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18F-prostate specific membrane antigen positron emission tomography/computerized tomography for lymph node staging in medium/high risk prostate cancer: A systematic review and meta-analysis

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中华医学杂志(英文版) 2024年第8期137卷 2023 Sep 8页

作者： Lv Zhengtong Song liuqi Wang Miao Hou Huimin li haodong Wang Xuan Wang Jianye Wang Jianlong liu Ming Beijing 100029 Department of Urology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing 100730 China Peking University Fifth School of Clinical Medicine Peking University China-Japan Friendship School of Clinical Medicine

Background: Lymph node staging of prostate cancer (PCa) is important for planning and monitoring of treatment.18F-prostate specific membrane antigen positron emission tomography/computerized tomography (18F-PSMA PET/CT) has several advantages over68Ga-PSMA PET/CT, but its diagnostic value requires further investigation. This meta-analysis focused on establishing the diagnostic utility of18F-PSMA PET/CT for lymph node staging in medium/high-risk PCa.Methods: We searched the EMBASE, PubMed, Cochrane library, and Web of Science databases from inception to October 1, 2022. Prostate cancer,18F, lymph node, PSMA, and PET/CT were used as search terms and the language was limited to English. We additionally performed a manual search using the reference lists of key articles. Patients and study characteristics were extracted and the QUADAS-2 tool was employed to evaluate the quality of included studies. Sensitivity, specificity, the positive and negative likelihood ratio (PLR and NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and 95% confidence interval (CI) were used to evaluate the diagnostic value of18F-PSMA PET/CT. Stata 17 software was employed for calculation and statistical analyses.Results: A total of eight diagnostic tests including 734 individual samples and 6346 lymph nodes were included in this meta-analysis. At the patient level, the results of each consolidated summary were as follows: sensitivity of 0.57 (95% CI 0.39-0.73), specificity of 0.95 (95% CI 0.92-0.97), PLR of 11.2 (95% CI 6.6-19.0), NLR of 0.46 (95% CI 0.31-0.68), DOR of 25 (95% CI 11-54), and AUC of 0.94 (95% CI 0.92-0.96). At the lesion level, the results of each consolidated summary were as follows: sensitivity of 0.40 (95% CI 0.21-0.62), specificity of 0.99 (95% CI 0.95-1.00), PLR of 40.0 (95% CI 9.1-176.3), NLR of 0.61 (95% CI 0.42-0.87), DOR of 66 (95% CI 14-311), and AUC of 0.86 (95% CI 0.83-0.89).Conclusions: 18F-PSMA PET/CT showed moderate sensitivity but high specificity in lymph node staging of medium/high-risk PCa. The

关键词： 18F-PSMA PET/CT Diagnostic test Lymph node Meta-analysis Prostate cancer

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Formation of South Tianshan suture and its geological significance

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Global Geology 2023年第1期26卷 9-20页

作者： li haodong ZHOU Jianbo College of Earth Sciences Jilin UniversityChangchun 130061China

South Tianshan–Solonker suture,is the largest and southernmost suture within the Central Asian orogenic belt(CAOB).It records the ultimate collision between Tarim–North China cratons and Siberia craton,and is commonly interpreted as marking the eventual closure of Paleo-Asian Ocean.South Tianshan suture belongs to the western segment of the suture zone,and its evolutionary features are important for defining the formation age of the South Tianshan–Solonker suture.In this paper,the authors review the geochronological,geochemical,petrographic,and paleontological evidence within South Tianshan suture to delineate its formation era and closure characteristics,and thus further revealing the ultimate evolutionary pattern of the western segment of Paleo-Asian Ocean.This suture records strong plate collision before Late Carboniferous,forming a series of high-pressure metamorphic rocks,characterized by the presence of blue schist,eclogite and mica schist.In Permian,the whole area was under a relatively stable post-orogenic setting,with the formation of bimodal volcanic rocks,post-collisional granites,and terrestrial molasses.Sedimentary facies gradually changed from marine to either lacustrine or fluvial during this period.An Early Permian granite dike crosscuts the HP metamorphic belt,and the HP metamorphic rocks also underwent retrograde metamorphism at this time,indicating the formation of the South Tianshan suture was earlier than Permian.Hence,the western section of Paleo-Asian Ocean closed during Late Carboniferous,and Tarim Craton moved northward to collide with Kazakhstan–Yili Block,leading to the formation of the South Tianshan suture.

关键词： South Tianshan suture Paleo-Asian Ocean Central Asian orogenic belt plate accretion/collision subduction polarity

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一种多点拟合的恒定立体角纤维重建模型

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小型微型计算机系统 2024年第5期45卷 1116-1121页

作者：李浩东王远军上海理工大学医学影像工程研究所上海200093

基于弥散磁共振成像DTI的纤维追踪技术是非侵入性活体脑神经研究的关键技术.恒定立体角重建模型CSA是基于DTI发展而来的一种纤维重建模型,能够根据采样球壳上的数据对弥散方向分布函数进行线性径向投影计算,从而进行纤维重建.目前,恒定... 详细信息

基于弥散磁共振成像DTI的纤维追踪技术是非侵入性活体脑神经研究的关键技术.恒定立体角重建模型CSA是基于DTI发展而来的一种纤维重建模型,能够根据采样球壳上的数据对弥散方向分布函数进行线性径向投影计算,从而进行纤维重建.目前,恒定立体角纤维重建模型存在鲁棒性较差,重建纤维过于杂乱以及弥散方向分布偏差的问题.针对上述问题,本文提出MCSA(Multipoint Constant Solid Angle)模型,首先引入可以使弥散方向分布函数更加准确的最小二乘法,接着通过自适应高斯函数引入多点拟合弥散信息提高模型鲁棒性和抗噪性.最后,本文分别使用Fibercup、ISMRM2015年模拟数据以及Stanford HARDI真实影像数据对传统CSA模型以及本文提出MCSA模型进行对比分析,结果表明,利用本文提出MCSA模型重建的纤维更加符合客观规律,并且在一定程度上减少了假阳性纤维的生成.

关键词：弥散张量成像纤维重建恒定立体角模型邻域信息移动最小二乘法

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甘肃某煤矿采矿活动引发地面塌陷地质灾害预测及防治措施研究

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四川地质学报 2024年第2期44卷 267-272页

作者：李皓东甘肃省地质矿产勘查开发局第二地质矿产勘查院兰州730020

煤矿开采最容易引发的地质灾害便是地面塌陷。为了准确反映出采煤带来地表移动和由此产生采空区地面塌陷范围变形的整体全貌,本文以甘肃省白银市某煤矿为例,采用国家有关部门近年推荐的并且在生产应用中较成熟的“三下规程”,利用充分... 详细信息

煤矿开采最容易引发的地质灾害便是地面塌陷。为了准确反映出采煤带来地表移动和由此产生采空区地面塌陷范围变形的整体全貌,本文以甘肃省白银市某煤矿为例,采用国家有关部门近年推荐的并且在生产应用中较成熟的“三下规程”,利用充分采动条件下多煤层多工作面概率积分法预计软件和等值线绘制程序对该煤矿进行了地面塌陷预测。根据预测结果,对地面塌陷可能造成的影响程度及危害性进行了分析;通过总结历史治理经验,提出了综合防治措施建议,为矿山进一步开展地面塌陷治理提供了参考依据。

关键词：煤矿采矿地面塌陷地质灾害预测治理措施

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树脂载钯双功能催化剂的制备及其催化碳四烯烃临氢叠合反应

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石油学报（石油加工） 2024年第3期40卷 629-636页

作者：李浩东温朗友高永恩夏玥穜苏鑫中石化石油化工科学研究院有限公司北京100083 中石化(大连)石油化工研究院有限公司辽宁大连116045

基于碳四烯烃叠合反应工艺,设计并制备了酸性树脂(KC110、Amberlyst35)载钯双功能催化剂,用于一步法催化1,3-丁二烯选择性加氢和异丁烯叠合反应。借助电子微区探针分析(EPMA)、N 2物理吸附-脱附(BET)、透射电子显微镜(TEM)、X射线光电... 详细信息

基于碳四烯烃叠合反应工艺,设计并制备了酸性树脂(KC110、Amberlyst35)载钯双功能催化剂,用于一步法催化1,3-丁二烯选择性加氢和异丁烯叠合反应。借助电子微区探针分析(EPMA)、N 2物理吸附-脱附(BET)、透射电子显微镜(TEM)、X射线光电子能谱(XPS)等手段对其物化性质进行表征,并进一步考察了双功能催化剂在碳四烯烃临氢叠合反应过程中的催化性能。结果表明:0.10%Pd/KC110双功能催化剂负载的钯纳米颗粒主要分布在树脂大孔表层结构,平均粒径为3~10 nm,且树脂载体本身的酸性和孔结构保存完好;在反应温度为25℃、压力为1.4~1.6 MPa、质量空速为2.7 h-1、氢气/丁二烯摩尔比为1.5的条件下进行0.10%Pd/KC110催化碳四烯烃临氢叠合反应,1,3-丁二烯可以完全脱除,异丁烯转化率高于81.5%,叠合产物中碳八选择性为75.1%。

关键词：阳离子交换树脂钯纳米颗粒双功能催化剂碳四馏分临氢叠合

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Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway

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Frigid Zone Medicine 2024年第1期4卷 31-40页

作者： Yanying Wang Jian Huang Han Sun Jie liu Yingchun Shao Manyu Gong Xuewen Yang Dongping liu Zhuo Wang haodong li Yanwei Zhang Xiyang Zhang Zhiyuan Du Xiaoping Leng Lei Jiao Ying Zhang State Key Laboratory of Frigid Zone Cardiovascular Diseases and Pharmacology Department of Pharmacy college of Harbin Medical UniversityHarbin 150081China The Fourth Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040China Department of Ultrasound Imaging the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao Cancer InstituteQingdao 266071China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081China

Objective:Myocardial ischemia-reperfusion injury(MIRI)is one of the leading causes of death from cardiovascular disease in humans,especially in individuals exposed to cold environments.Long non-coding RNAs(lncRNAs)regulate MIRI through multiple mechanisms.This study explored the regulatory effect of lncRNA-AK138945 on myocardial ischemia-reperfusion injury and its mechanism.Methods:In vivo,8-to 12-weeks-old C57BL/6 male mice underwent ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion for 48 hours.In vitro,the primary cultured neonatal mouse ventricular cardiomyocytes(NMVCs)were treated with 100μmol/L hydrogen peroxide(H_(2)O_(2)).The knockdown of lncRNA-AK138945 was evaluated to detect cardiomyocyte apoptosis,and a glucose-regulated,endoplasmic reticulum stress-related protein 94(GRP94)inhibitor was used to detect myocardial injury.Results:We found that the expression level of lncRNA-AK138945 was reduced in MIRI mouse heart tissue and H2O2-treated cardiomyocytes.Moreover,the proportion of apoptosis in cardiomyocytes increased after lncRNA-AK138945 was silenced.The expression level of Bcl2 protein was decreased,and the expression level of Bad,Caspase 9 and Caspase 3 protein was increased.Our further study found that miR-1a-3p is a direct target of lncRNA-AK138945,after lncRNA-AK138945 was silenced in cardiomyocytes,the expression level of miR-1a-3p was increased while the expression level of its downstream protein GRP94 was decreased.Interestingly,treatment with a GRP94 inhibitor(PU-WS13)intensified H2O2-induced cardiomyocyte apoptosis.After overexpression of FOXO3,the expression levels of lncRNA-AK138945 and GRP94 were increased,while the expression levels of miR-1a-3p were decreased.Conclusion:LncRNA-AK138945 inhibits GRP94 expression by regulating miR-1a-3p,leading to cardiomyocyte apoptosis.The transcription factor Forkhead Box Protein O3(FOXO3)participates in cardiomyocyte apoptosis induced by endoplasmic reticulum stress through up-regulation of lncRNA-AK138945.

关键词： myocardial ischemia reperfusion lncRNA apoptosis microRNAGRP94

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JPEG原图重构取证方法

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信号处理 2024年第6期40卷 1122-1140页

作者：黎溢轩李昊东曾吉申黄瑞灵黄继武广东省智能信息处理重点实验室广东深圳518060 阿里巴巴集团浙江杭州310000

数字图像已被广泛用于办理各类网上业务和作为司法证据。与此同时,利用流行的图像编辑软件,普通用户就可以对图像进行语义篡改而不留下视觉痕迹。因此,对数字图像的原始性和真实性进行辨识已成为迫切的应用需求。基于元数据的图像篡改... 详细信息

数字图像已被广泛用于办理各类网上业务和作为司法证据。与此同时,利用流行的图像编辑软件,普通用户就可以对图像进行语义篡改而不留下视觉痕迹。因此,对数字图像的原始性和真实性进行辨识已成为迫切的应用需求。基于元数据的图像篡改取证方法因准确性高、计算量小而得到重视。然而,原图重构技术(例如应用MagicEXIF元数据编辑器)的出现使上述方法完全失效。针对这一问题,本文提出一种JPEG图像原图重构取证方法,用于检测图像是否受到重构攻击。通过分析原图重构的过程,以及重构前后图像的像素统计特征差异,本文对深度学习隐写分析模型SRNet(Steganalysis Residual Network)进行轻量化改进:裁剪其冗余的下采样层以减少参数,引入通道注意力机制以提高对关键特征的提取能力,并采用知识蒸馏的方法进一步提升模型的准确率。进一步地,通过分析重构对不同颜色分量的影响,采用YCbCr颜色分量作为模型输入,以提高检测性能。为测试算法的性能,我们收集了由不同品牌和型号的手机拍摄的图像数据,构建了大规模重构图像数据库。实验表明,本文提出的模型在参数量显著减少的情况下性能优于流行的模型,对512×512大小的图像可取得98%以上的检测正确率,且具有良好的跨设备泛化能力。同时,通过应用迁移学习,本文方法对不同版本的重构软件也具有较好的泛化性。

关键词：图像元数据原图重构图像取证重构检测轻量化模型

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Profiling interfacial reaction features between diamond and Cu-Sn-Ti active filler metal brazed at 1223 K

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Journal of Materials Science & Technology 2022年第36期131卷 100-105页

作者： Yonggang Fan Kenan li haodong li Cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) School of MetallurgyNortheastern UniversityShenyang 110819China State Key Laboratory of Superabrasives Zhengzhou Research Institute for Abrasives&Grinding Co.Ltd.Zhengzhou 450001China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Diamond/Cu-Sn-Ti composites have been successfully prepared by cold-press forming in conjunction with high-temperature vacuum active brazing at 1223 K.Ensuing wetting behaviors between diamond and filler metal,interfacial characteristics of the reaction layer,and wear resistance of the bulky composite have been fully investigated.It is revealed that all diamond particles can only be fully coated when the TiH_(2)content exceeds 5 wt%,below which sharp edges on diamond can still be observed.The interfacial reaction layer is found to be composed of TiC,the thickness of which is demonstrated to increase as a function of TiH_(2)content,arriving at the peak value of 1.70μm and remaining almost constant afterwards.It is further shown that the maximum wear resistance occurs approaching 5 wt%TiH_(2)content.Potential mechanisms responsible for such interesting phenomena have been postulated.

关键词： Diamond Cu-Sn-Ti Brazing Interfacial layer Powder metallurgy

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基于市场渗透率的公交专用道规划策略

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综合运输 2024年第3期46卷 72-78页

作者：李昊东张哲闻邹鑫西南交通大学交通运输与物流学院四川成都611756 西南交通大学综合交通大数据应用技术国家工程实验室四川成都611756

公交作为公共交通的重要组成部分,其基础配套设施的规划是城市交通规划领域的重要组成部分。本文在当前公交专用道网络设计的研究基础上,针对部分城市公交专用道和公交需求不匹配,占用大量道路资源的问题,基于市场渗透率建立公交专用道... 详细信息

公交作为公共交通的重要组成部分,其基础配套设施的规划是城市交通规划领域的重要组成部分。本文在当前公交专用道网络设计的研究基础上,针对部分城市公交专用道和公交需求不匹配,占用大量道路资源的问题,基于市场渗透率建立公交专用道分阶段布局的双层规划模型,上层为政府分阶段新建公交车道或占用机动车道的决策模型,下层分别为公交车及小汽车的客流分配模型。根据决策变量特点,设计离散粒子群算法进行模型求解。采用Sioux Falls网络进行了数值算例分析,结果表明,本文的模型和算法能够有效的求得分阶段公交专用道布局方案,并降低路网总阻抗,提高公交企业效益。

关键词：公交专用道双层规划模型离散粒子群算法市场渗透率

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Stability and Convergence of the Canonical Euler Splitting Method for Nonlinear Composite Stiff Functional Differential-Algebraic Equations

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Advances in Applied Mathematics and Mechanics 2022年第6期14卷 1276-1301页

作者： Hongliang liu Yameng Zhang haodong li Shoufu li School of Mathematics and Computational Science&Hunan Key Laboratory for Computation and Simulation in Science and Engineering Xiangtan UniversityXiangtanHunan 411105China

A novel canonical Euler splitting method is proposed for nonlinear compositestiff functional differential-algebraic equations, the stability and convergence of themethod is evidenced, theoretical results are further confirmed by some numerical experiments.Especially, the numerical method and its theories can be applied to specialcases, such as delay differential-algebraic equations and integral differential-algebraicequations.

关键词： Canonical Euler splitting method nonlinear composite stiff functional differentialalgebraic equations stability convergence.

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