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Prognostic value of circulating tumor cells combined with neutrophil-lymphocyte ratio in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 372-385页

作者： jia-li chen Lu Guo Zhen-Ying Wu Kun He Han li Chi Yang Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Clinical Research Institute The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Plastic Surgery Meguiar's Medical Beauty HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Circulating tumor cell(CTC)count and neutrophil-to-lymphocyte ratio(NLR)are both closely associated with the prognosis of hepatocellular carcinoma(HCC).AIM To investigate the prognostic value of combining these two indicators in *** Clinical data were collected from patients with advanced HCC who received im-mune therapy combined with targeted therapy at the Department of Oncology,the Affiliated Hospital of Southwest Medical University,Sichuan,China,from 2021 to *** optimal cutoff values for CTC programmed death-ligand 1(PD-L1)(+)>1 or CTC PD-L1(+)≤1 and NLR>3.89 or NLR≤3.89 were evaluated using X-Tile *** were categorized into three groups based on CTC PD-L1(+)counts and NLR:CTC-NLR(0),CTC-NLR(1),and CTC-NLR(2).The relationship between CTC-NLR and clinical variables as well as survival rates was *** Patients with high CTC PD-L1(+)expression or NLR at baseline had shorter median progression-free survival(m-PFS)and median overall survival(mOS)than those with low levels of CTC PD-L1(+)or NLR(Pline CTC-NLR score may indicate low ***-NLR may serve as an effective prognostic indicator for patients with advanced HCC receiving immunotherapy combined with targeted therapy.

关键词： Circulating tumor cells Neutrophil–lymphocyte ratio Hepatocellular carcinoma Prognosis Survival Marker

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聚乙烯微塑料对盐渍化土壤微生物群落的影响

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环境科学 2024年第5期45卷 3088-3097页

作者：王志超李哲李嘉辰屈忠义杨文焕李卫平内蒙古科技大学能源与环境学院包头014010 黄河流域内蒙古段生态保护与综合利用自治区协同创新中心包头014010

地膜覆盖保墒已成为盐渍化土壤种植中重要的农艺措施,而盐渍化与微塑料双重胁迫对土壤微生物的影响越来越受到重视.为探究聚乙烯微塑料对盐渍化土壤微生物群落的影响,通过室内模拟盐渍化土壤环境中微塑料污染的方法,探究不同类型(氯盐... 详细信息

地膜覆盖保墒已成为盐渍化土壤种植中重要的农艺措施,而盐渍化与微塑料双重胁迫对土壤微生物的影响越来越受到重视.为探究聚乙烯微塑料对盐渍化土壤微生物群落的影响,通过室内模拟盐渍化土壤环境中微塑料污染的方法,探究不同类型(氯盐类和硫酸盐类)和不同含量(弱、中、强)的盐渍化土壤赋存不同丰度聚乙烯(PE)微塑料(土样干重的1%和4%)条件下对土壤微生物群落的影响.结果表明,PE微塑料会降低盐渍化土壤微生物群落多样性和丰富度,且硫酸盐类盐渍土处理受到的影响更强烈.赋存PE微塑料后不同处理微生物组成基本一致,但其相对丰度会发生变化,硫酸盐类盐渍土处理中各菌群相对丰度的变化较氯盐类盐渍土处理更强;门水平上,变形菌门相对丰度与赋存PE微塑料丰度呈正相关,而拟杆菌门、放线菌门和酸杆菌门相对丰度与赋存PE微塑料丰度呈负相关;科水平上,黄杆菌科、食碱菌科、盐单胞菌科和鞘脂单胞菌科相对丰度随赋存PE微塑料丰度增大而增大.KEGG代谢通路预测显示,赋存PE微塑料会降低微生物新陈代谢和遗传信息等功能相对丰度,硫酸盐类盐渍土对新陈代谢功能的抑制作用强于氯盐类盐渍土,而对遗传信息功能的抑制效果弱于氯盐类盐渍土;新陈代谢功能二级通道中氨基酸代谢、碳水化合物代谢、能量代谢等功能受到抑制,推测新陈代谢功能的降低可能是由于上述二级代谢通路相对丰度降低引起的.试验结果可为微塑料和盐渍化双重污染条件下对土壤环境的影响研究提供理论依据.

关键词：聚乙烯微塑料(PE MPs) 盐渍化土壤微生物组成和多样性功能

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公众人物抗辩理论的本土应用

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齐齐哈尔大学学报（哲学社会科学版） 2024年第7期 86-91页

作者：高勇李佳宸哈尔滨商业大学法学院黑龙江哈尔滨150028

公众人物抗辩理论主张,为了平衡人格权保护与言论自由,当发生侵犯公众人物人格权诉争时,如果侵权人主张被侵权人为公众人物即可减免自己的侵权责任。学界普遍认为,《民法典》第九百九十八条的规定实为公众人物抗辩理论在我国法律规范中... 详细信息

公众人物抗辩理论主张,为了平衡人格权保护与言论自由,当发生侵犯公众人物人格权诉争时,如果侵权人主张被侵权人为公众人物即可减免自己的侵权责任。学界普遍认为,《民法典》第九百九十八条的规定实为公众人物抗辩理论在我国法律规范中的具体体现。实际上公众人物抗辩理论早在20世纪90年代就已进入中国,21世纪初就有了应用,但在实践中却存在隐私权边界模糊、公众人物范畴泛化、公共利益的价值判断标准不确定以及脱离了适用于政治人物的主轨道等问题。对上述问题,应确立隐私权保护底线,限缩公众人物抗辩理论的适用范围,重构公众人物隐私侵权案件的证明责任,使该理论更好应用于本土司法实践。

关键词：公众人物隐私权真实恶意原则公众人物抗辩本土化

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PCNA、Bcl-2及EGFR在喉癌组织中的表达及与临床病理特征、生存的关系

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中国现代医学杂志 2024年第2期34卷 76-82页

作者：黄海平李佳宸苏州大学附属第一医院耳鼻喉科江苏苏州215006

目的探讨增殖细胞核抗原(PCNA)、B淋巴细胞瘤-2(Bcl-2)及表皮生长因子受体(EGFR)在喉癌组织中的表达及与临床病理特征、生存的关系。方法选取2017年3月—2020年1月在苏州大学附属第一医院因喉癌行手术治疗的92例患者的喉癌组织及对应癌... 详细信息

目的探讨增殖细胞核抗原(PCNA)、B淋巴细胞瘤-2(Bcl-2)及表皮生长因子受体(EGFR)在喉癌组织中的表达及与临床病理特征、生存的关系。方法选取2017年3月—2020年1月在苏州大学附属第一医院因喉癌行手术治疗的92例患者的喉癌组织及对应癌旁组织标本。检测癌组织与癌旁组织PCNA mRNA、Bcl-2mRNA、EGFR mRNA相对表达量,多元线性回归分析其癌组织表达与临床病理特征的关系。随访3年,采用Kaplain-Maier曲线分析不同PCNA、Bcl-2、EGFR表达水平患者生存情况差异。结果癌组织PCNA mRNA、Bcl-2 mRNA、EGFR mRNA相对表达量高于癌旁组织(P0.05);低分化,临床分期Ⅲ、Ⅳ期及淋巴结转移患者PCNA mRNA、Bcl-2 mRNA、EGFR mRNA相对表达量分别高于中、高分化,临床分期Ⅰ、Ⅱ期,无淋巴结转移患者(P<0.05)。多元线性回归分析结果显示,肿瘤分化程度、临床分期、淋巴结转移是喉癌组织PCNA mRNA、Bcl-2 mRNA、EGFR mRNA表达的影响因素。Kaplain-Maier曲线分析结果显示,PCNA mRNA高表达患者3年无进展生存率、总生存率分别为59.57%和70.21%,低于低表达患者的80.00%和88.89%(P<0.05);Bcl-2 mRNA高表达患者3年无进展生存率、总生存率分别为60.78%和70.59%,低于低表达患者的80.49%和90.24%(P<0.05);EGFR mRNA高表达患者3年无进展生存率、总生存率分别为59.09%和70.45%,低于低表达患者的79.17%、87.50%(P<0.05)。结论喉癌组织PCNA、Bcl-2、EGFR呈高表达,且其高表达状态与肿瘤分期高、分化程度低、淋巴结转移有关,PCNA、Bcl-2、EGFR表达水平可在一定程度上反映患者预后。

关键词：喉癌临床病理生存率增殖细胞核抗原 B淋巴细胞瘤-2 表皮生长因子受体

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Different types of fruit intake and colorectal cancer risk:A metaanalysis of observational studies

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World Journal of Gastroenterology 2023年第17期29卷 2679-2700页

作者： Zhen-Ying Wu jia-li chen Han li Ke Su Yun-Wei Han Department of Oncology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646099Sichuan ProvinceChina

BACKGROUND Multiple studies investigating the relationship between intake of different types of fruit and colorectal cancer(CRC)risk have yielded inconsistent *** To perform a meta-analysis of existing studies to assess the association between the intake of different kinds of fruit and the incidence of *** We searched online literature databases including PubMed,Embase,WOS,and Cochrane library for relevant articles available up to August *** data extracted from observational studies,odds ratios(ORs)with 95%confidence intervals(CIs)were assessed using random-effects models.A funnel plot and Egger’s test were used to determine publication ***,subgroup analysis and dose-response analysis were *** analyses were conducted using R(version 4.1.3).RESULTS Twenty-four eligible studies involving 1068158 participants were included in this *** meta-analysis showed that compared to a low intake,a higher intake of citrus,apples,watermelon,and kiwi reduced the risk of CRC by 9%[OR(95%CI)=0.91(0.85-0.97)],25%[OR(95%CI)=0.75(0.66-0.85)],26%[OR(95%CI)=0.74(0.58-0.94)],13%[OR(95%CI)=0.87(0.78-0.96)],*** significant association was observed between the intake of other types of fruit and the risk of *** the dose-response analysis,a nonlinear association was found[R(95%CI)=-0.0031(-0.0047 to-0.0014)]between citrus intake and CRC risk(Plinear dose-response relationship with the risk of *** meta-analysis provides further evidence that a higher intake of specific types of fruit is effective in preventing the occurrence of CRC.

关键词： Colorectal cancer Fruit Dose Systematic review Meta-analysis

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GW842166X Alleviates Osteoarthritis by Repressing LPS-mediated Chondrocyte Catabolism in Mice

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Current Medical Science 2022年第5期42卷 1046-1054页

作者： Wan-ran HUANG Jun-xue TU Ai-qing QIAO li-jia chen Department of Pharmacy The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325000China

Objective To explore the role and underlying mechanism of GW842166X on osteoarthritis and osteoarthritis-associated abnormal *** The extracted mouse chondrocytes were treated with GW842166X followed by lipopolysaccharide(LPS).The chondrocytes were divided into the control group,LPS group,LPS+50 nmol/L GW842166X group,and LPS+100 nmol/L GW842166X *** cytotoxicity of GW842166X was tested using the CCK-8 *** blot,RT-qPCR,and EliSA were applied to evaluate the expression of the inflammatory biomarkers in mouse *** expression of extracellular matrix molecules was detected by the Western blot,RT-qPCR,and ***,the activity of NF-κB was checked by the Western blot and *** mouse Hulth models were generated to examine the in vivo effects of GW842166X on *** and eosin staining,safranin O/fast green staining,and immunohistochemistry were applied to detect the histological *** GW842166X below 200µmol/L had no cytotoxicity on the mouse ***-induced high expression of TGF-β1,IL-10,TNF-α,and IL-6 was significantly reduced by *** addition,GW842166X upregulated the expression of aggrecan and collagen type III,which was downregulated after the LPS *** upregulated expression of ADAMTS-5 and MMP-13 by LPS stimulation was dropped in response to the GW842166X ***,LPS decreased the IκBαexpression in the cytoplasm and increased the nuclear p65 ***,these changes were reversed by the GW842166X ***,the damages in the knees caused by the Hulth surgery in mice were restored by *** GW842166X impeded the LPS-mediated catabolism in mouse chondrocytes,thereby inhibiting the progression of osteoarthritis.

关键词： GW842166X lipopolysaccharide osteoarthritis chondrocyte catabolism cartilage extracellular matrix

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Tailoring microenvironment for efficient CO_(2)electroreduction through nanoconfinement strategy

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Nano Research 2024年第9期17卷 7880-7899页

作者： Lulu chen Minhan li jia-Nan Zhang Key Laboratory of Advanced Energy Catalytic and Functional Materials Preparation Country College of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The electrocatalytic conversion of CO_(2)to produce fuels and chemicals holds great promise,not only to provide an alternative to fossil feedstocks,but also to use renewable electricity to convert and recycle the greenhouse gas CO_(2)to mitigate climate ***,the selectivity and reaction rates for the conversion of CO_(2)into desirable carbon-based products,especially multicarbon products with high added value,are still insufficient for commercial applications,which is attributed to insufficiently favourable microenvironmental conditions in the vicinity of the *** construction of catalysts/electrodes with confined structures can effectively improve the reaction microenvironment in the vicinity of the electrodes and thus effectively direct the reaction towards the desired *** this review,we firstly introduce the effects of the microenvironment at the electrode-electrolyte interface including local pH,local intermediate concentration,and local cation concentration on CO_(2)reduction reaction(CO_(2)RR)as well as the mechanism of action,and then shed light on the microenvironmental modulation within the confined space,and finally and most importantly,introduce the design strategy of CO_(2)RR catalyst/electrode based on the confinement effect.

关键词： CO_(2)reduction reaction microenvironment confinement effect catalyst design

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Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： WANG Zhibin li Zilong jia lisi DING Bin chen Ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis

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Transforming Adolescent Smiles:Correcting Skeletal Mandibular Retrusion and Bimaxillary Protrusion with Clear Aligners

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Current Medical Science 2024年第3期44卷 657-666页

作者： Wen-jie FAN jia-qi ZHANG jia-qi ZHAN li HU li-li chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Wuhan National High Magnetic Field Center Wuhan430074China The Affiliated lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of lianyungang Lianyungang222000China The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People’s Hospital of lianyungang Lianyungang222000China

Maxillary protrusion combined with mandibular retraction is a highly prevalent but extremely complex maxillofacial deformity that can have a serious negative impact on patients’facial aesthetics and mental *** traditional orthodontic treatment strategy often involves extracting 4 first premolars and conventional fixed techniques,combined with mini-implant screws,to retract the anterior teeth and improve facial *** recent years,an invisible orthodontic technique,without brackets,has become increasingly ***,while an invisible aligner has been used in some cases with reasonable results,there remain significant challenges in achieving a perfect *** case report presents an adolescent patient with bimaxillary protrusion and mandibular *** on the characteristics of the invisible aligners and the growth characteristics of the adolescent’s teeth and jawbone,we designed precise three-dimensional tooth movement and corresponding resistance/over-correction for each tooth,while utilizing the patient’s jawbone growth potential to promote rapid development of the mandible,accurately and efficiently correcting bimaxillary protrusion and skeletal mandibular *** patient’s facial aesthetics,especially the lateral morphology,have been greatly improved,and various aesthetic indicators have also shown significant changes,and to the patient’s great benefit,invasive mini-implant screws were not used during the *** case highlights the advantages of using invisible aligners in adolescent maxillary protrusion combined with mandibular retraction ***,comprehensive and accurate design combined with good application of growth potential can also enable invisible orthodontic technology to achieve perfect treatment effects in tooth extractions,providing clinical guidance for orthodontists.

关键词： mandibular retrusion esthetic orthodontic treatment clear aligners growth potential

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Evolution and control of inclusions of Ti-bearing ultra-low carbon steel during the steelmaking process

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Progress in Natural Science:Materials International 2024年第3期34卷 585-590页

作者： Wenjun Ma Bin chen Haibo li lixia Hao jianguan chen Yi jia Daozheng liu Shougang Research Institute of Technology Room 1107No.69Yangzhuang RoadShijingshan DistrictBeijing100043China Beijing Shougang co. ltdRoom 606Yang DianZi Town Riverside VillageQian'an064404China

This article investigates the evolution and control of inclusions in the smelting process of titanium containing ultra-low carbon *** industrial experiments,the influence of oxygen content before aluminum addition on inclusions in ultra-low carbon IF steel was explored,and the evolution process of inclusions was *** microstructure of different types of inclusions was observed using three-dimensional analysis *** has found that the oxygen content before aluminum addition has no significant effect on the final oxygen ***,under low aluminum and low oxygen conditions,the size of inclusions formed is small and difficult to float and *** if the cycle time is extended,the AF index of inclusions remains at a high *** three-dimensional morphology analysis of inclusions,it was found that alumina formed under high aluminum and high oxygen conditions is very dense,while inclusions are relatively loose under low aluminum and low oxygen *** addition,through the analysis of aluminum oxygen supersaturation before the formation of aluminum oxide inclusions,it was found that due to the low oxygen content,the nucleation rate of aluminum oxide in the early stage of inclusion formation is relatively low,and the inclusions grow along the trajectory of oxygen,ultimately forming polycrystalline aluminum oxide *** article also observed for the first time the initial three-dimensional morphology of Al Ti inclusions,providing a theoretical basis for further optimizing smelting processes and controlling inclusions.

关键词： Inclusions Ultra-low carbon steel Steelmaking process Morphology of Al_(2)O_(3) TiO_(x)complex oxide Al_(2)O_(3)cluster

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