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Low RASSF6 expression in pancreatic ductal adenocarcinoma is associated with poor survival

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World Journal of Gastroenterology 2015年第21期21卷 6621-6630页

作者： Hui-lin Ye dou-dou li Qing lin Yu Zhou Quan-Bo Zhou Bing Zeng Zhi-Qiang Fu Wen-Chao Gao Yi-Min liu Rui-Wan Chen Zhi-Hua li Ru-Fu Chen Department of Hepatobiliary Surgery Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiotherapy Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiotherapy the First Affiliated Hospital of Sun Yat-sen University Department of Medical Oncology Sun Yat-sen Memorial HospitalSun Yat-sen University

AIM:To analyze RASSF6 expression in pancreatic ductal adenocarcinoma(PDAC) and to determine whether RASSF6 has an independent prognostic value in ***:We studied RASSF6 expression in 96 histologically confirmed PDAC samples and 20 chronic pancreatitis specimens using immunohistochemistry and real-time quantitative reverse *** issues were then classified as RASSF6 strongly positive,weakly positive or ***6 mR NA and protein expression in PDAC samples with strong positive staining was further evaluated using real-time PCR and Western blot ***,correlations between RASSF6 staining and patients' clinicopathological variables and outcomes were ***:RASSF6 was negatively expressed in 51(53.1%) PDAC samples,weakly positively expressed in 29(30.2%) and strongly positively expressed in16(16.7%),while its expression was much higher in para-tumor tissues and chronic pancreatitis *** relationships between RASSF6 expression and T-stage(P = 0.047) and perineural invasion(P = 0.026) were *** median survival time of strongly and weakly positive and negative RASSF6 staining groups was 33 mo,15 mo and 11 mo,*** multivariate analysis indicated that RASSF6 was an independent prognostic indicator of overall survival in patients with PDAC.A survival curve analysis revealed that increased RASSF6 expression was correlated with better overall survival(P = 0.009).CONCLUSION:RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with PDAC.

关键词： Pancreatic cancer Pancreatic ductaladenocarcinoma Prognostic marker RASSF6 K-ras Immunohistochemistry Survival analysis

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面向控制的系统辨识研究进展

系统工程与电子技术 2009年第1期31卷 158-164页

作者：窦立谦宗群刘文静天津大学电气与自动化工程学院天津300072

面向控制的系统辨识,是以控制器设计为目的而建立系统数学模型的过程。近些年来,这一领域的研究越来越受到重视。本文首先对这一问题进行了分析。从辨识模型误差、模型不确定集合辨识、模型不确定结构、优化辨识实验设计4个方面分析了... 详细信息

面向控制的系统辨识,是以控制器设计为目的而建立系统数学模型的过程。近些年来,这一领域的研究越来越受到重视。本文首先对这一问题进行了分析。从辨识模型误差、模型不确定集合辨识、模型不确定结构、优化辨识实验设计4个方面分析了该领域研究的主要内容,对每个具体研究内容进行了较为全面的综述。最后,详细讨论了这一领域中存在的问题及发展趋势。

关键词：系统辨识面向控制的辨识鲁棒辨识模型不确定辨识优化实验设计

Evaluation of groundwater supply capacity for agricultural drought emergency relief of Hebei Plain

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Journal of Groundwater Science and Engineering 2014年第3期2卷 36-45页

作者： liU li-jun liU Zhi-gang li dou ZHANG Shao-cai CUI Qiu-ping WANG Juan Hydrological Engineering and Geological Prospecting Institute Geology and Mineral Bureau of Hebei Province Hebei Bureau of Geology and Mineral Resources Exploration and Exploitation

Drought is the uppermost natural disaster in the Hebei Plain,which during the past 20 years showed a trend of frequency increasing,range extension,longer duration and severer damage. In the Hebei Plain,as a major grain producing area,the agricultural drought emergency relief can only rely on groundwater exploitation. Thus the work to conduct evaluation of groundwater supply capacity for agricultural drought emergency relief of Hebei Plain is of great significance for disaster prevention and relief. In this paper,with the method of analytic hierarchy process,the evaluation index system with reference to 3 aspects and 7 indexes(the former including groundwater resources,groundwater exploitation technical conditions and water supply facilities) and the Arc GIS Desktop Arc MAP software,the work to assess the shallow groundwater supply capacity for agricultural drought emergency relief in the Hebei Plain was carried out.

关键词： Hebei Plain Drought emergency relief Groundwater supply capacity

Increased risk of cardio-cerebrovascular disease after hematopoietic cell transplantation in patients with previous history

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Chinese Medical Journal 2021年第12期134卷 1431-1440页

作者： Bo Peng li-li Wang li-Ping dou Fei li Xiang-Shu Jin Lu Wang Ming-Yu Jia Yan li Jian Bo Yu Zhao Hai-Yan Zhu Wen-Rong Huang Dai-Hong liu Department of Hematology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100071China Medical School of Chinese PLA Beijing 100853China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouGuangdong 510515China Department of Hematology Peking University Third HospitalBeijing 100191China

Background:The impacts of previous cardio-cerebrovascular disease(pre-CCVD)on the outcomes of hematopoietic cell transplantation(HCT)are not well *** with pre-CCVD may often be poor candidates for *** study aimed to investigate the impact of pre-CCVD on transplant ***:A retrospective study was conducted between patients with and without pre-CCVD who consecutively received allogeneic or autologous HCT between November 2013 and January 2020 with a matching of age and disease *** cardiovascular complications and HCT outcomes of the two groups were evaluated and *** primary endpoints were post-transplant cardio-cerebrovascular disease(post-CCVD)and non-relapse mortality(NRM).We used a multivariable Cox proportional hazard model and the Fine-Gray competing risk regressions for analyses to estimate the hazard ratios(HRs).Results:The outcomes of 23 HCT recipients with pre-CCVD were compared with those of 107 patients in the control *** significant differences were noted in terms of engraftment,overall survival(OS)(67.00%vs.67.90%,P=0.983),or relapse(29.78%vs.28.26%,P=0.561)between the pre-CCVD group and the control *** cumulative incidences of 2-year NRM were similar between patients with pre-CCVD and the controls(14.68%vs.17.08%,P=0.670).However,pre-CCVD was associated with an increased incidence of post-CCVD(HR:12.50,95%confidence interval[CI]:3.88–40.30,Plity directly but superpose the toxicity of the transplantation procedure,leading to a risk of ***-CCVD was a powerful predictor for high NRM and inferior *** risk stratification of pre-CCVD is needed to reduce NRM in various transplantation settings.

关键词： Hematopoietic cell transplantation Coronary artery disease Cardiovascular diseases Cerebrovascular disorders Mortality

数字经济、跨境电商与数字贸易耦合发展研究——兼论区块链技术在三者中的应用

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理论探讨 2020年第1期 115-121页

作者：张夏恒李豆豆西北政法大学商学院西安710122 浙江大学经济学院杭州310027

人类社会正在进入以数字化生产力为主要标志的新阶段,依托于物联网、大数据、云计算、移动互联网、人工智能等现代科技,数字经济、跨境电商与数字贸易得以产生并迅猛发展,厘清三者的理论边界与现实约束,制定推动其发展的政策,是我国实... 详细信息

人类社会正在进入以数字化生产力为主要标志的新阶段,依托于物联网、大数据、云计算、移动互联网、人工智能等现代科技,数字经济、跨境电商与数字贸易得以产生并迅猛发展,厘清三者的理论边界与现实约束,制定推动其发展的政策,是我国实现高质量发展的必然要求.将区块链技术深度融合到数字经济、跨境电商与数字贸易中,可以推动传统制造业升级、对外贸易转型,最终实现全球化发展,达到共同繁荣目标.

关键词：数字经济跨境电商数字贸易区块链

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轮式移动机器人滑移量重建与滑移补偿控制

控制与决策 2010年第5期25卷 701-705页

作者：方浩窦丽华陈杰北京理工大学自动化学院北京100081

为解决轮式移动机器人的滑移补偿控制问题,首先推导出车体侧滑角的表达式,然后将时变侧滑角的重建问题转化为对地面特性参数的辨识问题.利用Luenberger观测器设计出自适应辨识律,并证明了当控制输入满足持续激励条件时,可以准确辨识出... 详细信息

为解决轮式移动机器人的滑移补偿控制问题,首先推导出车体侧滑角的表达式,然后将时变侧滑角的重建问题转化为对地面特性参数的辨识问题.利用Luenberger观测器设计出自适应辨识律,并证明了当控制输入满足持续激励条件时,可以准确辨识出地面特性参数.基于链式系统模型设计出滑移补偿控制器,在滑移角精确已知的条件下,可以保证位置误差收敛,姿态误差有界.仿真结果表明,基于所设计的自适应辨识律,可以准确地重建出滑移角,提高滑移控制精度.

关键词：移动机器人观测器滑移补偿控制

基于Vinnicombe距离的迭代辨识与控制设计

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自动化学报 2008年第11期34卷 1431-1436页

作者：宗群窦立谦刘文静天津大学电气与自动化工程学院天津300072

迭代辨识与控制设计的主要问题在于保证控制设计的稳定性和闭环性能的不断改善.针对该问题,本文提出一种基于Vinnicombe距离的迭代辨识与控制设计方法.每次迭代辨识使用上次设计的控制器,通过闭环辨识得到包含真实系统的不确定模型集合... 详细信息

迭代辨识与控制设计的主要问题在于保证控制设计的稳定性和闭环性能的不断改善.针对该问题,本文提出一种基于Vinnicombe距离的迭代辨识与控制设计方法.每次迭代辨识使用上次设计的控制器,通过闭环辨识得到包含真实系统的不确定模型集合,设计镇定这个集合的控制器;同时提出迭代辨识过程闭环性能改善条件,以及控制器的设计方法.仿真结果显示了该方法的有效性.

关键词：迭代辨识控制设计 Vinnicombe距离

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复杂武器系统总体设计综合集成方法的实现

北京理工大学学报 2009年第5期29卷 415-419页

作者：张佳窦丽华陈杰北京理工大学信息科学技术学院自动控制系北京100081

为了解决复杂武器系统总体设计质量和设计周期难于保证的问题,应用从定性到定量的综合集成方法提出了武器系统设计的功能组成,并构建了总体优化设计的体系结构及其决策支持系统.实现了武器系统的方案设计与论证、方案评价、指标分配及... 详细信息

为了解决复杂武器系统总体设计质量和设计周期难于保证的问题,应用从定性到定量的综合集成方法提出了武器系统设计的功能组成,并构建了总体优化设计的体系结构及其决策支持系统.实现了武器系统的方案设计与论证、方案评价、指标分配及系统仿真.所实现的优化设计系统能够有效辅助总设计师进行新型武器系统的总体设计,使其更加规范化、科学化.

关键词：综合集成方法武器系统复杂系统优化设计

Exploring medication rules in Chinese randomized controlled trials of type 2 diabetes based on data mining technology

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Medical Data Mining 2023年第4期6卷 46-57页

作者： Zhi-li dou Hao-Nan Sun Yu-Nan Zhang Lei Zhao Zhe Huang Shu-Jing Xu Yi-Xing liu Dong-Ran Han Jin-Zhu Jia Department of Biostatistics School of Public HealthPeking UniversityBeijing 100191China The School of life Science Beijing University of Chinese MedicineBeijing 102446China The School of Management Beijing University of Chinese MedicineBeijing 102446China Center for Statistical Sciences Peking UniversityBeijing 100781China

Background:To systematically summarize and categorize the Chinese herbal medicine in the domestic traditional Chinese medicine(TCM)literature on type 2 diabetes mellitus(T2DM),in this paper,we mine traditional Chinese medicine data for relationships and provide for future practitioners and ***:Taking randomized controlled trials on the treatment of T2DM in TCM as the research theme,we searched for full-text literature in three major clinical databases,including CNKI,Wan Fang,and VIP,published between 1990 and *** then conducted frequency statistics,cluster analysis,association rules extraction,and principal component analysis based on a corpus of medical academic words extracted from 1116 research ***:The most frequently used is Astragali Radix,and the most commonly used two-herb combination in T2DM treatment consisted of Coptidis Rhizoma and Moutan *** Cortex,Alismatis Rhizoma,and Dioscoreae Rhizoma were the most frequently used three-herb *** found a“lung”and“liver”and“kidney”model and confirmed the value of classical meridian tropism theory and pattern *** treatment is mainly to fill deficiency and clear heat and consider water infiltration,dampness,blood circulation,and ***:This study provides an in-depth perspective on the TCM medication rules for T2DM and offers practitioners and researchers valuable information about the current status and frontier trends of TCM research on T2DM in terms of diagnosis and treatment.

关键词： type 2 diabetes mellitus traditional Chinese medicine syndromes Chinese herbal medicine data mining