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Cardiology Discovery 2024年第1期4卷 5-14页

作者： Chinese Society of Cardiology,Chinese Medical Association Editorial Board of Chinese Journal of Cardiology muwei li Yabin Wang Yaling Han Yun Zhang Feng Cao 不详 Fuwai Central China Cardiovascular Hospital Chinese People’s liberation Army General Hospital General Hospital of Northern Theater Command Qilu Hospital of Shandong University

Microcirculatory dysfunction(CMD)typically occurs in patients with acute ST-segment elevation myocardial infarction during percutaneous coronary intervention,which is associated with more severe myocardial injury and a worse *** the advancement of intracoronary physiology and imaging technology,the prevention and therapeutic interventions of CMD have attracted more ***,relevant guidelines or consensus on CMD are lacking in *** current consensus summarizes the prevention and diagnostic strategies of emergency percutaneous coronary intervention-related CMD and gives suggestions to improve the prognosis of ST-segment elevation myocardial infarction patients based on evidence from recent clinical studies,guidelines,and consensus from international sources.

关键词： Myocardial infarction Microcirculation dysfunction Percutaneous coronary intervention

冠状动脉迂曲与室间隔肥厚型心肌病患者不良预后的相关性分析

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中华心血管病杂志 2024年第7期52卷 798-805页

作者：黄一李文涛张优王山林青李牧蔚朱中玉王宪沛高传玉郑州大学华中阜外医院、阜外华中心血管病医院心内科郑州450003 郑州大学人民医院心内科郑州450001 郑州大学华中阜外医院、河南省心血管流行病学研究中心郑州450003 郑州大学华中阜外医院、阜外华中心血管病医院放射科郑州450003

目的:探讨室间隔肥厚型心肌病(HCM)患者中冠状动脉(冠脉)迂曲的发生率及其与不良预后的相关性。方法:本研究为回顾性队列研究。选取2017年12月1日至2021年6月10日在阜外华中心血管病医院和郑州大学人民医院住院的室间隔HCM患者,根据性... 详细信息

目的:探讨室间隔肥厚型心肌病(HCM)患者中冠状动脉(冠脉)迂曲的发生率及其与不良预后的相关性。方法:本研究为回顾性队列研究。选取2017年12月1日至2021年6月10日在阜外华中心血管病医院和郑州大学人民医院住院的室间隔HCM患者,根据性别、年龄、有无高血压1∶1配对非HCM患者作为对照组。按照有无冠脉迂曲将室间隔HCM组分为冠脉迂曲组和非冠脉迂曲组。比较室间隔HCM组和对照组患者基线临床资料和冠脉造影结果,采用多因素logistic分析导致冠脉迂曲的危险因素。随访室间隔HCM患者至2022年7月1日,主要终点事件是恶性心律失常、缺血性卒中、全因死亡的复合终点,比较冠脉迂曲组和非冠脉迂曲组主要终点事件发病密度,采用Cox风险比例回归模型分析影响室间隔HCM患者终点事件的危险因素。结果:室间隔HCM组和对照组各156例患者,年龄均为(57.0±11.4)岁,两组女性各75例(48.1%)。室间隔HCM组冠脉迂曲发生率高于对照组(63.5%比36.5%, P<0.01),冠脉迂曲评分高于对照组( P<0.01)。多因素logistic回归分析结果显示室间隔HCM是导致冠脉迂曲的危险因素( OR=3.27,95% CI:2.02~5.29, P<0.01)。经过(2.5±1.2)年随访,室间隔HCM患者中,冠脉迂曲组主要终点事件发病密度高于非冠脉迂曲组( P=0.02),冠脉迂曲评分每升高1分增加室间隔HCM患者53%的主要终点事件风险( HR=1.53,95% CI:1.26~1.86, P<0.01)。结论:室间隔HCM患者易伴发冠脉迂曲,且程度更重;冠脉迂曲是室间隔HCM患者出现不良事件的危险因素。

关键词：肥厚型心肌病室间隔冠状动脉迂曲预后冠状动脉迂曲评分危险因素

血管内超声评估“L-sandwich”术式在冠状动脉真性分叉病变介入治疗中的疗效——一项概念验证性研究

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中国循环杂志 2024年第6期39卷 547-553页

作者：李牧蔚聂铭郭权张智文饶立新彭亮马曹阜外华中心血管病医院冠心病二病区郑州451464 河南大学人民医院冠心病二病区郑州450000

目的:探讨血管内超声(IVUS)评估“L-sandwich”术式在冠状动脉真性分叉病变介入治疗中的疗效。方法:将入选的99例冠状动脉真分叉病变(medina分型:1.1.1)患者分为“L-sandwich”术式组(n=38)、双支架术式组(n=32)和主支药物洗脱支架(DES... 详细信息

目的:探讨血管内超声(IVUS)评估“L-sandwich”术式在冠状动脉真性分叉病变介入治疗中的疗效。方法:将入选的99例冠状动脉真分叉病变(medina分型:1.1.1)患者分为“L-sandwich”术式组(n=38)、双支架术式组(n=32)和主支药物洗脱支架(DES)分支单纯药物涂层球囊(DCB)组(n=29)。所有患者术中及复查均使用IVUS评估。主要研究终点为随访12个月时的主支血管、分支血管口部及分支血管体部的晚期管腔面积丢失(LLAL),次要终点为12个月时各部位的最小管腔面积(MLA)以及主要不良心脏事件(MACE),MACE包括非致死性心肌梗死、心原性死亡和靶血管血运重建。本研究为概念验证性研究,统计分析在接受治疗(as-treated,AT)分析集中进行。结果:随访12个月时,“L-sandwich”术式组、双支架术式组和主支DES分支单纯DCB组患者主支血管的LLAL[(0.12±0.42)mm^(2)vs.(0.07±0.38)mm^(2)vs.(-0.01±0.31)mm^(2),P=0.419]、分支血管体部的LLAL[(-0.11±0.45)mm^(2)vs.(-0.10±0.28)mm^(2)vs.(0.24±1.04)mm^(2),P=0.078]差异均无统计学意义,分支血管开口LLAL双支架术式组最大,“L-sandwich”术式组最小[(-0.48±0.78)mm^(2)vs(.0.45±0.64)mm^(2)vs(.0.14±1.37)mm^(2),P<0.001];三组主支血管MLA相似[(8.39±1.65)mm^(2)vs.(8.28±0.98)mm^(2)vs.(8.02±1.37)mm^(2),P=0.565],分支血管开口MLA双支架术式组最大,主支DES分支单纯DCB组最小[(5.08±0.74)mm^(2)vs.(5.63±0.80)mm^(2)vs.(3.57±1.35)mm^(2),P<0.001],分支血管体部MLA“L-sandwich”术式组与双支架术式组类似,主支DES分支单纯DCB组最小[(5.94±0.72)mm^(2)vs.(5.86±0.59)mm^(2)vs.(3.74±1.07)mm^(2),P<0.001]。双支架术式组中2例患者行靶血管重建,其他组患者均无MACE发生(P=0.118)。结论:“L-sandwich”术式治疗冠状动脉真性分叉病变安全可行,随访12个月时比双支架术式分支血管开口LLAL更小,各部位MLA相似,且明显简化操作步骤。与分支单纯应用DCB相比具有更好的分支获益,同时也是分支单纯DCB出现严重夹层时的补救手术方式。

关键词：冠心病真性分叉病变血管内超声药物洗脱支架药物涂层球囊

The pyramid representation of the functional network using resting-state fMRI

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Psychoradiology 2022年第3期2卷 100-112页

作者： Zhipeng Yang Luying li Yaxi Peng Yuanyuan Qin muwei li College of Electronic Engineering Chengdu University of Information TechnologyChengduSichuan 610225China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430000China Vanderbilt University Institute of Imaging Science Vanderbilt UniversityNashvilleTN 37232USA

Background Resting-state functional magnetic resonance imaging(RS-fMRI)has been proved to be a useful tool to study the brain mechanism in the quest to probe the distinct pattern of inter-region interactions in the *** an important application of RSfMRI,the graph-based approach characterizes the brain as a complex ***,the network is susceptible to its scale that determines the trade-off between sensitivity and anatomical *** To balance sensitivity and anatomical variability,a pyramid representation of the functional network is proposed,which is composed of five individual networks reconstructed at multiple *** The pyramid representation of the functional network was applied to two groups of participants,including patients with Alzheimer’s disease(AD)and normal elderly(NC)individuals,as a *** were extracted from the multi-scale networks andwere evaluated with their inter-group differences between AD andNC,aswell as the discriminative power in recognizing ***,the proposed method was also validated by another dataset from people with *** The different features reflect the highest sensitivity to distinguish AD at different *** addition,the combined features have higher accuracy than any single scale-based *** findings highlight the potential use ofmulti-scale features asmarkers of the disrupted topological organization in AD *** We believe that multi-scale metrics could provide a more comprehensive characterization of the functional network and thus provide a promising solution for representing the underlying functional mechanism in the human brain on a multi-scale basis.

关键词： multi-scale functional network graph theory resting-state fMRI support vector machine Alzheimer’s disease

中性粒细胞/淋巴细胞比值与非瓣膜性心房颤动患者左心房血栓的相关性研究

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中国循证心血管医学杂志 2024年第1期16卷 39-44页

作者：张智文王雪莹郭权杨海涛李牧蔚郑州大学人民医院心内科河南省人民医院心脏中心阜外华中心血管病医院郑州450003 新乡医学院附属河南省人民医院郑州450003

目的探讨中性粒细胞/淋巴细胞比值(NLR)与非瓣膜性心房颤动(房颤)患者左心房血栓的相关性,以及使用NLR预测非瓣膜性房颤患者合并左心房血栓的临床价值。方法回顾性分析2012年1月至2018年1月于河南省人民医院接受经食道超声心动图(TEE)... 详细信息

目的探讨中性粒细胞/淋巴细胞比值(NLR)与非瓣膜性心房颤动(房颤)患者左心房血栓的相关性,以及使用NLR预测非瓣膜性房颤患者合并左心房血栓的临床价值。方法回顾性分析2012年1月至2018年1月于河南省人民医院接受经食道超声心动图(TEE)检查的387例非瓣膜性房颤患者的临床资料,根据TEE检查患者左心房是否存在血栓,将患者分为血栓组(n=46)和非血栓组(n=341)。比较两组患者之间的一般临床资料、实验室检查指标及超声心动图检查指标是否存在差异,采用单因素及多因素Logistic回归方程分析非瓣膜性房颤患者发生左心房血栓的相关危险因素,使用受试者工作特征(ROC)曲线及曲线下面积(AUC)评价NLR预测非瓣膜性房颤患者合并左心房血栓的临床价值。结果一般临床资料方面比较,血栓组患者年龄、房颤病程、非阵发性房颤比例、心力衰竭、卒中史和CHA2DS2-VASc评分均高于非血栓组,差异有统计学意义(P<0.05);实验室检查指标方面比较,血栓组中性粒细胞、NLR、C反应蛋白(CRP)和N末端脑钠肽前体(NT-proBNP)均高于非血栓组,而淋巴细胞低于非血栓组,差异均有统计学意义(P<0.05);超声心动图检查指标方面比较,血栓组左心房内径高于非血栓组,而左心室射血分数低于非血栓组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,非阵发性房颤、卒中史、高CHA2DS2-VASc评分、NLR升高、C反应蛋白升高、左心房内径增大是非瓣膜性房颤患者合并左心房血栓的独立危险因素(P<0.05),而左心室射血分数则是其独立保护因素(P<0.05)。ROC曲线结果显示,NLR预测非瓣膜性房颤患者合并左心房血栓的AUC为0.733(95%CI:0.686~0.776,P<0.001),NLR联合CHA2DS2-VASc评分的AUC为0.771(95%CI:0.726~0.812,P<0.001)。结论高NLR是非瓣膜性房颤患者合并左心房血栓的独立危险因素,使用CHA2DS2-VASc评分联合NLR预测非瓣膜性房颤患者合并左心房血栓的价值优于单独使用CHA2DS2-VASc评分。

关键词：心房颤动中性粒细胞/淋巴细胞比值左心房血栓

冠状动脉粥样硬化斑块逆转临床治疗策略的研究进展

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中国循证心血管医学杂志 2024年第6期16卷 757-760,765页

作者：于浩森史博意史青博赵振舟李牧蔚郑州大学华中阜外医院、河南省人民医院心脏中心郑州450000 郑州大学第一临床医学院郑州450000 国家心血管病中心华中分中心郑州450000

《中国心血管健康与疾病报告2022》指出,我国目前心血管病的发病率和死亡率仍在升高,是重大的公共卫生问题[1]。冠状动脉粥样硬化斑块引起的管腔狭窄或阻塞是冠状动脉粥样硬化性心脏病(冠心病)及主要不良心血管事件(MACE)发生的主要原因... 详细信息

《中国心血管健康与疾病报告2022》指出,我国目前心血管病的发病率和死亡率仍在升高,是重大的公共卫生问题[1]。冠状动脉粥样硬化斑块引起的管腔狭窄或阻塞是冠状动脉粥样硬化性心脏病(冠心病)及主要不良心血管事件(MACE)发生的主要原因,经皮冠状动脉介入治疗和冠状动脉旁路移植术等血运重建方法是其有效治疗方法,但同时也带来了一系列的术后并发症[2]。

关键词：冠状动脉粥样硬化斑块经皮冠状动脉介入治疗主要不良心血管事件冠状动脉旁路移植术血运重建健康与疾病心血管病公共卫生问题

Generalized Predictive Control of Time-Delay Nonlinear Systems Based on Extreme Learning Machine

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Generalized Predictive Control of Time-Delay Nonlinear Syste...

Wavelet Neural Network Prediction Algorithm Based on Improved Implicit Generalized Predictive Control

第30届中国控制与决策会议

作者： li muwei Zhou Ying Wu Qiang Nanjing University of Posts and Telecommunications College of Automation

For a class of nonlinear controlled objects with time-delay,this paper proposes a generalized predictive self-tuning control method based on extreme learning *** the generalized predictive self-tuning control（GPC）,the predictive model of the nonlinear controlled object is established by the extreme learning machine（ELM）,and constantly revising forecast output data to improve the accuracy of the *** controller adopts a GPC implicit correction algorithm,without to identify the model parameters,the calculated amount is greatly *** simulation shows that the method in this paper is superior and practical,the prediction output track the reference trajectory better than the commonly used PID self-tuning method.

关键词： nonlinear time-delay generalized predictive control extreme learning machine multi-step prediction

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Wavelet Neural Network Prediction Algorithm Based on Improve...

Changes in process and outcome for ST elevation myocardial infarction in central China from 2011 to 2018

第30届中国控制与决策会议

作者： Wu Qiang Zhou Ying li muwei Nanjing University of Posts and Telecommunications College of Automation

In this paper, the wavelet neural network（WNN） is used to predict the delay period, and combined with implicit generalized predictive control to delay compensation for the networked control system. The random delay in the networked control system（NCS） leads to the performance degradation of the system, in order to solve this problem, a wavelet neural network is used to establish the prediction model of the random delay in the NCS, and the algorithm is used to predict Delay period combined with implicit generalized predictive control algorithm to compensate for the NCS random delay. The simulation results show that the wavelet neural network algorithm has higher prediction accuracy for the random delay period, and at the same time makes the network system have good signal tracking ability and improves the control performance of the traditional generalized predictive control algorithm.

关键词： Networked control system Implicit generalized prediction algorithm Wavelet neural network Time delay compensation

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Chinese Medical Journal 2023年第18期136卷 2203-2209页

作者： You Zhang Shan Wang Datun Qi Xianpei Wang muwei li Zhongyu Zhu Qianqian Cheng Dayi Hu Chuanyu Gao Department of Cardiology Central China Fuwai Hospital of Zhengzhou UniversityHenan Provincial People’s Hospital Heart CenterZhengzhouHenan 451464China Henan Institute of Cardiovascular Epidemiology ZhengzhouHenan 451464China Henan Key Laboratory for Prevention and Control of Coronary Heart Disease Central China Fuwai HospitalZhengzhouHenan 451464China Institute of Cardiovascular Disease Peking University People’s HospitalBeijing 100044China

Background:limited data are available on the changes in the quality of care for ST elevation myocardial infarction(STEMI)during China’s health system reform from 2009 to *** study aimed to assess the changes in care processes and outcome for STEMI patients in Henan province of central China between 2011 and ***:We compared the data from the Henan STEMI survey conducted in 2011-2012(n=1548,a cross-sectional study)and the Henan STEMI registry in 2016-2018(n=4748,a multicenter,prospective observational study).Changes in care processes and in-hospital mortality were *** of care measures included reperfusion therapies,aspirin,P2Y12 antagonists,β-blockers,angiotensin-converting enzyme inhibitors or angiotensin receptor blockers,and *** use was analyzed among patients who were considered ideal candidates for ***:STEMI patients in 2016-2018 were younger(median age:63.1 vs.63.8 years)with a lower proportion of women(24.4%[1156/4748]vs.28.2%[437/1548])than in *** composite use rate for guideline-recommended treatments increased significantly from 2011 to 2018(60.9%[5424/8901]vs.82.7%[22,439/27,129],Plity significantly decreased over time(6.1%[95/1548]vs.4.2%[198/4748],odds ratio[OR]:0.67,95%confidence interval[CI]:0.50-0.88,P=0.005)after ***:Gradual implementation of the guideline-recommended treatments in STEMI patients from 2011 to 2018 has been associated with decreased in-hospital ***,gaps persist between clinical practice and guideline *** awareness,reperfusion strategies,and construction of chest pain centers need to be further unders

关键词： ST elevation myocardial infarction Management Healthcare Mortality

Carbon materials for enhanced photothermal conversion:Preparation and applications on steam generation

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Materials Reports(Energy) 2024年第2期4卷 34-44页

作者： Jiayi Zhu liu Huang Feng Bao Guanli Chen Kangjin Song Zheling Wang Hong Xia Jinping Gao Yibing Song Caizhen Zhu Fushen Lu Tingting Zheng muwei Ji College of Chemistry and Chemical Engineering Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou515063China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan528458China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen518060China Department of Pharmacy Shandong University of Traditional Chinese MedicineJinan250355China

Photothermal conversion attracted lots of attention in the past years and sorts of materials were explored to enhance photothermal *** the past years,solar-driven desalination by photothermal conversion was proposed to release the shortage of fresh water and then it was considered much more important to prepare photothermal materials on large scales with high performance and low *** this review,we summarized the works on carbon-based photothermal materials in the past years,including the preparation as well as their application in steam *** these works,we give an outlook on the difficulties and chances of how to design and prepare carbon-based photothermal materials.

关键词： Photothermal conversion Carbon Composites Solar energy Steam generation