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热压印成型复合微透镜阵列的微光学照明特性

光学精密工程 2024年第9期32卷 1371-1383页

作者：胡满凤李磊谢晋广州铁路职业技术学院电气工程学院广东广州511300 华南理工大学机械与汽车工程学院广东广州510641

在LED照明中,光线分布不均产生的眩光及光线中的紫外光、蓝光成分容易造成视觉疲劳和眼睛损伤,目前主要是以调节光源为主,纳米级光波段调节的表面结构加工成本较高。因此,利用热压印快速成型技术开发了一种微米尺度的复合微透镜阵列导光... 详细信息

在LED照明中,光线分布不均产生的眩光及光线中的紫外光、蓝光成分容易造成视觉疲劳和眼睛损伤,目前主要是以调节光源为主,纳米级光波段调节的表面结构加工成本较高。因此,利用热压印快速成型技术开发了一种微米尺度的复合微透镜阵列导光板,探究健康照明的复合微透镜尺度效应。首先分析微棱镜表面小微透镜的深宽比与反射电场分布的关系,然后研究导光板的微结构参数对漫反射率、镜面反射率和透射率的影响。最后,对比市面上丝网印刷微点、微棱镜阵列等结构导光板,研究复合微透镜微米尺度对照度、均匀度等微光学性能的影响。分析表明:当小微透镜深宽比在0.6~1内时,紫外光和蓝光的反射面有更小的反射电场变异系数,说明其漫反射大。实验结果表明:热压印技术可以在4 s内将微透镜高5~30μm和微棱镜高10~80μm的复合微透镜阵列导光板加工成型;照度均匀度随着小微透镜深宽比的增大而增大,照度分别比微棱镜和丝网印刷微点阵列提高45%和83%;与微棱镜相比,紫外光和蓝光的漫反射率分别提高8%和18%,镜面反射率下降80%~83%。控制复合微透镜的深宽比可以减少照明眩光,抑制紫外光和蓝光。

关键词：复合微透镜阵列热压印微成型微光学性能健康照明

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Overdose the addiction—A new strategy to ablate cancer cells

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Science China(life Sciences) 2015年第11期58卷 1169-1170页

作者： li lei Department of Experimental Radiation Oncology Department of Genetics The University of Texas M.D.Anderson Cancer Center

In the field of antitumor drug development,it is common to see paired images of cultured cancer cells:one mocktreated,and the other subjected to a small molecular drug that leads to cell death or growth suppression(Figure 1).One’s common perception is that an inhibitor is at work to inactivate a critical factor or pathway essential for

关键词：癌细胞小分子药物药物开发肿瘤细胞抗肿瘤生长抑制细胞死亡细胞生存

High responsivity and fast response 8×8β-Ga_(2)O_(3)solar-blind ultraviolet imaging photodetector array

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Science China(Technological Sciences) 2023年第11期66卷 3259-3266页

作者： SHEN GaoHui liU Zeng TANG Kai SHA Shulin li lei TAN Chee-Keong GUO YuFeng TANG WeiHua Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China National and Local Joint Engineering Laboratory for RF Integration and Micro-Assembly Technologies Nanjing University of Posts and TelecommunicationsNanjing 210023China Key Laboratory of Aerospace Information Materials and Physics(NUAA) MIITNanjing 211106China College of Physics MIIT Key Laboratory of Aerospace Information Materials and PhysicsKey Laboratory for Intelligent Nano Materials and DevicesNanjing University of Aeronautics and AstronauticsNanjing 211106China Advanced Materials Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Nansha 511458China Department of Electronic and Computer Engineering School of EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China

In this work,an 8×8 Ga_(2)O_(3)solar-blind ultraviolet photodetector array is introduced for image sensing application.The 2-in wafer-scaled Ga_(2)O_(3)thin film was grown by metalorganic chemical vapor deposition technique;and the photodetector array was fabricated through ultraviolet photolithography,lift-off,and electron-beam evaporation.In addition to the high solar-blind/visible rejection ratio of 104,every photodetector cell in the array has high performance and fast response speed,such as responsivity of 49.4 A W^(-1),specific detectivity of 6.8×10^(14)Jones,external quantum efficiency of 1.9×10^(4)%,linear dynamic range of 117.8 d B,and response time of 41 ms,respectively,indicating the high photo-response performance of the photodetector.Moreover,the photodetector array displayed uniform responsivity with a standard deviation of~6%,and presented a sensing image of low chromatic aberration,owing to the high resolution of the photodetector array.In a word,this work may contribute to developing Ga_(2)O_(3)-based optoelectronic device applications.

关键词： Ga_(2)O_(3) photodetector array imaging photo-response

A Cloud Framework for High Spatial Resolution Soil Moisture Mapping from Radar and Optical Satellite Imageries

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Chinese Geographical Science 2023年第4期33卷 649-663页

作者： GUO Tianhao ZHENG Jia WANG Chunmei TAO Zui ZHENG Xingming WANG Qi li lei FENG Zhuangzhuang WANG Xigang li Xinbiao KE liwei Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Black Soils Conservation and Utilization Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Changchun Jingyuetan Remote Sensing Test Site Changchun 130102China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China China Centre for Resources Satellite Data and Application China Aerospace Science and Technology CorporationBeijing 100094China College of Geoexploration Science and Technology Jilin UniversityChangchun 130026China School of Geomatics and Prospecting Engineering Jilin Jianzhu UniversityChangchun 130118China

Soil moisture plays an important role in crop yield estimation,irrigation management,etc.Remote sensing technology has potential for large-scale and high spatial soil moisture mapping.However,offline remote sensing data processing is time-consuming and resource-intensive,and significantly hampers the efficiency and timeliness of soil moisture mapping.Due to the high-speed computing capabilities of remote sensing cloud platforms,a High Spatial Resolution Soil Moisture Estimation Framework(HSRSMEF)based on the Google Earth Engine(GEE)platform was developed in this study.The functions of the HSRSMEF include research area and input datasets customization,radar speckle noise filtering,optical-radar image spatio-temporal matching,soil moisture retrieving,soil moisture visualization and exporting.This paper tested the performance of HSRSMEF by combining Sentinel-1,Sentinel-2 images and insitu soil moisture data in the central farmland area of Jilin Province,China.Reconstructed Normalized Difference Vegetation Index(NDVI)based on the Savitzky-Golay algorithm conforms to the crop growth cycle,and its correlation with the original NDVI is about 0.99(Pline operations to cloud computing platforms,achieving rapid and simplified high spatial resolution soil moisture mapping.

关键词： soil moisture(SM) Google Earth Engine(GEE) Cloud Computing Platform High Spatial Resolution Soil Moisture Estimation Framework(HSRSMEF) remote sensing Sentienl-1 Sentinel-2 Northeast China

Retrospective Case Series on The Enduring Rotational Stability of The AcrySof IQ Toric Intraocular Lens in Cataract Patients Suffering from Myopia

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Journal of Clinical and Nursing Research 2024年第3期8卷 207-214页

作者： Jie Luo Yang liu Bing Wang lei li Junyu Yang The Daqing Oilfields General Hospital Daqing 163001Heilongjiang ProvinceChina

Objective:To analyze the enduring rotational steadiness of AcrySof IQ Toric intraocular lens(IOL)in cataract patients suffering from myopia in a long-term study.Methods:A retrospective study was conducted on a case series involving 78 patients.A total of 120 eyes with an axial length(AL)ranging from 24-30 mm and corneal astigmatism≥1.50 D underwent implantation of AcrySof IQ Toric IOL guided by the version navigation system.The eyes were divided into two groups based on AL.Group A included 60 eyes with high myopia(AL≥26 mm),while Group B consisted of eyes with low to moderate myopia(24 mm≤ALlightly higher average rotation of 2.87±1.31°,compared to the rotation of 2.59±1.27°observed in Group B.At both the 24-36 month and 26-48 month post-operation marks,the degree of IOL rotation did not show a statistically significant difference between the two groups,with none of the patients experiencing a rotation exceeding 10°(P>0.05).The percentage of rotation degrees under 5°was recorded as 98.22%.After the procedure,the BCDVA was 0.1322±0.03 LogMAR.There was a substantial increase in theχvalue after the operation as compared to the pre-operativeχ^(2) value(χ^(2)=76.79).The standard deviation of preoperative corneal astigmatism was statistically significant(Pliable solution for managing corneal astigmatism in cataract patients with myopia,demonstrating excellent long-term rotationa

关键词： Astigmatism Long-term Myopia Rotational stability

Huoxin Pill Reduces Myocardial Ischemia Reperfusion Injury in Rats via TLR4/NFκB/NLRP3 Signaling Pathway

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1066-1076页

作者： CAO Ce QI Yu-tong WANG Ao-ao WANG Zi-yan liU Zi-xin MENG Hong-xu li lei liU Jian-xun Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing Key Laboratory of Chinese Materia PharmacologyNational Clinical Research Center of Traditional Chinese Medicine for Cardiovascular DiseasesBeijing(100091)China Institute of Chinese Medicine Sciences Guangdong Pharmaceutical UniversityGuangzhou(510006)China

Objective:To explore the protective effect of Huoxin Pill(HXP)on acute myocardial ischemia-reperfusion(MIRI)injury in rats.Methods:Seventy-five adult SD rats were divided into the sham-operated group,model group,positive drug group(diltiazem hydrochloride,DH),high dose group(24 mg/kg,HXP-H)and low dose group(12 mg/kg,HXP-L)of Huoxin Pill(n=15 for every group)according to the complete randomization method.After 1 week of intragastric administration,the left anterior descending coronary artery of the rat's heart was ligated for 45 min and reperfused for 3 h.Serum was separated and the levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB)and lactate dehydrogenase(LDH),superoxide dismutase(SOD),and malondialdehyde(MDA),hypersensitive C-reactive protein(hs-CRP)and interleukin-1β(IL-1β)were measured.Myocardial ischemia rate,myocardial infarction rate and myocardial no-reflow rate were determined by staining with Evans blue and 2,3,5-triphenyltetrazolium chloride(TTC).Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine(BATMAN)databases were used to screen for possible active compounds of HXP and their potential therapeutic targets;the results of anti-inflammatory genes associated with MIRI were obtained from GeneC ards,Drugbank,Online Mendelian Inheritance in Man(OMIM),and Therapeutic Target Datebase(TTD)databases was performed;Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment were used to analyze the intersected targets;molecular docking was performed using AutoD ock Tools.Western blot was used to detect the protein expression of Toll-like receptor 4(TLR4)/nuclear factor kappa-B(NFκB)/NOD-like receptor protein 3(NLRP3).Results:Compared with the model group,all doses of HXP significantly reduced the levels of LDH,CK and CK-MB(P<0.05,P<0.01);HXP significantly increased serum activity of SOD(P<0.05,P<0.01);all doses of HXP significantly reduced the levels of hs-CRP

关键词： Houxin Pill myocardial ischemia-reperfusion injury TLR4/NFκB/NLRP3 signaling pathway network pharmacology molecular docking

Tumor recurrence and survival prognosis in patients with advanced gastric cancer after radical resection with radiotherapy and chemotherapy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1660-1669页

作者： Shuang-Fa Nie Chen-Yang Wang lei li Cheng Yang Zi-Ming Zhu Jian-Dong Fei Department of General Surgery The First Affiliated Hospital of Hebei North UniversityZhangjiakou 75000Hebei ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Fudan UniversityShanghai 200032China

BACKGROUND Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical treatment.Chemoradiotherapy,as one of the important treatment methods for gastric cancer,is of great significance for improving the survival rate of patients.However,the tumor recurrence and survival prognosis of gastric cancer patients after radio-therapy and chemotherapy are still uncertain.AIM To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for clinicians.METHODS A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to 2023.The Kaplan-Meier method was used to calculate the recurrence rate and survival rate;the log-rank method was used to analyze the single-factor prognosis;and the Cox model was used to analyze the prognosis associated with multiple factors.RESULTS The median follow-up time of the whole group was 63 months,and the follow-up rate was 93.6%.Stage II and III patients accounted for 31.0%and 66.7%,respec-tively.The incidences of Grade 3 and above acute gastrointestinal reactions and hematological adverse reactions were 8.8%and 9.9%,respectively.A total of 166 patients completed the entire chemoradiotherapy regimen,during which no adverse reaction-related deaths occurred.In terms of the recurrence pattern,17 patients had local recurrence,29 patients had distant metastasis,and 12 patients had peritoneal implantation metastasis.The 1-year,3-year,and 5-year overall survival(OS)rates were 83.7%,66.3%,and 60.0%,respectively.The 1-year,3-year,and 5-year disease-free survival rates were 75.5%,62.7%,and 56.5%,respectively.Multivariate analysis revealed that T stage,peripheral nerve invasion,and the lymph node metastasis rate(LNR)were independent prognostic factors for OS.CONCLUSION Postoperative intensity-modulated radiotherapy combined with chemothe

关键词： Tumor recurrence Survival prognosis Advanced gastric cancer Radical resection Retrospective study

Pressure-Driven Energy Band Gap Narrowing of λ-N_(2)

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Chinese Physics Letters 2024年第4期41卷 173-177页

作者：李月刘静仪吴彬彬陶雨耿延雷王晓丽雷力 Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China School of Physics and Electronic Information Yantai UniversityYantai 264005China

Probing the energy band gap of solid nitrogen at high pressures is of importance for understanding pressuredriven changes in electronic structures and insulator-to-metal transitions under high pressure.The λ-N_(2) formed by cold compression is known to be the most stable one in all solid nitrogen phases observed so far.By optimizing the optical system,we successfully measured the high-pressure absorption spectra of λ-N_(2) covering the polymericnitrogen synthetic pressures(124 GPa-165 GPa).The measured optical band gap decreases with increasing pressure,from 2.23 eV at 124 GPa to 1.55 eV at 165 GPa,with a negative pressure coefficient of-18.4 meV/GPa,which is consistent with the result from our ab initio total-energy calculations(-22.6 meV/GPa).The extrapolative metallization pressure for theλ-N_(2) is around 288(18)GPa,which is close to the metallization pressure(280 GPa)for the η-N_(2) expected by previous absorption edge and direct electrical measurements.Our results provide a direct spectroscopic evidence for the pressure-driven band gap narrowing of solid nitrogen.

关键词： absorption transitions spectroscopic

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精神与自由

湖北大学学报(哲学社会科学版) 2024年第1期51卷 1-11+175页

作者：江畅李累湖北大学哲学学院

亚里士多德的“人是理性动物”命题把人理解为动物本来就有其局限，而西方近代以来的哲学家进一步将理性视为人的唯一本质则问题更大。从宇宙演化和生物进化的角度看，人类本性就在于人类性，其基本含义就是谋求生存得更好，包含生存需... 详细信息

亚里士多德的“人是理性动物”命题把人理解为动物本来就有其局限，而西方近代以来的哲学家进一步将理性视为人的唯一本质则问题更大。从宇宙演化和生物进化的角度看，人类本性就在于人类性，其基本含义就是谋求生存得更好，包含生存需要、发展需要和精神需要的不断满足。精神需要被开发出来并得到满足，人就具有了精神性，也就获得了超越性和自由。这种精神性才是人类本性之所在，也是人的本然本质和应然本质，它使人成为高于动物的精神物种、自由物种。精神是高级自我意识的产物或体现，主导观念、最高理想和基本信念是其中的核心要素。精神是人的超越性和自由的根基，自由是精神追求的目的和结果，而精神状况通过自由来展现或彰显。精神所达到的境界决定着人的自由程度，人要获得更多更大的自由，必须不断提升自己的精神境界。精神之所以能使人自由，是因为只有精神才能使人具有超越性，而具有超越性正是自由之体现。

关键词：精神自由理性理性动物精神物种