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Cycloastragenol induces apoptosis and protective autophagy through AMPK/ULK1/mTOR axis in human non-small cell lung cancer cell lines

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Journal of Integrative Medicine 2024年第4期22卷 503-514页

作者： li-hua zhu Yu-pei liang lian Yang Feng zhu li-jun Jia He-gen li Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Cancer Institute of Traditional Chinese Medicine Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of Laboratory Medicine Huadong HospitalFudan UniversityShanghai 200237China

Objective:Studies have demonstrated that cycloastragenol induces antitumor effects in prostate,colorectal and gastric cancers;however,its efficacy for inhibiting the proliferation of lung cancer cells is largely *** study explores the efficacy of cycloastragenol for inhibiting non-small cell lung cancer(NSCLC)and elucidates the underlying molecular ***:The effects of cycloastragenol on lung cancer cell proliferation were assessed using an adenosine triphosphate monitoring system based on firefly luciferase and clonogenic formation ***-induced apoptosis in lung cancer cells was evaluated using dual staining flow cytometry with an annexin V-fluorescein isothiocyanate/propidium iodide *** elucidate the role of cycloastragenol in the induction of apoptosis,apoptosis-related proteins were examined using Western *** and Western blotting were used to determine whether cycloastragenol could induce autophagy in lung cancer *** techniques,including small interfering RNA technology,were used to investigate the underlying *** effects against lung cancer and biosafety of cycloastragenol were evaluated using a mouse subcutaneous tumor ***:Cycloastragenol triggered both autophagy and ***,cycloastragenol promoted apoptosis by facilitating the accumulation of phorbol-12-myristate-13-acetate-induced protein 1(NOXA),a critical apoptosis-related ***,cycloastragenol induced a protective autophagy response through modulation of the adenosine 5'-monophosphate-activated protein kinase(AMPK)/unc-51-like autophagy-activating kinase(ULK1)/mammalian target of rapamycin(mTOR)***:Our study sheds new light on the antitumor efficacy and mechanism of action of cycloastragenol in *** insight provides a scientific basis for exploring combination therapies that use cycloastragenol and inhibiting the AMPK/ULK1/mTOR pathway as a promising approach to

关键词： Non-small cell lung cancer Cycloastragenol Autophagy Apoptosis

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Carbon emission quantification and reduction in pavement use phase:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 69-91页

作者： linjie zhu Jin li Feipeng Xiao Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China

The carbon emissions arising from road pavement infrastructures have emerged as critical issue in recent *** life cycle of a pavement can be divided into five phases,namely raw materials and production,construction,use,maintenance and end of *** the use phase generates the highest carbon emissions throughout the pavement's life cycle,it is usually neglected in most pavement life cycle assessment(LCA)studies due to its complexity and ***,this review selected 126 relevant references,focuses on quantification methods,influential factors and reduction technologies of carbon emissions in pavement use *** the carbon accounting approached,the LCA approach,remains the most widely used for evaluating the environmental impact of ***,the primary influential factors on the use phase'carbon emission include pavement-vehicle interaction primarily affected by pavement roughness,pavement albedo and climate *** influential factors above indirectly cause changes in carbon emissions by influencing the pavement performance and subsequent vehicle ***,the review surveys carbon emission reduction technologies during pavement use phase,focusing mainly on reducing pavement rolling resistance and constructing cool *** pavements and permeable pavements are the most widely used cool pavement ***,the aspects involved in this paper hold significant promise for quantifying and reducing carbon emissions in the pavement use phase.

关键词： Pavement Carbon emission life cycle assessment Use phase Emission reduction

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Global practical stabilization of the double integrator system with an imperfect sensor and subject to a bounded disturbance

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Control Theory and Technology 2024年第3期22卷 468-478页

作者： Zhiyuan zhu Yuanlong li Zongli lin Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information Processing of Ministry of EducationShanghai 200240China Charles L.Brown Department of Electrical and Computer Engineering University of VirginiaP.0.Box 400743CharlottesvilleVA 22904-4743USA

This paper is concerned with global practical stabilization of the double integrator system with an imperfect sensor and subject to an additive bounded output *** imperfect sensor nonlinearity possesses the nonlinear characteristics of saturation and dead *** of the presence of output dead zone and the additive disturbance,the states cannot be expected to driven into an arbitrarily small neighborhood of the *** solve the global practical stabilization problem,we proposes a low gain-based linear dynamic output feedback law,under which the first state enters and remains in a bounded set whose size is depended on the bound of disturbance and the range of dead zone and the second state enters and remains in a pre-specified arbitrarily small set,both in finite *** results illustrate the effectiveness of our proposed control method.

关键词： Output saturation Disturbance rejection Output dead zone Low gain feedback-linear output feedback Practical stabilization

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Bifunctional electrolyte addition for longer life and higher capacity of aqueous zinc-ion hybrid supercapacitors

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Rare Metals 2024年第10期43卷 5060-5069页

作者： Fan Zhang Si-Qi li li-Nan Xia Chao Yang Lei li Kai-ming Wang Chen-liang Xu Yuan-Yuan Feng Bin Zhao Fei Shen Xiao-Gang Han ling-Yun zhu School of Electric Power Civil Engineering and ArchitectureShanxi University State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical EngineeringXi’an Jiaotong University Department of Science Materials and Engineering National University of Singapore School of Materials Science and Engineering Anhui University

Owing to uncontrolled and uneven electrodeposition and side reactions,Zn metal anodes inevitably suffer from issues such as dendrite growth,hydrogen evolution reactions,and surface *** paper proposes an efficient strategy to address these critical issues for realizing long-life and high-capacity aqueous zinc-ion hybrid supercapacitors （ZHSCs） by incorporating low-concentration (0.05 mol·L-1) redox RbI electrolyte ***,rubidium cations have the ability to influence the negative Zn electrode surface via an electrostatic shielding mechanism,effectively protecting the electrode and minimizing undesired side *** an aqueous solution,iodide anions actively solvate Zn2+ions by stabilizing and modulating the solvation shell surrounding Zn2+.Moreover,the presence of iodide ions promotes the uniform deposition of Zn2+species by selective adsorption onto the electrode *** synergistic effect of the electrostatic shielding and halogen ions enables the realization of aqueous symmetric Zn||Zn cells with a substantial cycle life of more than 2000 h Additionally,when applied to commercial activated carbon（AC）,the proposed strategy facilitates the development of aqueous ZHSCs,exhibiting high specific capacitances(148.8 F·g-1at 4 A·g-1) and ultra-long cycling stability.

关键词： Aqueous zinc-ion hybrid supercapacitor Rubidium iodide Synergistic effects of anions and cations Zn dendrite Zn metal anode

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For LEO Satellite Networks: Intelligent Interference Sensing and Signal Reconstruction Based on Blind Separation Technology

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China Communications 2024年第2期21卷 85-95页

作者： Chengjie li lidong zhu Zhen Zhang The Key Laboratory for Computer Systems of State Ethnic Affairs Commission School of Computer Science and Technology(Southwest Minzu University)Chengdu 610000China National Key Laboratory of Science and Technology on Communications(University of Electronic Science and Technology of China) Chengdu 610000China College of Computer Science(Sichuan University) Chengdu 610000China

In LEO satellite communication networks,the number of satellites has increased sharply, the relative velocity of satellites is very fast, then electronic signal aliasing occurs from time to time. Those aliasing signals make the receiving ability of the signal receiver worse, the signal processing ability weaker,and the anti-interference ability of the communication system lower. Aiming at the above problems, to save communication resources and improve communication efficiency, and considering the irregularity of interference signals, the underdetermined blind separation technology can effectively deal with the problem of interference sensing and signal reconstruction in this scenario. In order to improve the stability of source signal separation and the security of information transmission, a greedy optimization algorithm can be executed. At the same time, to improve network information transmission efficiency and prevent algorithms from getting trapped in local optima, delete low-energy points during each iteration process. Ultimately, simulation experiments validate that the algorithm presented in this paper enhances both the transmission efficiency of the network transmission system and the security of the communication system, achieving the process of interference sensing and signal reconstruction in the LEO satellite communication system.

关键词： blind source separation greedy optimization algorithm interference sensing LEO satellite communication networks signal reconstruction

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Electrochemical Cascade Annulation for the Synthesis of 3-Sulfanylquinoline Derivatives under Mild Conditions

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Chinese Journal of Chemistry 2024年第16期42卷 1833-1838页

作者： Ke li ming-Zhong Guo zhuo Chen Hao-Ran li Weisi Guo ming li lin-Bao Zhang State Key Laboratory Base of Eco-Chemical Engineering College of Chemistry and Molecular EngineeringQingdao University of Science&TechnologyQingdaoShandong 266042China

An efficient electrochemical approach has been developed for the construction of 3-sulfanylquinoline derivatives by treating phenylethynylbenzoxazinanones with disulfides in an undivided *** protocol provided a convenient route to functionalized quinolines with good functional group ***,it does not require any metal catalysts or additives,furnishing a series of biologicalquinolines inmoderatetogoodyields.

关键词： Electrocatalysis Electrooxidation Annulation 3-Sulfany quinoline C3-thioetherification

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Zokor activity promotes soil water infiltration in the Mu Us sandy land of northern Shaanxi,China

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Pedosphere 2024年第1期34卷 136-145页

作者： Miao GAN Xuchao zhu Xueqin YANG Xiaorong WEI Qingyin ZHANG Tongchuan li ming'an SHAO Meixia MI Xi YANG mingyu CHEN State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Henan Institute of Science and Technology Xinxiang 453003China College of Urban and Rural Construction Shanxi Agricultural UniversityJinzhong 030801China

Zokors are common subterranean rodents that inhabit agricultural fields, shrublands, and grasslands in the arid and semi-arid regions of China. Zokor burrowing activities can alter soil structure and affect soil hydrological processes;however, there are few studies regarding their effects on soil preferential flow in the Mu Us sandy land. An evaluation of the effects of zokor disturbance on their habitat and soil water is important for understanding the ecological role of zokors in the soil ecosystem of the Mu Us sandy land. A field dye-tracing experiment was conducted in the Gechougou watershed on the southeastern edge of the Mu Us sandy land to investigate the effect of zokor burrowing activity on soil preferential flow characteristics. Our results showed that the density of zokor tunnels was the highest(0.40–0.46 m m^(-2)) under 30%–50% vegetation coverage and that the tunnels were approximately 3 cm from the *** stained area ratio and stained path number were higher at sites with zokors than without zokors. Stained path widths were 10–80 and > 80 mm at zokor-harboring sites exhibiting homogeneous flow and heterogeneous finger flow, respectively. In the absence of zokors, homogeneous flow and highly interacted macropore flow were predominant. Soil water content below the zokor tunnels was higher than that above the tunnels. Moderate disturbance of soil structure by zokor activity facilitated soil water infiltration. These results enabled a better understanding of the effect of soil fauna on soil structure and hydrological processes and provided recommendations for ecological construction and renovation in arid and semi-arid regions.

关键词： eld dye-tracing experiment preferential flow soil fauna stained area ratio stained path number stained path width subterranean rodent surface tortoise crack

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A review of ultrafast laser micro/nano fabrication:Material processing,surface/interface controlling,and devices fabrication

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Nano Research 2024年第7期17卷 6212-6230页

作者： Heng Guo Jiawang Xie Guangzhi He Dezhi zhu ming Qiao Jianfeng Yan Jiachen Yu Jiaqun li Yuzhi Zhao Ma Luo Haoze Han State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Ultrafast laser processing technology has offered a wide range of opportunities in micro/nano fabrication and other fields such as nanotechnology,biotechnology,energy science,and photonics due to its controllable processing precision,diverse processing capabilities,and broad material *** processing abilities and applications of the ultrafast laser still need more *** the field of material processing,controlling the atomic scale structure in nanomaterials is *** effects exist in ultrafast laser surface/interface processing,making it difficult to modulate the nanostructure and properties of the surface/interface as *** the ultrafast laser fabrication of micro functional devices,the processing ability needs to be ***,we review the research progress of ultrafast laser micro/nano fabrication in the areas of material processing,surface/interface controlling,and micro functional devices *** useful ultrafast laser processing methods and applications in these areas are *** various processing effects and abilities,the ultrafast laser processing technology has demonstrated application values in multiple fields from science to industry.

关键词： ultrafast laser micro/nano fabrication material processing surface/interface controlling devices fabrication

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Evaluation of transmission risk of respiratory particles under different ventilation strategies in an elevator

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Building Simulation 2024年第5期17卷 771-784页

作者： liangyu zhu Xian li Bujin Feng Fan liu School of Civil Engineering and Architecture Linyi UniversityLinyi276000China College of Agriculture Shandong Agricultural UniversityTaian271018China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China

People in elevators are at risk of respiratory infection because the elevator cabin is crowded and has poor *** exhaled particles may be inhaled by the susceptible person,deposited on the surface and suspended in the elevator,which can result in direct and indirect ***,whether the air vent designs adopted in the elevator can effectively reduce the transmission risk of respiratory particles remains *** this study,the dispersion of particles under four common ventilation strategies used in the commercial elevator was investigated by proven computational fluid dynamics(CFD)*** flow field was simulated with the RNG κ-ξ turbulence model and the Lagrangian method was adopted to track particle *** effects of air vent layout and airflow rate on particle transmission were *** found that more than 50% of exhaled particles(average value)were suspended in the cabin and difficult to discharge under the investigated ventilation *** deposited fraction of particles on the susceptible person reached up to 39.14% for infiltration ventilation,which led to a high risk of contact *** the ventilation rate could not significantly reduce the inhalation proportion of particles due to the poor airflow distribution inside the elevator.A more proper ventilation strategy should be explored for the elevator to control transmission risk.

关键词： particle dispersion transmission risk elevator ventilation strategy computational fluid dynamics(CFD)

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Efficacy of Huoxue Qianyang Qutan Recipe on essential hypertension:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2024年第4期22卷 484-492页

作者： Jun Xie Yu-long Ma ming-tai Gui Lei Yao Jian-hua li ming-zhu Wang Xun-jie Zhou Yi-fan Wang ming-yi Zhao Hui Cao Bo Lu De-yu Fu Department of Cardiology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai University of Traditional Chinese Medicine Shanghai 200120China

Background:Hypertension,a prevalent disease,is a significant risk factor for coronary heart *** Qianyang Qutan Recipe (HQQR),a traditional Chinese herbal remedy,has been used for treating hypertension over several ***:This study assesses HQQR’s efficacy for controlling blood pressure among patients with hypertension related to blood stasis,yang hyperactivity and ***,setting,participants and interventions:A randomized controlled trial was conducted at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,China,from July 2020 to June *** components of HQQR were identified using thin-layer chromatography and high-performance liquid *** aged18–80 years,exhibiting traditional Chinese medicine syndromes of blood stasis,yang hyperactivity or phlegm,along with grades 1 or 2 hypertension,were randomly categorized into two *** intervention group was given HQQR granules alongside conventional hypertension treatment,while the control group was given placebo granules in addition to conventional treatment for 12 *** outcome measures:The primary outcome was clinic blood pressure,whereas secondary outcomes included metabolic indices (e.g.,homeostasis model assessment of insulin resistance[HOMA-IR],total cholesterol[TC],low-density lipoprotein cholesterol and triglyceride),target organ damage indices (left ventricular mass index and urinary albumin creatinine ratio[UACR]) and inflammation indices(interleukin-6[IL-6]and high-sensitivity C-reactive protein[hs-CRP]).Results:HQQR’s primary components were identified as salvianolic acid B,emodin and ferulic *** the 216 participants (108 in each group),compared to the control,the intervention group exhibited significant improvements (Plinic systolic blood pressure ([136.24±7.63]vs[130.06±8.50]mmHg),clinic diastolic blood pressure ([84.34±8.72]vs[80.46±6.05]mmHg),home systol

关键词： Huoxue Qianyang Qutan Recipe Hypertension Target organ damage Glycolipid metabolism Inflammatory Chinese herbal compound

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