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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第11期24卷 1037-1046页

作者： Yinan HE Yong WANG Yanqing ZHU li jan lo MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou310058China Pathology Department of Taizhou Hospital Zhejiang UniversityTaizhou317000China

The cell cycle consists of four distinct phases:GO/Gl,S(DNA synthesis),G2,and M(mitosis).The Gl to S transition is typified by an accumulation of 4',6-diamidino-2-phenylindole(DAPI)signal that indicates the rapid DNA ... 详细信息

关键词： synthesis initiated function

Stability and function of RCL1 are dependent on the interaction with BMS1

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Journal of Molecular Cell Biology 2023年第7期15卷 45-58页

作者： Yong Wang Zhenyu Zhao Hongyan Yu Hui Shi Boxiang Tao Yinan He Jun Chen Jinrong Peng Meifu Gan li jan lo Pathology Department of Taizhou Hospital Zhejiang UniversityTaizhou 317000China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China College of life Sciences Zhejiang UniversityHangzhou 310058China

During ribosome biogenesis,the small subunit(SSU)processome is responsible for 40S *** BMS1/RCL1 complex is a core component of the SSU processome that plays an important role in 18S rRNA processing and *** studies using zebrafish mutants indicate that both Bms1-like(Bms1l)and Rcl1 are essential for digestive organ *** spite of vital functions of this complex,the mutual dependence of these two nucleolar proteins for the stability and function remains *** this study,we identified an RCL1-interacting domain in BMS1,which is conserved in zebrafish and ***,both the protein stability and nucleolar entry of RCL1 depend on its interaction with BMS1,otherwise RCL1 degraded through the ubiquitination-proteasome *** studies revealed that overexpression of RCL1 in BMS1-knockdown cells can partially rescue the defects in 18S rRNA processing and cell proliferation,and hepatocyte-specific overexpression of Rcl1 can resume zebrafish liver development in the bms1l substitution mutant bms1l^(sq163/sq163)but not in the knockout mutant bms1l^(zju1/zju1),which is attributed to the nucleolar entry of Rcl1 in the former *** data demonstrate that BMS1 and RCL1 interaction is essential for not only pre-rRNA processing but also the communication between ribosome biogenesis and cell cycle regulation.

关键词： BMS1 RCL1 ribosome biogenesis ubiquitination liver development zebrafish

Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu li Steffen Tiedt Eng H.lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1

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Journal of Molecular Cell Biology 2019年第6期11卷 448-462页

作者： Ce Gao Weidong Huang Yuqi Gao li jan lo lingfei Luo Honghui Huang Jun Chen Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China College of life Sciences Southwest University Chongqing 400715 China College of life Sciences Zhejiang University 866 Yu Hang Tang Road Hangzhou 310058 China

The hepatopancreatic duct (HPD) system links the liver and pancreas to the intestinal tube and is composed of the extrahepatic biliary duct, gallbladder, and pancreatic duct. Haematopoietically expressed-homeobox (Hhex) protein plays an essential role in the establishment of HPD;however, the molecular mechanism remains elusive. Here, we show that zebrafish hhex-null mutants fail to develop the HPD system characterized by lacking the biliary marker Annexin A4 and the HPD marker sox9b. The hepatobiliary duct part of the mutant HPD system is replaced by an intrahepatic intestinal tube characterized by expressing the intestinal marker fatty acid-binding protein 2a (fabp2a). Cell lineage analysis showed that this intrahepatic intestinal tube is not originated from hepatocytes or cholangiocytes. Further analysis revealed that cdx1b and pdx1 are expressed ectopically in the intrahepatic intestinal tube and knockdown of cdx1b and pdx1 could restore the expression of sox9b in the mutant. Chromatin-immunoprecipitation analysis showed that Hhex binds to the promoters of pdx1 and cdx1b genes to repress their expression. We therefore propose that Hhex, Cdx1b, Pdx1, and Sox9b form a genetic network governing the patterning and morphogenesis of the HPD and digestive tract systems in zebrafish.

关键词： liver development hepatopancreatic duct (HPD) hhex pdx1 cdxlb

Refill friction stir spot welding (RFSSW): a review of processing, similar/dissimilar materials joining, mechanical properties and fracture mechanism

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Journal of Iron and Steel Research International 2024年第8期31卷 1825-1839页

作者： Yun-qiang Zhao Hao-kun Yang Aloshyn Andria Hong-hang lo Jia-xin li Guangdong Provincial Key Laboratory of Advanced Welding Technology China-Ukraine Institute of WeldingGuangdong Academy of SciencesGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China E.O.Paton Electric Welding Institute of National Academy of Sciences of Ukraine Kiev 01001KievanUkraine

Refill friction stir spot welding(RFSSW)provides a novel method to join similar and/or dissimilar metallic materials without a key-hole in the center of the *** the key-hole free characterization,the similar/dissimilar RFSSW joint exhibits remarkable and endurable characteristics,including high shear strength,long fatigue life,and strong corrosion *** the meanwhile,as the key-hole free joint has different microstructures compared with conventional friction stir spot welding,thus the RFSSW joint shall possess different shear and fatigue fracture mechanisms,which needs further *** explore the underlying failure mechanism,the similar/dissimilar metallic material joining parameters and pre-treatment,mechanical properties,as well as fracture mechanisms under this novel technology will be *** details,the welding tool design,welding parameters setting,and the influence of processing on the lap shear and fatigue properties,as well as the corrosion resistance will be mainly ***,the roadmap of RFFSW is also discussed.

关键词： Refill friction stir spot welding Processing Mechanism Similar materials joining Dissimilar materials joining Microstructure Mechanical property Fracture mechanism

Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes

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Journal of Genetics and Genomics 2018年第3期45卷 173-175页

作者： Ce Gao Zhihui Zhu Yuqi Gao li jan lo Jun Chen lingfei Luo Jinrong Peng College of Animal Sciences Zhejiang University College of life Sciences Zhejiang University College of life Sciences Southwest University

In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood（e.g.,～20 folds for a mouse）.Considering the fact that the liver-to-body weight ratio（LBR）stays relatively constant within species（Weglarz and Sandgren,2000;Kan et al.,2009）,the cell number in a liver must therefore keep increasing along with the growth of an individual organism. For example, during the growth of the zebrafish from 5 days post-fertilization （dpf） to 1.5 years old, the number of liver cells increased -900 folds （Figs. 1A and S1 ）.

关键词： In Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes ERT RSG

Interaction between Bms1 and Rcl1,two ribosome biogenesis factors,is evolutionally conserved in zebrafish and human

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Journal of Genetics and Genomics 2016年第7期43卷 467-469页

作者： Yong Wang Qinfang Zhu ling Huang Yanqing Zhu Jun Chen Jinrong Peng li jan lo MOE Key Laboratory for Molecular Animal -Nutrit-ion College of Animal Sciences Zhejiang University Hangzhou 310058 China College of life Sciences Zhejiang University Hangzhou 310058 China

Ribosomes are large RNA and protein complexes that function as the machinery for translation protein synthesis （Boisvert et al., 2007; Ben-Shem et al., 2011： Henras et al., 2015： Kbatter et al., 2015; McCann et al., 2015）. The eukaryotic ribosome is composed of two subunits, the 60S large subunit （LSU） and the 40S small sub- unit （SSU）, which collectively comprise of four different ribosomal RNA （rRNA） species and more than 70 proteins （Ben-Sbem et al., 2011： Henras et al., 2015; Khatter et al., 2015）. The LSU contains the 28S, 5.8S and 5S rRNAs and the SSU contains the 18S rRNA. The assembly of each subunit is initiated in the nucleolus using the respective rRNAs as backbones （Ben-Shem et al., 2011; Henras et al., 2015; Khatter et al., 2015）.

关键词： ribosome evolutionally human

Silicon-based optical phased array with a reconfigurable aperture for“gaze”scanning of liDAR

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Photonics Research 2024年第5期12卷 932-940页

作者： HEMING HU YAFANG HE BAISONG CHEN ZIMING WANG YINGZHI li QIJIE XIE QUANXIN NA ZIHAO ZHI XUETONG li HUAN QU PATRICK lo JUNFENG SONG State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Peng Cheng Laboratory Shenzhen 518000China Advance Micro Foundry Pte.Ltd. Singapore 117685Singapore

light detection and ranging(liDAR)serves as one of the key components in the fields of autonomous driving,surveying mapping,and environment ***,dense points clouds are pursued by liDAR systems to provide high-definition 3D ***,the liDAR is typically used to produce abundant yet redundant data for scanning the homogeneous background of scenes,resulting in power waste and excessive processing ***,it is highly desirable for a liDAR system to“gaze”at the target of interest by dense scanning and rough sparse scans on the uninteresting ***,we propose a liDAR structure based on an optical phased array(OPA)with reconfigurable apertures to achieve such a gaze scanning *** virtue of the cascaded optical switch integrated on the OPA chip,a 64-,128-,192-,or 256-channel antenna can be selected discretionarily to construct an aperture with variable *** corresponding divergence angles for the far-field beam are 0.32°,0.15°,0.10°,and 0.08°,*** reconfigurable-aperture OPA enables the liDAR system to perform rough scans via the large beam spots prior to fine scans of the target by using the tiny beam *** this way,the OPA-based liDAR can perform the“gaze”function and achieve full-range scanning *** scanning time and power consumption can be reduced by 1/4 while precise details of the target are ***,we embed the OPA into a frequency-modulated continuous-wave(FMCW)system to demonstrate the“gaze”function in beam *** results show that the number of precise scanning points can be reduced by 2/3 yet can obtain the reasonable outline of the *** reconfigurable-aperture OPA(RA-OPA)can be a promising candidate for the applications of rapid recognition,like car navigation and robot vision.

关键词： reconfigurable optical antenna

Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication

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Journal of Molecular Cell Biology 2021年第12期13卷 902-917页

作者： Yanqing Zhu Yong Wang Boxiang Tao Jinhua Han Hong Chen Qinfang Zhu ling Huang Yinan He Jian Hong Yunqin li Jun Chen Jun Huang li jan lo Jinrong Peng MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Taizhou Hospital Zhejiang UniversityTaizhou 317000China The MOE Key Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China Institute of Biotechnology Zhejiang UniversityHangzhou 310058China College of life Sciences Zhejiang UniversityHangzhou 310058China

18S,5.8S,and 28S ribosomal RNAs(rRNAs)are cotranscribed as a pre-ribosomal RNA(pre-rRNA)from the rDNA by RNA polymerase I whose activity is vigorous during the S-phase,leading to a conflict with rDNA *** conflict is resolved partly by replication-fork-barrier(RFB)-sites sequences located downstream of the rDNA and RFB-binding proteins such as ***,how Ttf1 is displaced from RFB-sites to allow replication fork progression remains ***,we reported that loss-of-function of Bms1l,a nucleolar GTPase,upregulates rDNA transcription,causes replication-fork stall,and arrests cell cycle at the S-to-G2 transition;however,the G1-to-S transition is constitutively active characterized by persisting DNA ***,ubf,tif-IA,and taf1b marking rDNA transcription,Chk2,Rad51,and p53 marking DNA-damage response,and Rpa2,PCNA,Fen1,and Ttf1 marking replication fork stall are all highly elevated in bms1l *** found that Bms1 interacts with Ttf1 in addition to ***,we identified RFB-sites for zebrafish Ttf1 through chromatin immunoprecipitation sequencing and showed that Bms1 disassociates the Ttf1–RFB complex with its GTPase *** propose that Bms1 functions to balance rDNA transcription and replication at the S-phase through interaction with Rcl1 and Ttf1,***1 and Bms1 together might impose an S-phase checkpoint at the rDNA loci.

关键词： Bms1 cell cycle nucleolus ribosome small subunit processome replication-fork barrier Ttf1 zebrafish

Geochronology and Petrogenesis of Late Carboniferous to Early Permian Basalts in the Central Lhasa Subterrane, Southern Tibet: Implications for the Evolution of the Sumdo Paleo-Tethys Ocean

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Acta Geologica Sinica(English Edition) 2024年第4期98卷 955-968页

作者： MA Wang liU Yingchao YANG Zhusen jan-Marten HUIZENGA li Zhenqing YUE longlong ZHAO Sibo School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Institute of Geology Sinoprobe LaboratoryChinese Academy of Geological SciencesBeijing 100037China MLR Key Laboratory of Metallogeny and Mineral Assessment Institute of Mineral ResourcesChinese Academy of Geological SciencesBeijing 100037China Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesNO-1432ÅsNorway Economic Geology Research Centre(EGRU) College of Science and EngineeringJames Cook UniversityTownsvilleQueensland 4811Australia Department of Geology University of JohannesburgAuckland Park 2006South Africa

Basalts from the Late Carboniferous to Early Permian are extensively developed in the central Lhasa subterrane, southern Tibet. Studying the petrogenesis of these rocks may have implications for the late Paleozoic arc magmatism along the central Lhasa subterrane uncovering more of the evolution of the Sumdo Paleo-Tethys Ocean and its dynamic mechanism. Basalt samples from the Luobadui Formation in the Leqingla area, NW of linzhou City in the central Lhasa subterrane, southern Tibet exhibit arc-like geochemical signatures in a subduction-zone tectonic setting characterized by high Al_(2)O_(3) and low TiO_(2) contents, fractionated REE patterns with low Nb/La ratios and high LREE concentrations, and negative HFSE anomalies. Based on their higher Th/Ce, Nb/Zr, and lower Ba/Th, Pb/Nd ratios, slightly negative to positive ε_(Nd)(t) values, and the relatively high Sr-Pb isotopic compositions, these samples were probably derived from partial melting of a depleted mantle source of garnet + spinel lherzolite, metasomatized by subducted sediments around 297 Ma. Modeling of the trace elements indicates that these basalts experienced fractional crystallization of olivine, clinopyroxene and minor plagioclase during magma ascent and eruption. It is proposed that these Late Carboniferous–Early Permian basalts are associated with the northward subduction of the Sumdo Paleo-Tethys Ocean seafloor along the southern margin of the central Lhasa subterrane.

关键词： geochemistry northward subduction Sumdo Paleo-Tethys Ocean Lhasa terrane Tibet