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SmartMat 2022年第2期3卷 298-310页

作者： Sili Qing lin-lin Wang li-ping jiang Xiaoge Wu Jun-Jie Zhu State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina Environment Science and Engineering College Yangzhou UniversityYangzhouChina

Electrochemical oxygen reduced reaction(ORR)is a critical element in clean energy development.Despite efforts to enhance gas transfer to the reaction interface,the low solubility of O_(2)molecules and slow diffusion rate in liquid electrolyte is still a significant challenge.Herein,we design an artificial outer membrane on microalgal cells,which consists of a carbon dots/bilirubin oxidase(CDs/BOD)ORR catalyst layer and a L-cystine/Au nanoporous O_(2)supply layer.O_(2)generated by photosynthesis from microalgal cells then can be directly transported to the CDs/BOD catalytic interfaces,overcoming the sluggish gas transfer in the electrolyte.Thus,the cathode constructed by the fabricated microalgal cells realizes an ORR current density of 655.2μA/cm^(2) with fast ORR kinetics,which is 2.68 times higher than that of a BOD cathode fed with pure O_(2).A membrane-less glucose/O_(2)biofuel cell is further developed using the hybrid artificial cells as the cathode,and the power density is 2.39 times higher than that of a BOD cathode biofuel cell in O_(2)saturated solution.This biomimetic design supplies O_(2)directly to the carbon dots/BOD catalyst layer from the microalgae membrane through a nanoporous L-cys/Au layer,providing an alternative solution for the transfer barrier of O_(2)in the electrolyte.

关键词： biofuel cells carbon dots microalgal cells O_(2)supply in situ

Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis)

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Zoological Research 2017年第4期38卷 180-190页

作者： li-ping jiang Qiu-Shuo Shen Cui-ping Yang Yong-Bin Chen Key Laboratory of Animal Models and Human Disease Mechanisms Kunming Institute of Zoology Chinese Academy of Sciences Kunming College of life Science University of Chinese Academy of Sciences

Basal cell carcinoma （BCC） is the most common skin cancer worldwide, with incidence rates continuing to increase. Ultraviolet radiation is the major environmental risk factor and dysregulation of the Hedgehog （Hh） signaling pathway has been identified in most BCCs. The treatment of locally advanced and metastatic BBCs is still a challenge and requires a better animal model than the widely used rodents for drug development and testing. Chinese tree shrews （Tupaia belangeri chinensis） are closely related to primates, bearing many physiological and biochemical advantages over rodents for characterizing human diseases. Here, we successfully established a Chinese tree shrew BCC model by infecting tail skins with lentiviral SmoA1, an active form of Smoothened （Smo） used to constitutively activate the Hh signaling pathway. The pathological characteristics were verified by immunohistochemical analysis. Interestingly, BCC progress was greatly enhanced by the combined usage of lenUviral SmoA1 and shRNA targeting Chinese tree shrew p53. This work provides a useful animal model for further BCC studies and future

关键词： Chinese lree shrew Basal cell carcinoma Hedgehog

Effect of maxillary expansion on orthodontics

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Asian Pacific Journal of Tropical Medicine 2015年第11期8卷 922-928页

作者： Zhen Tang li-ping jiang Jian-Yong Wu Department of Orthodontics Affiliated Stomatological Hospital of Nanchang University

Objective:To explore the effect of maxillary expansion on orthodontics.Methods:Eight beagle dogs were randomly divided into two groups,with 4 dogs in each group.Dogs in group1 were executed immediately and received the direct physical measurement.The magnetic expansion appliance was used in group 2 for the maxillary expansion.After the expansion,the model was taken again and they were executed after cone beam CT(CBCT) scanning.The model measurement method was adopted in group 1 to measure the dental measurement indicators and width of base bone arch.The CBCT measurement method was employed to measure the above dental indicators and bone indicators.The difference in the indicators measured by different methods was compared and analyzed.Results:Before the expansion,there was no significant difference in the bone measurement indicators between the CBCT measurement method and direct physical measurement method.After the expansion,there was no significant difference in indicators between the CBCT measurement method and direct physical measurement.But there was significant difference among the model measurement method,CBCT measurement method and direct physical measurement method.There was the significant difference in the dental indicators between the CBCT measurement method and model measurement,as well as the bone indicators of posterior marginal spacing of greater palatine foramen,posterior marginal spacing of incisive foramen,width of base bone arch and spacing of implant anchorage.Conclusions:There is no significant difference between the effect of CBCT measurement method and direct physical measurement method,but CBCT is significantly better than the model measurement.

关键词： Maxillary expansion Magnetic expansion Orthodontic

Synthesis and characterization of acetylated sept-D-glucopyranose carbamate as an oligosaccharide donor

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Chinese Chemical Letters 2014年第1期25卷 134-136页

作者： Chang-Ming lian li-ping jiang Dong-liang liu Key Laboratory of Science & Technology of Eco-Textile Ministry of EducationCollege of ChemistryChemical Engineering & BiotechnologyDonghua University

An oligosaccharide donor, acetylated sept-o-glucopyranose tetradecyl carbamate, was designed and synthesized. This compound could be easily linked to hydroxyl-containing compounds through an Oglycosidic bond. Characte... 详细信息

关键词： Oligosaccharide donor Carbamate β-Cyelodextrin Acidic cleavage Characterization

The diagnostic value of high-frequency ultrasonography in biliary atresia

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Hepatobiliary & Pancreatic Diseases International 2013年第4期12卷 415-422页

作者： li-ping jiang Yun-Chao Chen Lu Ding Xiao-ling liu Kai-Yan li Dao-Zhong Huang Ai-Yun Zhou Qing-ping Zhang Department of Ultrasound Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Department of Ultrasound the First Affiliated Hospital of Nanchang University

BACKGROUND: It is a globally challenging problem to differentially diagnose biliary atresia (BA) from other disease processes causing infantile cholestatic jaundice. The high frequency ultrasonography (HUS) yields much improved spatial resolution and therefore, might show better image in BA diagnostic examination. The present study was to evaluate the HUS on the diagnosis of BA in infants with jaundice. METHODS: Fifty-one infants with neonatal jaundice were scanned with ultrasonography. Images included gallbladder, bile duct, right hepatic artery (RHA), portal vein (PV) and triangular cord (TC) sign, magnetic resonance imaging and additionally laboratory tests and histopathology reports were assessed. RESULTS: Twenty-three BA and 28 non-BA cases were con firmed. The sensitivity, specificity, and accuracy of HUS were 91.3%, 92.9%, and 92.2%, respectively. All of these indices were significantly higher than those of conventional ultrasonography (Plity in the differential diagnosis of infantile jaundice.

关键词： neonatal jaundice biliary atresia high-frequency ultrasonography

Preparation and Application of Polymerized High Internal Phase Emulsion Monoliths for the Preconcentration and Determination of Malachite Green and Leucomalachite Green in Water Samples

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Journal of Analysis and Testing 2020年第4期4卷 264-272页

作者： li-ping jiang Na li lin-Qi liu Xian Zheng Fu-You Du Gui-Hua Ruan Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin 541004China College of Biological and Environmental Engineering Changsha UniversityChangsha 410022China

Polymerized high internal phase emulsion(polyHIPE)monoliths were prepared and applied as adsorbent materials for solid-phase extraction(SPE)of malachite green(MG)and leucomalachite green(LMG)from water samples.The polyHIPE monoliths were prepared by post-functionalization of monolithic surface with 6-aminocaproic acid(ACA)via ring opening reaction of epoxy groups in glycidyl methacrylate(GMA)-based polyHIPEs,and then applied to the preconcentration and determination of trace MG and LMG in environmental water samples by combing with high-performance liquid chromatog-raphy(HPLC).Taking MG and LMG as targets,main factors affecting SPE performance of the polyHIPE monoliths were investigated.Under the optimized conditions,the ACA-functionalized polyHIPE monoliths could effectively preconcentrate MG and LMG from 150 mL of water samples,and the recoveries of MG and LMG at three spiked levels were ranged from 84.8 to 97.4%with the relative standard deviations(RSDs)lower than 6%.The proposed method exhibited good linearity in the range of 2-200 ng mL^(-1),with low limits of detection of 17.0 and 8.7 pg mL^(-1)for MG and LMG,respectively.In addi-tion,the prepared ACA-modified polyHIPE monolith showed good durability and stability,and it could be reused for 200 cycles without obvious losing the extraction performance.

关键词： High internal phase emulsion Solid-phase extraction High-performance liquid chromatography Malachite green Leucomalachite green

有志者事成抑或有力者事成——省级数字政府专项政策采纳的影响因素和路径

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内蒙古大学学报（哲学社会科学版） 2024年第3期56卷 37-48页

作者：黎江平冷雪忠南开大学周恩来政府管理学院天津300350

数字政府专项政策旨在为数字政府发展把舵定向,厘清其扩散动因有利于协调政府数字化转型全局。既有研究疏于考察政策出台环节,多采用线性统计分析方法,在解释因果关系复杂的政策扩散时不无局限性。基于“动机—能力”视角,采用模糊集定... 详细信息

数字政府专项政策旨在为数字政府发展把舵定向,厘清其扩散动因有利于协调政府数字化转型全局。既有研究疏于考察政策出台环节,多采用线性统计分析方法,在解释因果关系复杂的政策扩散时不无局限性。基于“动机—能力”视角,采用模糊集定性比较分析法探究省级数字政府专项政策采纳的影响因素及机制,可知,中央信号感知是数字政府专项政策较早采纳的必要条件,而公众需求、同侪竞争、社会舆论、数字治理能力、政策积累和财政资源则是边缘条件。根据条件配置差异,数字政府专项政策扩散的组态路径可进一步概括为“造势赶超”“更上层楼”“水到渠成”三种类型。相较“有力者事成”,“有志者事成”逻辑体现得更为突出。动机和能力条件的差序配置格局及政策积累的双向影响,丰富了中国政策扩散研究的场景与视角。

关键词：数字政府政策采纳 “动机—能力”框架模糊集定性比较分析

Ultrasonic flaw detection of discontinuous defects in magnesium alloy materials

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China Foundry 2019年第4期16卷 256-261页

作者： Sheng-nan Xue Qi-chi Le Yong-hui Jia li-ping jiang Zhi-qiang Zhang Lei Bao Key Lab of Electromagnetic Processing of Materials Ministry of Education Northeastern University

Phased array ultrasonic testing, an effective ultrasonic testing(UT) technology, has been widely used in steel inspection because of its high accuracy, sensitivity, and efficiency. However, as its application in as-cast magnesium alloys has just begun, more research is needed. Considering the important role of the gain compensation in quantifying defects in magnesium alloys by ultrasonic phased array technology, the effects of microstructure, the position, size, and overlap of defects, and boundary distance(distance from the defect position to the side surface of the test casting) on gain compensation of as-cast AZ80 and AZ31 magnesium alloys were studied. Results show the gain compensation increases with the increase of grain size. There is a strict linear positive correlation between gain compensation and defect depth, but such relationship no longer exists due to the defects overlap, orientation and boundary distance. In addition, there is a strict linear negative correlation between the gain compensation and defect size.

关键词： magnesium alloy ultrasonic phased array defect detection gain compensation

Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage

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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： Min Jun Wei Jiu Geng Feng Zhi Qun jiang Chun Hui Zeng li ping jiang Tao Hong Deparment of Neurosurgery the First Affiliated Hosptial Nanchang University Yong wai zheng Street 6 Nanchang Jiangxi Province 330006People's Republic of China Department of Pharmacology School of Pharmacy Nanchang University461 Bayi Avenue Nanchang Jiangxi Province 330006 People's Republic of China

Cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) is a serious and significant health problem in the worldwide. There are still no effective therapies for treatment of CVS in patients suffering from SAH. Our early studies have demonstrated that the expression of connexin43 (Cx43, a member of gap junctional proteins) in cerebral spastic vessel is significantly up-regulated, and knocking down Cx43 with specific siRNA interference can significantly alleviate CVS after SAH. Therefore, Cx43 in cerebral vessel is a potential target in the treatment of CVS. However, Cx43 is widely distributed in many organs, particularly in the heart, and plays an important role in the physiological function. This study is aimed at identify whether OPN, TNC or E-selectin can be used as a target protein to be recognized in spastic cerebral vessels, then we can produce a carrier containing Cx43 siRNA or other inhibitors as a new potential treatment for CVS. Twenty eight male Sprague Dawley rats (weighing 300–350 g) were randomly divided into either SAH (n = 16) or sham group (n = 12). The double hemorrhage model was performed on day 0 and 1. All animals were sacrificed after performing India ink angiography on day 5. Initially, the expression of E-selectin, TNC and OPN in cerebral arteries, thoracic aorta and abdominal aorta were analyzed respectively by immunohistochemical staining, western blot in both groups. Then, only those with less expression in thoracic aorta, abdominal aorta and normal cerebral arteries, but higher expression in cerebral spastic arteries were further detected in the spinal cord, heart, kidney, liver, spleen, lung, pancreas, mesenteric and pulmonary arteries, retina and brain tissue, respectively. TNC, OPN and E-selectin were markedly elevated in the spastic cerebral arteries in SAH group but not in control group. The expression of TNC, but not OPN and E-selectin, is abundant in both groups of thoracic aorta and abdominal aorta. Further study demonstrated that expression of OPN, but not E-selecting, in

关键词： Cerebral vasospasm Gap junctional Cx43 OPN E-selectin Targeting protein

Convergent genomic signatures of high-altitude adaptation among domestic mammals

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National Science Review 2020年第6期7卷 952-963页

作者： Dong-Dong Wu Cui-ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen li-ping jiang Yan li lin Zeng He-Qun liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming li Yang Dong Wen Wang Peng Shi Hai-Peng li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-ping Zhang Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratoryfor Conservation and Utilization of Bio-resource Yunnan University State Key Laboratory of Genetic Resources and Evolution Kunming Instituteof Zoology Chinese Academy of Sciences Key Laboratory of Animal Nutrition and Feed Science of Yunnan Province Yunnan Agricultural University Departmentof Animal Science Faculty of Agriculture Shahid Bahonar University of Kerman State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology ChineseAcademy of Sciences Department of Laboratory Medicine and Pathobiology University of Toronto Kunming College of life Science University ofChinese Academy o fSciences CAS Key Laboratory ofComputational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Kunming College of lifeScience University of Chinese Academy of Sciences State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences State Key Laboratory for Conservation and Utilization of Bio-resource Yunnan University Kunming College of life Science University ofChinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences &Yunnan Province KunmingInstitute of Zoology Chinese Academy of Sciences Kunming College of life Science University of Chinese Academy of Sciences Institute of Animal Science Chinese Academy of Agricultural Sciences Key Laboratory of AnimalNutrition and Feed Science of Yunnan Province Yunnan Agricultural University CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational BiologyShanghai Institutes for Biological Sciences Chinese Academy of Sciences Departmentof Pathology the Secon

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep,goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10 orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.

关键词： high altitude Tibetan Plateau genome convergent evolution domestic animals