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Protective mechanism of L-arginine against liver ischemic-reperfusion injury in rats

hepatobiliary & pancreatic Diseases International 2003年第4期2卷 549-552页

作者： shao-Qiang li li-Jian liang the department of hepatobiliary surgery, first Affiliated hospital, sun Yat-sen University, Guangzhou 510080, china department of hepatobiliary surgery First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 China. lesq@***

OBJECTIVE: To investigate the protective effect of L-arginine (L-arg) against liver ischemic-reperfusion (I/R) injury in rat model and its possible mechanism. METHODs: Male sprague-Dawley rats were randomized into sham group: hepatoduodenal ligament mobilized, but not clamped; control group: hepatic ischemia only; Arg group: 5 minutes before hepatic ischemia, L-arg (200 mg/kg) injected via the dorsal penis vein; Arg+L group: 10 and 5 minutes before hepatic ischemia, L-NAME (30 mg/kg) and L-arg (200 mg/kg) injected via the dorsal penis vein, respectively; and Fink group: 5 minutes before, hepatic ischemia, ZVAD-fmk (15 mg/kg) injected via the dorsal penis vein. The liver was subjected to ischemia for 40 minutes by Pringle's maneuver, and reperfusion was initiated hy removing clamp. The 7-day survival rate, alanine transaminase (ALT) level, caspase-3 activity and apoptotic hepatocyte count were compared among these groups. REsULTs: After 40 minutes of ischemia and 6 hours of reperfusion, the 7-day survival rate of the Arg group was significantly higher than that of the control and Arg+L groups (Pspase-3 activity and apoptotic hepatocyte count in the Arg group were decreased significantly than those in the control and Arg+L groups (Pspase-3 activity and apoptotic hepatocyte count in the Arg group were slightly higher than those in the sham and Fmk groups, but there was no statistical significance. CONCLUsIONs: L-arg could ameliorate liver I/R injury and the possible protective mechanism is inhibition of hepatocyte apoptosis via inhibition of caspase-3 activity by nitric oxide synthesis.

关键词： liver ischemia nitirc oxide caspase-3 rat

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safety,immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly:a prospective longitudinal study

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signal Transduction and Targeted Therapy 2024年第6期9卷 2738-2747页

作者： Hong-Hong liu Yunbo Xie Bao-Peng Yang Huan-Yue Wen Peng-Hui Yang Jin-E Lu Yan liu Xi Chen Meng-Meng Qu Yang zhang Wei-Guo Hong Yong-Gang li Junliang Fu Fu-sheng Wang Out-patient department of Day Diagnosis and Treatment The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China senior department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Chinese PLA medical school Chinese PLA General HospitalBeijing 100039China Hunyuan County people’s hospital Datong 037499 Shanxi ProvinceChina Faculty of Hepato-Pancreato-Biliary surgery Institute of Hepatobiliary SurgeryThe First Medical CenterChinese PLA General HospitalBeijing 100853China

The safety and efficacy of COVID-19 vaccines in the elderly,a high-risk group for severe COVID-19 infection,have not been fully *** clarify these issues,this prospective study followed up 157 elderly and 73 young participants for 16 months and compared the safety,immunogenicity,and efficacy of two doses of the inactivated vaccine BBIBP-CorV followed by a booster dose of the recombinant protein vaccine *** results showed that this vaccination protocol was safe and tolerable in the *** administering two doses of the BBIBP-CorV,the positivity rates and titers of neutralizing and anti-RBD antibodies in the elderly were significantly lower than those in the young *** the ZF2001 booster dose,the antibody-positive rates in the elderly were comparable to those in the young;however,the antibody titers remained ***,age,and underlying diseases were independently associated with vaccine immunogenicity in elderly *** pseudovirus neutralization assay showed that,compared with those after receiving two doses of BBIBP-CorV priming,some participants obtained immunological protection against BA.5 and BF.7 after receiving the ZF2001 *** infection symptoms last longer in the infected elderly and pre-infection antibody titers were negatively associated with the severity of post-infection *** antibody levels in the elderly increased significantly after breakthrough infection but were still lower than those in the *** data suggest that multiple booster vaccinations at short intervals to maintain high antibody levels may be an effective strategy for protecting the elderly against COVID-19.

关键词： vaccination vaccine doses

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Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma:A case report

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1933-1938页

作者： Miao-Miao zhang Jie Tao Huan-Chen sha Yun li Xiao-Gang song Oliver J Muensterer Fang-Fang Dong li zhang Yi Lyu Xiao-Peng Yan department of hepatobiliary surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina department of Pediatric surgery Dr.von Hauner Children’s HospitalLudwig-Maximilians-University Medical CenterMunich 80337Germany

BACKGROUND The combination of magnetic compression anastomosis(MCA)and endoscopy has been used to treat biliary stricture after liver ***,its use for the treatment of complex biliary obstruction after major abdominal trauma has not been *** case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.A 23-year-old man underwent major abdominal surgery(repair of liver rupture,right half colon resection,and ileostomy)following a car accident one year *** abdominal drainage tube,positioned at the Winslow foramen,was draining approximately 600-800 mL of bile per *** the two endoscopic retrograde cholangiopancreatography procedures,the guide wire was unable to enter the common bile duct,which prevented placement of a biliary *** combined with endoscopy was used to successfully achieve magnetic anastomosis of the peritoneal sinus tract and duodenum,and then a choledochoduodenal stent was ***,the external biliary drainage tube was *** patient achieved internal biliary drainage leading to the removal of the external biliary drainage tube,which improved the quality of *** Magnetic compression technique can be used for the treatment of complex biliary obstruction with minimal operative trauma.

关键词： Magnetic compression anastomosis Magnetosurgery Endoscopy Magnetic surgery Clinic Biliary obstruction Case report

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Promise and challenges of traditional Chinese medicine,specifically Calculus bovis,in liver cancer treatment

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World Journal of Gastroenterology 2024年第40期30卷 4380-4385页

作者： Ao-Xi Xu Zhi-Feng Zhao li Zhu Yi-Heng zhang Yan li Yu-Fan Wei Bo-Ya zhang Bin Jiang Tian-Ze Gao Meng-si li Jia-Yu liu school of Medicine Nankai UniversityTianjin 300071China department of General surgery The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China medical school of Chinese people's liberation Army Medical School of Chinese People's Liberation ArmyBeijing 100853China department of hepatobiliary and Pancreative surgery The First Medical CenterChinese People's Liberation Army General HospitalBeijing 100853China department of surgery Mancheng District People's HospitalBaoding 072150Hebei ProvinceChina department of Neurosurgery First Medical Centre of Chinese People's Liberation Army General HospitalBeijing 100853China

liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in *** cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(Ps),ensuring individualized patient *** decisions require a MDT to tailor strategies based on tumor staging,liver function,and Ps,ensuring personalized *** approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall ***,many patients do not respond effectively to these treatments and ultimately succumb to the *** oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of *** et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment *** over 5000 years,TCM has been used in East Asian countries like china to treat various diseases,including liver *** of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.

关键词： Traditional Chinese medicine liver cancer Calculus bovis Treatment Promise Challenges

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Combined invagination and duct-to-mucosa techniques with modifications:anew method of pancreaticojejunal anastomosis

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hepatobiliary & pancreatic Diseases International 2011年第4期10卷 422-427页

作者： Bin Zhu,li Geng,You-Gang Ma,Yong-Jie zhang and Meng-Chao Wu second department of Biliary surgery and department of special Treatment,Eastern hepatobiliary surgery hospital,second Military medical University,shanghai 200438,china second department of Biliary surgery Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China department of special Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

BACKGROUND:soft pancreatic texture and a small main pancreatic duct are thought to be the most significant risk factors for the occurrence of pancreatic fistula (PF),a common and serious complication after pancreaticoduodenectomy (PD).This is in part due to the technical difficulties of pancreaticojejunostomy (PJ) posed by a soft gland with a normal-sized *** deal with this problem,we developed a new anastomotic technique which combines the two most widely used techniques,namely,the invagination technique and the duct-to-mucosa technique,with a modification of the suture route and insertion of a temporary stent ***:Between January 2003 and December 2009,ninetytwo consecutive patients underwent PD in which the new PJ technique was *** and follow-up data of these patients were reviewed for operative details,early postoperative events,and outcomes at 6 months after the *** was defined by the International study Group on pancreatic Fistula (IsGPF) guidelines and graded (A,B or C) according to the clinical procedures and ***:In this group of 92 patients,there was only 1 early death from acute renal *** was observed in 11 patients (12.0%),8 in grade A,1 in grade B,and 2 in grade *** the 2 patients in grade C,PF was surgically *** were no early or late deaths attributable to *** months after the operation,all of the patients were free of PJ-related symptoms except for 2,who were found to have ***:Our modified technique is simple and safe in *** data suggest that this technique produces excellent early and medium-term results.

关键词： pancreaticoduodenectomy pancreaticojejunostomy pancreatic fistula

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TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways

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hepatobiliary & pancreatic Diseases International 2024年第2期23卷 195-209页

作者： Yan zhang Zhen-Zhen Wang An-Qi Han Ming-Ya Yang li-Xin Zhu Fa-Ming Pan Yong Wang department of General surgery The Second Hospital of Anhui Medical UniversityHefei 230601China department of General surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China The Key Laboratory of Major Autoimmune Diseases Anhui Medical UniversityHefei 230032China

Background:As reported,γ-tubulin(TuBG1)is related to the occurrence and development of various types of malignant ***,its role in hepatocellular cancer(HCC)is not *** present study was to investigate the relationship between TuBG1 and clinical parameters and survival in HCC ***:The correlation between TuBG1 and clinical parameters and survival in HCC patients was ex-plored by bioinformatics *** was used for the *** molecular function of TuBG1 was measured using colony formation,scratch assay,trans-well assay and flow *** set enrichment analysis(GsEA)was used to pick up the enriched pathways,followed by investigating the target pathways using Western *** tumor-immune system interactions and drug bank database(TIsIDB)was used to evaluate TuBG1 and *** on the TuBG1-related immune genes,a prognostic model was constructed and was further validated internally and ***:The bioinformatic analysis found high expressed TuBG1 in HCC tissue,which was confirmed us-ing immunohistochemistry and Western *** silencing the TuBG1 in HCC cell lines,more G1 arrested cells were found,cell proliferation and invasion were inhibited,and apoptosis was ***,the silence of TuBG1 increased the expressions of Ataxia-Telangiectasia and Rad-3(ATR),phospho-P38 mitogen-activated protein kinase(P-P38MAPK),phospho-P53(P-P53),B-cell lymphoma-2 associated X protein(Bax),cleaved caspase 3 and P21;decreased the expressions of B-cell lymphoma-2(Bcl-2),cyclin D1,cyclin E2,cyclin-dependent kinase 2(CDK2)and *** correlation analysis of immunohistochemistry and clinical parameters and survival data revealed that TuBG1 was negatively corre-lated with the overall *** constructed immune prognosis model could effectively evaluate the ***:The increased expression of TuBG1 in HCC is associated with poor prognosis,which might be involved in the oc

关键词： TuBG1 Hepatocellular carcinoma Apoptosis Cell cycling Immunomodulators

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Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure

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Engineered Regeneration 2024年第1期5卷 70-79页

作者： Xiao Yi Feng Chen Kunjie Gao Huayan li Yuan Xie shao li Jiajun zhang Qing Peng Weijie Zhou shutao Wang Jun-Bing Fan Yi Gao Research Centre for Artificial Organ and Tissue Engineering&Institute of Regenerative Medicine department of hepatobiliary surgery II Zhujiang hospital Cancer Research InstituteSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong Province 510515P R China department of Gynecology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510515P R China CAs Key Laboratory of Bio-inspired Materials and Interfacial science CAS Center for Excellence in NanoscienceTechnical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190P R China department of Hepato-Biliary-pancreatic and Hernia surgery The First People’s Hospital of ZhaoqingZhaoqingGuangdong 526000P R China department of Pathology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515P R China

Inflammatory cytokine storms can trigger disease exacerbation and even death and have reached a consensus in the clinical treatment of acute organ ***,the existing strategies remain a great challenge to efficiently suppress inflammatory cytokine storms for promoting organ repair and ***,fully human umbilical cord(UC)-derived adhesive materials(UCAM)that integrate decellularized extracellular matrix(ECM)nanofiber hydrogel and homologous mesenchymal stem cells(MsCs)are demonstrated to greatly suppress inflammatory cytokine storms,demonstrating high efficacy in treating acute liver failure(ALF)in rats with 90%*** UC-derived adhesive materials have the capacity to secrete a significant quantity of cytokines by MsCs to recruit activated immune cells to migrate into their ECM nanofiber networks,segregating them away from the infection area and thereby greatly suppressing the inflammatory cytokine *** expected,the UC-derived adhesive materials can significantly promote hepatocyte proliferation to achieve functional recovery and regeneration of the liver,significantly improving the survival rate in *** fully human UC-derived adhesive materials provide a new avenue in suppressing inflammatory cytokine storms for promoting organ regeneration that would be really utility in clinical organ transplantation-related treatment.

关键词： Interfacial adhesive materials Extracellular matrix nanofibers Hydrogel Mesenchymal stem cells Acute liver failure

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Pre-ligation of afflicted hepatic inflow and outflow blood vessels of lesioned liver lobe during hepatectomy

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hepatobiliary & pancreatic Diseases International 2003年第3期2卷 358-361页

作者： Zhe-Fu li Min song the department of hepatobiliary, Qingdao Municipal hospital, Qingdao University medical college, Qingdao 266011, china department of hepatobiliary Qingdao Municipal Hospital Qingdao University Medical College Qingdao 266011 China. lizhefu@***

OBJECTIVE: To compare the merits of hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned liver lobe with those of Pringle's maneuver. METHODs: A total of 68 patients were divided into two groups A and B. In the group A (n=38), Pringle's maneuver was employed, whereas in the group B (n=30), hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned side of the liver was used. Perioperative blood loss, postoperative bleeding and drainage, time of liver function recovery as well as incidence of postoperative complications were compared between the 2 groups. REsULTs: The mean perioperative blood loss, the mean amount of postoperative bleeding and drainage, the time of liver function recovery as well as incidence of postoperative complications were significantly higher in the group A than in the group B (PsION: Hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned side of the liver is superior to Pringle's maneuver.

关键词： hepatectomy blood flow clamping

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Protective effects of ligustrazine,Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis

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hepatobiliary & pancreatic Diseases International 2011年第6期10卷 632-637页

作者： Xi-Ping zhang,Jun Jiang,Qi-Hui Cheng,Qian Ye,Wei-Juan li,Hua Zhu and Jun-Ya shen department of General surgery,department of Gynecology and Obstetrics and Central Laboratory department,Hangzhou first people’s hospital,Hangzhou 310006,china Zhejiang Chinese medical University,Hangzhou 310053,china department of General surgery Hangzhou First People's Hospital Hangzhou 310006 China Zhejiang Chinese medical University Hangzhou 310053 China department of Gynecology and Obstetrics Hangzhou First People's Hospital Hangzhou 310006 China Central Laboratory department Hangzhou First People's Hospital Hangzhou 310006 China

BACKGROUND:severe acute pancreatitis (sAP) is characterized by fatal pathogenic conditions and a high *** is important to study sAP complicated with multiple organ *** this study we compared the protective effects of three traditional Chinese medicines (ligustrazine,Kakonein and Panax Notoginsenoside) on the small intestine and immune organs (thymus,spleen and lymph nodes) of rats with sAP and explored their mechanism of ***:One hundred forty-four rats with sAP were randomly divided into model control,ligustrazine-treated,Kakonein-treated,and Panax Notoginsenoside-treated groups (n=36 per group).Another 36 normal rats comprised the sham-operated *** to the different time points after operation,the experimental rats in each group were subdivided into 3-,6-and 12-hour subgroups (n=12).At various time points after operation,the mortality rate of rats and pathological changes in the small intestine and immune organs were recorded and the serum amylase levels were ***:Compared to the model control groups,the mortality rates in all treated groups declined and the pathological changes in the small intestine and immune tissues were relieved to different *** serum amylase levels in the three treated groups were significantly lower than those in the model control group at 12 *** pathological severity scores for the small intestinal mucosa,thymus and spleen (at 3 and 12 hours) in the ligustrazine-treated group,for the thymus (at 3 and 12 hours) and spleen (at 3 and 6 hours) in the Kakonein-treated group,and for the thymus (at 3 hours)and spleen (at 3 hours) in the Panax Notoginsenoside-treated group were significantly lower than those in the model control *** pathological severity scores of the small intestinal mucosa (at 6 and 12 hours) and thymus (at 6 hours) in the ligustrazine-treated group were significantly lower than those in the Kakonein-and Panax Notoginsenoside-treated ***:All the t

关键词： severe acute pancreatitis traditional Chinese medicine small intestine multiple organs apoptosis

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Harmine induces apoptosis in HepG2 cells via mitochondrial signaling pathway

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hepatobiliary & pancreatic Diseases International 2011年第6期10卷 599-604页

作者： Ming-Rong Cao,Qiang li,Zhi-Long liu,Hui-Hui liu,Wei Wang,Xiao-li liao,Yun-Long Pan and Jian-Wei Jiang department of General surgery,first Affiliated hospital,Jinan University,Guangzhou 510632,china department of Anesthesiology,first Affiliated hospital,Guangzhou University of TCM,Guangzhou 510632,china department of Biochemistry,medical college of Jinan University,Guangzhou 510632,china department of General surgery First Affliated Hospital Jinan University Guangzhou 510632 China department of Anesthesiology First Affliated Hospital Guangzhou University of TCM Guangzhou 510632 China department of Biochemistry Medical College of Jinan University Guangzhou 510632 China

BACKGROUND:Harmine has antitumor and antinociceptive effects,and inhibits human DNA *** no detailed data are available on the mechanisms of action of harmine in hepatocellular *** study aimed to investigate the effects of harmine on proliferation and apoptosis and the underlying mechanisms in the human hepatocellular carcinoma cell line ***:The proliferation of HepG2 cells was determined by the cell counting kit-8 (CCK-8) assay and the clone formation *** morphology of HepG2 cells was examined using fluorescence microscopy after Hoechst 33258 staining Annexin V/propidium iodide (PI) was used to analyze apoptosis and PI to analyze the cell *** blotting was used to assess expression of the apoptosis-regulated genes Bcl-2,Bax,Bcl-xl,Mcl-1,caspase-3,and caspase-9 Mitochondrial transmembrane potential (Ψ m) was determined using ***:Harmine inhibited the proliferation of HepG2 cells in a dose-dependent *** 33258 staining revealed nuclear fragmentation and chromosomal condensation,cell shrinkage,and attachment loss in HepG2 cells treated with *** percentage of the sub/G1 fraction was increased in a concentration-dependent manner,indicating apoptotic cell *** staining showed that harmine changed the cell cycle distribution,by decreasing the proportion of cells inG0/G1 and increasing the proportion in s and G2/*** induced apoptosis in a concentration-dependent manner,with rates of 20.0%,32.7% and 64.9%,***-1 revealed a decrease in Ψ *** of HepG2 cells was associated with caspase-3 and caspase-9 activation,down-regulation of Bcl-2,Mcl-1,and Bcl-xl,and no change in ***:Harmine had an anti-proliferative effect in HepG2 cells by inducing *** signal pathways were involved in the *** cancer-specific selectivity shown in this study suggested that harmine is a promising novel drug for human hepatocellular carcinoma.

关键词： hepatocellular carcinoma harmine Bcl-2 protein caspase-3 apoptosis

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