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Melatonin mitigates cold-induced damage to pepper seedlings by promoting redox homeostasis and regulating antioxidant profiling

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Horticultural Plant Journal 2024年第2期10卷 532-544页

作者： Muhammad Ahsan Altaf Yuanyuan Hao Huangying Shu Weiheng Jin Chuhao Chen lin li Yu Zhang Muhammad Ali Mumtaz Huizhen Fu Shanhan Cheng Guopeng Zhu Zhiwei Wang Key Laboratory for Quality Regulation of Tropical Horticultural Crops of Hainan Province Sanya Nanfan Research InstituteHainan UniversitySanyaHainan 572025China Key Laboratory for Quality Regulation of Tropical Horticultural Crops of Hainan Province School of HorticultureHainan UniversityHaikouHainan 570228China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

This study assessed the influence of exogenous ME in the mitigation of cold damage in pepper seedlings. Melatonin(ME) is a dynamic molecule that helps plants cope with stress in several ways. Cold stress(CS) is one of the most important environmental factors that restrict plant growth and yield. Pepper(Capsicum annuum L.) is a valuable commercial crop, highly sensitive to CS. Thus, identifying an efficient strategy to mitigate cold damage is critical for long-term pepper production. For this purpose, the roots of pepper seedlings were pretreated with ME(5 μmol · L^(-1)) and exposed to CS for 7 d. The results indicated that CS suppressed pepper growth, hampered photosynthetic capacity, and damaged root architecture in pepper plants. In contrast, the production of reactive oxygen species(ROS), malondialdehyde(MDA), electrolyte leakage(EL), proline, and soluble sugars were enhanced in plants under CS. ME(5 μmol · L^(-1)) pretreatment reduced the negative effects of CS by recovering plant growth, root traits, gas exchange elements, and pigment molecules compared to CS control treatment. Furthermore, ME application efficiently reduced oxidative stress markers [hydrogen peroxide(H_(2)O_(2)), superoxide ion(O_(2)^(·-)), EL, and MDA] while increasing proline and soluble sugar content in pepper leaves. ME application combined with CS further increased antioxidant enzymes and related gene expression. Collectively, our results confirmed the mitigating potential of ME supplementation for CS by maintaining pepper seedling growth,improving the photosynthesis apparatus, regulating pigments, and osmolyte content.

关键词： Pepper Melatonin Cold stress Antioxidant enzyme Root trait

Industry Interaction,Structure Transformation and High-Quality Economic Development in China

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2023年第4期18卷 467-503页

作者： SONG Pei li lin BAI Xuejie School of Economics Nankai UniversityTianjin 300071China College of Economic and Social Development Nankai UniversityTianjin300071China Digital Economy Interdisciplinary Science Center Nankai UniversityTianjin 300071China

Industry interaction is becoming an important approach to promoting highquality economic development.In this paper,the multi-sector general equilibrium model is developed to clarify the theoretical mechanism among industry interaction,structure transformation,and high-quality economic development;the empirical tests are carried out based on the provincial panel data from 2000 to 2017;and the empowerment paths for digital technologies are explored to drive high-quality economic development.The findings are as follows.(1)The industry interaction can promote high-qualityy economic development in China on the whole,but it shows a significant imbalance and a healthy two-way promotion mode have not been formed.(2)The impact of industry interaction on high-quality economic development is significantly heterogeneous at the sector and regional levels.(3)The current unhealthy industry interaction may widen the productivity gap between manufacturing and service sectors,and transform China's economic into service-oriented structure,thus leading the economic development to a vicious circle of“low efficiency to low-end servitization and further to lower efficiency”and hindering the sustainability of high-quality economic development:.(4)Digitaltlechnologies can break the development dilemma and achieve high-quality economic development by alleviating structural contradictions,boosting healthy industry interaction,and narrowing the productivity gap among sectors.The conclusions provide empirical evidence for the government to promote the integration of advanced manufacturing and modern service sectors and achieve highquality economic development.

关键词： industry interaction industrial structure transformation high-quality economic development technological progress digital economy

Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang Ya-li lin Yin-yan Gao Jin-lu Song Lang Qin ling-qi li Wen-qi liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored yet.Objective:To investigate trial characteristics related to treatment effect estimates on CHM RCTs.Search strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July 2021.Inclusion criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one meta-analysis.Data extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included RCTs.They also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data analyses.The ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,respectively.Results:Ninety-one systematic reviews,comprising 1338 RCTs were identified.For binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect estimates.As for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30;95%CI:[0.18,0.43]),conducted at a single center

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

考虑基质吸力影响的非饱和路堤三维稳定性上限分析

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岩土力学 2024年第4期45卷 1014-1025页

作者：李林孙砖芹长安大学公路学院陕西西安710064

采用极限上限分析定理构建了路堤失稳的三维旋转破坏机构,继而根据Bishop非饱和土抗剪强度理论,考虑非饱路堤内部基质吸力的空间分布及其随地下水位的变化,建立了路堤破坏土体外力功率与内部能量耗散功率的能量守恒方程,并利用遗传算法... 详细信息

采用极限上限分析定理构建了路堤失稳的三维旋转破坏机构,继而根据Bishop非饱和土抗剪强度理论,考虑非饱路堤内部基质吸力的空间分布及其随地下水位的变化,建立了路堤破坏土体外力功率与内部能量耗散功率的能量守恒方程,并利用遗传算法编写了非饱和路堤最小上限解的高效搜索算法。通过将非饱和土路堤基底破坏模式退化为边坡破坏模式,并与现有非饱和土边坡稳定性计算结果对比,验证了所提上限解的正确性和遗传搜寻算法的准确性。进一步地,对路堤三维稳定性的关键影响因素展开了系统分析,研究了路堤填土孔径分布、基质吸力、进气值倒数、路堤倾角以及有效内摩擦角等因素对路堤三维稳定性的影响规律。研究表明,非饱和土质路堤的稳定性不仅取决于路堤填土性质,而且依赖于影响土体吸力大小与分布的填土孔径参数和进气值等因素。地下水位升降引起的基质吸力变化对路堤稳定性存在显著影响。研究结果为路堤稳定性精细化分析提供了重要的理论依据。

关键词：非饱和路堤基质吸力遗传算法三维稳定性上限分析

Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population: An integrated genomic and transcriptional analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 282-303页

作者： Yifei Wang Yidan Ma Lei He Jun Du Xiaoguang li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou li Yang Jing Di Changbin Zhu liming Xu Tianlin Sun lin li Dongge liu Zheng Wang Department of Pathology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Minimally Invasive Tumor Therapies Center Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Thoracic Surgery Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Oncology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Department of Respiratory and Critical Care Medicine Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Amoy Diagnostics Co. Ltd.

Objective: The clinical significance of homologous recombination deficiency(HRD) in breast cancer, ovarian cancer, and prostate cancer has been established, but the value of HRD in non-small cell lung cancer(NSCLC) has not been fully investigated. This study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical care.Methods: A total of 355 treatment-na?ve NSCLC patients were retrospectively enrolled. HRD status was assessed using the AmoyDx Genomic Scar Score(GSS), with a score of ≥50 considered HRD-positive. Genomic,transcriptomic, tumor microenvironmental characteristics and prognosis between HRD-positive and HRD-negative patients were analyzed.Results: Of the patients, 25.1%(89/355) were HRD-positive. Compared to HRD-negative patients, HRD-positive patients had more somatic pathogenic homologous recombination repair(HRR) mutations, higher tumor mutation burden(TMB)(Plifications in PI3K pathway and cell cycle genes, MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK) mutant NSCLC, and more PIK3CA and AURKA in EGFR/ALK wild-type NSCLC. HRD-positive NSCLC displayed higher tumor proliferation and immunosuppression activity.HRD-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-Ⅱ, interferon(IFN)-γ and effector memory CD8+ T cells. HRD-positive patients had a worse prognosis and shorter progression-free survival(PFS) to targeted therapy(first- and third-generation EGFR-TKIs)(P=0.042). Additionally, HRD-positive, EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy regimens.Conclusions: Unique genomic and transcriptional characteristics were found in HRD-positive NSCLC. Poor prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive NSCLC. This study highlights potential actionable alterations in HRD-posit

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

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早期儒家哲学中的教育隐喻探微

华东师范大学学报（教育科学版） 2024年第7期42卷 100-113页

作者：李林华东师范大学教育学系/基础教育改革与发展研究所上海200062

隐喻作为人类语言、认知、思维乃至“存在”中的重要议题,值得关注。基于汉字的独特表意系统,早期儒家以仁义为依归,以“成人”为宗旨,借助内发扩充和外铄转化诸种譬喻,殊途同归地辨析人接受教育而“作善”的可能性和必要性。儒家教育... 详细信息

隐喻作为人类语言、认知、思维乃至“存在”中的重要议题,值得关注。基于汉字的独特表意系统,早期儒家以仁义为依归,以“成人”为宗旨,借助内发扩充和外铄转化诸种譬喻,殊途同归地辨析人接受教育而“作善”的可能性和必要性。儒家教育隐喻中常用的玉、水、木及禾四类典型意象,皆具鲜明的自然属性及农耕特色,被借以讨论教育活动作用的对象及预期的理想。在过程层面,儒家借助诸如染色、熏香、品味、射箭,以及绳墨、规矩、影子、回声等隐喻,揭示教育的渐进、隐微、互动及规范等特征,同时呈现儒家教育重视具身经验、强调反身而诚的特征。儒家将“教-育”与“学-习”可能达至的趣妙境界、理想人格的完成以及良善秩序的实现,进行关联性的整体论述,乃至揭示教育这种世俗活动中所蕴含的“内在超越”可能。隐喻语言有其不足,却又普遍泛在。教育研究应当舍离以神秘或鄙弃态度对待隐喻,尝试超越客观主义和主观主义的二元对立,从经验主义的角度切入,审视教育隐喻的指称内涵、生发机理及运用效果,同时留意辨析其内在限度。

关键词：儒家哲学教育隐喻语言意味认知思维

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历史会通未来:试论未来素养的“历史之镜”

中国远程教育 2024年第6期44卷 62-71页

作者：李林华东师范大学教育学系华东师范大学基础教育改革与发展研究所上海200062

教育是需要同时兼顾文明传统、社会现实及未来发展的关键事业。其中,“未来”议题尤其是当前全球教育领域普遍关切、亟待推进的核心课题,联合国教育、科学及文化组织(United Nations Educational,Scientific and Cultural Organization,... 详细信息

教育是需要同时兼顾文明传统、社会现实及未来发展的关键事业。其中,“未来”议题尤其是当前全球教育领域普遍关切、亟待推进的核心课题,联合国教育、科学及文化组织(United Nations Educational,Scientific and Cultural Organization,UNESCO)倡行的“未来素养”理论架构和实践经验,为阐明该议题指明路向、贡献方案。未来素养内涵丰富,其中关联着重要的史学修养,具体表现为历史的知识与经验、视野与方法、责任与伦理、意识与意境,共同筑成未来素养的关键基底。历史会通未来的基本原理在于“时空相续”,在此种时空交织的场域之中,恰当地因人见事、察物明理,进而认清不变、以变应变,即是未来素养可以取资于“历史之镜”的要义所在。

关键词：未来素养 “历史之镜” 时空相续教育存在

户籍分割何以影响城市社区居民的志愿行为?——基于CSS2021调查数据的实证分析

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人口与发展 2024年第3期30卷 26-37页

作者：李霖中央民族大学管理学院北京100081

高速城镇化下的户籍分割现象改变了社会成员间的互动模式,深刻影响着城市社区居民的志愿行为。运用2021年中国社会状况综合调查数据,考察户籍分割的两重维度——户籍身份和户籍隔离对城市社区居民志愿行为的影响,以及户籍融合的中介作... 详细信息

高速城镇化下的户籍分割现象改变了社会成员间的互动模式,深刻影响着城市社区居民的志愿行为。运用2021年中国社会状况综合调查数据,考察户籍分割的两重维度——户籍身份和户籍隔离对城市社区居民志愿行为的影响,以及户籍融合的中介作用。研究发现,户籍分割更多通过户籍隔离而非户籍身份对居民志愿行为产生影响;作为户籍隔离衡量方式的异质性指数和孤立指数对志愿行为存在积极影响,分异性指数则产生了负向影响;孤立指数对志愿行为的影响会因个体户籍身份差异而产生变化;户籍融合的中介作用得到证实,其部分缓解了分异性指数对志愿行为的负向影响,也局部抵消了孤立指数对志愿行为的促进作用。

关键词：户籍分割居住隔离社区融合志愿行为

“歌仙”入雅部:蒋士铨《刘三妹》的文本生成与演史发现

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民族艺术 2024年第1期 106-114页

作者：李林广西艺术学院音乐学院

关于蒋士铨《雪中人·刘三妹》,以往关注多限于“首部《刘三姐》剧本”之头衔,对其文本来源及上演情况的认识相当有限。事实上,蒋氏《刘三妹》的文本有两个直接来源,一是屈大均《广东新语》,二是陆次云《峒溪纤志》。前者“刘三妹”条... 详细信息

关于蒋士铨《雪中人·刘三妹》,以往关注多限于“首部《刘三姐》剧本”之头衔,对其文本来源及上演情况的认识相当有限。事实上,蒋氏《刘三妹》的文本有两个直接来源,一是屈大均《广东新语》,二是陆次云《峒溪纤志》。前者“刘三妹”条经删繁就简,改编为该戏“报家门”片段;后者“声歌原始”条中10首粤地歌谣被全文收入,成为“蛮歌对唱”的创编素材。作为二者传抄原本的《粤风续九》,蒋氏从中直接受益的概率并不大。《菊部群英》和《梨园外史》中有关《雪中人》的史料,过去未得到应有重视。本文在剔除不实信息后对该剧演史概况做出描述,认为1870至1873年间的某个3月,《刘三妹》随全本《雪中人》在恭王府完成了首演。

关键词：蒋士铨《刘三妹》《粤风续九》蛮歌对唱上演概况