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ARHGAP4 variants are associated with X-linked early-onset temporal lobe epilepsy

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World Journal of Pediatrics 2024年第8期20卷 859-867页

作者： yuan-yuan Hu Wang Song Zhi-Gang liu Xing-Guang ye Hong-Wei Zhang Xin li Jun-Xia Luo Peng-yu Wang Jie Wang Xiao-Fei lin Hong-li zhu Wei-Ping liao Bin li xu-Qin chen Department of Neurology Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityChang-gang-dong RoadGuangzhou510260China Epilepsy Center and Neurology Department of Children’s Hospital of Soochow university Suzhou215000JiangsuChina Department of pediatrics Foshan Women and Children HospitalFoshan528000China Children’s Hospital Affiliated to Shandong university Jinan250000ShandongChina Second Hospital of Shandong university Jinan250000China Huai’an Maternity&Child Healthcare Hospital Huai’an223001China Institute of Neuroscience of Guangzhou Medical university and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of china Chang-gang-dong Road 250Guangzhou510260GuangdongChina

The ARHGAP4 gene(OMIM*300,023),also known as Rho GTPase activating protein 4,encodes a protein that has an essential role in the regulation of small ***4 message RNA(mRNA)is highly expressed during the developing and adult nervous *** the protein level,ARHGAP4 is exclusively present in certain brain regions,such as the mesial temporal lobe,specifically the stratum lucidum of the CA3 region[1].ARHGAP4 enhances the GTPase activity of Rho proteins,which modulate morphological alterations in neuron development and synaptic plasticity by interacting with the actin cytoskeleton[2].

关键词： epilepsy alterations stratum

Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of Vehicles

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Engineering 2024年第2期33卷 178-189页

作者： Xiaoming yuan Jiahui chen Ning Zhang Qiang(John)ye Changle li Chunsheng zhu xuemin Sherman Shen qinhuangdao Branch Campus Northeastern UniversityQinhuangdao 066004China State Key Laboratory of Integrated Services Networks&the Research Institute of Smart Transportation Xidian UniversityXi’an 710071China Department of Electrical and Computer Engineering University of WindsorWindsorON N9B 3P4Canada Department of Electrical and Software Engineering University of CalgaryCalgaryAB T2N 1N4Canada SUSTech Institute of Future Networks Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada

High-efficiency and low-cost knowledge sharing can improve the decision-making ability of autonomous vehicles by mining knowledge from the Internet of Vehicles(IoVs).However,it is challenging to ensure high efficiency of local data learning models while preventing privacy leakage in a high mobility *** order to protect data privacy and improve data learning efficiency in knowledge sharing,we propose an asynchronous federated broad learning(FBL)framework that integrates broad learning(BL)into federated learning(FL).In FBL,we design a broad fully connected model(BFCM)as a local model for training client *** enhance the wireless channel quality for knowledge sharing and reduce the communication and computation cost of participating clients,we construct a joint resource allocation and reconfigurable intelligent surface(RIS)configuration optimization framework for *** problem is decoupled into two convex *** to improve the resource scheduling efficiency in FBL,a double Davidon–Fletcher–Powell(DDFP)algorithm is presented to solve the time slot allocation and RIS configuration *** on the results of resource scheduling,we design a reward-allocation algorithm based on federated incentive learning(FIL)in FBL to compensate clients for their *** simulation results show that the proposed FBL framework achieves better performance than the comparison models in terms of efficiency,accuracy,and cost for knowledge sharing in the IoV.

关键词： Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces Resource allocation

SAliRI-based(raltitrexed plus irinotecan)therapy as a second-line treatment for patients with metastatic colorectal cancer(SALLY):A prospective,multicenter,non-interventional,registry study

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Cancer Communications 2024年第8期44卷 910-914页

作者： Shuqui Qin Jin li Aiping Zhou Yanqiao Zhang Xianglin yuan liangjun zhu Baoli Qin Shan Zeng lin Shen Ying yuan Weibo Wang Jun liang Xianwen Zhang Feng ye Ping chen HuaizhangWang Zhenyan yu Lu yue Yong Fang Jianping Xiong Jianwei Yang Yiye Wan Xianli Yin Wenling Wang Nong xu XiaohongWang Zemin Xiao Huafang Su YingWang Kangsheng Gu Shuiping Tu Zishu Wang Bo liu Xiaohua Hu Weixian liu Xiaofeng li Department of Oncology Nanjing Tianyinshan HospitalNanjingJiangsuP.R.China Department of Medical Oncology Shanghai East HospitalShanghaiP.R.China Department of Medical Oncology Cancer Hospital Chinese Academy of Medical SciencesBeijingP.R.China Department of Gastroenterology Harbin Medical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Medical Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology Jiangsu Cancer HospitalNanjingJiangsuP.R.China Department of Gastroenterology Liaoning Cancer Hospital&InstituteShenyangLiaoningP.R.China Department of Oncology Xiangya HospitalCentral South UniversityChangshaHunanP.R.China Department of Medical Oncology Beijing Cancer HospitalBeijingP.R.China Department of Medical Oncology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Chemotherapy Shandong Provincial HospitalJinanShandongP.R.China Department of Medical Oncology Peking University International HospitalBeijingP.R.China Department of Medical Oncology Northern Jiangsu People’s HospitalYangzhouJiangsuP.R.China Department of Medical Oncology The First Affiliated Hospital of Xiamen UniversityXiamenFujianP.R.China Department of Medical Oncology General Hospital of NingxiaMedical UniversityYinchuanNingxiaP.R.China Department of Integrated Chinese andWestern Medicine Henan Cancer HospitalZhengzhouHenanP.R.China Department of Medical Oncology Mudanjiang Tumor HospitalMudanjiangHeilongjiangP.R.China Department of Oncology Qingdao Municipal Hospital(Group)QingdaoShandongP.R.China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiangP.R.China Department of Medical Oncology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxiP.R.China Department of Abdominal Oncology Fujian Cancer HospitalFuzhouFujianP.R.China Department of Gastroent

Primary chemotherapy options for colorectal cancer(CRC)involve four key drugs:fluorouracils(5-FU),oxaliplatin,irinotecan and *** first-line regimen consists of 5-FU and leucovorin combined with oxaliplatin(FOLFOX),while the second-line regimen involves 5-FU and leucovorin combined with irinotecan(FOLFIRI)for metastatic CRC(mCRC)in china[1].

关键词： drugs chemotherapy FOLFIRI

Multimodality management for chronic subdural hematoma in china: protocol and characteristics of an ambidirectional, nationwide, multicenter registry study

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中华神经外科杂志(英文) 2024年第02期10卷 124-133页

作者： liu Tao Zhao Zhihao Huang Jinhao zhu Xide chen Weiliang lin Kun yu yunhu li Zhanying Fan Yibing liu Mingqi Nie Meng liu xuanhui Gao Chuang Quan Wei Qian yu Wu chenrui yuan Jiangyuan Wu Di Lv Chuanxiang Dong Shiying Mi liang Tian yu Tian ye Zhang Jianning Jiang Rongcai Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Ministry of Education Tianjin Neurological Institute Key Laboratory of Post Neuro-injury Neuro-repair and Regeneration in Central Nervous System Tianjin Medical University General Hospital Tianjin China Department of Neurosurgery Linyi People’s Hospital Shandong China Department of Neurosurgery Haining People’s Hospital Zhejiang China Department of Neurosurgery Fujian Provincial Hospital Fujian China Department of Clinical Research Center for Neurological Disease the People’s Hospital of HongHuaGang District of ZunYi Guizhou China Department of Neurosurgery Kailuan General Hospital Hebei China Department of Neurosurgery Tianjin First Central Hospital Tianjin China Department of Neurosurgery The First Hospital of Jilin University Changchun China

Background Despite its prevalence, there is ongoing debate regarding the optimal management strategy for chronic subdural hematoma (CSDH), reflecting the variability in clinical presentation and treatment outcomes. This ambidirectional, nationwide, multicenter registry study aims to assess the efficacy and safety of multimodality treatment approaches for CSDH in the Chinese ***/design A multicenter cohort of CSDH patients from 59 participating hospitals in mainland china was enrolled in this study. The treatment modalities encompassed a range of options and baseline demographics, clinical characteristics, radiographic findings, and surgical techniques were documented. Clinical outcomes, including hematoma resolution, recurrence rates, neurological status, and complications, were assessed at regular intervals during treatment, 3 months, 6 months, 1 year, and 2 years *** Between March 2022 and August 2023, a comprehensive cohort comprising 2173 individuals who met the criterion was assembled across 59 participating clinical sites. Of those patients, 81.1% were male, exhibiting an average age of 70.12 ± 14.53 years. A historical record of trauma was documented in 48.0% of cases, while headache constituted the predominant clinical presentation in 58.1% of patients. The foremost surgical modality employed was the burr hole (61.3%), with conservative management accounting for 25.6% of cases. Notably, a favorable clinical prognosis was observed in 88.9% of CSDH patients at 3 months, and the recurrence rate was found to be 2.4%.Conclusion This registry study provides critical insights into the multimodality treatment of CSDH in china, offering a foundation for advancing clinical practices, optimizing patient management, and ultimately, improving the quality of life for individuals suffering from this challenging neurosurgical *** registration ChiCTR2200057179

关键词： Chronic subdural hematoma Multimodality therapy Outcome Recurrence

High-spin states and band structures in the odd-odd 140Pm nucleus

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High-spin states and band structures in the odd-odd 140Pm nu...

波棱瓜子自组装纳米粒的制备及其肠吸收机制研究

第十三届全国核结构研讨会暨第九次全国“核结构与量子力学”专题讨论会

作者： WANG Jian-Guo~1 zhu Sheng-Jiang~(1,*) Gu Long~1 Xiao Zhi-Gang~1 Yang yun-Yi~1 Zhang Ming~1 liu yu~1 Ding Hui-Bo~1 xu Qiang~1 zhu li-hua~2 Wu Xiao-Guang~2 chen Yong-Shou~2 He Chuang-ye~2 li Guang-Sheng~2 Wang lie-lin~2 Zheng yun~2 Zhang Biao~2 1(Department of Physics,Tsinghua university,Beijing 100084,People's Republic of china) 2(china Institute of Atomic Energy,Beijing 102113,People's Republic of china)

The light rare earth nuclei with A～140 are located at a transitional region with the neutron numbers approaching the N = 82 closed *** low spins,the single-particle motion will be *** high spins,the proton Fermi surface lies near the lower h midshell and the neutron Fermi surface lies near the h upper *** alignment of a pair of protons tends to drive the nucleus toward to a prolate shape（γ～0°） and the alignment of a pair of neutrons tends to drive the nucleus to oblate shape（γ～—60°）. In the N = 79 isotones,the high spin states have been investigated extensively in La,Ce,Pr and Nd .Many interesting collective bands were ***,contrasting to the neighboring nuclei,the information of high spin states in the Z = 61 isotone Pm is still lacking,and needs to be further investigated. Here we report on the re-investigation of the high-spin states of Pm.

关键词： High-spin state fusion-evaporation reaction oblate band

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中国中药杂志 2024年第12期49卷 3212-3219页

作者：朱煜文邓翔陈莉申宝德薛玉叶杭凌宇袁海龙江西中医药大学现代中药制剂教育部重点实验室江西南昌330004 空军军医大学空军特色医学中心药学部北京100142

该实验采用微沉淀法制备波棱瓜子自组装纳米粒(micro-precipitation self-assembled nanoparticles, MP-SAN),以平均粒径和多分散指数(polydispersity index, PDI)为评价指标进行工艺优化,并对最终工艺的粒径、PDI、Zeta电位和微观结构进行表征。通过大鼠在体单向肠灌流试验考察MP-SAN中去氢双松柏醇(dehydrodiconiferyl alcohol, DA)和波棱甲素(herpetrione, Her)的肠吸收机制。结果表明,优化的工艺参数为搅拌转速800 r·min^(-1),搅拌时间5 min,旋蒸温度40℃。所制得的MP-SAN呈现类球状结构且形态均匀,其平均粒径为(267.63±13.27)nm、PDI为0.062 0±0.043 9、Zeta电位为(-46.18±3.66)mV。DA在回肠段的吸收速率常数(K_(a))和表观吸收系数(P_(app))显著高于空肠段(P1)。P-糖蛋白抑制剂维拉帕米的加入并未显著影响DA和Her的肠吸收。而加入吲哚美辛后,MP-SAN中DA和Her的吸收均显著增加(P2的底物。

关键词：波棱瓜子肠吸收自组装纳米粒单向肠灌流汤剂

Effects of resistance training on bone loss in 8 weeks hindlimb unloading rats

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应用复合磷脂脂质体人工皮肤膜表征香附四物汤活性部位生物药剂学性质

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Zhi-li li~(1,2),cheng TAN~1,Hui-Juan WANG~1,Wen-Juan chen~1,ye DING~3,yu zhu~1,Hong-Lei MA~1,De-Sheng WANG~1,Shi-Zhong JIANG~1,Jun WANG~2,Hong-Hui YANG~1 1 State Key Laboratory of Space Medicine Fundamentals and Application,china Astronaut Research and Training Center,Beijing 100094,china 2 Fourth Military Medical university,Xi ''an 710032,Shaanxi,china 3 College of Veterinary Medicine,china Agricultural university,Beijing 100193,china

＜正＞Objective:The purpose of this research was to determine the effectiveness of resistance training in attenuating bone loss in hindlimb unloading rats undergoing a resistance training program for a period of 8 weeks. Methods:Forty male Wistar rats were divided randomly into four groups:an age-matched control group（C,n=10）, a hindlimb unloading group（HU,n=10）,a hindlimb unloading + stand group（HU+S,n=10）,and a hindlimb unloading + resistance-training group（HU+RT,n=10）.In HU+RT,10 rats were resistance trained for 8 *** resistance-training protocol was performed with 4 sets of 12 repetitions 5 days/week using 65%to 75%of one repetition maximum（maximum lifted weight） measured every 2 *** the end of 8 week resistance training, bone mineral density（BMD） and biomechanical properties of the femur were measured by Micro CT and three point bending test ***:Before the resistance training period,all the groups had similar repetition maximums However,at the end of the resistance training period,the repetition maximum in C and HU+RT was approximately 3-fold the body weight more than that in HU and HU+*** significant differences were observed for any of the bone parameters when comparing HU and HU+S rats.C and HU+RT rats had higher trabecular BMD than HU and HU+S *** Thickness（***） was greater in HU+RT than that in HU+***,no significant differences in BMD of cortical bone area were detected among all the groups in the femur *** maximal load and stiffness of the femur midshaft of rats in HU+RT were significantly higher than that in HU,while lower than that in ***:These results demonstrate that the resistance training can counter bone loss completely and mitigate the bone strength reduction caused by simulated weightlessness by hindlimb unloading.

关键词： resistance training hindlimb unloading bone mineral density

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中草药 2018年第5期49卷 1048-1055页

作者：马敏瞿叶清殳叶婷李钰朱学敏刘培顾薇徐飞陈军段金廒南京中医药大学药学院药物制剂研究室江苏南京210023 南京中医药大学江苏省中药资源产业化过程协同创新中心江苏南京210023 南京大学医学院附属鼓楼医院动物实验中心江苏南京210008

目的评价应用复合磷脂脂质体人工皮肤膜(CPLASM)测定参数表征香附四物汤(XSD)活性部位透皮吸收生物药剂学性质的可行性。方法建立HPLC方法同时测定XSD活性部位中活性成分(阿魏酸、四氢非洲防己碱、延胡索乙素、洋川芎内酯I、洋川芎内酯H... 详细信息

目的评价应用复合磷脂脂质体人工皮肤膜(CPLASM)测定参数表征香附四物汤(XSD)活性部位透皮吸收生物药剂学性质的可行性。方法建立HPLC方法同时测定XSD活性部位中活性成分(阿魏酸、四氢非洲防己碱、延胡索乙素、洋川芎内酯I、洋川芎内酯H)的质量分数并测定其油水分配系数。制备CPLASM,用其测定XSD活性部位的体外透皮吸收参数,并与猪耳皮测得的透皮吸收参数进行比较。结果 XSD活性部位(pH 5.5)中阿魏酸、四氢非洲防己碱、延胡索乙素、洋川芎内酯I、洋川芎内酯H的油水分配系数分别为1.220±0.280、0.670±0.085、0.920±0.110、1.040±0.092、1.030±0.093(n=3)。应用CPLASM和猪耳皮测得的各成分透皮吸收参数显著相关,相关系数均高于0.9。与经典的油水分配系数相比,5种活性成分透过CPLASM 6 h的累积透过率可以有效表征其透过猪耳皮的渗透系数。结论应用CPLASM测定中药活性成分体外透皮吸收参数能够有效表征中药活性部位的生物药剂学性质。

关键词：香附四物汤生物药剂学复合磷脂脂质体人工皮肤膜透皮吸收阿魏酸四氢非洲防己碱延胡索乙素洋川芎内酯I 洋川芎内酯H

非晶态SiO_2过渡层上高C轴取向liNbO_3薄膜的PLD生长

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四川大学学报（自然科学版） 2005年第S1期42卷 434-436页

作者：何军辉朱骏毛翔宇陈小兵叶志镇扬州大学物理科学与技术学院浙江大学硅材料国家重点实验室

利用脉冲激光沉积(PLD)技术在单晶硅衬底的非晶态Si O2过渡层上外延生长了具有优良结晶品质和高度c轴取向性的li NbO3光波导薄膜.利用X射线衍射、高分辨电镜和原子力显微镜等手段对li NbO3薄膜的结晶品质和c轴取向性等进行了系统的分析... 详细信息

利用脉冲激光沉积(PLD)技术在单晶硅衬底的非晶态Si O2过渡层上外延生长了具有优良结晶品质和高度c轴取向性的li NbO3光波导薄膜.利用X射线衍射、高分辨电镜和原子力显微镜等手段对li NbO3薄膜的结晶品质和c轴取向性等进行了系统的分析,确定了薄膜c轴外延生长的最佳沉积参数.非晶态Si O2过渡层上的li NbO3薄膜由尺度约为150×150nm的四方柱状c轴取向的单晶畴紧密排列而成,并且具有陡峭的界面结构.此外,对于li NbO3薄膜在非晶过渡层上择优取向生长的物理机制和薄膜基底效应进行了初步探讨,提出其生长机制很可能符合光滑晶面上三维岛状成核生长的Vol mer模式.

关键词： liNbO_3薄膜 c轴取向光波导 PLD技术硅基