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Maternal-Fetal Medicine 2020年第4期2卷 240-243页

作者： li Hui-Fan Wang Dong li jun-Qi Zhang li Zhang Xu Qi Hong-Bo li jun-nan Department of Obstetrics and Fetal Medicine Unit the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Ultrasound The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Beijing G-Epigen Medical Technology Inc. Beijing 101300China

Fetal cardiac rhabdomyoma is associated with tuberous sclerosis complex(TSC)which is an autosomal dominant hereditary neurocutaneous disease with an incidence of approximately 1 in 5000 to 10000 live *** is caused by mutations in the TSC1 or TSC2 gene,de novo mutations accounting for approximately 80%of TSC cases,which can involve multiple organs and systems such as the heart,brain,kidney,lung,skin,and so *** rhabdomyoma is the most common fetal heart tumor,accounting for about 60%of *** is closely related to TSC and may be the only manifestation of TSC which occurs during *** study retrospectively analyzed the clinical data of a neonate with TSC diagnosed with fetal cardiac rhabdomyomas and confirmed by amniocentesis prenatal diagnosis as gene testing TSC1 gene *** parents had no such ***,due to the influence of the sudden coronavirus disease 2019(COVID-19)epidemic,the TSC genetic test report was not obtained until 38 weeks of *** hypo-pigmented spots(diameter>5 mm)were found immediately after *** characteristic cardiac feature of TSC is a rhabdomyoma and the diagnosis of TSC is based upon genetic testing and multiple ultrasound examinations or magnetic resonance *** patients with TSC have epilepsy,and one-half or more have cognitive deficits and learning *** rigorous follow-up will continue for the case we reported.

关键词： Tuberous sclerosis Cardiac rhabdomyoma Prenatal diagnosis Gene Mutation

Prenatal Diagnosis of Harlequin Ichthyosis:A Case Report

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Maternal-Fetal Medicine 2020年第4期2卷 244-247页

作者： Xia Qiu-ling Wang Xing Huang Shuai li jun-nan Department of Obstetrics and Fetal Medicine Unit the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Harlequin ichthyosis is a severe autosomal recessive skin *** deaths occur within the first few days after birth,and the survivors still have severe chronic skin disease throughout their *** all cases were associated with a pathogenic variant of adenosine triphosphate binding cassette transporter,subfamily A,member 12(ABCA12)*** described a case of HI diagnosed by ultrasound examination during the second-trimester and genetic diagnosis reveal two novel heterozygous ABCA12 mutations c.2563-2570delinsGGCAATT,p.(Leu855Glyfs*13),and c.6116delT,p.(Met2039Argfs*8)by the next-generation DNA sequencing,which further enriched our understanding of the pathogenic variation of ABCA12 gene.

关键词： Prenatal diagnosis Harlequin ichthyosis Ultrasound Gene Adenosine triphosphate binding cassette transporter,subfamily A,member 12(ABCA12)

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

表皮干细胞特性及其应用走向临床的路程还有多长?

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中国组织工程研究与临床康复 2010年第1期14卷 157-160页

作者：李俊男刘流昆明医学院第一附属医院口腔颌面外科云南省昆明市650032

背景:表皮干细胞作为皮肤组织的特异性干细胞,不仅是维持皮肤新陈代谢的主要功能细胞,而且与创面修复紧密相关,是皮肤及其附属器发生、修复的基础。目的:对近年来表皮干细胞的特性及临床应用研究现状做一综述。方法:应用计算机以Epiderm... 详细信息

背景:表皮干细胞作为皮肤组织的特异性干细胞,不仅是维持皮肤新陈代谢的主要功能细胞,而且与创面修复紧密相关,是皮肤及其附属器发生、修复的基础。目的:对近年来表皮干细胞的特性及临床应用研究现状做一综述。方法:应用计算机以Epidermal stem cell,Basic study,Gene therapy为检索词,检索PubMed数据库(2009/06-08);以表皮干细胞、基础研究、基因治疗为检索词,检索CNKI数据库(2009/06-08)。结果与结论:计算机初检得到532篇文献,中文283篇,英文249篇。阅读标题和摘要进行初筛,排除因研究目的与此文无关的127篇,内容重复性的研究158篇,Meta分析25篇,共保留31篇文献进行综述。表皮干细胞具有体内慢周期性、自我更新能力、对皮肤基底膜的黏附等典型特征,在组织结构中位置相对固定,位于表皮内血供丰富的基底层及毛囊隆突部。表皮干细胞的增殖分化受到外在因素和内在因素的影响,前者指干细胞所处的微环境,即干细胞"壁龛",后者则包括整合素-丝裂原激活蛋白激酶通路、Wnt信号通路、c-Myc原癌基因、Notch信号传导通路。目前常用的表皮干细胞标记物包括整合素、角蛋白以及p63,p75、表皮细胞表面转铁蛋白受体CD71等。在临床应用方面,表皮干细胞可用于组织工程与创伤修复、基因治疗及表皮肿瘤等领域。

关键词：表皮干细胞增殖分化标记物特性临床应用

Antenatal treatment of cystic mass of fetal chest wall with OK-432 (group A streptococcus preparation)

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Antenatal treatment of cystic mass of fetal chest wall with ...

The Mechanism of Heating Rate on the Secondary Recrystallization Evolution in Grain Oriented Silicon Steel

中华医学会第一届全球华人妇产科学术大会暨第三次全国妇产科中青年医师学术会议

作者： Department of Obstetrics and Gynecology,Southwest Hospital,Chongqing Gong-li Chen jun-nan li Zhi-qing liang

The cystic mass of the fetal chest wall may affect Fetal pulmonary expansion which determine the immediate neonatal *** labor would be performed if fatal malformations of the cystic mass was confmned. OK-432,a lyophilized incubation mixture of the group A streptococcus of human origin(avirulent Su swain),was initially used in treating malignant pleural effusion in the cancer patients,was recently used in treating pediatric, neonatal,and even fetal cystic mass and was reported to be effective.

关键词：

来源： cnki会议评论

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 275-282页

作者： GAO Qian li jun WANG Xianhui CAO Laifu GONG Jian li Bo Central Iron and Steel Research Institute Group Beijing 100081China Shougang Zhixin Electromagnetic Material R&D(Beijing)Co. Ltd.Beijing 101300China Beijing Shougang Co. Ltd.Qian’an 064404China

Grain-oriented silicon steels were prepared at different heating rates during high temperature annealing,in which the evolution of magnetic properties,grain orientations and precipitates were *** illustrate the Zener factor,the diameter and number density of precipitates of interrupted testing samples were statistically *** effect of precipitate ripening on the Goss texture and magnetic property was *** indicated that the trend of Zener factor was similar under different heating rates,first increasing and then decreasing,and that the precipitate maturing was greatly inhibited as the heating rate *** recrystallization was developed at the temperature of 1010℃when a heating rate of 5℃/h was used,resulting in Goss,Brass and{110}oriented grains growing abnormally and a magnetic induction intensity of ***,increasing the heating rate to 20℃/h would inhibit the development of undesirable oriented grains and obtain a sharp Goss ***,when the heating rate was extremely fast,such as 40℃/h,poor secondary recrystallization was developed with many island grains,corresponding to a decrease in magnetic induction intensity to 1.87 *** a suitable heating rate of 20℃/h,the sharpest Goss texture and the highest magnetic induction of 1.94 T with an onset secondary recrystallization temperature of 1020℃were found among the experimental variables in this *** heating rate affected the initial temperature of secondary recrystallization by controlling the maturation of precipitates,leading to the deviation and dispersion of Goss texture,thereby reducing the magnetic properties.

关键词： high temperature annealing heating rate secondary recrystallization grain oriented silicon steel

Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu Yue li jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

过量空气系数及旋流数对天然气燃烧特性的影响研究

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热能动力工程 2024年第4期39卷 114-121页

作者：谢俊李俊楠李润东沈阳航空航天大学能源与环境学院辽宁沈阳110136

针对天然气在O_(2)/N_(2)氛围下扩散燃烧时,过量空气系数和旋流数对WNS型燃气锅炉燃烧室内的温度分布、速度分布及NOx生成的影响,利用CFD软件,采用标准k-ε湍流模型、P-1辐射模型和涡耗散模型进行数值模拟。基于旋流对流动特性的影响,... 详细信息

针对天然气在O_(2)/N_(2)氛围下扩散燃烧时,过量空气系数和旋流数对WNS型燃气锅炉燃烧室内的温度分布、速度分布及NOx生成的影响,利用CFD软件,采用标准k-ε湍流模型、P-1辐射模型和涡耗散模型进行数值模拟。基于旋流对流动特性的影响,采用旋流数S来表示入口空气的旋流强度。结果表明:在过量空气系数α从1.0增大到1.3的过程中,火焰直径逐渐变小,排烟温度降低,燃烧室出口处NOx的质量分数逐渐减小;在空气旋流数从0提高到0.8的过程中,燃烧室内形成了中心回流区,火焰的径向流动分布逐渐改善,燃烧室内的温度分布更加均匀;旋流燃烧的火焰中心轴线温度分布高于直流射流燃烧,提高空气旋流数可以有效降低NOx的质量分数。

关键词：燃气锅炉过量空气系数旋流数数值模拟

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L-缬氨酸旋光异构的两种光反应可能途径

物理化学学报 2012年第8期28卷 1830-1836页

作者：马驰骋蒲敏卫敏李军男李志宏北京化工大学化工资源有效利用国家重点实验室北京100029 中国科学院高能物理研究所同步辐射实验室北京100049

利用密度泛函理论(DFT)和从头算分子轨道理论对L-缬氨酸的旋光异构光反应机理进行了研究.分别用B3LYP和MP2方法在6-311++G(d,p)基组级别上全优化得到了S0和T1态反应路径上的反应物、产物、中间体以及过渡态结构的几何构型,给出了反应能... 详细信息

利用密度泛函理论(DFT)和从头算分子轨道理论对L-缬氨酸的旋光异构光反应机理进行了研究.分别用B3LYP和MP2方法在6-311++G(d,p)基组级别上全优化得到了S0和T1态反应路径上的反应物、产物、中间体以及过渡态结构的几何构型,给出了反应能垒,利用含时密度泛函理论(TD-DFT)中的B3LYP/6-311++G(d,p)方法优化得到了S1态反应路径上的平衡态几何构型.通过分析反应途径上各个驻点的几何构型特征,确定了L-缬氨酸在激发态可能通过手性碳上的氢原子以羰基氧或氨基氮为中转媒介发生质子迁移来完成旋光异构反应.进一步用自洽反应场理论中的极化连续模型(PCM)方法探讨了溶剂化效应对旋光异构反应机理的影响.

关键词：缬氨酸:旋光异构:密度泛函理论:从头算分子轨道理论:溶剂化效应

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction