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中文学术论文全文语步识别研究

数据分析与知识发现 2024年第2期8卷 74-83页

作者：杜新玉李宁北京信息科技大学计算机学院北京100101

【目的】针对学术论文语步识别相关研究存在只能处理少量的语步、语步识别粒度较粗、缺少公开的语步分类数据集等问题,研究学术论文的全文语步识别,为机器自动理解论文内容提供基础。【方法】基于BERT模型,采用多阶段微调的方式构建学... 详细信息

【目的】针对学术论文语步识别相关研究存在只能处理少量的语步、语步识别粒度较粗、缺少公开的语步分类数据集等问题,研究学术论文的全文语步识别,为机器自动理解论文内容提供基础。【方法】基于BERT模型,采用多阶段微调的方式构建学术论文语步分类数据集,并提出一种融入章节标题文本的语步识别方法,在细粒度层面实现中文学术论文全文语步的识别。【结果】实验结果表明,学术论文语步的22类别分类任务中,RoBERTa-wwm-ext模型总体准确率提升0.031,达到0.909,Micro-F1值提升0.022,达到0.837。【局限】所构建的学术论文语步分类数据集尚存在少量数据不平衡问题,所提方法受限于论文质量,这些问题得到改进后,模型对语步的识别能力应能得到进一步提高。【结论】所提方法取得了较高的语步识别准确率,研究成果可用于学术论文的自动理解、论文质量评价及论文语义检索等领域,对科技文献的有效利用具有重要作用。

关键词：学术论文理解语步识别预训练模型

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Exploration of the relationship between the astronomical calendar and the origins of Qi,Yin and Yang,and the Five Elements

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History & Philosophy of Medicine 2024年第3期6卷 16-22页

作者： Qian-Wen He ning li School of Basic Medical Sciences Yunnan University of Traditional Chinese MedicineKunming 650500China.

Background:Traditional Chinese medicine(TCM)as a traditional Chinese medical practice,has gradually evolved into a coherent and systematic medical science based on natural principles and applied to human beings over *** publication of the“Huangdi Neijing”(The Yellow Emperor’s Classic of Internal Medicine,Written between the Warring States period and the Qin and Han Dynasties,and finally compiled in the Western Han Dynasty,from 475 B.C.E.-8 C.E.)signified the establishment of a comprehensive theoretical framework for Chinese *** to the perspective of the‘correspondence between heaven and man’in TCM,the purpose of this paper is to explore the origin and development of the basic theories of TCM under the ancient astronomical view and the connection between the ***:This paper emphases on the universe uninty with the humanities,philosophy,and medicine,starting with the forms of stargazing in ancient Chinese astronomy and the natural laws derived by the ancients from their observations of natural celestial ***:Astronomy,arts and crafts,divination and medical correlations are based on the sequential changes of natural ***:The operation of natural celestial phenomena and the characteristics of physical phenomena correspond to human physiology,and the development of the basic theories of Chinese medicine is inextricably linked to ancient astronomy,ancient philosophy,and ancient primeval science.

关键词： basic theories of TCM ancient astronomical calendar Huangdi Neijing divination

Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis

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Chinese Journal of Natural Medicines 2024年第7期22卷 643-653页

作者： DANG Wen GUO Tingting ZHOU Di MENG Qingqi FANG Mingxia CHEN Gang liN Bin HOU Yue li ning School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China College of life and Health Sciences Northeastern UniversityShenyang 110004China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia *** primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against *** this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of *** compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).

关键词： Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity

Nanoparticle drug delivery system for the treatment of brain tumors:Breaching the blood–brain barrier

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2786-2789页

作者： Qiyu Tang Guo Zhao Hong Fang Yale Jiang Peiwen Ma Jiawei Zhoua Dongyan liu Shujun Xing Gaoquan li Nian liu Huiyu Chen Shuhang Wang ning li Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chongqing Upgra Biotechnology Co. Ltd.Chongqing 401331China

To the Editor:Malignant brain tumors represent a substantial morbidity and mortality burden globally,with 308,102 new cases and 251,329 cancer-related deaths in *** tumors encompass primary tumors originating in the brain and brain metastases(BM)that have been spread from cancer lesions of other ***,BM are the most prevalent intracranial malignant tumor affecting approximately 20%e40%of cancer patients2.

关键词： Nanoparticle Drug delivery system Blood-brain barrier Tumor Glioma

Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： ning li Yong Wang Chun li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong Ming-Yan Shao Bing-Hua Tang Dong-Qing Guo School of life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

中坚农民促进农业农村高质量发展:理论逻辑与实现路径

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现代经济探讨 2024年第1期 124-132页

作者：李宁南开大学周恩来政府管理学院天津300350 常熟理工学院马克思主义学院常熟215500

农业农村高质量发展是实现乡村全面振兴的重要基础。实践中,“自上而下资源输入”与“自外而内资本下乡”的外源驱动模式难以促进农业农村高质量发展,亟需依托中坚农民实现向内生发展模式的转换。中坚农民促进农业农村高质量发展具有组... 详细信息

农业农村高质量发展是实现乡村全面振兴的重要基础。实践中,“自上而下资源输入”与“自外而内资本下乡”的外源驱动模式难以促进农业农村高质量发展,亟需依托中坚农民实现向内生发展模式的转换。中坚农民促进农业农村高质量发展具有组织发展逻辑、资源对接逻辑与利益联结逻辑三重理论逻辑。具体来说,中坚农民以其个体性发展引领激活农业农村整体性发展、以其关键群体的引领性发展重塑农村公共性以及以其高质量发展能力强化小农利益联结的系统性能力。为此,中坚农民促进农业农村高质量发展需要以“自内而外、联结上下”的整合型道路为引领,构建中坚农民发展联合体,发挥中坚农民的发展与稳定功能以及塑造中坚农民利益整合联结机制。

关键词：中坚农民农业农村高质量发展外源驱动内生发展

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科研院所绩效评价及灵敏度分析研究

科学学研究 2024年第6期42卷 1234-1237页

作者：吕远李宁中国科学院办公厅北京100032 中国科学院合肥物质科学研究院安徽合肥230031

数据包络分析(data envelopment analysis, DEA)是一种评价具有相同类型决策单位相对效率的有效工具,广泛应用于能源、教育、供应链管理等领域。逆DEA方法基于DEA方法的效率评价结果,提供后续灵敏度分析及资源分配方案。以中国科学院下... 详细信息

数据包络分析(data envelopment analysis, DEA)是一种评价具有相同类型决策单位相对效率的有效工具,广泛应用于能源、教育、供应链管理等领域。逆DEA方法基于DEA方法的效率评价结果,提供后续灵敏度分析及资源分配方案。以中国科学院下属部分科研院所为评价对象,选取指标体系,利用DEA模型,从科研成果和人才培养两方面进行科研绩效综合评价。进一步,基于所得评价结果,利用逆DEA模型进行投入产出指标灵敏度分析和预测,为科研院所不同类型科技资源的分配提供量化辅助决策支持。

关键词：科研院所绩效评价数据包络分析逆DEA

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Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection

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Chinese Herbal Medicines 2024年第1期16卷 151-161页

作者： Xiajing Xu Yongli Guo Menglin Chen ning li Yi Sun Shumeng Ren Jiao Xiao Dongmei Wang Xiaoqiu liu Yingni Pan School of Chinese Materia Medica Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic ***: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular ***: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory ***: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin.

关键词： anti-hyperglycemic activity anti-oxidant flowers of Xanthoceras sorbifolia Bunge NADPH oxidase off-line UPLC-QTOF-MS/MS-free radical scavenging

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常规育种技术在园林植物资源开发中的应用

分子植物育种 2024年第10期22卷 3405-3410页

作者：李宁河南职业技术学院郑州450046

园林植物资源开发是生态环境建设和人类生活质量提升的重要组成部分。常规育种技术作为植物遗传改良的主要手段之一,在园林植物资源开发中发挥着关键作用。本研究从园林植物资源的重要性出发,概述了园林植物资源的多样性与应用价值,以... 详细信息

园林植物资源开发是生态环境建设和人类生活质量提升的重要组成部分。常规育种技术作为植物遗传改良的主要手段之一,在园林植物资源开发中发挥着关键作用。本研究从园林植物资源的重要性出发,概述了园林植物资源的多样性与应用价值,以及资源开发面临的挑战,详细探讨了常规育种技术的基本原理、方法和其在植物资源开发中的应用价值,重点讨论了常规育种技术在新品种培育、技术改良、品质提升以及抗性与适应性改进等方面的应用。本研究通过案例分析和实证研究,阐释了常规育种技术在不同园林植物资源开发中的成功案例和实际应用情况,展望了常规育种技术在园林植物资源开发中的前景,强调了技术创新的重要性,并提出了面临挑战的解决途径,旨在为园林植物资源的可持续利用和未来发展提供有益参考。

关键词：园林植物资源开发常规育种技术案例分析生态环境开发与利用