检索结果-南通市图书馆

Metabolomic Profiling of Mice Exposed toα-amanitin Using Ultra-performance liquid Chromatography Quadrupole Time-of-flight Tandem Mass Spectrometry

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第3期36卷 289-294页

作者： li lei ZHENG Chong YE Jian Fang ZHU Kai ZHOU Yi Bing liU Jia GAO Ming WU Yu Tian liU Yong Ting liU li Ya liN Ye li Hai Chang ZHANG Quan GUO Hua Clinical Laboratory Guizhou Provincial Center for Disease Control and PreventionGuiyang 550004GuizhouChina Clinical Laboratory Guiyang Provincial Center for Disease Control and PreventionGuiyang 550002GuizhouChina

Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic compon... 详细信息

关键词： Metab ani annually

A Study on the Origin and Binding Form of Printing Edition of Qing Guangxu’s“Shanxi Tongzhi”

在线全文

学校读者我要写书评

暂无评论

Journal of literature and Art Studies 2023年第1期13卷 36-46页

作者： li lei Academy of Fine Arts Shanxi UniversityShanxiChina

Shanxi Tongzhi,written during the reign of Emperor Guangxu in the Qing Dynasty,is a typical example of the printed version of ancient Chinese books.Through the textual research of relevant cultural and historical materials,combined with the research on the publishing background and the formal binding system,this paper shows that“Shanxi Tongzhi”during Qing Guangxu has four editions since the original edition was compiled and published in 1892.With development and changes,its content has been continuously deepened and expanded.The version inherits the ancient system and extensive collection,the printing form is rigorous,and the binding is simple and exquisite,which has essential historical research value.At the same time,the traditional and straightforward Chinese-style aesthetics of the ancient printed version of“Shanxi Tongzhi”published during Qing Guangxu has a very high reference value for the exploration and development of the new connotation of the modern book form.

关键词： Shanxi Tongzhi original printed edition version origin binding form

A Basic Chemical Synaptic Euler Model and Its Triad Trigger Topology

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2017年第2期26卷 244-249页

作者： li Wenshi li lei SONG Jiajia Department of Microelectronics Soochow University

To deeply understand neuromorphic electronic systems,a basic chemical synapse model is given by logistic Euler inverse mapping and transformation in tandem,3T-MOS triod-trigger-topology(3T3) is designed in sub-threshold region at 100 mV supply for compact synaptic circuit,and the power consumption of synapse in brain-circuitry(ion-bump-city) is compared with its five mimic blocks of HfOx/AlOx typed memristor,modified 2T-MOS-K+-bump circuit,3T3 synaptic circuit and 4T-Schmitt-oscillator based synaptic circuit,and Chua's circuit on Power-delay-products'(PDP) levels.Above works will match searching for novel feature operators during pushing forward brain health microelectronics.

关键词： Chemical synapse Euler model 3T3 synaptic circuit 4T synaptic circuit Scaling PDPs

Chaos Criteria Design Based on Modified Sign Functions with One or Three-Threshold

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2019年第2期28卷 364-369页

作者： WU Senlin li Yaotian li Wenshi li lei Department of Microelectronics Soochow University Laboratory of Modern Acoustics of MOE Nanjing University Department of Chemical and Materials Engineering University of Alberta

The complexity measures of chaotic or periodic signals are perpetual topics of interest to data scientists. This work adheres to the framework of the traditional 0-1 test for chaos and replaces sine and cosine functions by modified sign functions. The compressive mapping rules chosen are one-threshold of three-value or three-threshold of five-value. In new criteria for chaos in forms of the 3s plot and Ks metric compared with 0-1 test results, the periodic state of data features a short beeline instead of a big ring in the pq plot and signs the nearest zero mark, while the chaotic state signs a simple curve instead of a random-walking shape in the pq plot, and shows the nearest one mark. By computing the Lorenz equation evolution under the contrast tests of the Poincare section and Lyapunov index, we visualize a new chaoscriteria design in symbolic dynamics and data compression principles, and our work may lay the foundation for further expressing the chaotic appearance of novel signals deep into future brainets.

关键词： Chaos criteria Symbolic dynamics Data compression Simplest 0-1 test Signed compression plot Ks metric Poincare section Lyapunov index

古埃及神谕研究(公元前3000年至前1550年)——基于原始文献与文化记忆理论的双重考略

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

东北师大学报（哲学社会科学版） 2024年第1期 69-78页

作者：李晓东李雷东北师范大学历史文化学院吉林长春130024

神谕仪式是一种普遍存在于早期人类文明的宗教活动。然而,直至古埃及文明诞生约1500年后的新王国时期才出现有关神谕仪式的直接记录。新王国的神谕仪式所呈现出的高度完善化且制度化特征,引发了学术界对古埃及神谕起源的争论。新王国以... 详细信息

神谕仪式是一种普遍存在于早期人类文明的宗教活动。然而,直至古埃及文明诞生约1500年后的新王国时期才出现有关神谕仪式的直接记录。新王国的神谕仪式所呈现出的高度完善化且制度化特征,引发了学术界对古埃及神谕起源的争论。新王国以前的文献史料能够反映神谕实践的部分表征,但不能作为证明神谕存在的直接证据,须辩证看待。早期神权与王权观念决定了神谕在当时属于“隐性文化”,故未被主流叙事所记录。阿蒙神崇拜的兴起、仪式时空单元的构建以及神权与王权观念的演变最终导致神谕由“隐性文化”转变成为“显性文化”。

关键词：古埃及新王国神谕扬·阿斯曼文化记忆

Progress of International Meridian Circle Program

在线全文

学校读者我要写书评

暂无评论

空间科学学报 2022年第4期42卷 584-587页

作者： liU William MICHEL Blanc WANG Chi XU Jiyao li Hui REN liwen liU Zhengkuan ZHU Yajun li Guozhu li lei ZEREN Zhima YANG Fang National Space Science Center Chinese Academy of SciencesBeijing 100190 Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100083 National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085

Based on the Chinese Meridian Project(CMP),the International Meridian Circle Program(IMCP)aims to coordinate the deployment of a comprehensive ground-based monitoring network along the 120°E-60°W Great Meridian Circle to track the propagation and evolution of space weather events from the Sun to the Earth,as well as the imprints of other major natural and anthropic hazards on the ionosphere,the middle and upper atmosphere.Currently,we have completed the IMCP headquarters building in Beijing and established the China-Brazil Joint Laboratory for Space Weather in cooperation with Brazil.Meanwhile,the Chinese Meridian Project PhaseⅡand different components of the IMCP observation system are under construction.

关键词： Chinese Meridian Project(CMP) Global ground monitoring Space weather International Meridian Circle Program(IMCP)

Role of RhoA in platelet-derived growth factor-BB-induced migration of rat hepatic stellate cells

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2010年第18期123卷 2502-2509页

作者： li lei li Jing WANG Ji-yao YANG Chang-qing JIA Ming-lei JIANG Wei Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Gastroenterology Tongji Hospital Tongji University Shanghai 200065 China Department of Gastroenterology Huadong Hospital Fudan University Shanghai 200040 China

Background Although the migration of hepatic stellate cells （HSCs） is essential for hepatic fibrotic response, the detailed mechanisms involved are poorly understood. The aim of this study was to examine the role of Rho GTPases （especially RhoA） in platelet-derived growth factor （PDGF）-BB-induced migration of HSCs. Methods The migration of primary rat HSCs was evaluated using transwell Boyden chamber, while cytoskeletal changes were visualized by immunofluorescence staining of intracellular actins and vinculin. Quantitative real-time PCR and Western blotting analysis were used to detect the expression of Rho GTPases （RhoA, Racl and Cdc42） within HSCs and their activation was determined by glutathione S-transferase pull-down assay. Finally, the effects of RhoA on PDGF-BB-induced cell migration and cytoskeletal remodeling were analyzed using HSC-T6 cells stably transfected with constitutively active （CA, Q63L） or dominant negative （DN, T19N） RhoA mutants. Data were analyzed using SPSS 16.0 software. Student＇s t test was used to analyze differences between two groups and one-way analysis of variance （ANOVA） was used among multiple groups. Results Rapid cytoskeletal remodeling led to a significant increase in the motility of primary rat HSCs after haptotactic （direct） and chemotactic （indirect） stimulation by PDGF-BB： PDGF-BB caused a dramatic elevation in the levels of both total and active RhoA protein. However, the levels of mRNA for Rho GTPases, including RhoA, Racl and Cdc42, were unaffected. Furthermore, PDGF-BB induced increased formation of stress fibers and focal adhesions in HSC-T6 cells transfected with CA-RhoA, but not in HSC-T6 transfected with DN-RhoA. Surprisingly, both CA- and DN-RhoA-transfected HSC-T6 cells showed decreased migratory potential in the absence or presence of PDGF-BB compared with controls. Conclusions PDGF-BB induced cytoskeletal remodeling in rat HSCs and promoted their migration via regulation of intracellular RhoA. RhoA may be one of the determinants in PDGF-BB-induced HSC miaratio

关键词： platelet-derived growth factor BB hepatic stellate cells cell movement RhoA protein liver fibrosis

改良Yamane法无缝线人工晶状体巩膜层间固定术的疗效观察

在线全文

学校读者我要写书评

暂无评论

中华眼科杂志 2024年第6期60卷 503-510页

作者：陈燕云周丹李蕾李栋军何雷于洁史翔宇首都医科大学附属北京同仁医院北京同仁眼科中心、北京市眼科研究所、北京市眼科学与视觉科学重点实验室北京100730

目的探讨改良Yamane法无缝线人工晶状体(IOL)巩膜层间固定术的临床疗效。方法回顾性病例系列研究。连续收集2022年1月至2023年9月在首都医科大学附属北京同仁医院北京同仁眼科中心行改良Yamane法无缝线IOL巩膜层间固定术的患者资料纳入... 详细信息

目的探讨改良Yamane法无缝线人工晶状体(IOL)巩膜层间固定术的临床疗效。方法回顾性病例系列研究。连续收集2022年1月至2023年9月在首都医科大学附属北京同仁医院北京同仁眼科中心行改良Yamane法无缝线IOL巩膜层间固定术的患者资料纳入研究。患者于术前及术后1 d、3 d、7 d、1个月、3个月等时间点检查裸眼视力和最佳矫正视力(BCVA)并记录为最小分辨角的对数, 检查屈光度数和眼压, 行裂隙灯显微镜检查眼前节、眼底检查、前节相干光层析成像术(OCT)和后节OCT。记录术中及术后眼部并发症。结果最终纳入53例(53只眼)患者的资料, 其中男性40例, 女性13例;年龄为60(49, 68)岁。伴有外伤史的患眼占比22.6%(12/53)。术中发生玻璃体出血1只眼(1.9%)。所有术眼术后1周均未发生低眼压、前房内炎性反应和瞳孔异常。术后随访时间为(8.0±3.3)个月(3~16个月), 随访中均未出现IOL瞳孔夹持、IOL再脱位、IOL襻暴露。术前和术后角膜内皮细胞计数为(2 236±704)和(1 964±628)个/mm2, 差异有统计学意义(P0.05)。术后1和3个月BCVA≤0的患眼占比分别为81.1%(43/53)和83.0%(44/53)。术后1 个月IOL倾斜度为(5.18±2.60)°, 术后3个月则为(5.08±2.48)°, IOL离心度分别为(0.35±0.24)和(0.32±0.24)mm, 差异均无统计学意义(均P>0.05)。结论改良Yamane法为IOL提供了稳定且居中的固定, 手术简单微创, 并发症少, 视力预后良好。

关键词：晶体,人工巩膜无缝线外科手术视敏度预后

在线全文

学校读者我要写书评

暂无评论

正颌外科虚拟手术规划研究现状

中华整形外科杂志 2024年第1期40卷 124-128页

作者：李磊乔嘉牛峰中国医学科学院北京协和医学院整形外科医院颅颌面整形一科北京100144

正颌手术是治疗牙颌面畸形的经典手术。由于牙颌面解剖结构的复杂性, 术前通常需要进行详细而准确的手术规划。随着近年来医学成像技术和手术规划软件的快速发展, 虚拟手术规划(VSP)越来越多地被用于正颌外科, 以提供准确、高效、可预... 详细信息

正颌手术是治疗牙颌面畸形的经典手术。由于牙颌面解剖结构的复杂性, 术前通常需要进行详细而准确的手术规划。随着近年来医学成像技术和手术规划软件的快速发展, 虚拟手术规划(VSP)越来越多地被用于正颌外科, 以提供准确、高效、可预测的规划和模拟。正颌外科VSP的设计和发展涉及图像采集和复合头部模型构建、三维参考框架定义、虚拟咬合设置、虚拟截骨和手术模拟、软组织预测、转移工具等几个方面, 该文对相关步骤的研究进行了总结, 以为临床提供参考。

关键词：外科手术计算机辅助虚拟手术规划正颌外科手术