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Injectable“cocktail”hydrogel with dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic effect

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SmartMat 2024年第2期5卷 43-53页

作者： li Zhao Jiawen Xu Yao Tong Pengyu Gong fucheng Gao Hui li Yanyan Jiang Key Laboratory for liquid-Solid Structural Evolution&Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinanChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanChina Department of Clinical Laboratory The Second HospitalCheeloo College of MedicineShandong UniversityJinanChina

The combination of the first-line standard chemotherapeutic drug doxorubicin hydrochloride(DOX)and the molecular-targeted drug Herceptin(HCT)has emerged as a promising strategy for human epidermal growth receptor 2(HER-2)overexpressing breast cancer treatment.However,insufficient drug accumulation and severe cardiotoxicity are two major challenges that limit its clinical application.Herein,an in situ forming gold nanorods(AuNRs)-sodium alginate(ALG)hybrid hydrogel encapsulating DOX and HCT was engineered for tumor synergistic therapy involving injectable,dual-stimuli-responsive drug release,photothermal ablation,and drug-antibody synergistic therapy.The photothermal agent AuNRs,anticancer drug DOX,and anticancer antibody HCT were mixed in ALG solution,and after injection,the soluble ALG was quickly transformed into a hydrogel in the presence of Ca^(2+)in the body.Significantly,the hybrid hydrogel exhibits an extremely high photothermal conversion efficiency of 70%under 808 nm laser irradiation.The thermal effect can also provide photothermal stimulation to trigger the drug release from the gel matrix.In addition,the drug release rate and the releasing degree are also sensitive to the pH.In vitro studies demonstrated that the PEI-AuNR/DOX/HCT/ALG hydrogel has facilitated the therapeutic efficiency of each payload and demonstrated a strong synergistic killing effect on SK-BR-3 cells.In vivo imaging results showed that the local drug delivery system can effectively reduce the nonspecific distribution in normal tissues and increase drug concentration at tumor sites.The proposed hydrogel system shows significant clinical implications by easily introducing a sustainable photothermal therapy and a potential universal carrier for the local delivery of multiple drugs to overcome the challenges faced in HER-2 overexpressing cancer therapy.

关键词： dual-stimuli-responsive drug release HER-2 overexpressing breast cancer injectable hydrogel photothermal therapy synergistic effect

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TSR: algorithm of image hole-filling based on three-step repairing

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The Journal of China Universities of Posts and Telecommunications 2022年第5期29卷 83-91页

作者： li fucheng Deng Junyong Zhu Yun Luo Jiaying Ren Han School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

In order to solve the hole-filling mismatch problem in virtual view synthesis, a three-step repairing(TSR) algorithm was proposed. Firstly, the image with marked holes is decomposed by the non-subsampled shear wave transform(NSST), which will generate high-/low-frequency sub-images with different resolutions. Then the improved Criminisi algorithm was used to repair the texture information in the high-frequency sub-images, while the improved curvature driven diffusion(CDD) algorithm was used to repair the low-frequency sub-images with the image structure information. Finally, the repaired parts of high-frequency and low-frequency sub-images are synthesized to obtain the final image through inverse NSST. Experiments show that the peak signal-to-noise ratio(PSNR) of the TSR algorithm is improved by an average of 2-3 dB and 1-2 dB compared with the Criminisi algorithm and the nearest neighbor interpolation(NNI) algorithm, respectively.

关键词： virtual view point synthesis hole-filling three-step repairing(TSR) Criminisi algorithm curvature driven diffusions(CDD)algorithm

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税收征管能力、征管强度异质性与企业间税负不平等

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中国经济问题 2024年第1期 62-76页

作者：魏福成李瑶瑶中南财经政法大学财政税务学院三一重工股份有限公司

探究企业间税负不平等的成因,对于建设公平市场环境具有重要意义。税收征管能力可能通过影响税务机关对不同企业的征管强度差异,进而影响企业间税负不平等。本文基于税收征管的边际报酬变化,构建理论模型论证了这一思想;同时,基于制造... 详细信息

探究企业间税负不平等的成因,对于建设公平市场环境具有重要意义。税收征管能力可能通过影响税务机关对不同企业的征管强度差异,进而影响企业间税负不平等。本文基于税收征管的边际报酬变化,构建理论模型论证了这一思想;同时,基于制造业数据测算了省际层面企业间税负不平等和税收征管能力,采用固定效应模型实证分析了这一思想。研究表明,税收征管能力上升能显著降低企业间税负不平等,且在政府行为规范性低的地区以及财政压力更大的地区的效应更显著。本研究拓展了对征管能力影响效应和税负不平等影响因素的认识。

关键词：税收征管能力征管强度企业间税负不平等征管的边际报酬

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Reconfigurable(4, 6^(2)) and(4, 8^(2)) Archimedean plasma photonic crystals in dielectric barrier discharge

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Plasma Science and Technology 2024年第6期26卷 70-78页

作者：李蕊王启晗刘富成高匡雅侯笑含贾萌萌李庆范伟丽 College of Physics Science and Technology Hebei UniversityBaoding 071002People’s Republic of China Institute of Electrostatic Technology Hebei UniversityBaoding 071002People’s Republic of China

Archimedean photonic crystal has become a research area of great interest due to its various unique properties. Here, we experimentally demonstrate the realization of reconfigurable(4, 6^(2))and(4, 8^(2)) Archimedean plasma photonic crystals(APPCs) by use of dielectric barrier discharges in air. Dynamical control on both the macrostructures including the lattice symmetry and the crystal orientation, and the microstructures including the fine structures of scattering elements has been achieved. The formation mechanisms of APPCs are studied by time-resolved measurements together with numerical simulations. Large omnidirectional band gaps of APPCs have been obtained. The tunable topology of APPCs may offer new opportunities for fabricating multi-functional and highly-integrated microwave devices.

关键词： Archimedean lattice plasma photonic crystals dielectric barrier discharge

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Changes in SOC and Nutrients under Intensive Tillage in Two Types of Slope Landscapes

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Journal of Mountain Science 2012年第1期9卷 67-76页

作者： li fucheng ZHANG Jianhui SU Zhengan Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China The Graduate School of the Chinese Academy of Sciences Beifing 100049China Key Laboratory of Mountain Hazards and Earth Surface Processes Chinese Academy of SciencesChengdu 610041China

The net effect of tillage erosion on soil properties would be associated with the spatial variation in soil constituents,and therefore plays an important role in ecological agriculture.We conducted a consecutive tillage by hoeing 15 times during a period with no rainfall in the two slope landscapes(a linear slope and complex slope) of the Yangtze Three Gorges reservoir areas,to examine the relationship between soil erosion rates and the variations in soil chemical properties and compare the effects of soil redistribution on SOC and nutrients between the linear and complex slopes.After the simulated tillage,notable changes in 137 Cs inventories of the soil occurred in the summit and toeslope positions on the linear slope,while there were significant changes in 137 Cs inventories at convex and concave positions on the complex slope.Soil profile disappeared at the summit slope boundary,with the exposure area of 16.0% and 7.6% of the experimental plot,respectively,for the linear and complex slopes due to no soil replacement.Soil organic C and nutrients were completely depleted with the disappearance of soil profiles at soil eroding zones,whereas a remarkable increase in SOC,total N and available nutrient concentrations of the post-tillage surface soil and a decrease in total nutrient concentrations(P and K) were found at depositional zones on the linear slope.For the complex slope,however,changes in SOC and nutrient concentrations of the post-tillage surface soil exhibited a patterndifferent from that on the linear slope,which showed a remarkable decrease in SOC and total nutrient concentrations but a slight increase in available nutrient concentrations after tillage in the toeslope position.Due to the gradual increase in soil depth from top to bottom of the slope,SOC and nutrient inventories in the soil profiles were significantly correlated with soil redistribution rates on both the linear and complex slopes.Tillage causes remarkable changes of soil chemical properties in the surface soil layer and soil profile,and

关键词：土壤养分含量耕作侵蚀 SOC 景观土壤有机碳土壤侵蚀速率土壤成分土壤剖面

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空心微瓶腔回音壁模式谐振的调谐方法及应变传感特性

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光学学报 2024年第2期44卷 213-220页

作者：蔡露李尚文王进刘俊相夫程李忠嘉东北大学秦皇岛分校控制工程学院河北秦皇岛066004 东北大学信息科学与工程学院辽宁沈阳110819 东北大学秦皇岛分校河北省微纳精密光学传感与检测技术重点实验室河北秦皇岛066004

提出了一种双柄空心微瓶腔结构,利用微纳光纤耦合激发出了回音壁模式(WGM)谐振,通过控制轴向拉伸应变,实现了回音壁模式的谐振波长和品质因子Q的调谐,通过非对称拉锥的方式改变微腔结构,增大了双柄微腔结构轴向拉伸对腔长和壁厚的改变量... 详细信息

提出了一种双柄空心微瓶腔结构,利用微纳光纤耦合激发出了回音壁模式(WGM)谐振,通过控制轴向拉伸应变,实现了回音壁模式的谐振波长和品质因子Q的调谐,通过非对称拉锥的方式改变微腔结构,增大了双柄微腔结构轴向拉伸对腔长和壁厚的改变量,从而使谐振波长的调谐范围达到了0.66 nm。所提结构在激光器、滤波器和传感检测等应用方面具有实际意义。实验中进一步探究了非对称双柄回音壁模式微腔的应变传感特性,结果表明,WGM谐振峰对轴向拉伸应变的灵敏度可达0.795 pm/με,分辨率小于25με,线性度达0.999。由于回音壁模式谐振腔具有极窄的谐振峰,该传感方法能够实现更高的传感分辨率,为高分辨率应变传感提供了新思路。

关键词：集成光学回音壁模式空心微瓶腔谐振峰调谐应变传感

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A Method for Evaluating the Suitability of CO2 Geological Storage in Deep Saline Aquifers

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1838-1851页

作者： li fucheng ZHANG Yang JIA Xiaofeng li Xufeng JIA Xiaoleng GUO Shengxiu Center for Hydrogeology and Environmental Geology China Geological Survey Baoding 071051 Hebei China School of Environmental Science and Engineering Chang'an University Xi'an 710054 Shaanxi China Hydrogeology and Engineering Geology Prospecting Institute of Qinghai Province Xining 810008 Qinghai China

This work established an evaluation index system based on a comprehensive analysis of those factors affecting the suitability of CO2 geological storage.This evaluation index system includes three evaluation index layers of geological safety,storage scale and social economy,nine evaluation index sub-layers,and 28 evaluation index factors,and adopts the analytic hierarchy process（AHP）and index overlay methods.Taking the Xining Basin in northwest China as an example,we conducted comprehensive analysis of geological conditions and performed quantitative evaluation based on this evaluation index system,which indicates that the Shuangshu depression of the Xining Basin is comparatively suitable for CO2 geological storage.It is suggested that this evaluation index system and the evaluation method proposed in this study are suitable for most continental sedimentary basins in China and should be widely applied.

关键词： CO2 geological storage suitability evaluation evaluation index system AHP Xining Basin

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热处理工艺对Nb-Ti-Al基低密度铌合金力学性能及组织形貌的影响

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湖南工业大学学报 2024年第3期38卷 102-106页

作者：李福成国家钽铌特种金属材料工程技术研究中心宁夏石嘴山753000 西北稀有金属材料研究院稀有金属特种材料国家重点实验室宁夏石嘴山753000 中色(宁夏)东方集团有限公司宁夏东方钽业股份有限公司宁夏石嘴山753000

将Nb-Ti-Al基低密度铌合金在不同的高温条件下进行热加工处理,并对合金涂层后的试样在1300℃高温熔烧30 min,利用INSTRON4505型万能试验机、金相显微镜、扫描电镜和能谱分析仪对热处理后试样的室温(25℃)力学性能(抗拉强度бb、屈服强度... 详细信息

将Nb-Ti-Al基低密度铌合金在不同的高温条件下进行热加工处理,并对合金涂层后的试样在1300℃高温熔烧30 min,利用INSTRON4505型万能试验机、金相显微镜、扫描电镜和能谱分析仪对热处理后试样的室温(25℃)力学性能(抗拉强度бb、屈服强度б0.2和延伸率)、金相组织、断口形貌等进行了对比分析。结果表明,当熔烧温度(t≥900℃)每升高100℃,抗拉强度下降9.23%,屈服强度下降9.11%,延伸率下降9.59%,晶粒度增大比例为21.43%,在熔烧温度高于1200℃时试样仅测出抗拉强度值就断裂了,表现出铌合金试样随着熔烧温度梯度的升高,样品基材的力学性能下降,晶粒度和硬度不断增大,塑性和韧性不断下降的规律。

关键词： Nb-Ti-Al基低密度铌合金热处理工艺力学性能金相组织断口形貌

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种植密度和深度对甘蔗产量及抗倒伏的影响

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热带作物学报 2024年第2期45卷 330-339页

作者：刘富成李照杰蔡文伟吴伟海南大学热带作物学院/海南省耐盐作物生物技术重点实验室海南海口570228 中国热带农业科学院热带生物技术研究所海南海口571101

为进一步提高甘蔗单位面积产量,合理的种植密度和深度一直是常用的栽培技术手段。但在增加产量的同时,往往忽略了对甘蔗倒伏的影响。为确定不同种植密度和深度对甘蔗产量及倒伏的影响,以甘蔗品种中糖3号为试验材料进行研究,试验共设计3.... 详细信息

为进一步提高甘蔗单位面积产量,合理的种植密度和深度一直是常用的栽培技术手段。但在增加产量的同时,往往忽略了对甘蔗倒伏的影响。为确定不同种植密度和深度对甘蔗产量及倒伏的影响,以甘蔗品种中糖3号为试验材料进行研究,试验共设计3.0、4.5、6.0、7.5芽/m^(2)四个种植密度梯度及浅植(30 cm)、深植(40 cm)2种种植深度,对甘蔗的农艺性状、倒伏相关指数(根系倒伏与茎秆倒伏)和产量等进行测定。结果表明:随着甘蔗生育期不断推进,甘蔗根系和茎秆安全系数逐渐降低,在下种后180 d甘蔗根系倒伏和茎秆倒伏风险较大,处于敏感时期。种植密度从3芽/m^(2)增加至6芽/m^(2),甘蔗产糖量(+32%)和产量(+36%)显著增加,同时甘蔗的茎秆倒伏抗性也随之增加。但进一步增加种植密度到7.5芽/m^(2)时,产糖量和产量没有进一步显著增加,但增加了甘蔗的根倒伏风险。与种植深度30 cm相比,种植深度40 cm具有增加甘蔗产糖量(+2.8%)和产量(+4.8%)的趋势,二者差异不显著。因此,综合甘蔗产糖量、产量及抗倒伏等多个性状,认为种植深度40 cm,种植密度为6芽/m^(2)可以在保证产量和产糖量的同时,提高甘蔗的倒伏抗性。

关键词：甘蔗种植深度种植密度倒伏产量

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石墨烯基聚合物复合涂层及湿法涂覆在金属双极板领域的应用进展

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广州化学 2024年第3期49卷 25-30,I0002页

作者：郭福成李静上海理工大学材料与化学学院上海200093

简单介绍真空气相沉积制备双极板涂层的优缺点;提出石墨烯作为理想防腐填料应用于双极板涂层的可能性;指出石墨烯基聚合物复合涂层的分散性难题及解决方案;详细综述了几种湿法涂覆石墨烯衍生物或二维纳米材料聚合物复合涂层的制备方法,... 详细信息

简单介绍真空气相沉积制备双极板涂层的优缺点;提出石墨烯作为理想防腐填料应用于双极板涂层的可能性;指出石墨烯基聚合物复合涂层的分散性难题及解决方案;详细综述了几种湿法涂覆石墨烯衍生物或二维纳米材料聚合物复合涂层的制备方法,以及各自涂层形貌、导电性、耐蚀性上的特点;最后展望了现阶段的石墨烯基聚合物复合涂层的缺陷以及改进方向。

关键词：金属双极板石墨烯基聚合物复合材料腐蚀与防护

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