检索结果-南通市图书馆

Ultra-highly selective recognition of nucleosides over nucleotides by rational modification of tetralactam macrocycle and its application in enzyme assay

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 274-278页

作者： Huan Yao Jian Qin Yan-Fang wang Song-Meng wang liu-Huan Yi Shi-Yao li Fangfang Du liu-Pan Yang li-li wang School of Pharmaceutical Science Postdoctoral Research Station of Basic MedicineHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055China

Artificial macrocycle with high binding selectivity in water is often challenging but urgently needed in various research and application ***,we report a new water-soluble biomimetic tetralactam macrocycle and realize the ultra-high selectivity to nucleosides over corresponding monophosphate nucleotides by rational *** introduction of charged groups at the periphery of endofunctionalized cavity makes the selectivity(guanosine to guanosine 5-monophosphate)increase remarkably from 100 to *** on the ultra-high selectivity of biomimetic tetralactam macrocycle,the sensitive CD73 enzyme activity assay was then achieved through product-selective fluorescence indicator displacement ***,the capability of the proposed method for inhibitor screening was successfully displayed.

关键词： Rational modification Biomimetic macrocycle Ultra-high selectivity Enzyme assay

Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus ***-2

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第9期35卷 206-209页

作者： Hong Zhang Cui-Ping li li-li wang Zhuo-Da Zhou Wen-Sen li ling-Yi Kong Ming-Hua Yang Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus *** structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction *** A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral *** structures were proposed as heterotrimeric and heterodimeric products of aromatic *** addition,asperochone A exhibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.

关键词： Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity

Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第2期16卷 241-250页

作者： Ting li li-li wang Ya-Ping li Jian Gan Xi-Sheng Wei Xiao-Rong Mao Jun-Feng li Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina Department of Radiology First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Yantai Affiliated Hospital of Binzhou Medical UniversityYantai 264100Shandong ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Portal vein thrombosis(PVT)is a commonthsn complication after splenectomy in patients with ***,the predictors of postoperative PVT are not *** To investigate the predictors of PVT after splenectomy in patient with *** A total of 45 patients with cirrhosis who underwent splenectomy were consecutively enrolled from January 2017 to December *** incidence of PVT at 1 months,3 months,and 12 months after splenectomy in patients with cirrhosis was *** hematological indicators,biochemical and coagulation parameters,and imaging features were recorded at baseline and at each observation *** univariable,multivariable,receiver operating characteristic curve and timedependent curve analyses were *** The cumulative incidence of PVT was 40.0%,46.6%,and 48.9%at 1 months,3 months,and 12 months after *** analysis showed that portal vein diameter(PVD)≥14.5 mm and monthsdel end-stage liver disease(MELD)score>10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy(P10(P10 were independent predictors of PVT at 1 months,3 months,and 12 months after splenectomy in patient with cirrhosis.

关键词： Cirrhosis Splenectomy Portal vein thrombosis Predictors

Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4263-4273页

作者： Xin liang Dong-Qing Zhao Qian-Qian Huang Sheng liang li-li wang Lei Hu ling-li liu Kun-Hong Hu Chong-Hai Deng Sheng Cheng Er-Tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with li||li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： li–S battery Membrane MoO2/MoS2 Nanofiber

Preoperative prediction of lymphovascular and perineural invasion in gastric cancer using spectral computed tomography imaging and machine learning

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第6期30卷 542-555页

作者： Hui-Ting Ge Jian-Wu Chen li-li wang Tian-Xiu Zou Bin Zheng Yuan-Fen liu Yun-Jing Xue Wei-Wen lin Department of Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Digestive Hematological and Breast MalignanciesClinical Research Center for Radiology and Radiotherapy of Fujian ProvinceFuzhou 350001Fujian ProvinceChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Diagnostic Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Electrical and Computer Engineering University of OklahomaOklahomaOK 73019United States

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are important prognostic factors for gastric cancer(GC)that indicate an increased risk of metastasis and poor *** preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment ***,prior models using conventional computed tomography(CT)images to predict LVI or PNI separately have had limited *** CT provides quantitative enhancement parameters that may better capture tumor *** hypothesized that a predictive model combining clinical and spectral CT parameters would accurately preoperatively predict LVI/PNI status in GC *** To develop and test a machine learning model that fuses spectral CT parameters and clinical indicators to predict LVI/PNI status *** This study used a retrospective dataset involving 257 GC patients(training cohort,n=172;validation cohort,n=85).First,several clinical indicators,including serum tumor markers,CT-TN stages and CT-detected extramural vein invasion(CT-EMVI),were extracted,as were quantitative spectral CT parameters from the delineated tumor ***,a two-step feature selection approach using correlation-based methods and information gain ranking inside a 10-fold cross-validation loop was utilized to select informative clinical and spectral CT parameters.A logistic regression(LR)-based nomogram model was subsequently constructed to predict LVI/PNI status,and its performance was evaluated using the area under the receiver operating characteristic curve(AUC).RESULTS In both the training and validation cohorts,CT T3-4 stage,CT-N positive status,and CT-EMVI positive status are more prevalent in the LVI/PNI-positive group and these differences are statistically significant(P<0.05).LR analysis of the training group showed preoperative CT-T stage,CT-EMVI,single-energy CT values of 70 keV of venous phase(VP-70 keV),and the ratio of standardized iodine co

关键词： Spectral computed tomography Gastric cancer Lymphovascular invasion Perineural invasion

A versatile framework for analyzing galaxy image data by incorporating Human-in-the-loop in a large vision model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第9期48卷 176-187页

作者： Ming-Xiang Fu Yu Song Jia-Meng Lv liang Cao Peng Jia Nan li Xiang-Ru li Ji-Feng liu A-li Luo Bo Qiu Shi-Yin Shen liang-Ping Tu li-li wang Shou-lin Wei Hai-Feng Yang Zhen-Ping Yi Zhi-Qiang Zou National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China College of Electronic Information and Optical Engineering Taiyuan University of TechnologyTaiyuan 030024China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Key lab of Space Astronomy and Technology National Astronomical ObservatoriesBeijing 100101China School of Computer Science South China Normal UniversityGuangzhou 510631China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesBeijing 100101China University of Chinese Academy of Sciences NanjingNanjing 211135China University of Science and Technology Beijing Beijing 100083China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China School of Computer and Information Dezhou UniversityDezhou 253023China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650500China School of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 30024China School of Mechanical Electrical and Information EngineeringShandong UniversityWeihai 264209China Nanjing University of Posts&Telecommunications Nanjing 210023China School of Science University of Science and Technology LiaoningAnshan 114051China

The exponential growth of astronomical datasets provides an unprecedented opportunity for humans to gain insight into the ***,effectively analyzing this vast amount of data poses a significant *** response,astronomers are turning to deep learning techniques,but these methods are limited by their specific training sets,leading to considerable duplicate *** overcome this issue,we built a framework for the general analysis of galaxy images based on a large vision model(LVM)plus downstream tasks(DST),including galaxy morphological classification,image restoration object detection,parameter extraction,and *** the low signal-to-noise ratios of galaxy images and the imbalanced distribution of galaxy categories,we designed our LVM to incorporate a Human-in-the-loop(HITL)module,which leverages human knowledge to enhance the reliability and interpretability of processing galaxy images *** proposed framework exhibits notable fewshot learning capabilities and versatile adaptability for all the abovementioned tasks on galaxy images in the DESI Legacy Imaging *** particular,for the object detection task,which was trained using 1000 data points,our DST in the LVM achieved an accuracy of 96.7%,while ResNet50 plus Mask R-CNN reached an accuracy of 93.1%.For morphological classification,to obtain an area under the curve(AUC)of~0.9,LVM plus DST and HITL only requested 1/50 of the training sets that ResNet18 *** addition,multimodal data can be integrated,which creates possibilities for conducting joint analyses with datasets spanning diverse domains in the era of multi-messenger astronomy.

关键词： artificial intelligence large vision model human-in-the-loop astronomy galaxies

Prediction of pathological complete response and prognosis in locally advanced rectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2520-2530页

作者： Yi-Jun Xu Dan Tao Song-Bing Qin Xiao-Yan Xu Kai-Wen Yang Zhong-Xu Xing Ju-Ying Zhou Yang Jiao li-li wang Department of Radiation Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Radiation Oncology The Fourth Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina School of Radiation Medicine and Protection Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death *** chemoradiotherapy(nCRT)is standard for locally advanced rectal cancer(LARC).Except for pathological examination after resection,it is not known exactly whether LARC patients have achieved pathological complete response(pCR)before *** date,there are no clear clinical indicators that can predict the efficacy of nCRT and patient *** To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with *** Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively *** were categorized into pCR and non-pCR *** analysis(using the χ^(2) test or Fisher’s exact test)and logistic multivariate regression analysis were used to study clinical predictors affecting *** 5-year disease-free survival(DFS)and overall survival(OS)rates were calculated using Kaplan-Meier analysis,and differences in survival curves were assessed with the log-rank *** Univariate analysis showed that pretreatment carcinoembryonic antigen(CEA)level,lymphocyte-monocyte ratio(LMR),time interval between neoadjuvant therapy completion and total mesorectal excision,and tumor size were correlated with *** results showed that CEA≤5 ng/mL(P=0.039),LMR>2.73(P=0.023),and time interval>10 wk(P=0.039)were independent predictors for *** analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates(94.7%vs 59.7%,P=0.002)and 5-year OS rates(95.8%vs 80.1%,P=0.019)compared to the non-pCR *** deposits(TDs)were significantly correlated with shorter DFS(P=0.002)and OS(P<0.001).CONCLUSION Pretreatment CEA,LMR,and time interval contribute to predicting nCRT efficacy in LARC *** pCR demonstrates longer DFS and *** correlate with poor pr

关键词： Locally advanced rectal cancer Neoadjuvant chemoradiotherapy Pathological complete response Carcinoembryonic antigen Inflammation-related markers Tumor deposit Prognosis

Synergy effect of regulated li-plating and functional solid electrolyte interphase on graphite anodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 8077-8085页

作者： Panpan wang Baojia Xia Jianling li State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 201800China

The growth of li dendrites poses potential safety hazard to lithium-ion batteries(liBs),and eliminating li dendrites thoroughly stills face tough difficulties ***,regulating li-plating is a critical optimization-direction to address the ***,a“graphite-li hybrid”anode with high reversibility is realized under the constant-capacity lithiation(CCL).Within CCL,the uniform distribution of li-plating on the graphite surface is successfully *** evolution in different states of solid electrolyte interphase(SEI)is investigated in detail to study the interaction between the potentials and impedance during the process of liintercalation and *** the potential below 0 V and the state of charge(SOC)of 110%relative to the theoretical capacity,the F-rich SEI with high stability is constructed to hinder the emergency of li dendrites and maintain the intact structure of graphite anode under long *** cell presents more than 100%Coulombic efficiency(CE)with the 900 cycles,demonstrating the reversible li-plating and the utilization of *** the CCL half-cell provides a good cycling performance and specific capacity of 900 cycles at 0.5 C,it is attributed to the synergy effect of stable inorganic-rich SEI and regulated active li-plating.

关键词： "graphite-li hybrid"anode li-plating reversibility solid electrolyte interphase(SEI)

Three-dimensional unstructured-mesh eutrophication model and its application to the Xiangxi River,China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2012年第9期24卷 1569-1578页

作者： Jian li Danxun li Xingkui wang State Key Laboratory of Hydroscience and Engineering Department of Hydraulic Engineering Tsinghua University Beijing 100084 China

The Xiangxi River is one of the main tributaries in the Three Gorges reservoir, with the shortest distance to the Three Gorges Project Dam. Severe and frequent algal bloom events have occurred frequently in the Xiangxi River in recent years. Therefore, the current study develops a three-dimensional unstructured-mesh model to investigate the dynamic process of algal bloom. The developed model comprises three modules, namely, hydrodynamics, nutrient cycles, and phytoplankton ecological dynamics. A number of factors, including hydrodynamic condition, nutrient concentration, temperature, and light illumination, that would affect the evolution of phytoplankton were considered. Moreover, the wave equation was used to solve the free surface fluctuations and vertical Z-coordinates with adjustable layered thicknesses. These values, in turn, are suitable for solving the algal bloom problems that occurred in the fiver style reservoir that has a complex boundary and dramatically changing hydrodynamic conditions. The comparisons between the modeling results and field data of years 2007 and 2008 indicate that the developed model is capable of simulating the algal bloom process in the Xiangxi River with reasonable accuracy. However, hydrodynamic force and external pollution loads affect the concentrations of nutrients, which, along with the underwater light intensity, could consequently affect phytoplankton evolution. Thus, flow velocity cannot be ignored in the analysis of fiver algal bloom. Based on the modeling results, building an impounding reservoir and increasing the releasing discharge at appropriate times are effective ways for controlling algal bloom.

关键词： unstructured-mesh model algal bloom phytoplankton Xiangxi River