检索结果-南通市图书馆

Comparison of fondaparinux sodium and low molecular weight heparin in the treatment of hypercoagulability secondary to traumatic infection

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2015年第3期18卷 147-149页

作者： Baiqiang li Kang Wang Xin Zhao Chao lin Haichen Sun Department of General Surgery Jinling Hospital School of Medicine Nanjing University Nanjing 210002 China Department of Cardiothoracic Surgery Jinling Hospital School of Medicine Nanjing University Nanjing 210002 China Institute of Neurological Surgery Jinling Hospital School of Medicine Nanjing University Nanjing 210002 China

Purpose: To compare the effects and side-effects of fondaparinux sodium and low molecular weight heparin in patients with hypercoagulability accompanied with traumatic infection. Methods: Thirty-six patients with post-traumatic infections in our hospital intensive care center were diagnosed with hypercoagulability from February 2012 to February 2013. These patients were randomly divided into 2 groups. In group F (18 patients), the patients were treated with fondaparinux sodium, 2.5 mg, 1/d for 11 d. In group L (18 patients), the patients were treated with low molecular weight heparin, 4100 U, 1/12 h for 11 d. The incidence of deep vein thrombosis, bleeding events and multiple organ dysfunction syndrome (MODS) and mortality of two groups after anticoagulation therapy were analyzed. Fibrinogen, D-dimer level and activity of antithrombin III were measured by the coagulation analyzer. Results: The incidence of deep vein thrombosis, MODS incidence and mortality were not significantly different between the two groups. The rate of bleeding evens in group F was lower than group L ( p 0.05). D-dimer was significantly decreased after anticoagulant therapy for 5 d ( p 0.05). Conclusion: Fondaparinux sodium and low molecular weight heparin can effectively improve coagulopathy in patients with traumatic infection. Compared with low molecular weight heparin, fondaparinux sodium may reduce the risk of bleeding events in patients with hypercoagulability accompanied by traumatic infection.

关键词：低分子肝素肝素钠治疗状态继发感染外伤性抗凝血酶Ⅲ 纤维蛋白原

在线全文

学校读者我要写书评

暂无评论

统计能量分析方法及应用综述

振动与冲击 2021年第13期40卷 222-238页

作者：林天然李震青岛理工大学结构声与机械故障诊断实验室青岛266520

统计能量分析(statistical energy analysis,SEA)是一种处理复杂耦合系统高频动力学响应的常用计算方法。该综述从经典统计能量分析(classical statistical energy analysis,CSEA)入手,详细介绍CSEA演化为SEA的进展历程,并从理论发展和... 详细信息

统计能量分析(statistical energy analysis,SEA)是一种处理复杂耦合系统高频动力学响应的常用计算方法。该综述从经典统计能量分析(classical statistical energy analysis,CSEA)入手,详细介绍CSEA演化为SEA的进展历程,并从理论发展和实际工程应用过程两方面对前人所做的大量工作进行概述,对SEA提出至今的理论推导及应用最新进展进行了系统归纳分析和总结。详细介绍总结了统计能量分析在工程实际中的一些典型成功应用案例及未来研究趋势。

关键词：统计能量分析模态密度内损耗因子耦合损耗因子中高频声振响应

VOC emitted by biopharmaceutical industries:Source profiles,health risks,and secondary pollution

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第1期135卷 570-584页

作者： Jiawei Ma lin li State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China National Engineering Laboratory for VOCs Pollution Control Material&Technology University of Chinese Academy of SciencesBeijing 101408China

The biopharmaceutical industry contributes substantially to volatile organic compounds(VOCs)emissions,causing growing concerns and social developmental conflicts.This study conducted an on-site investigation of the process-based emission of VOCs from three biopharmaceutical enterprises.In the workshops of the three enterprises,26 VOCs were detected,which could be sorted into 4 classes:hydrocarbons,aromatic hydrocarbons,oxygen-containing compounds,and nitrogen-containing compounds.Ketones were the main components of waste gases,accounting for 44.13%-77.85%of the overall VOCs.Process-based source profiles were compiled for each process unit,with the fermentation and extraction units of tiamulin fumarate being the main source of VOC emissions.Dimethyl heptanone,vinyl acetate,diethylamine,propylene glycol methyl ether(PGME),and benzene were screened as priority pollutants through a fuzzy comprehensive evaluation system.Ground level concentration simulation results of the Gauss plume diffusion model demonstrated that the diffusivity of VOCs in the atmosphere was relatively high,indicating potential non-carcinogenic and carcinogenic risks 1.5-2 km downwind.Furthermore,the process-based formation potentials of ozone and secondary organic aerosols(SOAs)were determined and indicated that N-methyl-2-pyrrolidone,dimethyl heptanone,and PGME should be preferentially controlled to reduce the ozone formation potential,whereas the control of benzene and chlorobenzene should be prioritized to reduce the generation of SOAs.Our results provide a basis for understanding the characteristics of VOC emission by biopharmaceutical industries and their diffusion,potentially allowing the development of measures to reduce health risks and secondary pollution.

关键词： Biopharmaceutical Volatile organic compound Priority pollutant Exposure risk Secondary pollution

Resolution Enhancement in Ultrasonic TOFD Imaging by Combining Sparse Deconvolution and Synthetic Aperture Focusing Technique(Sparse-SAFT)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2022年第5期35卷 141-149页

作者： Xu Sun Li Lin Shijie Jin School of Materials Science and Engineering Dalian University of TechnologyDalianChina

The shallow subsurface defects are difficult to be identified and quantified by ultrasonic time-of-flight diffraction(TOFD)due to the low resolution induced by pulse width and beam spreading.In this paper,Sparse-SAFT is proposed to improve the time resolution and lateral resolution in TOFD imaging by combining sparse deconvolution and synthetic aperture focusing technique(SAFT).The mathematical model in the frequency domain is established based on the l1 and l2 norm constraints,and the optimization problem is solved for enhancing time resolution.On this basis,SAFT is employed to improve lateral resolution by delay-and-sum beamforming.The simulated and experimental results indicate that the lateral wave and tip-diffracted waves can be decoupled with Sparse-SAFT.The shallow subsurface defects with a height of 3.0 mm at the depth of 3.0 mm were detected quantitatively,and the relative measurement errors of flaw heights and depths were no more than 10.3%.Compared to conventional SAFT,the time resolution and lateral resolution are enhanced by 72.5 and 56%with Sparse-SAFT,respectively.Finally,the proposed method is also suitable for improving resolution to detect the defects beyond dead zone.

关键词： Time resolution Lateral resolution Time-of-flight diffraction(TOFD) Sparse deconvolution Synthetic aperture focusing technique(SAFT) Sparse-SAFT

Hybrid Organic-metal Oxide Transistors with High Operational Stability

在线全文

学校读者我要写书评

暂无评论

材料导报 2020年第8期34卷 1-2页

作者： Li Lin Shaanxi Institute of Flexible Electronics(SIFE)&Xi’an Key Laboratory of Biomedical Materials&Engineering Northwestern Polytechnical University(NPU)Xi’an 710072China

Fig.1(a)Schematic of hybrid organic-metal oxide multilayer channel transistors architecture;(b)cross-sectional high-resolution scanning transmission electron microscopy image for hybrid organic-metal oxide TFTs;(c)corresponding band structures Thin-film transistors(TFTs)made from metal oxides,which have useful properties,including high charge carrier mobility and optical transparency,have been widely used in recent years,particularly in organic light-emitting diode displays[1-3].Currently,most metal oxide TFTs are manufactured by physical vapor deposition techniques,but solution-based processing methods could be promising for simpler and more cost-effective strategy[4-5].So far,solution-processed metal oxide TFTs still face significant challenges in carrier mobility and operational stability[6-7].

关键词： transparency simpler sectional

Reduction of photodynamic damage of blood vessels in the protected region by(–)-epigallocatechin gallate

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2024年第3期17卷 93-104页

作者： Tianlong Chen Yi Shen Li Lin Huiyun lin Xuejiao Song Defu Chen Buhong li MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory of Photonics TechnologyFujian Normal UniversityFuzhou 350117P.R.China Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Technology UniversityNanjing 211800P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China

Photodynamic therapy(PDT)has been increasingly used in the clinical treatment of neoplastic,inflammatory and infectious skin diseases.However,the generation of reactive oxygen species(ROS)may induce undesired side effects in normal tissue surrounding the treatment lesion,which is a big challenge for the clinical application of PDT.To date,(–)-Epigallocatechin gallate(EGCG)has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative damage.This study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether(Hemoporfin)-mediated PDT.The quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be 6.8×10^(8)M^(−1)S^(−1),respectively.The vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel,suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with EGCG.This study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2,and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.

关键词： (–)-Epigallocatechin gallate(EGCG) photodynamic therapy hemopor¯n singlet oxygen blood vessel vasoconstriction.

Segmentation of the Ventricle Membranes in Short-Axis Sequences by Optical Flow Base on DLSRE Model

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2021年第3期30卷 460-470页

作者： Li Lin WU Hengfei li Junhua Department of Electronics and Information Engineering Bozhou University Key Laboratory of Jiangxi Province for Image Processing and Pattern Recognition Nanchang Hangkong University

Recent studies have pointed out that the boundary of the extracted ventricle membranes is unsmooth, and the segmentation of the cardiac papillary muscle and trabecular muscle do inconformity the clinical requirements. To address these issues, this paper proposes an automatic segment algorithm for continuously extracting ventricle membranes boundary, which adopts optical flow field information and sequential images information. The images are cropped by frame difference method, which according to the continuity of adjacent slices of cardiac MRI images. The roughly boundary of epicardium is extracted by the Double level set region evolution(DLSRE) model, which combines image global information, local information and edge information. The ventricle endocardium and epicardial contours are tracked according to the optical flow field information between image sequences. The segmentation results are optimized by Delaunay triangulation algorithm. The experimental results demonstrate that the proposed method can improve the accuracy of segmenting the ventricle endocardium and epicardium contours, and segment the contour of the smooth ventricle membrane edge that meets the clinical definition.

关键词： Optical, image and video signal processing Biomedical magnetic resonance imaging and spectroscopy Computer vision and image processing techniques Medical magnetic resonance imaging and spectroscopy Patient diagnostic methods and instrumentation Biology and medical computing Double-level set region evolution Optical flow Left ventricle Image segmentation

Experimental Study of Heat Transfer and Film Cooling Performance of Upstream Ejected Coolant on a Turbine Endwall

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2023年第2期32卷 718-728页

作者： ZHANG Jie liU Cunliang ZHANG li YAO Chunyi Li Lin School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China

An upstream coolant injection that is different from the known leakage flow was introduced to protect the turbine endwall.This coolant is ejected tangentially from a row of cylindrical holes situated at the side of a backward-facing step.In this experiment,the effects of mass flow ratio and leakage slot width on the endwall heat transfer characteristics were investigated.The dimensionless heat transfer coefficient(Nu)and adiabatic film cooling effectiveness(η)on an axisymmetric turbine endwall were measured by the stable-state thermochromic liquid crystal(TLC)technique and the pressure sensitive paint(PSP)technique,respectively.Three mass flow ratios(MFR)of 0.64%,0.85%,and 1.07%,as well as two leakage slot widths(W)of 3.93 mm,and 7.86 mm were considered.Results indicate that the injection film suppresses the strength of the passage vortex,which leads to the coolant covering almost the entire endwall.This result is more evident for the higher MFR cases,meanwhile,the corresponding averaged film cooling effectiveness is increased with the enhancement of the MFR.However,the case with a higher MFR produces a higher heat transfer coefficient distribution,especially in the region close to the leakage slot edge.Besides,when the W is lower,the endwall presents a higherηand a lower Nu for all the cases,which can guide the optimal design of the endwall.

关键词： axisymmetric turbine endwall film cooling effectiveness heat transfer coefficient coolant injection leakage slot

Internal light source for deep photodynamic therapy

在线全文

学校读者我要写书评

暂无评论

light(Science & Applications) 2022年第5期11卷 727-729页

作者： Buhong li Li Lin MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory for Photonics TechnologyFujian Normal UniversityFuzhou 350117China

Photodynamic therapy(PDT)for deep-seated lesion is seriously hindered by the limited depth of visible light penetration.Most recently,researchers have designed a genetically-encoded NanoLuc-miniSOG with internal light... 详细信息

关键词： Internal therapy source