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Soy Isoflavone and Its Effect to Regulate Hypothalamus and Peripheral Orexigenic Gene Expression in Ovariectomized Rats Fed on A High-Fat Diet

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Biomedical and Environmental Sciences 2010年第1期23卷 68-75页

作者： YUN-BO ZHANG YANG ZHANG li-na li XIN-YU ZHAO XIAO-liN na Department of Environmental Hygiene Department of Environmental Hygiene Toxicology Nutrition and Food Hygiene College of Public Health Harbin Medical University Harbin 150086 Heilongjiang China

Objective To explore the effect of soy isoflavone on obesity in the light of hypothalamus and peripheral orexigenic gene regulation. Methods Fifty-four female rats were randomly assigned to 6 groups： one sham-operated group （SHAM）, one ovariectomized （OVX） control group, three OVX groups fed with 400 ppm （L-SI）, 1 200 ppm （M-SI） and 3 600 ppm （H-SI） isoflavone respectively, and one OVX group receiving 0.45 ppm diethylstilbestrol （EC）. All rats were allowed to take high-fat diet for 4 weeks. Some neuropeptides were measured by RT-PCR. These neuropeptides included NPY, pro-opiomelanocortin （POMC）, cocaine and amphetamine regulated transcript （CART）, orexin, melanin-concentrating hormone （MCH）, ting hormone precursor （P-MCH）, ghrelin, and leptin. Results Compared with the OVX control group, the body weight and food intake in the H-S1 group were reduced significantly and there was a significant dose-dependent manner in the 3 isoflavone groups. The results of RT-PCR showed that the NPY level in the 3 isoflavone groups was significantly increased and the POMC/CART gene expression decreased significantly in rats＇ hypothalamus compared with that in the OVX control group. However, the expression of orexin, MCH and P-MCH had no change. The peripheral grelin mRna expression was higher in the 3 isoflavone groups, while leptin gene expression in the fat was not consistent. Conclusions This research showed that isoflavone could prevent obesity induced by high-fat diet and ovariectomy through regulating hypothalamus and peripheral orexigenic gene expressions associated with food intake.

关键词： Isoflavone Hypothalamus Orexigenic gene express Obesity

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Clinical characteristics and treatment of ovarian serous borderline tumors

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生殖医学杂志 2004年第z1期13卷 59-64页

作者： lian li-jian Guo li-na Peking Union Medical College Hospital Beijing 100730 China Peking Union Medical College Hospital Beijing 100730 China

Ovarian serous borderline tumors (SBTs) are characterized by good prognosis and occasional late recurrence. The 5-year and 10-year survival rates are all more than 90%. But traditionally patients with SBTs used to be treated with bilateral oophorectomy, hysterectomy and postoperative chemotherapy. A high proportion of SBTs occurred in young patients. The traditional treatment with complete excision of reproductive organs seemed to be too aggressive for young patients. It is imperative that conservative surgical procedures with fertility sparing should be employed to them. In this paper the literatures in regard to the final outcome of the conservative surgical therapy for SBTs were reviewed and the appropriate extent of conservative surgical procedures was discussed in detail.

关键词： Serous borderline tumors Ovarian tumors

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Application of Ship Maneuvering Simulator's Technology on Research of Vessels Automatic Anti-Collision

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航海教育研究 2007年第z1期24卷 15-21页

作者： li li-na YANG Shen-hua SUN Teng-da navigation College JiMei Univ. XiaMen 361021 China

In this paper, the authors make a summary of current situation of research on the Auto Anti-Collision, briefly introduce the components and functions of the NSACA Simulation Platform and bring forward the project to realize the simulation of an Automatic Anti-Collision control, based on the NSACA Simulation Platform. Finally give typical examples from a great deal of simulating tests and analyze them.

关键词： ship maneurering somulator's technology vessels automatic anti-collision

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Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection

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International Journal of Oral Science 2010年第2期2卷 66-73页

作者： li-na li li-hong Guo Renate Lux Randal Eckert Daniel Yarbrough Jian He Maxwell Anderson Wen-yuan Shi UCLA School of Dentistry University of Califomia Los Angeles USA UCLA Molecular Biology Institute University of Califomia Los Angeles USA Department of Oral Biology Peking University Dental School Beijing China C3 Jian Inc Inglewood USA

Aim Dental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans （S. mutans） can become predominant when host factors such as dietary sucrose intake imbalance the biofilm ecology. Current approaches to control S. mutans infection are not pathogen-specific and eliminate the entire oral community along with any protective benefits provided. Here, we tested the hypothesis that removal of S. mutans from the oral community through targeted antimicrobial therapy achieves protection against subsequent S. mutans colonization. Methodology Controlled amounts of S. mutans were mixed with S. mutans-free saliva, grown into biofilms and visualized by antibody staining and cfu quantization. Two specifically-targeted antimicrobial peptides （STAMPs） against S. mutans were tested for their ability to reduce S. mutans biofilm incorporation upon treatment of the inocula. The resulting biofilms were also evaluated for their ability to resist subsequent exogenous S. mutans colonization. Results S. mutans colonization was considerably reduced （9 ± 0.4 fold reduction, P=0.01） when the surface was preoccupied with saliva-derived biofilms. Furthermore, treatment with S. mutans-specific STAMPs yielded S. mutans-deficient biofilms with significant protection against further S. mutans colonization （5 minutes treatment： 38 ± 13 fold reduction P=0.01; 16 hours treatment： 96 ± 28 fold reduction P=0.07）. Conclusion S. mutans infection is reduced by the pre- sence of existing biofilms. Thus maintaining a healthy or ＂normal＂ biofilm through targeted antimicrobial therapy （such as the STAMPs） could represent an effective strategy for the treatment and prevention of S. mutans colonization in the oral cavity and caries progression.

关键词： targeted antimicrobial therapy antimicrobial peptide biofilm Streptococcus mutans protective colonization caries

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Human leukocyte antigen and donor-specific antibodies in liver transplantation

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World Journal of Gastroenterology 2025年第2期31卷 157-160页

作者： Qimudesiren Sha-na Chen li-Ren Qian School of Clinical Medicine Inner Mongolia Minzu UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Department of Hematology International Mongolian Hospital of Inner MongoliaHohhot 010065Inner Mongolia Autonomous RegionChina Senior Department of Hematology The Fifth Medical Center of PLA General HospitalBeijing 100071China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

In this article,we comment on an article published in a recent issue of the World Journal of *** specifically focus on the roles of human leukocyte antigen(HLA)and donor-specific antibodies(DSAs)in pediatric liver transpl-antation(LT),as well as the relationship between immune rejection after LT and ***,LT remains the standard of care for pediatric patients with end-stage liver disease or severe acute liver ***,acute and chronic re-jection continues to be a significant cause of graft dysfunction and *** mismatch significantly reduces graft survival and increases the risk of acute *** them,D→R one-way mismatch at three loci was significantly related to graft-versus-host disease incidence after *** adverse impact of HLA-DSAs on LT recipients is already ***,the evaluation of HLA and DSA is crucial in pediatric LT.

关键词： liver transplantation Human leukocyte antigen Donor-specific antibodies De novo donor-specific antibody Antibody-mediated rejection

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Phylogeny Constructed by Using Diversity Increment

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Wuhan University Journal of natural Sciences 2003年第S1期8卷 303-306页

作者： Shi Feng, li na-na, li Yuan-xiang, Zhou Huai-beiSchool of Mathematics and Statistics, Wuhan University, Wuhan 430072,Hubei,ChinaAdvanced Research Center for Science and Technology, Wuhan University, Wuhan 430072, Hubei,ChinaState Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072,Hubei,China Wuhan University School of Mathematics and Statistics Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University Advanced Research Center for Science and Technology Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University Advanced Research Center for Science and Technology Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***) Wuhan University State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

A new approach based on the concept of the diversity increment is applied to reconstruct a phylogeny. The phylogeny of the Eutherian orders use concatenated H-stran-ded amino acid sequences, and the result is consiste... 详细信息

关键词： diversity indicator phylogeny distance

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Antarctic ice sheet GliMMER model test and its simplified model on 2-dimensional ice flow

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Progress in natural Science:Materials International 2008年第2期18卷 173-180页

作者： Xueyuan Tang a,,Zhanhai Zhang a,Bo Sun a,Yuansheng li a,na li a,Bangbing Wang a,b,Xiangpei Zhang a,b a Polar Research Institute of China,Shanghai 200136,China b College of Geo-exploration Science and Technology,Jilin University,Changchun 130026,China Polar Research Institute of China Shanghai 200136 China College of Geo-exploration Science and Technology Jilin University Changchun 130026 China

The 3-dimensional finite difference thermodynamic coupled model on Antarctic ice sheet,GliMMER model,is described. An ide-alized ice sheet numerical test was conducted under the EISMINT-1 benchmark,and the characteristic curves of ice sheets under steady state were obtained. Based on this,this model was simplified from a 3-dimensional one to 2-dimensional one. Improvement of the dif-ference method and coordinate system was proposed. Evolution of the 2-dimensional ice flow was simulated under coupled temperature field conditions. The results showed that the characteristic curves deriving from the conservation of the mass,momentum and energy agree with the results of ice sheet profile simulated with GliMMER model and with the theoretical results. The application prospect of the simplified 2-dimensional ice flow model to simulate the relation of age-depth-accumulation in Dome A region was discussed.

关键词： Antarctic ice sheet GliMMER model Numerical simulation 2-Dimensional ice flow

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Effect of short term intensive multitherapy on carotid intima-media thickness in patients with newly diagnosed type 2 diabetes mellitus

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Chinese Medical Journal 2008年第8期121卷 687-690页

作者： GUO li-xin PAN Qi WANG Xiao-xia li Hui ZHANG li-na CHI Jia-min WANG Yao Department of Endocrinology Beijing Hospital Beijing 100730 China

Background Controlling plasma glucose levels, blood pressure and lipid levels is proven to reduce the risk of vascular complications in patients with type 2 diabetes mellitus. This has prompted intensive multitherapy targeted at several macrovascular risk factors. Carotid intima-media thickness （cIMT） is a reliable measure of early atherosclerosis. We sought to determine whether a 6-month intensive mutiltherapy program resulted in better goal attainment than usual care and its effect on the development of cIMT among patients with newly diagnosed type 2 diabetes mellitus. Methods The study randomly assigned 220 patients with newly diagnosed type 2 diabetes mellitus to intensive or traditional therapy groups. The clinical parameters, such as fasting plasma glucose, total cholesterol, triglyceride, blood pressure, body weight and insulin were assessed at the baseline and after the 6-month therapy, cIMT of the patients was also obtained. Results The average levels of fasting plasma glucose, hemoglobin Alc, total cholesterol （TC） and low-density lipoprotein cholesterol （LDL-C） in the intensive group were significantly lower than those in the control group at the end of 6-month treatment. By 6 months, a higher proportion of patients in the intensive therapy group than in the control group attained goals for fasting plasma glucose （FPG）, TC, LDL-C and hemoglobin Alc. With intensive multherapy the level of carotid intima-media thickness in the intensive therapy group was lower than that in the control group （（0.88±0.26） mm vs （0.96±0.22） mm, P 〈0.01）. Conclusions The evidence from this clinical trial demonstrates that intensive glucose, lipid and blood pressure control in patients with newly diagnosed type 2 diabetes is associated with diabetic macrovascular benefits. Intensive multitherapy allows more patients to achieve aims of control and may reduce macrovascular complications and delay disease progression.

关键词： intensive multitherapy type 2 diabetes carotid intima-media thickness

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Mutagenesis of Arachidonic Acid-producing Mortierella Isabellina and Analyses of Δ~6-desaturase Role by qPCR

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Journal of Northeast Agricultural University(English Edition) 2013年第3期20卷 63-70页

作者： Yao Di Yu Chang-qing Yang Jian li li-na College of Food Heilongjiang Bayi Agricultural University Quality Supervision and Inspection Center of Agricultural Processed Products on Agriculture Ministry

Arachidonic acid （AA or ARA）, an essential to-6 polyunsaturated fatty acid （PUFA）, can be produced by Mortierella isabellina. Mutagenesis on Mortierella isabellina As3.3410 was induced to raise ARA production. The mutant strain of YZ-124 had the highest ARA of 4.72 g. L-1, which was 5.5 times higher than that of the original strain 3.3410. mRna expression level of △ 6- desaturase was determined in five different kinds of ARA-producing Mortierella isabellina after cultured for 7 days, and in the mutant strain YZ-124 over a 3-8 day time-course. In addition, the desaturase activity and ARA content were measured at the selected time points. The lowest expression of △6-desaturase was observed in the original strain and the highest expression in the mutant strain YZ-124, which increased with increasing time in culture. Furthermore, a positive correlation was observed between the expression levels of △6-desaturase and ARA content. Based on this, △6-desaturase played a significant role in ARA synthesis pathway in Mortierella isabellina.

关键词： Mortierella isabellina,△6-desaturases arachidonic acid real-time PCR

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Fine structure of hypobranchial gland of Haliotis diversicolor

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Journal of life Sciences 2007年第1期1卷 1-6页

作者： li Hai-yun li na ZHAO Hui-hong ZHU Wei-yi College of Animal Science South China Agricultural University Guangzhou 510642 China

Fine structure of the hypobranchial gland of Haliotis diversicolor has been studied by light and electron microscopy. The results showed that the gland is folded pleats organ, which is highly glandular area of the epidermal lining the roof of the mantle cavity. Two such glandular areas, one on each side of the rectum, occur in H. diversicolor. Left one is much larger than fight one. By light microscope, on H-E stained section, four cell types can be divided： cells with weak basophilic fibrillar elements; with acidophilic granular substance; with strong basophiIic fibrillar elements and ciliated ceils. In the basal lamina region under the gland epithelium, there are a few connective tissues. Surface view of the gland could be seen by scanning electron microscope, there are cilia and different kinds of secretions distributed. By transmission electron microscope, supporting cells, sensory cells and seven types gland cells were observed to form the glandular epithelium. Cells are rich in rough endoplasmic reticulum, smooth muscle fiber and nerve endings were found beneath glandular epithelium, between basal lamina.

关键词： Haliotis diversicolor hypobranchial gland finestructure

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