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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： li jie CHEN Ya-feng GAO Lei li Yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each group.Samples of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(EliSA),and Western blot.In vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON groups.The tight connection level was determined by transmission electron microscopy and fluorescein isothiocyanate-labeled.The location and acetylation of HMGB1 were measured by Western blot.Finally,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on HMGB1.The protein expression levels of HMGB1,JAK,and STAT1 were detected using Western blot.Results Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted histology.Mice in the SAP+HON group had significantly fewer pathological changes.Mice with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and procalcitonin.Mice in the SAP+HON group did not show these abnormalities(Plity,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these effects.Studies of macrophages indicated that LPS led to low nucle

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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A unified stochastic damage model for concrete based on multi-scale energy dissipation analysis

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Science China(Technological Sciences) 2024年第3期67卷 863-877页

作者： GUO ChengGong li jie College of Civil Engineering Tongji UniversityShanghai 200092China State Key Laboratory of Disaster Reduction in Civil Engineering Shanghai 200092China

This work proposes a unified damage model for concrete within the framework of stochastic damage mechanics. Based on the micro-meso stochastic fracture model(MMSF), the nonlinear energy dissipation process of the microspring from nanoscale to microscale is investigated. In nanoscale, the rate process theory is adopted to describe the crack growth rate;therefore, the corresponding energy dissipation caused by a representative crack propagation can be obtained. The scale gap from nanoscale to microscale is bridged by a crack hierarchy model. Thus, the total energy dissipated by all cracks from the nanoscale to the microscale is gained. It is found that the fracture strain of the microspring can be derived from the above multi-scale energy dissipation analysis. When energy dissipation is regarded as some microdamage to the microspring, the constitutive law of the microspring is no longer linearly elastic, as previously assumed. By changing the expression of the damage evolution law from fracture strain to energy dissipation threshold, the new damage evolution model is derived. The proposed model can not only replicate the original static model but also extend to cases of rate dependence. By deriving the fracture strain under different strain rates, the rate sensitivity of concrete materials can be reflected. The model parameters can be conveniently obtained by identifying them with experimental data. Finally, several numerical examples are presented to verify the proposed model.

关键词： concrete damage model stochastic damage rate dependent energy dissipation

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Assessment of cheese sign and its association with vascular risk factors: Data from PUMCH dementia cohort

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中华医学杂志(英文版) 2024年第7期137卷 830-836页

作者： Huang Xinying Hou Bo Wang jie li jie Shang li Mao Chenhui Dong liling liu Caiyan Feng Feng Gao Jing Peng Bin Department of Neurology State Key Laboratory of Complex Severe and Rare Disease Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College

Background: In the clinic, practitioners encounter many patients with an abnormal pattern of dense punctate magnetic resonance imaging (MRI) signal in the basal ganglia, a phenomenon known as "cheese sign". This sign is reported as common in cerebrovascular diseases, dementia, and old age. Recently, cheese sign has been speculated to consist of dense perivascular space (PVS). This study aimed to assess the lesion types of cheese sign and analyze the correlation between this sign and vascular disease risk factors.Methods: A total of 812 patients from Peking Union Medical College Hospital (PUMCH) dementia cohort were enrolled. We analyzed the relationship between cheese sign and vascular risk. For assessing cheese sign and defining its degree, the abnormal punctate signals were classified into basal ganglia hyperintensity (BGH), PVS, lacunae/infarctions and microbleeds, and counted separately. Each type of lesion was rated on a four-level scale, and then the sum was calculated; this total was defined as the cheese sign score. Fazekas and Age-Related White Matter Changes (ARWMC) scores were used to evaluate the paraventricular, deep, and subcortical gray/white matter hyperintensities.Results: A total of 118 patients (14.5%) in this dementia cohort were found to have cheese sign. Age (odds ratio [OR]: 1.090, 95% confidence interval [CI]: 1.064-1.120,P lipidemia, and cheese sign. The main components of cheese sign were BGH, PVS, and lacunae/infarction. The proportion of PVS increased with cheese sign severity.Conclusions: The risk factors for cheese sign were hypertension, age, and stroke. Cheese sign consists of BGH, PVS, and lacunae/infarction.

关键词： Dementia Cerebrovascular disease Cheese sign Dense punctate lesions Basal ganglia Risk factor White matter

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Research on denoising of joint detection signal of water quality with multi-parameter based on IEEMD

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Optoelectronics Letters 2024年第2期20卷 107-115页

作者： li Wen li Dejian MA Yongyue TIAN Wang WEN Xin li jie Institute of Mechanical and Electrical Engineering North China University of TechnologyBeijing 100144China1

An improved ensemble empirical mode decomposition(IEEMD) is suggested to process water quality spectral signals in order to address the issue that noise interference makes it difficult to extract and evaluate water quality spectral signals.This algorithm effectively solves the problems of modal mixing,poor reconstruction accuracy in the empirical mode decomposition(EMD),and a large amount of calculation in the ensemble empirical mode decomposition(EEMD).Based on EEMD,IEEMD firstly preprocesses the original water quality spectral signals,then performs Savitzky-Golay(S-G) smoothing on the decomposed effective intrinsic mode function(IMF) components,and finally reconstructs them to obtain the denoised signals.Water sample data at different concentrations can be accurately analyzed based on the noise-reduced spectral signals.In this paper,three water quality parameters are used as research objects:benzene(C_(6)H_(6)),benzo(b)fluoranthene(C_(20)H_(12)),and chemical oxygen demand(COD).The original water quality multi-parameter(C_(6)H_(6),C_(20)H_(12),COD) spectral signals were subjected to denoising based on the IEEMD and the water quality multi-parameter joint detection technology.The signal-to-noise ratio(SNR) and the correlation coefficient(R^(2)) of the fitted curves obtained from the processing of the IEEMD were compared and analyzed with those obtained from the processing of the EMD and the EEMD.The experimental results show that the SNR of the spectral signals and the R^(2) of the fitting curve in three water quality parameters have been significantly improved.Therefore,the IEEMD effectively improves the phenomenon of modal mixing,reduces the amount of calculation,improves the reconstruction accuracy,and provides an important guarantee for the effective extraction of multi-parameter spectral signals of water quality.

关键词： signal parameter noise

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Upper extremity motor function before and after the cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus: A retrospective study

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中华医学杂志(英文版) 2024年第7期137卷 877-879页

作者： liu Caiyan Wei Junji Dong liling Mao Chenhui li jie Huang Xinying Hou Bo Feng Feng Cui liying Gao Jing Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Neurosurgery Department of Neurosurgery and Radiology

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Yields,growth and water use under chemical topping in relations to row configuration and plant density in drip-irrigated cotton

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Journal of Cotton Research 2024年第2期7卷 123-136页

作者： Wang Xuejiao Hu Yanping Ji Chunrong Chen Yongfan Sun Shuai Zhang Zeshan Zhang Yutong Wang Sen Yang Mingfeng Ji Fen Guo Yanyun li jie Zhang lizhen Xinjiang Agriculture Network Information Center Xinjiang Agrometeorological ObservatoryUrumqi 830002China College of Resources and Environmental Sciences Xinjiang Agricultural UniversityUrumqi 830091China College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China China Meteorological Administration Institute of Desert MeteorologyUrumqi 830002China Wulanwusu Agrometeorological Station Shihezi 832199China Xinjiang Academy of Agricultural Sciences China National Cotton R&D CenterUrumqi 830091China

Background Water deficit is an important problem in agricultural production in arid regions.With the advent of wholly mechanized technology for cotton planting in Xinjiang,it is important to determine which planting mode could achieve high yield,fiber quality and water use efficiency(WUE).This study aimed to explore if chemical topping affected cotton yield,quality and water use in relation to row configuration and plant densities.Results Experiments were carried out in Xinjiang China,in 2020 and 2021 with two topping method,manual topping and chemical topping,two plant densities,low and high,and two row configurations,i.e.,76 cm equal rows and 10+66 cm narrow-wide rows,which were commonly applied in matching harvest machine.Chemical topping increased seed cotton yield,but did not affect cotton fiber quality comparing to traditional manual topping.Under equal row spacing,the WUE in higher density was 62.4%higher than in the lower one.However,under narrow-wide row spacing,the WUE in lower density was 53.3%higher than in higher one(farmers’practice).For machine-harvest cotton in Xinjiang,the optimal row configuration and plant density for chemical topping was narrow-wide rows with 15 plants m-2 or equal rows with 18 plants m-2.Conclusion The plant density recommended in narrow-wide rows was less than farmers’practice and the density in equal rows was moderate with local practice.Our results provide new knowledge on optimizing agronomic managements of machine-harvested cotton for both high yield and water efficient.

关键词： Yield components Fiber quality Transpiration Water use efficiency Heat ratio method(HRM)

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Perspective on new cell-free DNA technologies for early cancer detection

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Cancer Biology & Medicine 2024年第2期21卷 139-143页

作者： jie li Xun Lan Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China MOE Key Laboratory of Bioinformatics Tsinghua UniversityBeijing 100084China Tsinghua-Peking Joint Center for life Sciences Tsinghua UniversityBeijing 100084China

High cancer heterogeneity and aggressiveness are major factors contributing to the poor prognosis of patients with advanced cancer~(1-5).Early detection of cancer can significantly improve the prognosis of patients with early-stage cancer after standard treatment.Although traditional cancer detection technologies,such as endoscopy for gastrointestinal cancer,mammography for breast cancer。

关键词： prognosis cancer patients

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Neural Stem Cell Competition

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Neuroscience Bulletin 2024年第2期40卷 277-279页

作者： Yanan li jie He State Key Laboratory of Neuroscience Institute of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China

Cell competition is an adaptive surveillance mechanism to ensure the robustness of developmental outputs,maintain tissue integrity,and regulate tumor progression in multicellular organisms,which is highly conserved from invertebrates to vertebrates[1].At the cellular level,cell competition represents a non-cell-autonomous process in that cells can sense the fitness of their neighbors through cellular interactions,thereby eliminating low-fitness cells and expanding high-fitness counterparts,however,cells develop normally in homogenous populations.

关键词： thereby maintain eliminating

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Prevention of ventilator-associated pneumonia with inhaled antibiotics

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World Journal of Emergency Medicine 2024年第3期15卷 165-168页

作者： Stephan Ehrmann jie li Intensive Care Medicine INSERM CIC 1415CRICS-TriggerSep FCRIN research networkUniversity Hospital Center in ToursTours 37044France Respiratory Pathology Research Center National Institute of Health and Medical ResearchTours 37000France Department of Cardiopulmonary Sciences Division of Respiratory CareRush UniversityChicago 60612USA

The direct delivery of inhaled antibiotics to the respiratory tract has been a subject of enduring interest among medical practitioners and researchers due to the associated favorable pharmacokinetics.This interest has been particularly pronounced in the context of critically illpatients,wherehealthcare-associatedpulmonary infections represent a significant challenge,driving continued exploration of inhaled antibiotics for intubated patients.Recent high-level evidence has shown a very promising application in the field of ventilator-associated pneumonia (VAP) prevention.^([1]).

关键词： pneumonia ventilator respiratory

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Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamics

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Virologica Sinica 2024年第1期39卷 9-23页

作者： jie-li Hu Ai-Long Huang Key Laboratory of Molecular Biology on Infectious Diseases Ministry of EducationChongqing Medical UniversityChongqing400016China

The achievement of a functional cure for chronic hepatitis B(CHB)remains limited to a minority of patients treated with currently approved drugs.The primary objective in developing new anti-HBV drugs is to enhance the functional cure rates for CHB.A critical prerequisite for the functional cure of CHB is a substantial reduction,or even eradication of covalently closed circular DNA(cccDNA).Within this context,the changes in cccDNA levels during treatment become as a pivotal concern.We have previously analyzed the factors influencing cccDNA dynamics and introduced a preliminary classification of hepatitis B treatment strategies based on these dynamics.In this review,we employ a systems thinking perspective to elucidate the fundamental aspects of the HBV replication cycle and to rationalize the classification of treatment strategies according to their impact on the dynamic equilibrium of cccDNA.Building upon this foundation,we categorize current anti-HBV strategies into two distinct groups and advocate for their combined use to significantly reduce cccDNA levels within a well-defined timeframe.

关键词： Hepatitis B cccDNA Functional cure Dynamics Treatment Strategy

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