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Endoscopic diagnosis of early-stage primary esophageal small cell carcinoma: Report of two cases

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World Journal of Clinical Cases 2021年第11期9卷 2562-2568页

作者： li-Mian er Yan Ding Xiao-Fang Sun Wen-Qian Ma li Yuan Xiu-li Zheng Na-Na An Ming-li Wu Department of Endoscopy The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of Endoscopy People's Hospital of XingtaiXingtai 054000Hebei ProvinceChina

BACKGROUND Primary esophageal small cell carcinoma(PESCC)is a highly aggressive malignancy,and its detailed clinical behaviors have remained virtually *** of the rapid tumor progression,the diagnosis of esophageal small cell carcinoma at early stage is extremely difficult in clinical ***,only a handful of PESCC cases have been *** SUMMARY Case 1:A 62-year-old man was diagnosed with an esophageal submucosal tumor by *** ultrasonography showed a 0.8 cm low echo nodule in the muscularis *** the patient refused to undergo endoscopic resection,neoplasia was detected by endoscopy 1 year *** 2:A 68-year-old woman was diagnosed as having an esophageal submucosal tumor by endoscopy at a local *** 2 wk later,we performed endoscopic ultrasonography and found a 1 cm low echo nodule in the muscularis mucosa;the submucosal was thinner than normal but still continuous;mucosal hyperemia and erosion were found on the surface of the *** submucosal dissection(ESD)was performed and the histopathological finding showed a small cell carcinoma invading the submucosal *** Early esophageal small cell carcinoma shows submucosal infiltrating growth with a hypoechoic mass in the muscularis mucosa as diagnosed by endoscopic *** is easily misdiagnosed as submucosal *** manifestations should be identified and pathological biopsies should beemployed. ESD may be performed to provide an opportunity for early treatmentof PESCC.

关键词： Primary esophageal small cell carcinoma Early stage Endoscopic submucosal dissection Endoscopic ultrasonography Small submucosal masses Poor prognosis Case report

Clinical efficacy of tocilizumab treatment in severe and critical COVID-19 patients

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World Journal of Clinical Cases 2020年第17期8卷 3763-3773页

作者： Jia Zeng Ming-Hui Xie Jing Yang Sheng-Wu Chao er-li Xu Department of Aviation Disease Naval Medical Center of PLAShanghai 200052China No.1 Department of Infection Optical Valley Campus of Hubei Maternal and Child Health Care HospitalWuhan 430073Hubei ProvinceChina Department of Interventional Therapy First Affiliated Hospitalthe Second Military Medical UniversityShanghai 200433China Department of Nephrology Naval Medical Center of PLAShanghai 200052China Department of Cardiovascular Medicine Naval Medical Center of PLAShanghai 200052China

BACKGROUND The main pathophysiological basis of coronavirus disease 2019(COVID-19)causing respiratory failure is a cytokine storm and interleukin-6(IL-6)is an important component of the COVID-19 cytokine *** a specific antagonist of IL-6,tocilizumab may block the cytokine storm of *** Diagnosis and Treatment Guidelines of New Coronavirus Pneumonia(7 th Edition)includes tocilizumab as a recommended drug for immunotherapy in severe and critical COVID-19 ***,the specific clinical efficacy of tocilizumab in the treatment of COVID-19 patients is worth *** To determine the clinical efficacy of tocilizumab in inhibiting the cytokine storm in *** In total,19 severe and critical COVID-19 patients were enrolled in this study,and were treated with tocilizumab in Optical Valley Campus of Hubei Maternal and Child Health Care Hospital from February 20 to March 31,*** imaging manifestations and clinical data before and after treatment were analyzed retrospectively,including routine peripheral venous blood tests,routine blood biochemical tests,coagulation test,C-reactive protein(CRP),IL-6,and arterial blood gas *** Of the 19 patients in this group,13(68.4%)had significantly improved symptoms of COVID-19(5 patients were discharged directly and 8 patients were transferred after improvement)following *** case was invalid,1 case was exacerbated,and 4 deaths(21.1%)were observed(all critical cases).The lymphocyte count,CRP,lactic acid,oxygenation index,fibrinogen(FIB)and IL-6 levels were significantly different in the improved *** Tocilizumab treatment is effective against IL-6 in COVID-19 patients,but it does not completely inhibit the inflammation and cytokine storm in all patients with *** the clinical treatment of COVID-19 patients,attention should be paid to the timing of drug administration and other adjuvant treatments.

关键词： COVID-19 Cytokine storm Tocilizumab Interleukin-6

三相四线制APF支撑电容电压脉动分析与设计

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兰州文理学院学报（自然科学版） 2024年第4期38卷 49-53页

作者：郑小朋李二伟钱明王琰琳安徽城市管理职业学院轨道交通学院安徽合肥230011 国网浙江省电力有限公司海宁市供电公司浙江海宁314400

为保证有源电力滤波器交流侧输出相电压的准确性,有效进行谐波跟踪补偿,提升电能质量,直流侧母线电压必须保持足够稳定,因此直流侧电容容值合理取值至关重要.为此,本文综合考虑母线电压取值、电容纹波电流与电容损耗等限制因素,基于瞬... 详细信息

为保证有源电力滤波器交流侧输出相电压的准确性,有效进行谐波跟踪补偿,提升电能质量,直流侧母线电压必须保持足够稳定,因此直流侧电容容值合理取值至关重要.为此,本文综合考虑母线电压取值、电容纹波电流与电容损耗等限制因素,基于瞬时功率平衡推导出针对于三相四线制母线支撑电容容量设计方法,在有效抑制直流侧电压波动维持补偿性能的同时避免母线电容过取值,降低硬件成本,实验结果证明了所提方法的有效性.

关键词：有源电力滤波器母线电压电容损耗瞬时功率电容容量

Up-regulation of a homeodomain-leucine zipper gene HD-1 contributes to trichome initiation and development in cotton

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Journal of Integrative Agriculture 2019年第2期18卷 361-371页

作者： NIU er-li CAI Cai-ping BAO Jiang-hao WU Shuang ZHAO liang GUO Wang-zhen State Key Laboratory of Crop Genetics&Germplasm Enhancement Ministry of Science and Technology/Hybrid Cotton R&D Engineering Research CenterMinistry of Education/College of AgricultureNanjing Agricultural UniversityNanjing 210095P.R.China

Plant trichomes originate from epidermal *** this work,we demonstrated that a homeodomain-leucine zipper(HD-Zip)gene,Gh_A06G1283(Gh HD-1A),was related to the leaf trichome trait in allotetraploid cotton and could be a candidate gene for the T_1 *** ortholog of GhHD-1A in the hairless accession Gossypium barbadense ***7124 was interrupted by a long terminal repeat(LTR)retrotransposon,while GhHD-1A worked well in the hairy accession Gossypium hirsutum *** and phylogenetic analysis showed that GhHD-1A belonged to the HD-Zip IV gene family,which mainly regulated epidermis hair development in *** of GhHD-1A and its homoeologs GhHD-1D in allotetraploid T586and Hai7124 could significantly reduce the density of leaf hairs and affect the expression levels of other genes related to leaf trichome *** analysis found that GhHD-1A mainly regulated trichome initiation on the upper epidermal hairs of leaves in cotton,while the up-regulated expression of GhHD-1A in different organs/tissues also altered epidermal trichome *** study not only helps to unravel the important roles of GhHD-1A in regulating trichome initiation in cotton,but also provides a reference for exploring the different forms of trichome development in plants.

关键词： leaf trichome map-based cloning a homeodomain-leucine zipper gene HD-1 virus-induced gene silencing (VIGS) functional differentiation

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十一个桑黄菌株的形态学观察与分子鉴定

浙江农业学报 2024年第4期36卷 800-810页

作者：陆春霞刘开莉梁贵秋肖潇韦伟徐雯雯陈菁莫炳巧李小群黎尔纳黄旭华李安华韦师妮广西壮族自治区蚕业技术推广站广西南宁530007 广西壮族自治区蚕业科学研究院广西南宁530007 广西蚕桑遗传改良与高效种养重点实验室广西南宁530007 广东省农业科学院蚕业与农产品加工研究所广东广州510610 农业农村部功能食品重点实验室广东广州510610 广东省农产品加工重点实验室广东广州510610

为明确桑黄菌株的种属,对采集自国内不同地区的11个桑黄类似菌株开展分子鉴定和形态学特性观察,主要采用核糖体基因rDNA内转录间隔区(ITS)对桑黄菌株进行基因鉴定和遗传性状分析,运用Mega7.0软件的neighbor-joining(NJ)法构建基于桑黄rD... 详细信息

为明确桑黄菌株的种属,对采集自国内不同地区的11个桑黄类似菌株开展分子鉴定和形态学特性观察,主要采用核糖体基因rDNA内转录间隔区(ITS)对桑黄菌株进行基因鉴定和遗传性状分析,运用Mega7.0软件的neighbor-joining(NJ)法构建基于桑黄rDNA ITS序列的系统发育进化树,结合桑黄菌株的形态学观察(菌丝生长情况、菌丝的显微结构、孢子形态特征、子实体电镜扫描结构)进行分析鉴定。结果表明:11个桑黄菌株分为两大类群,其中菌株SH-1为一类,属于纤孔菌属(Inonotus);其他菌株(SH-2、SH-3、SH-4、SH-5、SH-6、SH-7、SH-8、SH-9、SH-10、SH-11)属于另一类,为桑黄孔菌属(Sanghuangporus),菌株SH-3和SH-6属于桑树桑黄(***),其余8个菌株属于暴马桑黄(***)。通过rDNA ITS序列分析技术结合桑黄菌丝形态特征、孢子形态特征和子实体显微结构特征分析,能明确桑黄的种属与遗传性状,可为今后桑黄品种选育与人工规模化生产提供理论依据。

关键词：桑黄纤孔菌属桑黄孔菌属桑树桑黄暴马桑黄分子鉴定

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Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions:Rapid,scalable and sustainable approach to 2-arylpropionic acids

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Chinese Chemical Letters 2024年第2期35卷 366-369页

作者： Qiao li Minjie liu Meifen Jiang li Wan Yingtang Ning Fen-er Chen College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014China Engineering Center of Catalysis and Synthesis for Chiral Molecules Fudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs Shanghai 200433China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

We report the photo-mediated 1,2-aryl migration of 2‑chloro-1-arylpropanones to 2-arylpropionic acids using HCOONa as an acid *** pragmatically focused study obviates the multiple-step sequence in the industrially employed,ZnO-promoted rearrangement strategy,and offers rapid access to various 2-arylpropionic acids under environmentally friendly ***,the successful transfer of this batch photochemistry to a continuous flow platform led to improved scalability and enabled the gram-scale synthesis of loxoprofen.

关键词： Green chemistry Flow chemistry 2-Arylpropionic acids Photo-Favorskii reaction

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电外科设备的研究现状与未来展望

中国医疗器械信息 2024年第3期30卷 60-63页

作者：刘草廖海东李蓁珥谢洋曾祥泰赣南医学院第一附属医院甲状腺疝外科江西赣州341000 赣州市甲状腺肿瘤重点实验室江西赣州341000 龙南市第一人民医院普外二科江西赣州341000 赣南医学院甲状腺疾病研究所江西赣州341000

简要介绍电外科设备的诞生及发展,并详细阐述普通高频电刀、自适应电刀、氩气刀、双极血管封闭技术和LEEP刀的原理以及各种高频电刀功能亚型的研究现状。系统分析不同类型高频电刀使用情况和性能特征,针对系列高频电刀的不足和缺陷,探... 详细信息

简要介绍电外科设备的诞生及发展,并详细阐述普通高频电刀、自适应电刀、氩气刀、双极血管封闭技术和LEEP刀的原理以及各种高频电刀功能亚型的研究现状。系统分析不同类型高频电刀使用情况和性能特征,针对系列高频电刀的不足和缺陷,探讨高频电刀未来的发展方向。

关键词：电外科高频电刀自适应电刀氩气刀

Electrochemical Scanning Tunneling Microscopy──An Ex－situ Study of the Growth of Polypyrrole Films on Electrodes

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Chemical Research in Chinese Universities 1994年第2期10卷 72-78页

作者： li Jing and WANG er-kang (Laboratory of Electroanalytical Chemistiy, Changchun Institute of Applied Chemistr, Chinese Acadeniy of Sciences, Changchun, 130022 )

his paper covers the electropolymerized polypyrrole doped with p-toluenesul-fonate studied using scanning tunneling microscope. The growth processes of polypyrrole films on the electrode surface were observed. Polypyrrole chain struc-ture with many separated micro-holes of 0. 15 nm diameter at the initial state ofelectropolymerization can be seen from obtained STM images. This structure is ex-tremely similar to the pioneer-proposed ideal structure of polypyrrole chains. Thereexisted some helical structure and simple strands on the electrode surface, which isdue to different existing states of polypyrrole chains on electrode surface. STM ex-periments showed that polypyrrole chains were firstly formed on the electrode sur-face, then, they growed gradually by 3-dimensional mode during slow oxidation toform many separated micro-islands. Finally, a large corrugation area of polymerfilms occurred on the electrodes.

关键词： Electrochemical scanning tunneling microscopy Polypyrrole films,Electrochemistry

THerMODYNAMIC ANALYSIS OF Mo-La_2O_3 THerMIONIC CATHODE WIRE

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中国有色金属学会会刊：英文版 1996年第4期6卷 57-60页

作者： Zhou Meiling Wang Jinshu Zhang Jiuxing Nie Zuoren li er Zuo Tieyong(Department of Materials Science and Engineering,Beijing Polytechnic University,Beijing 100022) Department of Materials Science and Engineering Beijing Polytechnic University Beijing 100022 China

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关键词： molybdenum La2O3 cathode thermodynamics