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Reducing the global cancer burden with gastrointestinal screening: China's 30 years practice

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Cancer Biology & Medicine 2024年第3期21卷 204-212页

作者： Lei Yang li feng Yong Zhu Ning Wang Xinpu Lu Fanghui Gu Xiaotian Zhang Jiafu Ji Peking University Cancer Hospital(Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University Inner Mongolia Cancer CenterHohhot 010020China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing) Bejing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBejing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Bejing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Gastrointestinal(GI) cancers include esophageal [EC(International Classification of Disease 10^(th) revision: C15)], gastric [GC(C16)], and colorectal [CRC(C18-C21)] cancers. China is a high-incidence country of GI ca... 详细信息

关键词： esophageal colorectal gastrointestinal

Endoscopic treatment of bleeding gastric ulcer causing gastric wall necrosis:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1203-1207页

作者： Wei-feng li Ruo-Yu Gao Jing-Wen Xu Xi-Qiu Yu Department of Gastroenterology Shenzhen Luohu People’s HospitalShenzhen 518020Guangdong ProvinceChina

BACKGROUND Gastric wall necrosis is a rare complication of endoscopic treatment for bleeding gastric ulcer,which may exacerbate the patient’s condition once it occurs and may even require surgical intervention for *** SUMMARY A 59-year-old man was admitted to our department with *** revealed a giant ulcer in the gastric antrum with a visible vessel in its center,which was treated with sclerosants and tissue glue injection and resulted in necrosis of the gastric *** Injection of sclerosants and tissue glue may lead to gastric wall necrosis,which is a serious ***,before administering this treatment to patients,we should consider other more effective methods of hemostasis to avoid gastric wall necrosis.

关键词： Bleeding gastric ulcer Sclerotherapy Lauromacrogol Tissue adhesive Gastric wall necrosis Case report

Critical Opalescence and Its Impact on the Jet Quenching Parameter q

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Chinese Physics Letters 2024年第3期41卷 23-29页

作者：武警曹杉杉李峰 School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Research Center for Hadron and CSR Physics Lanzhou University and Institute of Modern Physics of CASLanzhou 730000China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Frontiers Science Center for Rare IsotopesLanzhou UniversityLanzhou 730000China Frontiers Science Center for Rare Isotopes Lanzhou UniversityLanzhou 730000China

Jet quenching parameter q is essential for characterizing the interaction strength between jet partons and nuclear *** on the quark-meson model,we develop a new framework for calculating q at finite chemical potential... 详细信息

关键词： parameter quark calculating

Sesamin is an effective spleen tyrosine kinase inhibitor against IgE-mediated food allergy in computational， cell-based and animal studies

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Food Science and Human Wellness 2024年

作者： Yu li Xuerui Chen Longhua Xu Xintong Tan Dapeng li Dongxiao Sun-Waterhouse feng li School of Chemical Sciences， The University of Auckland Key Laboratory of Food Nutrition and Human Health in Universities of Shandong College of Food Science and Engineering， Shandong Agricultural University

Food allergy has become a global concern. Spleen tyrosine kinase (SYK) inhibitors are promising therapeutics against allergic disorders. In this study， a total of 300 natural phenolic compounds were firstly subjected to virtual screening. Sesamin and its metabolites， sesamin monocatechol (SC-1) and sesamin dicatechol (SC-2)， were identified as potential SYK inhibitors， showing high binding affinity and inhibition efficiency towards SYK. Compared with R406 (a traditional SYK inhibitor)， sesamin， SC-1， and SC-2 had lower binding energy and inhibition constant (Ki) during molecular docking， exhibited higher bioavailability， safety， metabolism/clearance rate， and distribution uniformity ADMET predictions， and showed high stability in occupying the ATP-binding pocket of SYK during molecular dynamics simulations. In anti-dinitrophenyl-immunoglobulin E (Anti-DNP-IgE)/dinitrophenyl-human serum albumin (DNP-HSA)-stimulated rat basophilic leukemia (RBL-2H3) cells， sesamin in the concentration range of (5 – 80) μmol/L influenced significantly the degranulation and cytokine release， with 54.00% inhibition against β-hexosaminidase release and 58.45% decrease in histamine. In BALB/c mice， sesamin could ameliorate Anti-DNP-IgE/DNP-HSA-induced passive cutaneous anaphylaxis and ovalbumin (OVA)-induced active systemic anaphylaxis reactions， reduce the levels of allergic mediators (immunoglobulins and pro-inflammatory cytokines)， partially correct the imbalance of T helper (Th) cells differentiation in the spleen， and inhibit the phosphorylation of SYK and its downstream signaling proteins， including p38 mitogen-activated protein kinases (p38 MAPK)， extracellular signal-regulated kinases (ERK)， and p65 nuclear factor-κB (p65 NF-κB) in the spleen. Thus， sesamin may be a safe and versatile SYK inhibitor that can alleviate IgE-mediated food allergies.

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Milestone progress of the HEPS booster commissioning

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Nuclear Science and Techniques 2024年第1期35卷 170-177页

作者： Yue-Mei Peng Jian-She Cao Jin-Hui Chen Hai-Yi Dong Ping He Yi Jiao ling Kang Wen Kang Jian li Jing-Yi li Guo-Ping lin Fang liu feng-li Long Cai Meng Xin Qi Hua-Min Qu Yan-feng Sui Sheng Wang Gang Xu Qiang Ye Jing Zhang Pei Zhang Wei-Min Pan Key Laboratory of Particle Acceleration Physics and Technology Institute of High Energy PhysicsChinese Academy of Sciences19B Yuquan RoadShijingshan DistrictBeijing 100049China University of the Chinese Academy of Sciences 19A Yuquan RoadShijingshan DistrictBeijing 100049China

The high-energy photon source(HEPS)is the first fourth-generation synchrotron light source facility in *** HEPS injector consists of a linear accelerator(linac)and a full energy *** booster captures the electron beam from the linac and increases its energy to the value required for the storage *** full-energy beam could be injected to the storage ring directly or after“high-energy accumulation.”On November 17,2023,the key booster parameters successfully reached their corresponding target *** milestone results were achieved based on numerous contributions,including nearly a decade of physical design,years of equipment development and installation,and months of beam *** measured at the extraction energy of 6 GeV,the averaged beam current and emittance reached 8.57 mA with 5 bunches and 30.37 nm rad with a single-bunch charge of 5.58 nC,compared with the corresponding target values of 6.6 mA and 35 nm rad,*** paper presents the physical design,equipment development,installation,and commissioning process of the HEPS booster.

关键词： High energy photon source Booster Beam commissioning

All-sky Guide Star Catalog for CSST

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Research in Astronomy and Astrophysics 2024年第4期24卷 35-59页

作者： Hui-Mei feng Zi-Huang Cao Man I Lam Ran li Hao Tian Da-Yi Yin Yuan-Yu Yang Xin Zhang Dong-Wei Fan Yi-Qiao Dong Xin-feng li Wei Wang Long li Hugh RAJones Yi-Han Tao Jia-Lu Nie Pei-Pei Wang Mao-Yuan liu He-jun Yang Chao liu Key Laboratory of Cosmic Rays(Tibet University) Ministry of EducationLhasa 850000China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of ChineseAcademy of Sciences Beijing 100049China Shanghai Institute of Technical Physics Chinese Academy of SciencesShanghai200083China Technology and Engineering Center for Space Utilization.Chinese Academy of Sciences Beijing 100094China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Centre for Astrophysics University of HertfordshireHatfieldUK Beijing University of Technology Beijing 100124China

The China Space Station Telescope(CSST)is a two-meter space telescope with multiple back-end *** Fine Guidance Sensor(FGS)is an essential subsystem of the CSST Precision Image Stability System to ensure the required absolute pointing accuracy and line-of-sight *** this study,we construct the Main Guide Star Catalog for *** accomplish this,we utilize the information about the FGS and object information from the Gaia Data Release *** provide an FGS instrument magnitude and exclude variables,binaries,and high proper motion stars from the catalog to ensure uniform FGS guidance ***,we generate a HEALPix index,which provides a hierarchical tessellation of the celestial sphere,and employ the Voronoi algorithm to achieve a homogeneous distribution of stars across the *** distribution ensures adequate coverage and sampling of the *** performance of the CSST guide star catalog was assessed by simulating the field of view of the FGS according to the CSST mock survey strategy *** analysis of the results indicates that this catalog provides adequate coverage and *** catalog's performance meets the FGS requirements,ensuring the functioning of the FGS and its guidance capabilities.

关键词： catalogs astrometry instrumentation:detectors

Potential and application of abortive transcripts as a novel molecular marker of cancers

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World Journal of Experimental Medicine 2024年第2期14卷 53-61页

作者： Tian-Miao Zhang Xiao-Nian Zhu Shao-Wei Qin Xue-feng Guo Xue-Kun Xing li-feng Zhao Sheng-Kui Tan Guangxi Key Laboratory of Environmental Exposomics and Entire lifecycle Health Guilin Medical UniversityGuilin 541199Guangxi Zhuang Autonomous RegionChina School of Leisure and Health Guilin Tourism UniversityGuilin 541006Guangxi Zhuang Autonomous RegionChina

Abortive transcript(AT)is a 2-19 nt long non-coding RNA that is produced in the abortive initiation *** initiation was found to be closely related to RNA polymerase through in vitro ***,the distribution of AT length and the scale of abortive initiation are correlated to the promoter,discriminator,and transcription initiation sequence,and can be affected by transcription elongation *** plays an important role in the occurrence and development of various *** we summarize the discovery of AT,the factors responsible for AT formation,the detection methods and biological functions of AT,to provide new clues for finding potential targets in the early diagnosis and treatment of cancers.

关键词： Abortive transcript Abortive initiation RNA polymerase Transcription Tumor marker

Integrating single Ni site and PtNi alloy on two-dimensional porous carbon nanosheet for efficient catalysis in fuel cell

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Nano Research 2024年第8期17卷 6916-6921页

作者： Fangyao Zhou Yaner Ruan feng li lin Tian Mengzhao Zhu Wenan Tie Xiaoyan Tian Bo Wang Peigen liu Jie Xu Xiaoping Gao Peng li Huang Zhou Yuen Wu Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China Shanxi Yanchang Petroleum(Group)Co.Ltd. Xian 710065China College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035China

The performance of catalyst depends on the intrinsic activity of active sites and the structural characteristics of the ***,we simultaneously integrate single nickel(Ni)sites and platinum-nickel(PtNi)alloy nanoparticles(NPs)on a two-dimensional(2D)porous carbon nanosheet,demonstrating remarkable catalytic performance in the oxygen reduction reaction(ORR).The single Ni sites can activate the oxygen molecules into key oxygen-containing intermediate that is further efficiently transferred to the adjacent PtNi alloy NPs and rapidly reduced to H_(2)O,which establishes a relay catalysis between active *** porous structure on the carbon nanosheet support promotes the transfer of active intermediates between these active sites,which assists the relay catalysis by improving mass ***,the obtained catalyst demonstrates a half-wave potential of up to 0.942 V,a high mass activity of 0.54 A·mgPt^(−1),and negligible decay of activity after 30,000 cycles,which are all superior to the commercial Pt/C catalysts with comparable loading of *** theoretical calculation results reveal that the obtained catalyst with defect structure of carbon support presents enhanced relay catalytic effect of PtNi alloy NPs and single Ni sites,ultimately realizing improved catalytic *** work provides valuable inspiration for developing low platinum loading catalyst,integrating single atoms and alloy with outstanding performance in fuel cell.

关键词： two-dimensional porous carbon nanosheet Pt-based alloy single atom catalysts relay effect proton-exchange membrane fuel cells

Al-doped ZnO/WO_(3) heterostructure films prepared by magnetron sputtering for isopropanol sensors

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Rare Metals 2024年第1期43卷 247-256页

作者： Wei-Xiang Gao Xue-Ting Chang Xiao-Jie Zhu Jun-feng li Ying-Chang Jiang Dong-Sheng Wang Chuan-Xiao Yang Shi-Bin Sun College of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China

Metal oxide semiconductors(MOSs) are ideal sensing materials for detecting volatile organic compounds due to their low cost, diversity, high stability, and ease of production. However, it remains a grand challenge to develop the MOSs-based gas sensors for sensing isopropanol with desired performance via a simple, effective,and controllable method. Herein, we reported the preparation of the Al-doped Zn O(AZO)/WO_(3) heterostructure films by directly depositing the AZO coating onto the WO_(3) coating using a strategy of magnetron sputtering. The AZO/WO_(3) heterostructure films were constructed by numbers of irregular nanoparticles that were interconnected with each other. The AZO/WO_(3) heterostructure films-based gas sensors exhibited excellent isopropanolsensing performance with high response, promising selectivity, low detection limit, fast response rate, wide detection range, and ideal reproducibility. The promising isopropanol-sensing performance of the AZO/WO_(3) heterostructure films arises mainly from their high uniformity, unique microstructures with high surface roughness,and the construction of the heterostructure between the AZO and WO_(3) coatings. This work provides a versatile approach to prepare the MOSs-based heterostructure films for assembling the gas sensors.

关键词： Metal oxide semiconductors Gas sensors Aldoped ZnO/WO_(3) Heterostructure films Isopropanol Magnetron sputtering