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乡村振兴战略下体育旅游与民俗体育耦合发展机制研究

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当代体育科技 2024年第14期14卷 85-87页

作者：李晖周琥邓勇李九龙郴州职业技术学院马克思主义学院湘南学院体育学院郴州市第九中学湖南郴州423000

乡村振兴是我国政府针对我国国情提出的一项发展部署,旨在推进农村建设发展,核心内容是产业兴旺、生态宜居、乡风文明、治理有效、生活富裕。乡村振兴视域下,民族文化和新兴体育旅游形式耦合发展尤为必要。该文立足乡村振兴背景,从体育... 详细信息

乡村振兴是我国政府针对我国国情提出的一项发展部署,旨在推进农村建设发展,核心内容是产业兴旺、生态宜居、乡风文明、治理有效、生活富裕。乡村振兴视域下,民族文化和新兴体育旅游形式耦合发展尤为必要。该文立足乡村振兴背景,从体育旅游与民俗体育耦合发展动因入手,在对实现体育旅游与民俗体育耦合发展重要意义进行分析的基础上,探讨了体育旅游与民俗体育耦合发展模式。

关键词：乡村振兴体育旅游民俗体育耦合发展

Enrichment of nano delivery platforms for mRNA-based nanotherapeutics

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Medical Review 2023年第4期3卷 356-361页

作者： Xiao liu Xu Zhang jiulong li Huan Meng Department of Gastroenterology Beijing HospitalNational Center of GerontologyInstitute of Geriatrics MedicineChinese Academy of Medical SciencesBeijingChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology BeijingChina University of Chinese Academy of Sciences BeijingChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology 11 ZhongguancunbeiyitiaoHaidian DistrictBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

lipid-based nanoparticles(LNP)have shown significant progress in delivering mRNA for therapeutics,particularly with the success of coronavirus disease 2019(COVID-19)***,there are still challenges,such as organ-specific targeting,sustained protein expression,immunogenicity,and storage that need to be ***,there is interest in developing additional nano drug delivery systems(DDS)to complement LNP *** of these include polymer,lipid-polymer hybrid,organic/inorganic hybrid nanostructure,and inorganic *** our opinion,LNP technology may not be suitable for every disease scenario in categories such as infection disease,cancer,pulmonary disease,autoimmune disorders and genetic rare disease(among others).This is because different diseases may require distinct administration routes,doses,and treatment durations,as well as considerations for biological barriers that may lower the efficacy and/or exert safety *** this perspective,we will highlight the need and potential for enhancing the diversity of nano delivery platforms for mRNA-based nanotherapeutics.

关键词： high throughput screening mRNA nano/bio interface nano drug delivery system non-LNP nanocarrier nanosafety

Earth rotation parameter and variation during 2005—2010 solved with LAGEOS SLR data

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Geodesy and Geodynamics 2015年第1期6卷 55-60页

作者： Shen Yi Guo Jinyun Zhao Chunmei Yu Xuemin li jiulong College of Geodesy and Geomatics Shandong University of Science and Technology State Key Laboratory of Mining Disaster and Prevention and Control Co-founded by Shandong Province and Ministry of Science & Technology Shandong University of Science and Technology Chinese Academy of Surveying and Mapping

Time series of Earth rotation parameters were estimated from range data measured by the satellite laser ranging technique to the Laser Geodynamics Satellites（LAGEOS）-1/2 through 2005 to 2010 using the dynamic method. Compared with Earth orientation parameter（EOP）C04, released by the International Earth Rotation and Reference Systems Service, the root mean square errors for the measured X and Y of polar motion（PM） and length of day（LOD）were 0.24 and 0.25 milliarcseconds（mas）, and 0.068 milliseconds（ms）, *** with ILRSA EOP, the X and Y of PM and LOD were 0.27 and 0.30 mas, and 0.054 ms, respectively. The time series were analyzed using the wavelet transformation and least squares methods. Wavelet analysis showed obvious seasonal and interannual variations of LOD, and both annual and Chandler variations of PM; however, the annual variation could not be distinguished from the Chandler variation because the two frequencies were very close. The trends and periodic variations of LOD and PM were obtained in the least squares sense, and PM showed semi-annual, annual, and Chandler ***-annual, annual, and quasi-biennial cycles for LOD were also detected. The trend rates of PM in the X and Y directions were 3.17 and 1.60 mas per year, respectively, and the North Pole moved to 26.8E relative to the crust during 2005—2010. The trend rate of the LOD change was 0.028 ms per year.

关键词： Geodesy Satellite laser range(SLR) Earth rotation parameter(ERP) Laser Geodynamics Satellites(LAGEOS) Earth orientation paramete

Zero drift and solid Earth tide extracted from relative gravimetric data with principal component analysis

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Geodesy and Geodynamics 2015年第2期6卷 143-150页

作者： Yu Hongjuan Guo Jinyun li jiulong Mu Dapeng Kong Qiaoli College of Geodesy and Geomatics Shandong University of Science and Technology State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and Ministry of Science & Technology Shandong University of Science and Technology Institute of Geodesy and Geophysics Chinese Academy of Science

Zero drift and solid Earth tide corrections to static relative gravirnetric data cannot be ignored. In this paper, a new principal component analysis （PCA） algorithm is presented to extract the zero drift and the solid Earth tide, as signals, from static relative gravimetric data assuming that the components contained in the relative gravimetric data are uncorrelated. Static relative gravity observations from Aug. 15 to Aug. 23, 2014 are used as statistical variables to separate the signal and noise with PCA to obtain desired signals. The results of the linear drift extracted by PCA are consistent with those calculated by the least squares linear fitting, and the differences only reach to 10-2μGal/day order of magnitude. Furthermore, PCA is used to estimate the solid Earth tide from the relative gravimetric data corrected by the zero drift. The statistical results are consistent with the results derived from the solid Earth tide correction provided by the internal software of the CG-5 gravimeter （SCINTREX limited Ontario Canada）. The statistical results of the differences between the two methods are both less than 8 ,Gal, and the RMSs for 9 days are all less than 5 μGal.

关键词： Principal component analysis Zero drift Solid Earth tide Relative gravimetry CG-5 gravimeter

NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung

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Journal of Environmental Sciences 2022年第1期34卷 429-441页

作者： Wei Cao Xiang Wang jiulong li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei liao Shannon Tseng Sydney Kusumoputro Candice Lau Marissa Huang Pengli Han Pengju Lu Tian Xia Translational Medical Center Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China Division of NanoMedicine Department of MedicineUniversity of CaliforniaLos Angeles 90095CAUnited States Basic Medical College Zhengzhou UniversityZhengzhou 450001China Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles 90095CAUnited States Department of Integrative Biology and Physiology University of CaliforniaLos Angeles 90095CAUnited States Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos Angeles 90095CAUnited States

Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung ***3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this *** collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung *** vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial *** the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1β*** was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 *** of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary *** ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen *** summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis.

关键词： Particulate matter Predictive toxicology NLRP3 inflammasome IL-1β Lung fibrosis Lung inflammation

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直拉法单晶硅中位错影响因素研究进展

硅酸盐学报 2021年第4期49卷 723-735页

作者：苏文佳李九龙杨伟李琛王军锋江苏大学能源与动力工程学院江苏镇江212013

在介绍了直拉法单晶硅中位错形成及运动机理的基础上,归纳了其生长过程中籽晶热冲击、固液界面、晶体直径和杂质等因素对位错的影响,分析了硼、锗、氮、磷、砷掺杂元素和氧杂质对单晶硅位错行为的影响.籽晶热冲击会引起位错,而通过缩颈... 详细信息

在介绍了直拉法单晶硅中位错形成及运动机理的基础上,归纳了其生长过程中籽晶热冲击、固液界面、晶体直径和杂质等因素对位错的影响,分析了硼、锗、氮、磷、砷掺杂元素和氧杂质对单晶硅位错行为的影响.籽晶热冲击会引起位错,而通过缩颈、回熔、籽晶预热以及采用掺杂的籽晶等方式可以使其得到抑制.凸向熔体的固液界面引起较大的边缘切应力产生边缘位错,当形状为平面时,可抑制位错形成;在重掺n型单晶硅中,固液界面的演变和{111}边缘面的形成可能促进过冷区域产生并中断顶锥生长,进而引发位错,并且边缘面的长度与熔融等温线的曲率有关;引晶时籽晶的不完全引晶,会产生位错且无法排出晶体,进而延伸至硅棒中;单晶硅直径增大和长晶过程中的直径波动都会增加位错的形成风险.掺杂是抑制位错形成与运动的有效方法,硼、锗、氮、磷、砷以及氧杂质对位错都起着不同程度的抑制作用,主要原因在于杂质原子对位错的钉扎效应.最后,针对缩颈工艺、热场设计、掺杂工艺和理论建模等方面,对未来的研究工作做出了展望.

关键词：直拉法单晶硅位错固液界面籽晶热冲击晶体直径

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耐辐射奇球菌对受损湿地土壤的生态修复研究

核农学报 2017年第7期31卷 1397-1403页

作者：李九龙田兵华跃进浙江大学原子核农业科学研究所/农业部和浙江省核农学重点实验室浙江杭州310029

为探究微生物和植物在受损入海河口附近重金属污染的盐碱滩涂湿地上的生态修复效果,选择适合于该类型区域的生态修复方法,通过极端微生物——耐辐射奇球菌、盐生翅碱蓬及其组合处理等方式在受损滩涂湿地进行修复作用研究,分析不同处理... 详细信息

为探究微生物和植物在受损入海河口附近重金属污染的盐碱滩涂湿地上的生态修复效果,选择适合于该类型区域的生态修复方法,通过极端微生物——耐辐射奇球菌、盐生翅碱蓬及其组合处理等方式在受损滩涂湿地进行修复作用研究,分析不同处理对滨海湿地的修复效果。结果表明,上述处理均能部分改良试验区域土壤的物理、化学、生物学性质;添加耐辐射奇球菌后,土壤微生物数量显著增加、重金属Cd(II)含量降幅达25.24%、有效磷含量增加12.75%、有机质含量增加13.1%、水溶性盐含量降低3.37%;耐辐射奇球菌处理在增加土壤有效磷、有机质和微生物数量,降低Cd(II)和水溶性盐含量等指标方面优于其它处理,表现出更为明显的修复效果。本研究结果为利用极端微生物进行受损湿地生态修复提供了理论依据和实践参考。

关键词：受损湿地生态修复耐辐射奇球菌盐生翅碱蓬土壤理化性质

钻孔瞬变电磁法接收线圈定向屏蔽物理模拟研究

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煤炭学报 2024年第7期49卷 3178-3187页

作者：辛成涛程久龙李垚孔孟行中国矿业大学(北京)地球科学与测绘工程学院北京100083

钻孔瞬变电磁(BTEM)扫描探测方法可以利用巷道已有超前探查钻孔,通过旋转置于钻孔内收发线圈对孔壁外围隐蔽地质异常体进行扫描探测,因收发装置位于钻孔内,不仅避免了巷道内电气设备和金属物的电磁干扰,而且可以提高钻孔利用率,减少钻... 详细信息

钻孔瞬变电磁(BTEM)扫描探测方法可以利用巷道已有超前探查钻孔,通过旋转置于钻孔内收发线圈对孔壁外围隐蔽地质异常体进行扫描探测,因收发装置位于钻孔内,不仅避免了巷道内电气设备和金属物的电磁干扰,而且可以提高钻孔利用率,减少钻探工作量。然而,钻孔瞬变电磁法受全空间效应的影响,在扫描探测过程中,以收发线圈法线方向为探测方向接收异常体二次场信号的同时,还易受到其他方向信号的叠加干扰。若无法有效压制干扰信号,将直接影响对钻孔孔壁外围地质异常体的精确定位。利用屏蔽的方法,在接收线圈上安装屏蔽罩,尽可能保留线圈法线与屏蔽罩开口一致的探测方向的响应信号,而对其他方向的信号进行压制,从而实现钻孔孔壁径向一定范围内指向性探测。首先通过物理模拟实验探讨了不同匝数、尺寸的收发线圈对瞬变电磁场响应特征的影响,对适用于钻孔内的收发线圈参数进行组合优选。然后针对所要屏蔽的电磁波,选择不同种类的屏蔽材料,开展不同材料对不同方向电磁波的屏蔽效果实验。通过对比探测方向和其他方向的感应电动势,证实以泡沫镍制作的屏蔽罩能有效地压制非探测方向的干扰信号。通过实验分别对屏蔽罩的不同形状、磁导率等物性参数进行瞬变电磁场响应特征对比分析,并探讨屏蔽罩开口角度与定向屏蔽效果的关系,优化定向屏蔽罩参数,增强屏蔽效果。最后使用参数优化后的收发线圈和定向屏蔽装置进行钻孔瞬变电磁法径向断面扫描探测现场实验,采用基于混合分布的混沌量子粒子群和Levenberg-Marquarat及Occam组合算法的反演方法进行电阻率成像。研究表明:以泡沫镍为屏蔽材料,安装在接收线圈上的弧形屏蔽罩定向屏蔽效果较好,可以有效地压制钻孔瞬变电磁法扫描探测过程中非探测方向的信号干扰,且能较大程度的保留探测方向的异常响应信号,进而可以实现对钻孔孔壁外围隐蔽地质异常体的精确定位。

关键词：钻孔瞬变电磁法定向屏蔽瞬变电磁场特征扫描探测

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钻孔瞬变电磁法方位线圈扫描探测定位方法

煤炭学报 2024年第1期49卷 616-627页

作者：程久龙姜成麟李垚白仁喜中国矿业大学(北京)地球科学与测绘工程学院北京100083 中国石油集团测井有限公司地质研究院陕西西安710077 国家能源集团陕西神延煤炭公司陕西榆林719000

利用掘进巷道超前探水钻孔进行钻孔瞬变电磁法探测钻孔孔壁外围远距离含水体,避免了常规测井方法仅能探测钻孔孔壁岩层的“一孔之见”。目前钻孔瞬变电磁法受全空间效应的影响,接收到的单分量响应不能判别异常体方位;多分量响应可以近... 详细信息

利用掘进巷道超前探水钻孔进行钻孔瞬变电磁法探测钻孔孔壁外围远距离含水体,避免了常规测井方法仅能探测钻孔孔壁岩层的“一孔之见”。目前钻孔瞬变电磁法受全空间效应的影响,接收到的单分量响应不能判别异常体方位;多分量响应可以近似判断异常体的大致方位,但难以通过成像等直观有效的方法对其进行精确定位。基于钻孔瞬变电磁法和方位电磁波测井相关理论,提出了钻孔瞬变电磁法方位线圈扫描探测定位方法,采用方位线圈作为探测装置,减小线圈互感,增强钻孔瞬变电磁法的探测效果。同时,通过改变线圈旋转角,对钻孔孔壁进行360°扫描,形成钻孔径向全方位探测,旨在对钻孔孔壁外围岩体中的低阻体进行精确定位。首先推导方位线圈的互感解析表达式,探讨方位角对方位线圈互感的影响,通过数值计算确定最佳方位角取值。分别建立均匀介质和含低阻异常体的钻孔全空间三维地质-地球物理模型进行瞬变电磁场数值模拟,分析方位线圈的瞬变电磁法扫描探测多分量响应特征,总结方位线圈扫描探测瞬变电磁响应规律,确定了钻孔瞬变电磁法方位线圈扫描探测定位方法,即通过钻孔轴向和径向的瞬变电磁响应特征判别钻孔孔壁外围岩体中低阻异常体的位置。最后建立含2个低阻体的地质-地球物理模型,采用最佳方位角的方位线圈进行数值实验,验证了该方法能有效地判别低阻异常体的方位。研究表明:钻孔瞬变电磁法方位线圈扫描探测结果可以较好地反映钻孔径向外围岩体中低阻异常体引起的瞬变电磁场异常,全空间视电阻率成像结果分辨率较高。依据钻孔轴向和径向的瞬变电磁响应特征,钻孔瞬变电磁法方位线圈扫描探测定位方法对钻孔孔壁外围岩体中的低阻异常体具有较高的分辨率及定位精度。研究结果可以为钻孔瞬变电磁法方位线圈扫描探测定位方法的实际应用提供理论依据。

关键词：钻孔瞬变电磁法方位线圈扫描探测数值模拟定位