirrhosis. Triage of patients based on these predictors will allow for more cost-effect management of CHE.

关键词： Covert hepatic encephalopathy Overt hepatic encephalopathy Natural history liver cirrhosis

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Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial

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Stroke & Vascular Neurology 2016年第2期1卷 29-36页

作者： David Wang li Gui Yi Dong Hao li Shujuan li Huaguang Zheng Anxin Wang Xia Meng li-ping liu Yi-Long Wang Guangyao Wang Jing Jing Zixiao li Xing-Quan Zhao Yong-Jun Wang on behalf of the investigators for the CHANCE trial Illinois Neurological Institute Stroke Network Sisters of the Third Order of St.Francis Healthcare SystemUniversity of Illinois College of MedicinePeoriaIllinoisUSA Southwest Hospital Stroke Center Third Military University of Medical SciencesChongqingChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina China National Clinical Research Center for Neurological Diseases BeijingChina Chaoyang Hospital Neurology Department Capital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalTiantan Clinical Trial and Research Center for StrokeCapital Medical UniversityBeijingChina Neurological Intensive Care Unit Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalVascular NeurologyCapital Medical UniversityBeijingChina 不详

Aim:The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events(CHANCE)***:This was an ad hoc analysis of the CHANCE trial;data on all patients with any haemorrhagic event were reviewed and *** proportional hazards regression was used to determine factors association with any ***:In the CHANCE trial,there were a total of 101(2%)haemorrhagic events reported from 50 different *** clopidogrel–aspirin group had 60(2.3%)cases and the aspirin group had 41(1.6%,p=0.09).Moderate or severe haemorrhagic events occurred in 7 patients(0.3%)in the clopidogrel–aspirin group and in 8(0.3%)in the aspirin group(p=0.73).Of 36(0.7%)cases of intracranial haemorrhages,20(0.4%)were in the clopidogrel–aspirin group and 16(0.3%)in the aspirin *** group had 8(0.3%)cases of symptomatic haemorrhagic *** common haemorrhagic events included 24(0.5%)cases of skin bruises,13(0.3%)gastrointestinal haemorrhages,9(0.2%)gum haemorrhages and 8(0.2%)intraocular ***:There was no overall significant difference in haemorrhagic events(p=0.29),especially in the rate of intracranial haemorrhages between the 2 treatment ***,patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group,not seen in patients with high-risk transient ischaemic *** elderly,of male gender and with a history of aspirin or proton pump inhibitor usage were associated with increased risk of *** with higher body mass index had lower risk of haemorrhagic events.

关键词： patients intracranial analysis

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Comprehensive silk gland multi-omics comparison illuminates two alternative mechanisms in silkworm heterosis

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Zoological Research 2022年第4期43卷 585-596页

作者： Han Xu Lei Chen Xiao-ling Tong Hai Hu li-Yuan liu Gui-Chun liu Ya-Nan Zhu Ruo-ping Zhao Wen Wang Fang-Yin Dai Xin li Hui Xiang School of Medicine Shenzhen Campus of Sun Yat-Sen UniversityShenzhenGuangdong 518107China Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China School of Ecology and Environment Northwestern Polytechnical UniversityXi’anShaanxi 710072China State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest UniversityChongqing 400715China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Heterosis is a common phenomenon in plants and animals with diverse underlying ***,we applied two widely used silkworm hybrid systems and performed multi-omics analysis to identify possible intrinsic associations between different hybrid strategies and epigenetic mechanisms with silkworm *** found significant differences in the silk gland transcriptomic landscape between the two systems,including differentially expressed genes and expression patterns in the hybrid offspring compared to their *** the quaternary hybrid system,hybrid vigor was primarily due to upregulated genes and the parent-dominant upregulated expression pattern,involving multiple transport processes,cellular nitrogen compound catabolism,glucose metabolism,and tricarboxylic acid *** the binary system,hybrid vigor was mainly due to the down-regulated genes and transgressively down-regulated expression pattern,mainly involving basic nitrogen synthesis metabolism and body *** also demonstrated that DNA methylation may affect hybrid vigor by regulating the expression of several heterosis-related ***,this study revealed two alternative mechanisms that may contribute to silkworm heterosis,both of which facilitate the efficient utilization of energy and nitrogen for silk production.

关键词： Heterosis Silkworm Hybrid systems Multi-omics Silk production

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Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring

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Biomedical and Environmental Sciences 2022年第1期35卷 45-57页

作者： QIN Jia Bi LUO liu SUN Meng Ting HUANG Peng WANG Ting Ting ZHANG Sen Mao li Jin Qi li Yi Huan CHEN Le Tao DIAO Jing Yi ZHU ping Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510100GuangdongChina Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078HunanChina NHC Key Laboratory of Birth Defect for Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangsha 410008HunanChina Hunan Children's Hospital Changsha 410007HunanChina

Objective This study aimed to assess the associations between maternal drug use,cytochrome P450(CYP450)genetic polymorphisms,and their interactions with the risk of congenital heart defects(CHDs)in *** A case-control study involving 569 mothers of CHD cases and 652 controls was conducted from November 2017 to January *** After adjusting for potential confounding factors,the results show that mothers who used ovulatory drugs(adjusted odds ratio[a OR]=2.12;95% confidence interval[CI]:1.08-4.16),antidepressants(a OR=2.56;95%CI:1.36-4.82),antiabortifacients(a OR=1.55;95%CI:1.00-2.40),or traditional Chinese drugs(a OR=1.97;95%CI:1.26-3.09)during pregnancy were at a significantly higher risk of CHDs in *** CYP450 genetic polymorphisms at rs1065852(A/T vs.A/A:OR=1.53,95%CI:1.10-2.14;T/T vs.A/A:OR=1.57,95%CI:1.07-2.31)and rs16947(G/G vs.C/C:OR=3.41,95%CI:1.82-6.39)were also significantly associated with the risk of CHDs in ***,significant interactions were observed between the CYP450 genetic variants and drug use on the development of *** In those of Chinese descent,ovulatory drugs,antidepressants,antiabortifacients,and traditional Chinese medicines may be associated with the risk of CHDs in *** CYP450 genes may regulate the effects of maternal drug exposure on fetal heart development.

关键词： Congenital heart defect Maternal drug use Cytochrome P450 genes Case-control study

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Metal-mediated catalysis in the gas phase: A review

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Chinese Journal of Catalysis 2017年第9期38卷 1515-1527页

作者： Xiao‐Na li Xiu‐ping Zou Sheng‐Gui He Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510641 Guangdong China

This review summarizes a variety of experimentally identified gas‐phase catalytic cycles,all of which are mediated by atomic metal ions,bare metal clusters,metal oxide clusters or metal *** is placed on the latest advances in the unique catalytic reactivity of cluster‐confined single noble metal *** cycles discussed in this paper cover a wide range of inorganic and organic *** use of start‐of‐the‐art mass spectrometric instrumentation in conjunction with quantum chemistry calculations is also reported,as these techniques have determined the mechanistic details of the elementary steps of such catalytic *** important role of gas‐phase data in guiding the rational design of better‐performing catalysts in related condensed phase reactions is also *** particular,this review focuses on the following three topics:(1)the catalytic oxidation of carbon monoxide,(2)the catalytic functionalization of methane,and(3)catalytic decarboxylation.

关键词： Metal catalysis Clusters Single atom catalysts Carbon monoxide Methane

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Interventional Radionuclide Therapy of Hepatocellular Carcinoma： Assessment of Intratumoral Retention of HPMA Copolymers

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Chemical Research in Chinese Universities 2013年第1期29卷 183-188页

作者： YUAN Jian-chao MIAO Cheng-ping ZENG Xian-wu GUO Hong-yun WANG Xiao-qi liAO Shi-qi XIE Xiao-li Key Laboratory of Eco-environment-related Polymer Materials Ministry of Education Key Laboratory of Polymer Materials of Gansu Province College of Chemistry and Chemical Engineering Department of Nuclear Medicine Gansu Academy of Medical Sciences & Gansu Provincial Tumor Hospital Lanzhou 730050 P. R. China

To develop new radiopharmaceuticals for the interventional radionuclide therapy of recurrent hepatocellular carcinoma, poly（HPMA）-APMA-DTPA[HPMA=N-（2-hydroxypropyl） methacrylamide; APMA=N-（3-aminopropyl）methacrylamide; DTPA=diethylenetriaminepentaacetic acidl was synthesized by free radical precipitation polymerization in acetone/dimethylsulfoxide with N,N＇-azobis（isobutyronitrile） as the initiator. The copolymers were characterized with nuclear magnetic resonance（NMR） spectroscopy and gel permeation chromatography（GPC, Mn=2.2xl04, Mw/Mn=l.38）. Subsequently, poly（HPMA）-APMA-DTPA was conjugated with 99mTC radionuclide. Prolonged retention of poly（HPMA）-APMA-DTPA conjugate within the tumor tissues was demonstrated by single-photon emission computed tomography computed tomography（SPECT-CT） at 1, 2, 4 and 24 h following intra-tumoral injection of the conjugate to hepatocellular carcinoma xenografts in mice. DTPA-99mTc was also synthesized and characterized for comparison. The data suggest that the poly（HPMA）-APMA-DTPA conjugates might be useful for the interventional radionuclide therapy of recurrent hepatocellular carcinoma in humans.

关键词： Hepatocellular carcinoma Interventional radionuclide therapy HPMA copolymer Radiotracer

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2019 Chinese guideline for the management of hypertension in the elderly

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Journal of Geriatric Cardiology 2019年第2期16卷 67-99页

作者：无 Qi HUA li FAN Jun CAI Lu-Yuan CHEN Wei-Wei CHEN ping-Jin GAO Yi-Fang GUO Qing HE Jing li Nan-Fang li Wei-Min li Yue li Mei-lin liU Ning-ling SUN Wen WANG liang-Di XIE Jin-Gang YANG Hong YUAN Hypertension Branch of Chinese Geriatrics Society National Clinical Research Center of the Geriatric Diseases-Chinese Alliance of Geriatric Cardiovascular Disease Beijing Xuanwu Hospital Capi-tal Medical University Chinese PLA General Hospital 不详

Table of contents Preamble 1 Introduction 1.1 Class of recommendations and level of evidences 1.2 Definition and categories of hypertension in the elderly 1.3 Current status of epidemiology of hypertension in the elde... 详细信息

关键词： Class Definition categories

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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

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Neural Regeneration Research 2024年第9期19卷 2010-2018页

作者： Yan Wang Dai li Lan Zhang Zhenyu Yin Zhaoli Han Xintong Ge Meimei li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang Xiong Han Gao Qiang liu Fanglian Chen ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institute Tianjin Medical University General HospitalTianjinChina

We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain ***,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains *** this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of *** found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum ***,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured ***,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly *** findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum ***,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

关键词： apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-124-3p neuron repetitive mild traumatic brain injury X-box binding protein 1

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