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Novel conductive metallo-supramolecular polymer AIE gel for multi-channel highly sensitive detection of hydrazine hydrate

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Chinese Chemical Letters 2023年第8期34卷 167-170页

作者： Yu Jia Wen-li guan Juan liu Jian-Peng Hu Bingbing Shi Hong Yao You-Ming Zhang Tai-Bao Wei Qi lin Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education Key Laboratory of Eco-environmental Polymer Materials of Gansu ProvinceCollege of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhou 730070China College of Chemical Engineering Key Laboratory for Utility of Environment Friendly Composite Materials and Biomass in University of Gansu ProvinceNorthwest Minzu University(Northwest University for Nationalities)Lanzhou 730070China

Hydrazine hydrate(DH)is an important fine chemical intermediate and as fuel for rockets,however,it also has serious toxic for humans and *** novel materials and methods for sensitive detection of DH in water and air is an important *** order to effectively detect DH,a novel conductive supramolecular polymer metallogel(PQ-Ag)has been constructed by the coordination of bis-5-hydroxyquinoline functionalized pillar[5]arene(PQ5)with Ag+.The metallogel PQ-Ag could realize the multi-channel sensitive detection of DH through naked-eye,fluorescence,and electrochemical *** lowest limit of detection(LOD)is 0.1 mg/m^(3)in air and 2.68×10^(−8)mol/L in water,which is lower than the standard of the US Environmental Protection Agency(EPA)for DH of maximum allowable concentration in drinking *** importantly,an electronic device for DH detection based on the metallogel PQ-Ag was designed and prepared,which can realize conveniently and efficiently multi-channel detection and alert of DH through sound and light alarms not only in water but also in air.

关键词： Supramolecular metallogel Hydrazine hydrate sensor Sensitive detection Electronic sensing detection device

Effect of hyperbaric oxygen on post-stroke depression

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World Journal of Psychiatry 2023年第5期13卷 226-233页

作者： Hong Guo Yi-Ran Ge Yan-Bin Dong Xiao-Chuan Zhao guan-li Su Jin-Cheng Wang Department of Psychology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Clinical Psychology The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND In patients with post-stroke depression(PSD)in diabetes,the situation may be more complex,requiring simultaneous treatment of blood glucose,depressive symptoms,and neurological *** oxygen(HBO)therapy can improve tissue oxygen content and improve the situation of ischemia and hypoxia,thus playing a role in protecting brain cells and restoring the function of brain ***,there are few studies on HBO therapy for patients with *** study explores the clinical efficacy of such therapy for stroke complicated with depression and diabetes mellitus,and to provide reference and basis for clinical treatment and development through the application of relevant rating scales and laboratory test *** To evaluate the clinical effects of HBO therapy on patients with diabetes with *** A total of 190 diabetic patients with PSD were randomly divided into observation and control groups(95 patients per group).The control group received escitalopram oxalate 10mg once a day for eight *** addition,the observation group was also given HBO therapy,once a day,five times a week,for eight *** Montgomery Depression Rating Scale(MADRS),National Institutes of Health Stroke Scale(NIHSS),hypersensitive C-reactive protein,tumor necrosis factor(TNF)-α,and fasting glucose levels were *** There were no significant differences in age,sex,or depression course between the groups(P>0.05).After HBO treatment,MADRS scores in both groups decreased significantly(14.3±5.2),and were significantly lower in the control group(18.1±3.5).After HBO treatment,NIHSS scores in both groups decreased significantly,and scores in the observation group(12.2±4.0)decreased more than in the control group(16.1±3.4),the difference was statistically significant(P<0.001).The levels of hypersensitive C-reactive protein and TNF-αin both groups were significantly decreased,and the observation group was significantly lower than the control group(P<0.001).F

关键词： therapy clinical patients

Analysis and Design of Wireless Networked Control System Utilizing Adaptive Coded ModulationAnalysis and Design of Wireless Networked Control System Utilizing Adaptive Coded Modulation

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自动化学报 2009年第7期35卷 911-918页

作者： YANG li guan Xin-Ping LONG Cheng-Nian LUO Xiao-Yuan Department of Electrical Engineering Yanshan University Qinhuangdao 066004 P. R. China

In this paper, we explore the analysis and design of wireless networked control system (WNCS) utilizing adaptive coded modulation (ACM) schemes, which can improve the energy efficiency and increase data rate over a fading channel. To capture the characteristics of varying rate, interference, and routing in wireless transmission channel, we introduce the concept of equivalent delay (ED). Based on the time-varying network condition, the analytic lower and upper bounds of EDs are given. Whereafter, WNCS is modelled as a discrete-time system with time-varying input delay. Sufficient stabilization condition of the closed-loop WNCS is derived by making use of novel techniques of time-delay system. Finally, the numerical result shows the validity of our proposed control strategies.

关键词：无线网络控制系统计算机技术自动化系统网络条件

Proteomic analysis and miRNA profiling of human testicular endothelial cell-derived exosomes:the potential effects on spermatogenesis

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Asian Journal of Andrology 2022年第5期24卷 478-486页

作者： Wen-Peng Song Sheng-Ji Gu Xiao-Hui Tan Yang-Yang Gu Wei-Dong Song Jian-Yu Zeng Zhong-Cheng Xin Rui-li guan Department of Urology Peking University First HospitalBeijing 100034China Institute of Urology Peking UniversityBeijing 100034China Beijing Key Laboratory of Urogenital Diseases(Male)Molecular Diagnosis and Treatment Center Beijing 100034China Department of Dental Implant Center Beijing Stomatological HospitalSchool of StomatologyCapital Medical UniversityBeijing 100050China Department of Radiation Medicine Institute of Systems BiomedicineSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Testicular endothelial cells have been found to play an important role in spermatogenesis and fertility,but their mechanism is *** released by various cells are recognized as cell–cell communication mediators during the initiation and progression of many ***,the current study aimed to investigate the protein and miRNA components of human testicular endothelial cell-derived exosomes(HTEC-Exos)and to explore their potential effects on *** this study,HTEC-Exos were first isolated by the ultracentrifugation method,and then identified by nanoparticle tracking analysis,transmission electron microscopy(TEM),and western *** characteristics of HTEC-Exos were examined by liquid chromatography–mass spectrometry and microRNA(miRNA)chip *** analysis was performed to explore the potential role of the exosomal content on spermatogenesis.A total of 945 proteins were identified,11 of which were closely related to spermatogenesis.A total of 2578 miRNAs were *** them,30 miRNAs demonstrated potential associations with male reproductive disorders,such as azoospermia,and spermatogenesis *** particular,11 out of these 30 miRNAs have been proven to be involved in spermatogenesis based on available *** study provides a global view of the proteins and miRNAs from HTEC-Exos,suggesting that HTEC-Exos may function as potential effectors during the process of spermatogenesis.

关键词： exosomes microRNAs proteomics testicular endothelial cells

Effect of percutaneous electrical stimulation at the Baliao point on preventing postpartum urinary retention after labor analgesia

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World Journal of Clinical Cases 2024年第16期12卷 2758-2764页

作者： Xiao-Qing Wang li-Sha guan Department of Obstetrics and Gynecology Suzhou Ninth Affiliated Hospital of Suzhou UniversitySuzhou 215200Jiangsu ProvinceChina

BACKGROUND Anesthetic drugs used in labor analgesia also paralyze the bladder muscle by blocking the sacral plexus,thereby affecting maternal postpartum spontaneous urination and increasing the risk of postpartum urinary retention(PUR).AIM To analyze the effect of percutaneous electrical stimulation at the Baliao point combined with biofeedback therapy for PUR *** We selected 182 pregnant women who received labor analgesia in obstetrics between June 2022 and December *** were divided into the combined therapy group(transcutaneous electrical stimulation of the Baliao point combined with biofeedback therapy)and the control group(biofeedback therapy alone).The first spontaneous urination time,first postpartum urine volume,bladder residual urine volume,postpartum hemorrhage volume,pre-urination waiting time,PUR incidence,adverse reactions,and the intervention’s clinical efficacy were compared between the two *** The first spontaneous urination time after delivery was more delayed(2.92±1.04 h vs 3.61±1.13 h,Plinical total efficacy rate of the intervention was significantly higher in the combined therapy group than in the control group(95.35%vs 84.15%,P=0.016).CONCLUSION Percutaneous electrical stimulation of the Baliao point combined with biofeedback can significantly promote postpartum micturition of parturients with labor analgesia,thereby effectively preventing PUR occurrence.

关键词： Transcutaneous electrical stimulation Baliao acupoint Biofeedback Pain relief during childbirth Postpartum uroschesis

Identification of novel epithelial-mesenchymal transition-related gene features to predict survival outcome in patients with pancreatic cancer

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中国药理学与毒理学杂志 2019年第10期 892-893页

作者： ZHANG Qiang JIANG Long-yang li Xue-ping YUAN guan-li guan Qiu-tong QI Ao-shuang SONG Xin-yue Song JIA Zhen ZHAO lin WEI Min-jie Department of Pharmacology School of PharmacyChina Medical University liaoning Engineering Technology Research Center China Medical University Department of Emergency the First Hospital of Qinhuangdao

OBJECTIVE To find a novel genetic marker to improve the prediction of PC metastasis is urgently needed. In 2018, pancreatic cancer caused the seventh mostly common cancer-death in the world. The mortality rate of pancreatic cancer is closely related to the incidence, making PC the deadliest cancer. Most of the existing biomarkers related to the survival and prognosis of mining are single-gene biomarkers, but its prediction effect is not specific enough. METHODS GSEA(http://***/gsea/***) was conducted to explore whether the identified sets showed significant differences between the two groups. We used Univariate Cox regression analysis to identify genes that related to OS with Plished a prognostic risk score formula. RESULTS We analyzed the m RNA expression data collected from 171 PC patients from the TCGA database and obtained 197 m RNA significantly associated with epithelial-mesenchymal transition by gene set enrichment analysis(GSEA). We built a Cox proportional regression model and obtained a set of genes that are remarkably associated with overall survival(OS) and lymph node metastasis in the test series. Multivariate Cox regression analysis was used to figure out a three-gene signature and to calculate the risky score. Based on this, patients in the test series can be divided into high-risk or low-risk subgroups. The prognostic ability of the three gene features was not affected by clinical features. CONCLUSION Therefore, the set of genetic-marker combinations related to epithelial-mesenchymal transition is able to predict the prognosis of lymph node metastasis in PC. It provides a new idea for understanding the epithelial-mesenchymal transition and the prognosis of PC metastasis.

关键词： cancer epithelial-mesenchymal transition

Protective Effects ofNew ethyl pyruvate derivative on Ionizing Radiation-Induced Intestinal Injury

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Protective Effects ofNew ethyl pyruvate derivative on Ionizi...

Construction of SNP genetic maps based on targeted next-generation sequencing and QTL mapping of vital agronomic traits in faba bean(Vicia faba L.)

中国毒理学会第九次全国毒理学大会

作者： WU Jing li De-guan Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation MedicineChinese Academy of Medical Science＆Peking Union Medical College

OBJECTIVE Small intestine tissue is extremely sensitive to radiation. There is currently no specific treatment for radiation-induced intestinal injury in the clinic. We designed and synthesized a compound named new ethyl pyruvate derivative（TZC02）, whose radioprotectiveeffects on ionizing radiation-induced intestinal injury were investigated. MATERIALS and METHODS MaleC57 BL/6 J mice were randomly divided into three groups: control, IR and TZC02. Mice inIR and TZC02 were treated by gavage with solventor TZC02 one hour before12 Gy abdominal irradiation（ABI）,continuous administration for two days after irradiation. The mice 30 d survival rate was ***, at 3 d after IR,the small intestine tissues were *** number of small intestine crypts was counted by HE staining. The apoptosis of small intestine crypt cells was detected by TUNEL. The expressions of Lgr5,Ki67, Lysozyme and Villus were detected by immunohistochemistry. The expressions of γH2 AX and caspase-3 were detected by immunofluorescence. RESULTS TZC02 improved the survival rate of mice exposed to 12 Gy ABI, protected the small intestinal morphology against radiation-induced injury,reduced structural damage of the small intestine, decreased apoptosis rate of small intestine crypt cells and DNA *** These data demonstrated that TZC02 had protective effects on the intestine injury induced by IR, suggesting TZC02 might be a promising radioprotector.

关键词： Abdominal irradiation Small intestine Apoptosis DNA damage

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Journal of Integrative Agriculture 2023年第9期22卷 2648-2659页

作者： li Meng-wei HE Yu-hua liU Rong li guan WANG Dong JI Yi-shan YAN Xin HUANG Shu-xian WANG Chen-yu MA Yu liU Bei YANG Tao ZONG Xu-xiao National Key Facility for Crop Gene Resources and Genetic Improvement/Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Grain Crops Yunnan Academy of Agricultural SciencesKunming 650205P.R.China Department of Horticulture Washington State UniversityPullmanWA 99164USA China Golden Marker(Beijing)Biotech Co. Ltd.Beijing 102200P.R.China

Owing to the limitation of a large genome size(~13 Gb),the genetic and gene mapping studies on faba bean(Vicia faba L.)are lagging far behind those for other *** this study,we selected three purified faba bean lines(Yundou 8137,H0003712,and H000572)as parents and constructed two F2 *** two F2 populations,namely 167 F2 plants in Pop1(Yundou 8137×H0003712)and 204 F2 plants in Pop2(H000572×Yundou 8137),were genotyped using a targeted next-generation sequencing(TNGS)genotyping platform,and two high-density single nucleotide polymorphisms(SNP)genetic linkage maps of faba bean were *** map constructed from Pop1 contained 5103 SNPs with a length of 1333.31 cM and an average marker density of 0.26 *** map constructed from Pop2 contained 1904 SNPs with a greater length of 1610.61 *** these two F2 populations,QTL mapping identified 98 QTLs for 14 agronomic traits related to the flowers,pods,plant types and *** two maps were then merged into an integrated genetic linkage map containing 6895 SNPs,with a length of 3324.48 *** results not only lay the foundation for fine mapping and map-based cloning of related genes,but can also accelerate the molecular marker-assisted breeding of faba bean.

关键词： faba bean targeted next-generation sequencing single nucleotide polymorphisms genetic linkage map QTL mapping

基于星载红外高光谱观测用机器学习算法反演大气温湿廓线

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红外与激光工程 2022年第8期51卷 451-462页

作者：姚姝含官莉南京信息工程大学气象灾害教育部重点实验室/气象灾害预报预警与评估协同创新中心江苏南京210044

星载红外高光谱垂直探测仪GIIRS(Geostationary Interferometric Infrared Sounder)能够实现大气温度和湿度参数高垂直分辨率的观测,为数值天气预报提供精度更高的初始场。基于GIIRS观测辐射值采用BP神经网络(Back Propagation Neural N... 详细信息

星载红外高光谱垂直探测仪GIIRS(Geostationary Interferometric Infrared Sounder)能够实现大气温度和湿度参数高垂直分辨率的观测,为数值天气预报提供精度更高的初始场。基于GIIRS观测辐射值采用BP神经网络(Back Propagation Neural Network)法和深度学习的卷积神经网络(Convolutional Neural Networks,CNN)法反演大气温度、湿度垂直廓线,重点在于CNN法模型的构建与参数的优化,得到反演精度最高的网络模型配置。将训练样本根据不同地表类型和是否有云的影响分为三种方案(方案一:不分类、方案二:陆地/洋面分类、方案三:晴空/有云分类),分别进行建模、反演和检验。结果表明两种反演算法都有较好的反演精度,相对而言CNN法在所有高度层上反演偏差、均方根误差和平均相对误差均较小,反演精度更高。CNN法温度反演在高层10~200 hPa改进较大,三种分类方案改进的最大值分别为1.15 K、1.06 K和1.02 K;湿度反演在对流层低层500~1000 hPa改进较大,三种分类方案分别平均改进了0.43 g/kg、0.41 g/kg和0.34 g/kg。BP神经网络法方案三时(即分晴空和云时)温度和水汽混合比廓线反演精度最好;CNN算法方案一时(即不对样本数据进行任何分类)反演精度最高。

关键词： GIIRS 大气温湿度廓线 BP神经网络卷积神经网络反演

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