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Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

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Zoological Research 2024年第2期45卷 341-354页

作者： Yu-Han Niu li-Hong Guan Cheng Wang Hai-Feng Jiang guo-Gang li lian-dong Yang Shun-Ping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of life Sciences Qinghai Normal UniversityXiningQinghai 810008China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Qinghai Normal UniversityXiningQinghai 810008China College of life Sciences and Technology Xinxiang Medical UniversityXinxiangHenan 453003China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving *** a period of dormancy,organisms often exhibit exceptional *** period is typically divided into hibernation and aestivation based on seasonal ***,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further ***,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,*** on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across *** analyses revealed noteworthy disparities between the two dormant species in their responses to extreme ***,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and *** further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available *** comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent *** conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

关键词： Hibernation Aestivation Multi-organs Convergent evolution

cKBET:assessing goodness of batch effect correction for single-cell RNA-seq

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Frontiers of Computer Science 2024年第1期18卷 215-228页

作者： Yameng ZHAO Yin guo limin li School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

Single-cell RNA sequencing reveals the gene structure and gene expression status of a single cell,which can reflect the heterogeneity between ***,batch effects caused by non-biological factors may hinder data integration and downstream *** the batch effect can be evaluated by visualizing the data,which actually is subjective and *** this work,we propose a quantitative method cKBET,which considers the batch and cell type information *** cKBET method accesses batch effects by comparing the global and local fraction of cells of different batches in different cell *** verify the performance of our cKBET method on simulated and real biological data *** experimental results show that our cKBET method is superior to existing methods in most *** general,our cKBET method can detect batch effect with either balanced or unbalanced cell types,and thus evaluate batch correction methods.

关键词： single-cell RNA-seq dataset b batch effect assessment cKBET method

A Retrodirective Array Enabled by CMOS Chips for Two-Way Wireless Communication with Automatic Beam Tracking

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Engineering 2024年第6期37卷 196-207页

作者： Jiacheng guo Yizhu Shen guoqing dong Zhuang Han Sanming Hu State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast UniversityNanjing 210096China Purple Mountain Laboratories Nanjing 211111China

This article proposes and demonstrates a retrodirective array(RDA)for two-way wireless communication with automatic beam *** proposed RDA is enabled by specifically designed chips made using a domestic complementary metal-oxide semiconductor(CMOS)*** highly integrated CMOS chip includes a receiving(Rx)chain,a transmitting(Tx)chain,and a unique tracking phaselocked loop(PLL)for the crucial conjugated phase recovery in the *** article also proposes a method to reduce the beam pointing error(BPE)in a conventional *** validate the above ideas simply yet without loss of generality,a 2.4 GHz RDA is demonstrated through two-way communication links between the Rx and Tx chains,and an on-chip quadrature coupler is designed to achieve a nonretrodirective signal suppression of 23 *** experimental results demonstrate that the proposed RDA,which incorporates domestically manufactured low-cost 0.18 lm CMOS chips,is capable of automatically tracking beams covering±40with a reduced *** CMOS chip in the RDA has a compact size of 4.62 mm^(2) and a low power consumption of 0.15 *** the best of the authors’knowledge,this is the first research to demonstrate an RDA with a fully customized CMOS chip for wireless communication with automatic beam tracking。

关键词： Automatic beam tracking CMOS Retrodirective array Two-way communication

Highly efficient nonuniform finite difference method for three-dimensional electrically stimulated liquid crystal photonic devices

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Photonics Research 2024年第4期12卷 865-875页

作者： ZHENGHAO guo MENGJUN liU ZIJIA CHEN RUIZHI YANG PEIYUN li HAIXIA DA dong YUAN guoFU ZHOU liNGliNG SHUI HUAPENG YE Guangdong Provincial Key Laboratory of Optical Information Materials and Technology&Institute of Electronic Paper Displays South China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China SCNU-TUE Joint Lab of Device Integrated Responsive Materials(DIRM) National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Joint Laboratory of Optofluidic Technology and Systems National Center for International Research on Green OptoelectronicsSouth China Academy of Advanced OptoelectronicsSouth China Normal UniversityGuangzhou 510006China College of Electronic and Optical Engineering&College of Microelectronics Nanjing University of Posts and TelecommunicationsNanjing 210046China Key Laboratory of Radio Frequency and Micro-Nano Electronics of Jiangsu Province Nanjing 210023China

liquid crystal(LC)photonic devices have attracted intensive attention in recent decades,due to the merits of tunability,cost-effectiveness,and high ***,the precise and efficient simulation of large-scale three-dimensional electrically stimulated LC photonic devices remains challenging and resource *** we report a straightforward nonuniform finite difference method(NFDM)for efficiently simulating largescale LC photonic devices by employing a spatially nonuniform mesh grid.

关键词： nonuniform crystal finite

Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of Clinical Cases 2024年第2期12卷 285-292页

作者： Sha-Sha Sun Xiao-Di guo Wen-dong li Jing-Long Chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** HCC patients with Barcelona Clinic liver Cancer stage C treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TACE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse *** Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DCR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma Combination therapy Tumor response

Endoscopic treatment of extreme esophageal stenosis complicated with esophagotracheal fistula: A case report

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 239-247页

作者： Jia-Heng Fang Wei-Min li Cheng-Hai He Jian-liang Wu Yun guo Zhi-Chao Lai guo-dong li Department of Gastroenterology Hangzhou Normal University Affiliated HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND At present,there is no unified and effective treatment for extreme corrosive esophageal stenosis(CES)with esophagotracheal fistula(ETF).This case had extreme and severe esophageal stenosis(ES)and ETF after ingesting an enzyme-based chemical detergent,resulting in a serious pulmonary infection and severe *** gastrointestinal imaging showed that he had an ETF,and endoscopy showed that he had extreme and severe esophageal *** case was complex and difficult to *** to the domestic and foreign lite-rature,there is no universal treatment that is *** SUMMARY A patient came to our hospital with extreme ES,an ETF,and severe malnutrition complicated with pulmonary tuberculosis 1 mo after the consumption of an enzy-me-based *** ES was serious,and the endoscope was unable to pass through the *** treated him by endoscopic incision method(EIM),esophageal stent placement(ESP),and endoscopic balloon dilation(EBD)by using the bronchoscope and *** treatment not only closed the ETF,but also expanded the esophagus,with minimal trauma,greatly reducing the pain of the *** to the literature,there are no similar reported *** We report,for the first time,a patient with extreme CES complicated with ETF,where the endoscope could not be passed through his esophagus but he could be examined by bronchoscopy and treated by EIM,ESP,and EBD.

关键词： Extreme corrosive esophageal stenosis Esophagotracheal fistula Endoscopic incision method Esophageal stent placement Endoscopic balloon dilation Case report

Thermodynamic and experimental study of high-temperature roasting of blast furnace gas ash for recovery of metallic zinc and iron

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Journal of Iron and Steel Research(International) 2024年第1期31卷 108-120页

作者： Zi-han Wang Jing guo Han-jie guo Bin li School of Metallurgical Engineering University of Science and Technology BeijingBeijing100083China School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina

A high-temperature reduction roasting method was used to achieve metallic iron and zinc recovery from blast furnace gas ash(BFA).The reduction processes for Zn-containing and Fe-containing oxides were analyzed in detail by using ther-modynamic equilibrium calculation and the principle of minimum free *** results showed that the main reaction in the system is the reduction of ZnFe_(2)_(4)and iron *** the full temperature range,iron oxides were more easily reduced than zinc *** of the amount of CO contained in the system,the reduction of ZnO to Zn was difficult to proceed below the boiling point(906℃)of *** the reduction temperature is below 906℃,the reduction process of zinc ferrate was ZnFe_(2)_(4)→ZnO;when the reduction temperature is above 906℃,its reduction process becomed ZnFe_(2)_(4)→ZnO→Zn(g).The metallization and dezincification rates of the BFA gradually increased with increasing reaction *** the C/O ratio increased,the metallization and dezincification rates first increased and then *** effect of reduction time on BFA reduction was similar to that of reaction temperature.

关键词： Blast furnace gas ash Thermodynamics Zinc removal Iron reduction High-temperature reduction roasting Integrated utilization

Dual-salt poly(tetrahydrofuran)electrolyte enables quasi-solid-state lithium metal batteries to operate at−30℃

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Journal of Energy Chemistry 2024年第9期96卷 456-463页

作者： Zhiyong li Zhuo li Rui Yu Xin guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiChina The State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The stable operation of solid-state lithium metal batteries at low temperatures is plagued by severe restrictions from inferior electrolyte-electrode interface compatibility and increased energy barrier for li^(+)***,we prepare a dual-salt poly(tetrahydrofuran)-based electrolyte consisting of lithium hexafluorophosphate and lithium difluoro(oxalato)borate(liDFOB).The li-salt anions(DFOB−)not only accelerate the ring-opening polymerization of tetrahydrofuran,but also promote the formation of highly ion-conductive and sustainable interphases on li metal anodes without sacrificing the li^(+)conductivity of electrolytes,which is favorable for li^(+)transport kinetics at low *** of this polymer electrolyte in li||liFePO_(4)cells show 82.3%capacity retention over 1000 cycles at 30℃and endow stable discharge capacity at−30℃.Remarkably,the li||liFePO4 cells retain 52%of their room-temperature capacity at−20℃and 0.1 *** rational design of dual-salt polymer-based electrolytes may provide a new perspective for the stable operation of quasi-solid-state batteries at low temperatures.

关键词： Poly(tetrahydrofuran) Dual-salt electrolyte Solidel ectrolyte interphase Low-temperature operation Quasi-solid-state battery

Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-li WANG Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-Yuan SONG Yu-Bin liU Qi-Guang WANG He XU Yu-Xin ZHANG dong li li-Jie dong Yu guo CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta