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Science China Mathematics 2024年

作者： Yanqing Yin huiqin li Zhidong Bai School of Mathematics and Statistics Chongqing University School of Mathematics and Statistics Northeast Normal University

In this paper, we focus on the test for high-dimensional covariance structures using doublenormalized observations for an elliptical population. By investigating the limiting spectral properties of the sample covariance matrix of double-normalized observations, we propose test statistics applicable for testing the diagonality of the population covariance matrix. Extensive simulations are conducted to investigate the performances of the proposed test in various situations.

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GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease

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Neuroscience Bulletin 2024年第4期40卷 451-465页

作者： huiqin li Xiang Cao Xinya Gu Mengqi Dong lili Huang Chenglu Mao Shengnan Xia Haiyan Yang Xinyu Bao Yongbo Yang Yun Xu Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalState Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical DiseasesNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal *** inflammation is associated with the occurrence and development of ***,the mechanisms underlying the formation of the abnormal vascular network remain ***-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in *** found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and *** summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

关键词： Moyamoya disease Vascular endothelial cells GM-CSF VEGF

Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS

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The Journal of Biomedical Research 2024年第1期38卷 37-50页

作者： Sumeng Wang Silu Chen huiqin li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu lingxiang liu Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China.

The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is *** address this gap,we conducted a study aiming to investigate this association and identify relevant *** analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune ***,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)*** employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune *** findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal ***,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA *** conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets.

关键词： trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis

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延安时期中国共产党涉藏民族工作探析

西藏大学学报（社会科学版） 2024年第2期39卷 170-176页

作者：陈鹏辉李荟芹西藏民族大学民族研究院陕西咸阳712082 西藏民族大学马克思主义学院陕西咸阳712082

长征时期红军途经四川西部藏族地区,因红四方面军主要领导人张国焘在民族工作方面存在失误,导致红军和当地藏族群众关系紧张。延安时期,中国共产党认真总结民族工作经验教训,形成了比较明确的民族理论与政策。同时,延安时期党中央注意... 详细信息

长征时期红军途经四川西部藏族地区,因红四方面军主要领导人张国焘在民族工作方面存在失误,导致红军和当地藏族群众关系紧张。延安时期,中国共产党认真总结民族工作经验教训,形成了比较明确的民族理论与政策。同时,延安时期党中央注意培养藏族民族干部骨干,形成了一支对涉藏工作有深入研究的专业人才队伍,产生了一批涉藏工作的研究成果,党的民族政策宣传增强了藏族群众的中华民族认同。延安时期实现了民族政策的转变,改变了民族工作的思路,储备了干部和人才,对之后和平解放西藏及治理西藏和四省涉藏地区奠定了政治、理论和干部基础。

关键词：延安时期中国共产党涉藏工作

基于德尔菲法的优化管理在手术室防控感染中的应用效果

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中国民康医学 2024年第7期36卷 152-155页

作者：李惠琴福安市妇幼保健院门诊手术室福建宁德355000

目的:观察基于德尔菲法的优化管理在手术室防控感染中的应用效果。方法:回顾性分析2021年6月至2022年7月21名手术室护理人员的临床资料,于2021年6—12月实施常规管理,2022年1—7月实施基于德尔菲法的优化管理,比较基于德尔菲法的优化管... 详细信息

目的:观察基于德尔菲法的优化管理在手术室防控感染中的应用效果。方法:回顾性分析2021年6月至2022年7月21名手术室护理人员的临床资料,于2021年6—12月实施常规管理,2022年1—7月实施基于德尔菲法的优化管理,比较基于德尔菲法的优化管理实施前后手术室环境卫生合格率、手术室护理质量、手术室护理人员技术操作评分和防控知信行评分。结果:实施后手术室空气质量、手卫生、物品表面、消毒剂、消毒物品合格率均高于实施前,差异有统计学意义(P<0.05);实施后手术室消毒灭菌质量、手术器械准备、仪器设备使用及管理、巡回护士配合度等护理质量评分和总分均高于实施前,差异有统计学意义(P<0.05);实施后手术室护理人员标本送检、用药准确、器械消毒和感染防护等技术操作评分均高于实施前,差异有统计学意义(P<0.05);实施后护理人员知识、态度、行为等防控知信行评分均高于对照组,差异有统计学意义(P<0.05)。结论:基于德尔菲法的优化管理应用于手术室防控感染可提高手术室环境卫生合格率、手术室护理质量评分、手术室护理人员技术操作评分和防控知信行评分,效果优于常规管理。

关键词：德尔菲法优化管理手术室防控感染合格率护理质量知信行

引领与赋能:联合国教科文组织STEM教育理念与实践

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世界教育信息 2024年第6期37卷 32-37页

作者：谭焱卿李慧勤北京外国语大学国际教育学院北京100089 联合国教科文组织国际农村教育研究与培训中心北京100080

STEM教育是提升国家科技竞争力、培养创新人才、提高国民科学素养的重要基础。联合国教科文组织作为思想实验室、准则制定者、信息交流中心、成员国能力建设者和国际合作促进者,在推动STEM教育方面发挥着关键作用。联合国教科文组织创新... 详细信息

STEM教育是提升国家科技竞争力、培养创新人才、提高国民科学素养的重要基础。联合国教科文组织作为思想实验室、准则制定者、信息交流中心、成员国能力建设者和国际合作促进者,在推动STEM教育方面发挥着关键作用。联合国教科文组织创新STEM教育理念与标准,为实践提供遵循;传播STEM教育创新举措,为实践者提供课程资源;促进各国制定STEM教育政策,提升STEM教育能力;搭建全球合作交流网络,激励青年投身STEM教育事业。联合国教科文组织的STEM理念和实践研究有助于我国推进STEM教育治理和拔尖创新人才培养。

关键词：联合国教科文组织 STEM教育教育政策教育实践

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Prevalence of echocardiographic abnormalities in HIV-infected adults on long-term combination antiretroviral therapy

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中华医学杂志(英文版) 2024年第19期

作者： Luo ling li Xiaodi Song Xiaojing Lyu Wei liu Zhengyin Wang Huanling Han Yang li Xiaoxia li Yanling Chen Tielong Xiong Yong He Yun li huiqin Ye Hanhui Cao Wei li Taisheng Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Department of Infectious Diseases Zhongnan Hospital of Wuhan University Wuhan Hubei China National Clinical Research Center for Infectious Diseases HKU AIDS Institute Shenzhen Research Laboratory The Third People’s Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen Guangdong China Department of HIV/AIDS Clinical Research Yunnan Provincial Hospital of Infectious Disease AIDS Care Center (YNACC) Kunming Yunnan China Department of infection Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou Fujian China Department of Basic Medical Sciences School of Medicine Tsinghua University Beijing China Tsinghua-Peking Center for life Sciences Beijing China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China

认知行为干预结合疼痛控制管理对SICU严重创伤骨折患者术后康复的影响

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新疆医学 2024年第3期54卷 352-355,364页

作者：张艺洋李会勤河南省驻马店市中心医院重症医学科SICU 河南驻马店463000

目的探讨认知行为干预结合疼痛控制管理对SICU严重创伤骨折患者术后康复的影响。方法选取驻马店市中心医院重症医学科SICU于2020年11月-2022年10月收治的75例创伤骨折患者,以随机数字表法分为对照组(37例)和观察组(38例)。予以两组患... 详细信息

目的探讨认知行为干预结合疼痛控制管理对SICU严重创伤骨折患者术后康复的影响。方法选取驻马店市中心医院重症医学科SICU于2020年11月-2022年10月收治的75例创伤骨折患者,以随机数字表法分为对照组(37例)和观察组(38例)。予以两组患者急诊救治后,实施早期微创内固定手术治疗,治疗期间,对照组患者接受科室规范化护理管理,观察组同时联合认知行为干预结合疼痛控制管理;术后随访3个月。分别于干预前和出院时对患者进行疼痛、睡眠质量评分评估;分别于出院时及干预后1个月、3个月对患者进行Berg平衡量表、中文版活动平衡信心量表评分评估;采用我院自行设计的护理满意度调查问卷评估2组护理满意度。结果经过术后住院期间的护理干预,经比较,观察组出院时VAS和睡眠PSQI评分均较干预前降低,且比对照组降低显著(均P <0.05)。与出院时比较,干预后1个月和3个月时,两组患者平衡能力、活动平衡信心评分升高,各个观察时间点,观察组高于对照组(均P <0.05)。观察组总满意率为97.37%,显著高于对照组总满意率(81.08%)(P <0.05)。结论认知行为干预结合疼痛控制管理对SICU严重创伤骨折应用效果确切,可有效减轻患者术后疼痛,改善睡眠质量;同时重建患者对疾病和术后康复的认知,缓解恐惧心理,有效提高了患者术后康复的积极性,进而提升活动平衡信心和平衡能力;患者对护理的满意度高,具有较高的推广价值。

关键词：创伤骨折微创内固定认知行为干预疼痛控制管理术后康复

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全过程工程咨询项目中土方水冲泵送法的应用

建设监理 2024年第5期 72-76页

作者：黄程龙李慧琴浙江江南工程管理股份有限公司浙江杭州310013 合肥工大建设监理有限责任公司安徽合肥230009

根据项目基坑规模、地质特征、地方政策及进度工期等因素,开展技术经济比选及验证,科学合理选择最佳土方挖运方案,是项目前期全过程工程咨询应统筹考虑的重要课题。采用水冲泵送法进行土方开挖及远距离运输,对比传统的挖掘机+渣土运输... 详细信息

根据项目基坑规模、地质特征、地方政策及进度工期等因素,开展技术经济比选及验证,科学合理选择最佳土方挖运方案,是项目前期全过程工程咨询应统筹考虑的重要课题。采用水冲泵送法进行土方开挖及远距离运输,对比传统的挖掘机+渣土运输车挖运组合是工法工艺的革新及飞跃,有利于确保土方工程流程合规、管理受控,优化施工部署、劳动力及资源投入。

关键词：水冲泵送法泵送工艺全过程工程咨询

Relaxor behavior and Raman spectra of CuO-doped Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)ferroelectric ceramics

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Journal of Advanced Ceramics 2014年第3期3卷 177-183页

作者： huiqin li Jingsong liU Hongtao YU Shuren ZHANG State Key Laboratory Cultivation Base for Nonmetal Composite and Functional Materials Southwest University of Science and TechnologyMianyangSichuanChina State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengduSichuanChina

In this work,Raman spectra and dielectricity-temperature dependence measurements were used to investigate the B-site order degree in CuO-doped Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3)ferroelectric *** measurement results indicated a typical relaxor characteristic for all *** the increasing of CuO doping content,the B-site order degree increased first and then ***,the frequency dispersion and the relaxation degree decreased first and then increased while the CuO addition content was increasing,which was thought to be strongly correlated with the variations of the B-site *** opposite variation tendency of the B-site order degree and the relaxation degree revealed that the phase transition dispersity is closely related to the order-disorder behaviors.

关键词： relaxor ferroelectrics dielectric properties Raman spectra