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Recent Progress in Covalent Organic Frameworks(COFs) for Electrocatalysis

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Chinese Journal of Structural Chemistry 2022年第11期41卷 84-99页

作者： cha li Zining Qiu Hongming Sun Yijie Yang Cheng-Peng li College of Chemistry Tianjin Key Laboratory of Structure and Performance for Functional MoleculesTianjin Normal UniversityTianjin 300387China

Electrocatalysis provides various technologies for energy storage and conversion,which is an important part of realizing sustainable clean energy for the ***,as emerging porous crystalline polymers,possess high specific surface areas,tunable pore structures,high crystallinity and tailorable *** features endow COFs with abundant active sites and fast electron transport channels,making them potentially efficient *** recent years,COF-based electrocatalysts have been widely developed for hydrogen evolution reaction(HER),hydrogen oxidation reaction(HOR),oxygen evolution reaction(OER),oxygen reduction reaction(ORR),nitrogen reduction reaction(NRR)and carbon dioxide reduction reaction(CO_(2)RR).In this review,design strategies of COF-based electrocatalysts are briefly summarized,including applying COF as supports,introducing active metals in COF,constructing two-dimensional conductive COF,formation of COF-based hybrid and pyrolysis of COF to obtain carbon ***,the recent research progress in COF-derived catalysts for specific electrocatalytic reactions is introduced ***,the outlook and challenges of future applications of COFs in electrocatalysis are highlighted.

关键词： covalent organic frameworks electrocatalyst catalytic performance catalytic kinetics energy conversion

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民法典时代医疗健康APP用户隐私的保护

山西省政法管理干部学院学报 2024年第1期37卷 58-61页

作者：茶丽华仇光梓中央财经大学法学院北京100081 北京工商大学法学院北京102400

医疗健康产业与互联网的不断融合和发展,使得一系列医疗健康APP不断涌现。医疗健康APP相比较其他类型的APP具有特殊的社会性和经济性,其汇集了用户的健康医疗敏感信息和生物信息,对个人信息的隐私保护要求更高。目前市场上相当多的医疗... 详细信息

医疗健康产业与互联网的不断融合和发展,使得一系列医疗健康APP不断涌现。医疗健康APP相比较其他类型的APP具有特殊的社会性和经济性,其汇集了用户的健康医疗敏感信息和生物信息,对个人信息的隐私保护要求更高。目前市场上相当多的医疗健康APP用户协议中的隐私条款存在可读性差、文本内容模糊、缺失关键性条款、缺少针对未成年的个人信息保护条款等方面的问题,还存在数据泄露问题。建议从完善保护原则、优化隐私政策、规范监管机制等方面入手,进一步规制医疗健康APP的个人健康信息保护机制,规制不公平隐私政策对用户的影响。

关键词：医疗健康APP 隐私政策用户隐私法律规制

Hisense计算机辅助手术系统在腹腔镜肝癌切除术围手术期的应用

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中国现代普通外科进展 2024年第6期27卷 435-441页

作者：李昕雨臧子琪郝启胜查立超宫明凯董国飞李庆泽田蓝天青岛大学医学部山东青岛266000 青岛大学附属医院肝胆胰外科山东青岛266000 青岛大学附属医院小儿外科山东青岛266000 青岛大学附属医院腹膜后肿瘤外科山东青岛266000

目的:探讨Hisense计算机辅助手术系统(CAS)在腹腔镜肝癌切除术围手术期的临床应用。方法:收集2021年1月至2022年12月行腹腔镜肝切除术(LH)的肝癌患者的临床资料。将患者按手术难度分为低、中、高难度3个组,再根据术前是否使用CAS辅助系... 详细信息

目的:探讨Hisense计算机辅助手术系统(CAS)在腹腔镜肝癌切除术围手术期的临床应用。方法:收集2021年1月至2022年12月行腹腔镜肝切除术(LH)的肝癌患者的临床资料。将患者按手术难度分为低、中、高难度3个组,再根据术前是否使用CAS辅助系统分成CAS辅助亚组和对照组,比较不同组别患者的人口学及围手术期资料。结果:共收集317例患者临床资料,其中低难度组31例,中难度组132例,高难度组154例;CAS辅助亚组108例(34.1%),对照组209例(65.9%)。中难度组CAS辅助亚组的手术时间、引流管留置时间和术后住院时间均短于对照组(P<0.001),术后1月AFP低于对照组(P<0.001)。高难度组CAS辅助亚组的手术时间、引流管留置时间和术后住院时间均短于对照组,术中出血量少于对照组,术后1月AFP低于对照组(P均<0.001)。结论:中、高难度LH术前行CAS的患者围手术期结局更佳。Hisense CAS可有效协助普外科医生清晰确定肝肿瘤解剖部位,提供精准术前模拟和术中导航,为患者制定最佳手术方案。

关键词：肝肿瘤计算机辅助手术系统腹腔镜围手术期

物质成瘾者系统家庭动力治疗关键技术创建及应用研究

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中国药物滥用防治杂志 2024年第7期30卷 1193-1197页

作者：杨丽萍李昕悦郑玲周勤陆毅程璇茶丽王珏邹云东张官柏云南省药物依赖防治研究所云南昆明650228 云南省第五强制隔离戒毒所云南昆明650211 大理州强制隔离戒毒所云南大理671000 云南省第六强制隔离戒毒所云南芒市678400 楚雄市疾病预防控制中心云南楚雄675000

目的:探索符合我国文化的、适合我国禁毒和戒毒实际的系统家庭动力治疗理论,开发一套能够满足毒品成瘾者及家庭成员需求的便于规范操作的家庭治疗方案,并评估实施效果,编撰操作手册。方法:根据入组标准选择100名物质成瘾者家庭为团体家... 详细信息

目的:探索符合我国文化的、适合我国禁毒和戒毒实际的系统家庭动力治疗理论,开发一套能够满足毒品成瘾者及家庭成员需求的便于规范操作的家庭治疗方案,并评估实施效果,编撰操作手册。方法:根据入组标准选择100名物质成瘾者家庭为团体家庭治疗研究对象(大理、楚雄各50名),随机分为干预组和对照组,各25名。对照组按照常规开展戒治工作,干预组除了开展常规戒治工作外,增加两项强化干预措施:以家庭治疗为导向的团辅和家属参与的团体家庭治疗。比较两组SSFD总分及各因子评分。结果:干预组SSFD总分及各因子评分低于对照组,差异有统计学意义(P<0.05);研究对象在治疗前后SSFD总分及各因子评分比较,差异有统计学意义(P<0.05)。家庭个人态度评分比较,差异有统计学差异(P<0.05)。结论:这套针对物质成瘾者的家庭治疗方法使家庭氛围得到了显著的改善,自我分化水平也得到了提升,系统逻辑也从单一的模式转变为多元的模式,家庭和个人对“症状”的理解也得到了增强,而且还有助于提升主观能动性。

关键词：物质成瘾者家庭治疗心理干预干预模式

TRAIL and Celastrol Combinational Treatment Suppresses Proliferation, Migration, and Invasion of Human Glioblastoma Cells via Targeting Wnt/β-catenin Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 322-329页

作者： QIN Jing-jing NIU Meng-da cha Zhe GENG Qing-hua li Yu-lin REN Chun-guang David P.Molloy YU Hua-rong Research Center of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChongqing Medical UniversityChongqing(400016)China

Objective To investigate the mechanistic basis for the anti-proliferation and anti-invasion effect of tumor necrosis factor-related apoptosis-induced ligand(TRAIL)and celastrol combination treatment(TCCT)in glioblastoma *** Cell counting kit-8 was used to detect the effects of different concentrations of celastrol(0-16µmol/L)and TRAIL(0-500 ng/mL)on the cell viability of glioblastoma cells.U87 cells were randomly divided into 4 groups,namely control,TRAIL(TRAIL 100 ng/mL),Cel(celastrol 0.5µmol/L)and TCCT(TRAIL 100 ng/mL+celastrol 0.5µmol/L).Cell proliferation,migration,and invasion were detected by colony formation,wound healing,and Transwell assays,*** reverse transcription polymerase chain reaction and Western blotting were performed to assess the levels of epithelial-mesenchymal transition(EMT)markers(zona occludens,N-cadherin,vimentin,zinc finger E-box-binding homeobox,Slug,and β-catenin).Wnt pathway was activated by lithium chloride(liCl,20 mol/L)and the mechanism for action of TCCT was *** Celastrol and TRAIL synergistically inhibited the proliferation,migration,invasion,and EMT of U87 cells(Plin-D1,and matrix metalloproteinase(MMP)-*** addition,liCl,an activator of the Wnt signaling pathway,restored the inhibitory effects of TCCT on the expression of β-catenin and its downstream genes,as well as the migration and invasion of glioblastoma cells(Plioblastoma cell migration,invasion,and EMT,potentially through inhibition of Wnt/β-catenin *** underlies a novel mechanism of action for TCCT as an effective therapy for glioblastoma.

关键词： celastrol Chinese medicine tumor necrosis factor-related apoptosis-induced ligand glioblastoma β-catenin Tripterygium wilfordii

Des-Arg(9)bradykinin as a causal metabolite for autism spectrum disorder

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World Journal of Psychiatry 2024年第1期14卷 88-101页

作者： Zhong-Yu Huang Zi-Pan Lyu Hong-Gui li Hua-Zhi You Xiang-Na Yang Cai-Hui cha Center for Medical Research on Innovation and Translation Institute of Clinical MedicineGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510000Guangdong ProvinceChina School of Biological Sciences Nanyang Technological UniversityNanyang Ave 639798Singapore Department of Pediatrics First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Nutrition First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Pediatric Traditional Chinese Medicine Clinic Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina Department of Psychology Guangzhou Women and Children's Medical CenterGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Early diagnosis and therapeutic interventions can greatly enhance the developmental trajectory of children with autism spectrum disorder(ASD).However,the etiology of ASD is not completely *** presence of confounding factors from environment and genetics has increased the difficulty of the identification of diagnostic biomarkers for *** To estimate and interpret the causal relationship between ASD and metabolite profile,taking into consideration both genetic and environmental *** A two-sample Mendelian randomization(MR)analysis was conducted using summarized data from large-scale genome-wide association studies(GWAS)including a metabolite GWAS dataset covering 453 metabolites from 7824 European and an ASD GWAS dataset comprising 18381 ASD cases and 27969 healthy *** in plasma were set as exposures with ASD as the main *** causal relationships were estimated using the inverse variant weight(IVW)*** also performed leave-one-out sensitivity tests to validate the robustness of the *** on the drafted metabolites,enrichment analysis was conducted to interpret the association via constructing a protein-protein interaction network with multi-scale evidence from databases including Infinome,SwissTargetPrediction,STRING,and *** Des-Arg(9)-bradykinin was identified as a causal metabolite that increases the risk of ASD(β=0.262,SE=0.064,P_(IVW)=4.64×10^(-5)).The association was robust,with no significant heterogeneity among instrument variables(P_(MR Egger)=0.663,P_(IVW)=0.906)and no evidence of pleiotropy(P=0.949).Neuroinflammation and the response to stimulus were suggested as potential biological processes mediating the association between Des-Arg(9)bradykinin and *** Through the application of MR,this study provides practical insights into the potential causal association between plasma metabolites and *** findings offer perspectives for the discovery of diagnos

关键词： Des-Arg(9)bradykinin Autism spectrum disorder Mendelian randomization Metabolite Enrichment analysis

中国大学生英语口语自我效能量表构建及其信效度检验

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中国外语 2022年第1期19卷 79-89页

作者：李茶隋铭才东北师范大学外国语学院长春人文学院外国语言文学学院

本研究旨在构建中国大学生英语口语自我效能量表(ESSS-CCS),并对其进行信效度检验。首先基于Zimmerman等人的自我效能理论,借鉴写作自我效能结构,融合口语复杂度、准确度、流利度多维框架,构建出英语口语自我效能五大维度:口语任务自我... 详细信息

本研究旨在构建中国大学生英语口语自我效能量表(ESSS-CCS),并对其进行信效度检验。首先基于Zimmerman等人的自我效能理论,借鉴写作自我效能结构,融合口语复杂度、准确度、流利度多维框架,构建出英语口语自我效能五大维度:口语任务自我效能、口语复杂度自我效能、口语准确度自我效能、口语流利度自我效能、口语自律学习自我效能。然后依据理论、前人量表及中国大学生特点编制初版量表(35个题项),经探索性和验证性因子分析,最终得出由18个题项构成的五因子理想模型。基于800份问卷的信度分析表明,该量表信度较高。ESSS-CCS不仅为测量中国大学生英语口语自我效能提供了有效工具,还为英语口语自我效能的构成提供了新依据。

关键词：英语口语自我效能量表信度效度

Fabrication of Nb2O5/C nanocomposites as a high performance anode for lithium ion battery

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Chinese Chemical Letters 2017年第4期28卷 755-758页

作者： Gan-Ying Zeng Hao Wang Jing Guo li-Mei cha Yu-Hai Dou Jian-Min Ma Schcool of Physics and Electronics Hunan University Changsha 410082 China College of Materials Science and Engineering Hunan University Changsha 410082 China Institute for Superconducting and Electronic Materials Australian Institute for Innovative Materials University of Wollongong Wollongong New South Wales 2500 Australia Science and Technology on Surface Physics and Chemistry Laboratory China Academy of Engineering Physics Mianyang 621908 China

Nb_2O_5/C nanosheets are successfully prepared through a mixing process and followed by heating *** Nb_2O_5/C based electrode exhibits high rate performance and remarkable cycling ability,showing a high and stable specific capacity of ~380mAhg^（-1） at the current density of 50 mAg^（-1）（much higher than the theoretical capacity of Nb_2O_5）.Further more,at a current density of 500mAg^（-1）,the nanocomposites electrode still exhibits a specific capacity of above 150 mAh g^（-1） after 100 *** results suggest the Nb_2O_5/C nanocomposite is a high performance anode material for lithium-ion batteries.

关键词： N2O5 Carbon Composite Anode lithium-ion battery

经腋无充气腔镜与传统颈部开放手术治疗PTC的疗效分析

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中华耳鼻咽喉头颈外科杂志 2023年第4期58卷 351-357页

作者：陈孝磊李超周雨秋蔡永聪宁玉东税春燕汪旭曾梓洵覃纲葛明华郑传铭西南医科大学附属医院耳鼻咽喉头颈外科泸州646000 四川省肿瘤临床医学中心、四川省肿瘤医院研究所、四川省癌症防治中心电子科技大学附属肿瘤医院头颈外科成都610041 浙江省人民医院、杭州医学院附属人民医院头颈外科杭州310014

目的比较经腋无充气腔镜与开放术式在甲状腺乳头状癌(PTC)的疗效及术后生活质量的差异。方法回顾性分析四川省肿瘤医院头颈外科2019年5月至2021年12月采用经腋无充气腔镜手术(142例)与传统颈部开放手术(201例)治疗单侧PTC的343例患者的... 详细信息

目的比较经腋无充气腔镜与开放术式在甲状腺乳头状癌(PTC)的疗效及术后生活质量的差异。方法回顾性分析四川省肿瘤医院头颈外科2019年5月至2021年12月采用经腋无充气腔镜手术(142例)与传统颈部开放手术(201例)治疗单侧PTC的343例患者的病例资料,其中男性97例,女性246例,年龄20~69岁。对入组患者进行1∶1倾向评分匹配(PSM),对匹配成功后的2组患者的基本特征、围手术期临床结果、术后并发症、术后生活质量(采用甲状腺癌特异性生活质量量表)、美观满意度等方面进行比较。应用SPSS 26.0软件进行统计学分析。结果PSM后共纳入190例患者,腔镜组和开放组各95例,在术中失血量[20(20)ml比20(10)ml,M(IQR),下同,Z=-2.22]、术后引流量[170(70)ml比101(55)ml,Z=-7.91]、手术时间[135(35)min比95(35)min,Z=-7.34]、住院费用[(28188.7±2765.1)元比(25643.5±2610.7)元,x¯±s,下同,t=0.73]、术后住院时间[(3.1±0.9)d比(2.6±0.9)d,t=-3.24]、引流管放置时间[(2.5±0.8)d比(2.0±1.0)d,t=-4.16],腔镜组患者高于开放组,差异均有统计学意义(P值均0.05)。2组患者的术后生活质量在神经肌肉、心理、瘢痕、感觉冷方面差异有统计学意义(P值均0.05)。在术后6个月美观满意度上腔镜组优于开放组,差异有统计学意义(χ^(2)=41.47,P<0.05)。结论无充气经腋窝腔镜手术是一种安全可靠的手术方式,与传统经颈部入路的甲状腺癌根治术相比,其美容效果显著,并且可在一定程度上提高患者术后的生活质量。

关键词：甲状腺切除术外科手术,微创性无充气腋窝入路生活质量