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SGLT2 inhibitor monotherapy alleviates hyperglycemia in heredity severe insulin resistance syndrome

中华医学杂志(英文版) 2024年第11期137卷 1372-1374页

作者： Wu Huixuan Iqbal Junaid li Long Jiang Hongli Chao Chen Zhang Meibiao li ou Zhou Houde Department of Metabolism and Endocrinology National Clinical Research Center for Metabolic Diseases Hunan Provincial Key Laboratory for Metabolic Bone Diseases Key Laboratory of Diabetes Immunology Ministry of Education The Second Xiangya Hospital of Central South University Changsha Hunan China Department of Endocrinology and Metabolism The First People’s Hospital of Huaihua Huaihua Hunan China Department of Metabolism and Endocrinology San-Sui County Traditional Chinese Medicine Hospital Qiandongnan Miao and Dong Autonomous Prefecture Guizhou China

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Production of high-energy neutron beam from deuteron breakup

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Nuclear Science and Techniques 2022年第7期33卷 125-132页

作者： Ren-Sheng Wang li ou Zhi-Gang Xiao School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou215123China Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions Suzhou215123China College of Physics and Technology Guangxi Key Laboratory of Nuclear Physics and TechnologyGuangxi Normal UniversityGuilin541004China Department of Physics Tsinghua UniversityBeijing100084China

The deuteron breakup on heavy targets has been investigated in the framework of an improved quantum molecular dynamics model,focusing on the production of neutrons near zero degrees.The experimental differential cross sections of neutron production in the 102 MeV d+C reactions were reproduced by simulations.Based on the consistency between the model prediction and experiment,the feasibility of producing a neutron beam through the breakup of deuteron on a carbon target was demonstrated.Because of the nucleon Fermi motion inside the deuteron,the energy spectrum of the inclusive neutron near 0°in the laboratory exhibits considerable energy broadening in the main peak,whereas the long tail on the low-energy side is suppressed.By coincidentally measuring the accompanying deuteron breakup proton,the energy of the neutron can be tagged with an intrinsic uncertainty of approximately 5%(1σ).The tagging efficiency of the accompanying proton on the forward-emitted neutron can reach 90%,which ensures that the differential cross section in the(d,np)channel remains two orders higher than that in(p,n)after considering the measurement of accompanying protons.This enables the application of a well-defined energy neutron beam in an event-by-event scheme.

关键词： Deuteron breakup Monochromatic neutron High energy Quantum molecular dynamics

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Efficacy and safety of Yiqi Peiyuan granules for improving the short-term prognosis of patients with acute kidney injury:A multicenter,double-blind,placebo-controlled,randomized trial

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Journal of Integrative Medicine 2024年第3期22卷 279-285页

作者： Jia-jia Wu Tian-yi Zhang Ying-hui Qi Min-yan Zhu Yan Fang Chao-jun Qi li-ou Cao Ji-fang Lu Bo-han Lu Lu-min Tang Jian-xiao Shen Shan Mou Department of Nephrology Molecular Cell Lab for Kidney DiseaseShanghai Peritoneal Dialysis Research CenterUremia Diagnosis and Treatment CenterRenji Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200127China Department of Nephrology Shanghai Pudong New Area Punan HospitalShanghai 200125China Department of Nephrology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

Background:Yiqi Peiyuan(YQPY)prescription,a composite prescription of traditional Chinese medicine,has been used to prevent or delay the continued deterioration of renal function after acute kidney injury(AKI)in some institutions and has shown considerable efficacy.Objective:This is the first randomized controlled trial to assess efficacy and safety of YQPY for improving short-term prognosis in adult patients with AKI.Design,setting,participants and interventions:This is a prospective,double-blind,multicenter,randomized,and placebo-controlled clinical trial.A total of 144 enrolled participants were randomly allocated to two groups according to a randomization schedule.Participants,caregivers and investigators assessing the outcomes were blinded to group assignment.Patients in the YQPY group received 36 g YQPY granules twice a day for 28 days.Patients in the placebo group received a placebo in the same dose as the YQPY granules.Main outcome measures:The primary outcome was the change in the estimated glomerular filtration rate(eGFR)between baseline and after 4 and 24 weeks of treatment.The secondary outcomes were the change of serum creatinine(Scr)level between baseline and after treatment,and the incidence of endpoint events,defined as eGFR increasing by more than 25%above baseline,eGFR>75 mL/min per1.73 m2or the composite endpoint,which was defined as the sum of patients meeting either of the above criteria.Results:Data from a total of 114 patients(59 in the YQPY group and 55 in the control group)were analyzed.The mean changes in eGFR and Scr in weeks 4 and 24 had no difference between the two groups.In further subgroup analysis(22 in the YQPY group and 31 in the control group),the mean change in eGFR after treatment for 4 weeks was 27.39 mL/min per 1.73 m2in the YQPY group and 5.78 mL/min per1.73 m2in the placebo group,and the mean difference between groups was 21.61 mL/min per 1.73 m2(Poup and 5(16.1%)in the placebo group reached the composite endpoints(P=0.002).Du

关键词： Chinese herbal medicine Randomized controlled trial Acute kidney injury Renal function

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儿童心肌炎与基因多态性相关性研究进展

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中国实用儿科杂志 2024年第3期39卷 216-222页

作者：黎文静李小鸥何兵武汉大学人民医院儿科湖北武汉430060

心肌炎是由各种致病因素引起的心肌炎症性疾病,儿童心肌炎临床表现复杂多样,病情严重程度不一。由于心肌炎起病隐匿,尽早诊断、及时治疗对改善心肌炎预后尤为重要。基因多态性在儿童心肌炎发生发展中扮演重要角色。文章通过介绍柯萨奇-... 详细信息

心肌炎是由各种致病因素引起的心肌炎症性疾病,儿童心肌炎临床表现复杂多样,病情严重程度不一。由于心肌炎起病隐匿,尽早诊断、及时治疗对改善心肌炎预后尤为重要。基因多态性在儿童心肌炎发生发展中扮演重要角色。文章通过介绍柯萨奇-腺病毒受体、人类白细胞抗原、基质金属蛋白酶,诱导型一氧化氮合酶、白介素(IL)-17、维生素D受体、单核细胞趋化蛋白-1、非编码RNA等基因多态性与心肌炎相关性的研究进展,希望有助于深入理解儿童心肌炎发病机制,对易感人群做好筛查预防工作,并为儿童心肌炎的早期诊断及治疗提供新思路。

关键词：心肌炎儿童基因多态性

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Adaptive Spectr um Decision Method for Heterogeneous Cognitive Radio Networks

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China Communications 2012年第11期9卷 31-40页

作者： Sun Wujian liu Yang li Na li ou li Caiping Department of Communication Engineering Zhengzhou Information Science and Technology Institute Zhengzhou 450001 P. R. China Institute of North Electronic Equipment Beijing 100083 P. R. China Department of Computer Engineering Zhong Zhou University Zhengzhou 450054 P. R. China

To improve spectrum utilization and minimize interference to Primary User (PU), an adaptive spectrum decision method is proposed for Secondary User (SU), while taking traffic load balancing and spectrum heterogeneity into consideration. Long-term statistics and current sensing results are integrated into the proposed decision method of spectrum access. Two decision methods, namely probability based and sensing based, are presented, compared and followed by performance analysis in terms of delay. For probability based spectrum decision, Short-Time-Job-First (STJF) priority queuing discipline is employed to minimize average residual time and theoretical conclusion is derived in a novel way. For sensing based decision we treat the interrupted service of SU as newly incoming and re-decision process is initialized to find available spectrum in a First-Available-First-Access (FAFA) fashion. Effect of sensing error in PHY layer is also analyzed in terms of extended average residual time. Simulation results show that, for relatively low arriving rate of SU traffic, the proposed spectrum decision method yields at least a delay reduction of 39.5% compared with non-adaptive method. The proposed spectrum decision can significantly improve delay performance even facing sensing errors, which cause performance degeneration to both PU and SU.

关键词：自适应方法决策方法无线电网络光谱学频谱利用率 UM 异构检测结果

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地方财政压力能否提升城市商业银行贷款质量

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财政科学 2024年第1期97卷 62-73页

作者：谢欣魏彧李鸥浙江万里学院商学院贵州财经大学大数据应用与经济学院

本文基于手工收集的2010—2019年我国122个城市商业银行样本,从信贷供给侧角度研究地方财政压力是否有助于提升城市商业银行贷款质量。研究表明,地方财政压力与城市商业银行贷款质量呈现出显著的非线性关系;城市商业银行信贷投放与地方... 详细信息

本文基于手工收集的2010—2019年我国122个城市商业银行样本,从信贷供给侧角度研究地方财政压力是否有助于提升城市商业银行贷款质量。研究表明,地方财政压力与城市商业银行贷款质量呈现出显著的非线性关系;城市商业银行信贷投放与地方政府中长期发展规划一致度较高时,地方财政压力显著提升城市商业银行贷款质量。实证证据反映出地方财政压力下,政府对信贷资源配置影响具有前瞻性,引导信贷资源配置在具有较好发展前景的产业,更好发挥“有形之手”调控作用。因此,随着政府治理体系的完善,适度财政压力能够更好调动地方政府善治兴业积极性,促进城市商业银行贷款质量的提升,从而有利于金融系统稳定和地区经济高质量发展。

关键词：地方财政压力城市商业银行贷款质量政府干预

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A Dynamic Protocol Stack Structure for Diversified QoS Requirements in Ad Hoc Network

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China Communications 2016年第S1期13卷 43-53页

作者： DONG Fang li ou RAN Xiaomin JIN Feicai National Digital Switching System Engineering & Technological Research Center Zhongxing Telecommunication Equipment Corporation

A dynamic protocol stack(DPS) for ad hoc networks, together with a protocol stack construction scheme that is modeled as a multiconstrained knapsack problem is proposed. Compared to the traditional static protocol stack, DPS operates in a dynamic and adaptive manner and is scalable to network condition changes. In addition, a protocol construction algorithm is proposed to dynamically construct of the protocol stack each network node. Simulation results show that, the processing and forwarding performance of our scheme is close to 1 Gb/s, and the performance of our algorithm is close to that of the classical algorithms with much lower complexity.

关键词： ad hoc network QoS guarantee dynamic protocol stack protocol construction algorithm

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解淀粉芽孢杆菌SQ-2对水稻的促生作用

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生物技术通报 2024年第2期40卷 109-119页

作者：李雪李容欧孔美懿黄磊天津理工大学化学化工学院天津300384

【目的】对实验室分离筛选得到的一株解淀粉芽孢杆菌SQ-2进行促生特性研究,确定该菌株对水稻促生的浓度范围与作用机制,并分析接种菌株前后的土壤菌群结构。【方法】利用钼蓝比色法与固氮酶试剂盒对菌株SQ-2的溶磷能力及固氮酶活性进行... 详细信息

【目的】对实验室分离筛选得到的一株解淀粉芽孢杆菌SQ-2进行促生特性研究,确定该菌株对水稻促生的浓度范围与作用机制,并分析接种菌株前后的土壤菌群结构。【方法】利用钼蓝比色法与固氮酶试剂盒对菌株SQ-2的溶磷能力及固氮酶活性进行检测。将10^(2)、10^(4)、10^(6)、10^(8)和3×10^(8)CFU/mL的菌悬液接种至水培与土培水稻中,分别培养14 d和20 d后测定其水培、土培水稻的根茎干鲜重、茎长与茎粗。采用苯酚-次氯酸钠比色法、茚三酮检测法与3,5-二硝基水杨酸比色法测定土培水稻土壤中脲酶、蛋白酶与蔗糖酶的活性。利用pH计电位法检测土壤pH值,用对应试剂盒检测土壤速效氮磷钾含量及酸性磷酸酶活性,并对接种3×10^(8)CFU/mL组的土培水稻土壤进行根际细菌群落结构分析。【结果】菌株SQ-2对磷酸三钙的溶解量为229.63 mg/L,固氮酶活性为55.07 U/L。与对照相比,接种菌悬液浓度在10^(4)CFU/mL时,水培水稻根的干、鲜重增长最为显著;在接种浓度为3×10^(8)CFU/mL时,土培水稻根茎的干、鲜重增长最为显著。随着接种菌悬液浓度的升高,上述土壤酶活性与速效氮磷钾浓度都有着不同程度的增加,而接种菌株3×10^(8)CFU/mL的土壤pH值则由原来的7.83降至7.26。接种菌株SQ-2改变了水稻根际土壤中的菌落构成,显著提高了土壤α多样性的Ace、Chao、Sobs与Shannon指数。【结论】解淀粉芽孢杆菌SQ-2对土培、水培水稻均有不同程度的促生效果。在土培实验中,能够通过提高土壤酶活性、速效氮磷钾水平及改变土壤菌群结构来起到促生作用,为细菌菌肥的研发提供了新的菌株资源。

关键词：解淀粉芽孢杆菌促生溶磷固氮土壤酶活性根际细菌水稻细菌群落

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半导体量子计算芯片

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中国科学：信息科学 2024年第1期54卷 102-109页

作者：张建军李海欧郭国平中国科学院物理研究所北京100190 中国科学技术大学中国科学院量子信息重点实验室合肥230026 合肥国家实验室合肥230088

近年来,量子计算受到国内外越来越广泛的关注,美国、欧洲、日本和澳大利亚等国都投入了大量资金,量子计算应用研究成果开始涌现.在众多的量子计算物理系统中,半导体量子计算因具有与现有集成电路工艺兼容及可扩展、可集成的优点而备受重... 详细信息

近年来,量子计算受到国内外越来越广泛的关注,美国、欧洲、日本和澳大利亚等国都投入了大量资金,量子计算应用研究成果开始涌现.在众多的量子计算物理系统中,半导体量子计算因具有与现有集成电路工艺兼容及可扩展、可集成的优点而备受重视.本文在介绍国内外半导体量子计算研究进展的基础上,探讨半导体量子计算发展中面临的关键科学技术难题,以及未来半导体量子计算规模化、集成化、产线化的发展趋势.

关键词：硅锗量子点量子比特量子计算

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Electric field dependence of spin qubit in a Si-MOS quantum dot

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Chinese Physics B 2024年第6期33卷 248-253页

作者：马荣龙倪铭周雨晨孔真真王桂磊刘頔罗刚曹刚李海欧郭国平 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Origin Quantum Computing Company limited Hefei 230026China

Valley, the intrinsic feature of silicon, is an inescapable subject in silicon-based quantum computing. At the spin–valley hotspot, both Rabi frequency and state relaxation rate are significantly enhanced. With protection against charge noise, the valley degree of freedom is also conceived to encode a qubit to realize noise-resistant quantum computing.Here, based on the spin qubit composed of one or three electrons, we characterize the intrinsic properties of valley in an isotopically enriched silicon quantum dot(QD) device. For one-electron qubit, we measure two electric-dipole spin resonance(EDSR) signals which are attributed to partial occupation of two valley states. The resonance frequencies of two EDSR signals have opposite electric field dependences. Moreover, we characterize the electric field dependence of the upper valley state based on three-electron qubit experiments. The difference of electric field dependences of the two valleys is 52.02 MHz/V, which is beneficial for tuning qubit frequency to meet different experimental requirements. As an extension of electrical control spin qubits, the opposite electric field dependence is crucial for qubit addressability,individual single-qubit control and two-qubit gate approaches in scalable quantum computing.

关键词： silicon-based quantum computing valley electric-dipole spin resonance

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