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Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第8期9卷 616-622页

作者： Zhou-wen chen li-ying chen Hong-lei DAI Jian-hua chen li-zheng fang Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective： To investigate the relationship between alanine aminotransferase （ALT） levels and metabolic syndrome （MS） in nonalcoholic fatty liver disease （NAFLD）. Methods： A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study. The diagnosis of fatty liver was based on ultrasound imaging. MS was defined according to the criteria of the Adult Treatment Panel III. ALT, triglyceride （TG）, high density lipoprotein cholesterol （HDL-c）, fasting plasma glucose （FPG）, height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） were measured in each subject to analyze the relationship between MS and ALT activity Results：（1） The prevalence of NAFLD in men （30.94%） was significantly higher than that in women （15.65%）; （2） The incidence of MS in NAFLD （33.83%） was significantly greater than that in non-NAFLD （10.62%）; （3） Of the 6470 subjects with NAFLD, in the age-adjusted partial correlation analysis, there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex （P〈0.01）, except that ALT levels multiple stepwise regression analysis, SBP lost its significance, and had no correlation with HDL-c in women. Moreover, in the WC, body mass index （BMI）, age, DBP, TG and FPG were independently associated with ALT levels in both sexes （P〈0.05）. HDL-c remained significant and was independently related to ALT levels in men; （4） ALT levels were significantly higher in subjects with MS compared to those without MS （P〈0.001）. Mean ALT levels increased with the number of MS components in each sex （P〈0.05 for trend）. Conclusion： We found a strong relationship between ALT levels and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.

关键词： Nonalcoholic fatty liver disease (NAFLD) Alanine aminotransferase (ALT) Metabolic syndrome (MS)

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Comparison of an SMS text messaging and phone reminder to improve attendance at a health promotion center:A randomized controlled trial

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第1期9卷 34-38页

作者： Zhou-wen chen li-zheng fang li-ying chen Hong-lei DAI Department of General Practice Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Objective: To compare the efficacy of a short messaging service (SMS) text messaging and phone reminder to im-prove attendance rates at a health promotion center. Methods: A total of 1 859 participants who had scheduled appointments in the health promotion center of our hospital from April 2007 to May 2007 were enrolled in the study and randomly assigned into 3 groups: control (no reminder) group,SMS text messaging reminder group and telephone reminder group. Attendance rates and costs of interventions were collected. Results: A total of 1848 participants were eligible for analysis. Attendance rates of control,SMS and telephone groups were 80.5%,87.5% and 88.3%,respectively. The attendance rates were significantly higher in SMS and telephone groups than that in the control group,with odds ratio 1.698,95% confidence interval 1.224 to 2.316,P=0.001 in the SMS group,and odds ratio 1.829,95% confidence interval 1.333 to 2.509,P<0.001 in the telephone group. However,there was no difference between the SMS group and the telephone group (P=0.670). The cost effectiveness analysis showed that the cost per attendance for the SMS group (0.31 Yuan) was significantly lower than that for the telephone group (0.48 Yuan). Conclusion: SMS and telephone are effective reminders for improving attendance rate at a health promotion center. SMS reminder may be more cost-effective compared with the telephone reminder.

关键词： Reminder Short messaging service (SMS) Telephone Failure to attend (FTA) Randomized controlled trial (RCT)

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The First Total Synthesis of Natural 6β-Cinnamoyloxy-1α- hydroxy-5, 10-bis-epi-eudesm-4-en-3-one

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Chinese Chemical Letters 2006年第10期17卷 1290-1292页

作者： chen ZHANG Guo Jun ZHEN Jin Chun chen li Jing fang Yu lin li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

The first total synthesis of natural 6β-cinnamoyloxy-1α-hydroxy-5, 10-bis-epi- eudesm-4-en-3-one （1）, a highly complex natural eudesmane, was described.

关键词： 6β-Cinnamoyloxy-1α-hydroxy-5,10-bis-epi-eudesm-4-en-3-one C- 1 oxygenated eudesmane total synthesis.

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First total synthesis of 10α-hydroxy-4-muurolen-3-one and its C_(10)-isomer

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Chinese Chemical Letters 2008年第11期19卷 1265-1267页

作者： Fu Qiang Bi li Jing fang chen Xi Zhang Yu lin li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou 730000 China

An efficient synthetic route to muurolane type sesquiterpenes starting from （R）-carvone, employing allylic diazene rearrangement and the ring closing methesis （RCM） reaction as key steps, is described. The first asymmetric total synthesis of （-）-10α- hydroxy-4-muurolen-3-one 11 and （-）-10β-hydroxy-4-muurolen-3-one C was accomplished. Through the total synthesis, the absolute configurations of the natural products A, B and C were established.

关键词： 10α-Hydroxy-4-muurolen-3-one 10β-Hydroxy-4-muurolen-3-one Allylic diazene rearrangement RCM reaction Total synthesis

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EXPERIMENTAL STUDY OF EFFECTS OF AIR CONTENT ON CAVITATION AND PRESSURE FLUCTUATIONS

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Journal of Hydrodynamics 2010年第5期22卷 634-638页

作者： YE Jin-ming XIONG Ying li fang chen Shuang-qiao College of Naval Architecture and Power Naval University of Engineering Wuhan 430033 China

This article studies the effects of air content on propeller cavitation and pressure fluctuations. The cavitation is observed while the pressure fluctuations on the hull are measured. When adjusting the air content, the sheet cavitation range does not change distinctly, but the pressure fluctuations see obvious differences. The amplitudes of the pressure fluctuations increase with the decrease of the air content. The results indicate that the air content has little effect on the sheet cavitation range but has an important effect on the bubble cavitation and the tip vortex cavitation. When the air content decreases, the water tensile force increases, which results in the instability of the bubble cavitation and the tip vortex cavitation and the increase of the pressure fluctuations. To minimize the scale effects, the experiments should be run at a high Reynolds number with a high nuclei content. The high Reynolds number is often realized by increasing the flow velocity and the propeller rotation speed, and the high nuclei content is often made by increasing the dissolved air content.

关键词： cavitation pressure fluctuations model test air content

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Jordan Left Derivations of Generalized Matrix Algebras

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Communications in Mathematical Research 2014年第4期30卷 301-306页

作者： li chen-fang li Yan-Bo School of Mathematics and Statistics Northeastern University at Qinhuangdao

In this paper, it is proved that under certain conditions, each Jordan left derivation on a generalized matrix algebra is zero and each generalized Jordan left derivation is a generalized left derivation.

关键词： generalized Jordan left derivation Jordan left derivation generalized matrix algebra generalized left derivation

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Expression of tumor necrosis factor-alpha converting enzyme in liver regeneration after partial hepatectomy

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World Journal of Gastroenterology 2008年第9期14卷 1353-1357页

作者： Xian-Ming lin Ying-Bin liu Fan Zhou Yu-lian Wu li chen He-Qing fang Department of Surgery The Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China

AIM:To study the expression of tumor necrosis factor- alpha converting enzyme (TACE) and evaluate its significance in liver regeneration after partial hepatectomy in vivo. METHODS: Male SD rats underwent 70% partial hepatec- tomy. The remaining liver and spleen tissue samples were collected at indicated time points after hepatectomy. TACE expression was investigated by Western blotting, immunohistochemistry, and serial section immunostaining. RESULTS: Expression of TACE in liver and spleen tissues after partial hepatectomy was a time-dependent alteration, reaching a maximal level between 24 and 48 h and remaining elevated for more than 168 h. TACE protein was localized to mononuclear cells (MNC), which infiltrated the liver from the spleen after hepatectomy. The kinetics of TACE expression was in accordance with the number of TACE-staining MNCs and synchronized with those of transforming growth factor-α (TGFα). In addition, TACE-staining MNC partially overlapped with CD3+ T lymphocytes. CONCLUSION: TACE may be involved in liver regenera- tion by pathway mediated with TGFα-EGFR in the cell- cycle progressive phase in vivo. TACE production and effect by paracrine may be a pathway of involvement in liver regeneration for the activated CD3+ T lymphocytes.

关键词： Tumor necrosis factor-alpha converting enzyme liver regeneration Partial hepatectomy

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Effects of Soybean Isoflavones on In vitro Antioxidative Capacity of Satellite Cells of Porcine Skeletal Muscles

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Agricultural Sciences in China 2011年第1期10卷 120-125页

作者： JIANG Zong-yong ZHOU Gui-lian liN Ying-cai JIANG Shou-qun ZHENG Chun-tian HAN li-ming chen fang Key Laboratory of Animal Nutrition and Feed Science （South China） Ministry of Agriculture/Institute of Animal Science Guangdong Academy of Agricultural Science Guangzhou 510640 P.R.China

A synthetic isoflavone （ISO-S） or genistein was added in culture medium at different concentrations （0, 10, 20, 30, 40, and 80 *** L^-1） to investigate the effects of soybean isoflavones on antioxidative capacity of porcine skeletal muscle satellite cells. After 48 h incubation, the suspension was cryopreserved for the determination of superoxide dismutase （SOD）, catalase （CAT）, glutathione peroxidase （GSH-Px） activities, and malondialdehyde （MDA） content. The mRNA levels of SOD, CAT, and GSH-Px gene in cells were detected with Taqman fluorescent probe method. The results showed that the content of MDA and the activities and the mRNA levels of SOD of porcine skeletal muscle satellite cells were influenced by supplemented soybean isoflavone （P〈0.05） when adding 10-80 μmol L^-1 ISO-S or genistein in the medium. The MDA contents, SOD and CAT activities and their mRNA expression levels of porcine skeletal muscle cells responded quadratically （P〈 0.05） as the level of ISO-S or genistein increased. Pre-incubation of porcine skeletal muscle satellite cells with ISO-S or genistein at 10-40 pmol L-1 elevated the activities and the mRNA expression levels of SOD and CAT in cells concurrently and decreased the cellular content of MDA （P〈 0.05）. The results indicated that pre-incubation of ISO-S or genistein at 10- 40μmol L^-1 could improve the antioxidative capacity of porcine skeletal muscle satellite cells.

关键词： soybean isoflavone antioxidative capacity superoxide dismutase catalase skeletal muscle satellite cells

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The impact of metabolic dysfunction-associated fatty liver disease on the prognosis of patients with hepatocellular carcinoma after radical resection

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 366-372页

作者： Ke-Gong Xiong Kun-Yu Ke li-fang chen Jin-Feng Kong Tai-Shun lin Qing-Biao lin Su lin Yue-Yong Zhu Department of Hepatology Hepatology Research Institutethe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350001China Department of Hepatology Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350001China Fujian Clinical Research Center for liver and Intestinal Diseases Fuzhou 350001China

Background:Metabolic dysfunction-associated fatty liver disease(MAFLD)is recently proposed an entity by a group of international ***,the impact of MAFLD on the prognosis of patients with hepatocellular carcinoma(HCC)is not *** aim of this study was to explore the influence of MAFLD for the prognosis of HCC after radical ***:HCC patients who received radical resection were *** recurrence-free survival(RFS)and overall survival(OS)were compared between MAFLD and ***:A total of 576 HCC patients were included,and among them 114(19.8%)met the diagnostic criteria of *** median RFS was 34.0 months in the MAFLD group and 19.0 months in the non-MAFLD *** 1-,3-,and 5-year RFS rates were 64.9%,49.1%and 36.1%in the MAFLD group,which were higher than those of the non-MAFLD group(59.4%,35.3%and 26.5%,respectively,P=0.01).The mean OS was 57.0 months in the MAFLD group and 52.2 months in the non-MAFLD *** was no statistical difference in OS rate between the MAFLD group and non-MAFLD *** results were found in HBV-related HCC patients in the subgroup *** analysis revealed that MAFLD was a protective factor for RFS in HCC patients after radical resection(P0.05).Multivariate analysis demonstrated that MAFLD was not an independent protective factor for HCC patients with radical ***:MAFLD improves RFS rate in HCC patients with radical resection,but is not an independent protective factor and not associated with OS rate.

关键词： Metabolic dysfunction-associated fatty liver disease Hepatocellular carcinoma Radical resection Prognosis

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Isobaric enzymatic assays reveal depth-dependent variation in microbial ectoenzyme activities in the deepest ocean on Earth

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Science China Earth Sciences 2025年第1期68卷 185-194页

作者： Junwei CAO Jiahua WANG Hongge ZHANG Junhao DENG Binbin PAN Jiawang chen li ZHANG Jiasong fang College of Oceanography and Ecological Science Shanghai Ocean University Ocean College Zhejiang University Laboratory for Marine Biology and Biotechnology Qingdao National Laboratory for Marine Science and Technology

Microbial ectoenzymes play essential roles in the transformation and mineralization of organic matter in the ***, conventional methods for measuring microbial ectoenzyme activities(MEAs) in the deep ocean under atmospheric conditions can misrepresent the metabolic activities of indigenous microbial communities. To overcome this limitation, we measured the activities of three microbial ectoenzymes(aminopeptidase, α-glucosidase, and β-glucosidase) under both atmospheric and in situ pressure conditions in seawater collected using pressure-retaining and non-pressure-retaining samplers in the Challenger Deep, Mariana Trench. In the case of aminopeptidase and α-glucosidase, the highest isobaric MEAs were observed in the surface layer(50 m), followed by those at abyssopelagic depths(4,000–6,000 m) for aminopeptidase, hadal realm(10,903 m)for α-glucosidase, while β-glucosidase activity exhibited the highest value at 10,903 m. Furthermore, the isobaric MEAs in hadal waters were commonly found to be higher than the decompressed counterparts, highlighting the importance of pressure-retaining sampling and isobaric enzymatic assays. The half-saturation constant(Km) showed a general decreasing trend with depth,suggesting that the deep ocean microbes might have adapted to the high-pressure and oligotrophic environment by increasing their ectoenzyme's affinity to substrate. Furthermore, particle-free MEAs contribute more to the total MEAs in the deep ocean than particle-associated MEAs, suggesting the significance of cell-associated and dissolved ectoenzymes in ocean *** study provides a foundation for future investigations of MEAs in the ocean and has important implications for understanding the dynamics of microbially mediated biogeochemical cycling in marine ecosystems.

关键词： Pressure-retaining sampling Microbial ectoenzyme activity Deep-sea microbes High pressure Mariana Trench

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