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Nonadiabatic Population Transfer in a Tangent-Pulse Driven Quantum Model

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Chinese Physics Letters 2018年第1期35卷 27-30页

作者： Guang Yang Wei li li-Xiang cen center of Theoretical Physics College of Physical Science and Technology Sichuan University

Fine control of the dynamics of a quantum system is the key element to perform quantum information processing and coherent manipulations for atomic and molecular systems. We propose a control protocol using a tangentpulse driven model and demonstrate that it indicates a desirable design, i.e., of being both fast and accurate for population transfer. As opposed to other existing strategies, a remarkable character of the present scheme is that high velocity of the nonadiabatic evolution itself not only will not lead to unwanted transitions but also can suppress the error caused by the truncation of the driving pulse.

关键词： Nonadiabatic Population Transfer in a Tangent-Pulse Driven Quantum Model

Preparation and thermal stability of Pd_(40.5)Ni_(40.5)Si_xP_(19-x) bulk metallic glasses

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 204-207页

作者： Yang li Yao-cen Wang Ke-fu Yao Department of Mechanical Engineering Tsinghua University Beijing 100084 China

With the addition of Si to replace some P,Pd40.5Ni40.5SixP19-x（x=0,2.5,5,9.5,14,and 19 in atomic number fraction） bulk glassy samples with the diameter of about 5 mm were successfully prepared by use of flux treatment and water quenching *** the increase of Si content,the glass forming ability of Pd40.5Ni40.5Si-xP19-x increases first for low Si content and then decreases for high Si content （Si≥9.5at%）.The Pd40.50Ni40.5Si5P14 glassy alloy possesses the largest supercooled liquid region△T of 119 K,the largest reduced glass transition temperature of 0.621,and the largestγparameter of 0.460,indicating that this glassy alloy possesses very large glass forming ability and very high thermal stability.

关键词： bulk metallic glass flux method glass forming ability water quenching thermal stability

Stabilized quantum coherence and remote state preparation in structured environments

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Chinese Science Bulletin 2014年第29期59卷 3841-3846页

作者： Ping Zhang Bo You li-Xiang cen center of Theoretical Physics College of Physical Science and TechnologySichuan University

The radiation decay of a two-level atom could be inhibited within structured environments even under longtime *** investigate the stabilized quantum coherence of composite systems undergoing local dissipation and exploit it further as a resource for remote state *** focus on outputs of quantum states with solely quantum discord(i.e.,without entanglement)and demonstrate that they could be resulted from various initial states providing specific spectral structure of the *** detail,we elaborate the behavior of stabilized quantum discord and the corresponding fidelity for remote state preparation in connection with structural spectra of Ohmic class reservoir and of photonic band gap mediums.

关键词：远程态制备量子相干性结构化环境稳定初始状态二能级原子复合系统储层结构

Design,synthesis and preliminary biological evaluation of brain targeting L-ascorbic acid prodrugs of ibuprofen

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Chinese Chemical Letters 2013年第2期24卷 117-119页

作者： Xue-Ying Wu Xiao-cen li Jie Mi Jing You li Hai College of Pharmacy Chengdu University of Traditional Chinese Medicine Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry Department of Medicinal ChemistryWest China School of PharmacySichuan University

Received 4 November 2012 Received in revised form 17 December 2012 Accepted 31 December 2012 Available online 4 February 2013

关键词： Vitamin CBrain targetProdrugGLUT1 transporterSVCT2 transporterIbuprofen

A CRISPR/Cas9-based visual toolkit enabling multiplex integration at specific genomic loci in Aspergillus niger

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Synthetic and Systems Biotechnology 2024年第2期9卷 209-216页

作者： Yangyang li cen li Yishan Fu Quan Zhang Jianing Ma Jingwen Zhou Jianghua li Guocheng Du Song liu National Engineering Research center for Cereal Fermentation and Food Biomanufacturing Jiangnan UniversityWuxi214122China Science center for Future Foods Jiangnan UniversityWuxi214122China School of Biotechnology Jiangnan University1800 Lihu RoadWuxi214122China Jiangsu Provisional Research center for Bioactive Product Processing Technology Jiangnan University1800 Lihu RoadWuxiJiangsu214122China Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region(Ministry of Education) College of Life Sciences/Institute of Agro-bioengineeringGuizhou UniversityGuiyang550025China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian116000China School of Chemical Engineering Dalian University of TechnologyDalian116000China

Aspergillus niger is a highly versatile fungal strain utilized in industrial *** expression levels of recombinant genes in *** can be enhanced by increasing the copy ***,given the prolonged gene editing cycle of ***,a“one-step”strategy facilitating the simultaneous integration of recombinant genes into multiple genomic loci would provide a definitive *** our previous study,a visual multigene editing system(VMS)was designed to knock out five genes,employing a tRNA-sgRNA array that includes the pigment gene albA and the target *** upon this system,hybrid donor DNAs(dDNAs)were introduced to establish a clustered regularly interspaced short palindromic repeats(CRISPR)-based multiplex integration ***,a CRISPR-Cas9 homology-directed repair(CRISPR-HDR)system was constructed in *** by co-transforming the CRISPR-Cas9 plasmid(with a highly efficient sgRNA)and the dDNA,resulting in precise integration of recombinant xylanase gene xynA into the target loci(theβ-glucosidase gene bgl,the amylase gene amyA,and the acid amylase gene ammA).Subsequently,the length of homology arms in the dDNA was optimized to achieve 100%editing efficiency at each of the three gene *** achieve efficient multiplex integration in ***,the CRISPR plasmid pLM2 carrying a sgRNA-tRNA array was employed for concurrent double-strand breaks at multiple loci(bgl,amyA,ammA,and albA).Hybrid dDNAs were then employed for repair,including dDNA1-3(containing xynA expression cassettes without selection markers)and dDNAalbA(for albA knockout).Among the obtained white colonies(RLM2′),23.5%exhibited concurrent replacement of the bgl,amyA,and ammA genes with xynA(three copies).Notably,the xynA activity obtained by simultaneous insertion into three loci was 48.6%higher compared to that obtained by insertion into only the bgl ***,this multiple integration toolkit successfully enhanced the expression of endogenous pectinase pelA and

关键词： Multiplex integration Aspergillus niger CRISPR-Cas9 homologous direct repair White colony

Role of juvenile hormone receptor Methoprene-tolerant 1 in silkworm larval brain development and domestication

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Zoological Research 2021年第5期42卷 637-649页

作者： Yong Cui Zu-lian liu cen-cen li Xiang-Min Wei Yong-Jian lin Lang You Zi-Dan Zhu Hui-Min Deng Qi-li Feng Yong-Ping Huang Hui Xiang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdong 510631China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200032China College of life Sciences Xinyang Normal UniversityXinyangHenan 464000China

The insect brain is the central part of the neurosecretory system,which controls morphology,physiology,and behavior during the insect’s *** are holometabolous insects,and their brains develop during the larval period and metamorphosis into the adult *** the only fully domesticated insect,the Lepidoptera silkworm Bombyx mori experienced changes in larval brain morphology and certain behaviors during the domestication *** regulation in insects is a key factor in multiple ***,how juvenile hormone(JH)signals regulate brain development in Lepidoptera species,especially in the larval stage,remains *** recently identified the JH receptor Methoprene tolerant 1(Met1)as a putative domestication *** artificial selection on Met1 impacts brain and behavioral domestication is another important issue addressing Darwin’s theory on ***,CRISPR/Cas9-mediated knockout of Bombyx Met1 caused developmental retardation in the brain,unlike precocious pupation of the *** the whole transcriptomelevel,theecdysteroid(20-hydroxyecdysone,20 E)signaling and downstream pathways were overactivated in the mutant cuticle but not in the *** related to cell proliferation and specialization processes,such as extracellular matrix(ECM)-receptor interaction and tyrosine metabolism pathways,were suppressed in the *** evolutionary analysis and in vitro assay identified an amino acid replacement located in a novel motif under positive selection in ***,which decreased transcriptional binding *** *** MET1 protein showed a changed structure and dynamic features,as well as a weakened co-expression gene network,compared with *** on comparative transcriptomic analyses,we proposed a pathway downstream of JH signaling(i.e.,tyrosine metabolism pathway)that likely contributed to silkworm larval brain development and domestication and highlighted the importance of the biogenic amine syste

关键词： Met1 Brain Artificial selection Tyrosine metabolism pathway Silkworm

Long survival after immunotherapy plus paclitaxel in advanced intrahepatic cholangiocarcinoma: A case report and review of literature

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World Journal of Clinical Cases 2022年第32期10卷 11889-11897页

作者： Meng-Ye He Fei-Fei Yan Kai-li cen Peng Shen Department of Medical Oncology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Intrahepatic cholangiocarcinoma(iCCA)is the second most common primary hepatic malignancy ***,currently available systemic therapies are of limited effectiveness,and the median overall survival of patients treated with first-line standard chemotherapy is less than one *** checkpoint inhibitors have been used to treat solid *** studies recently explored the combination of chemotherapy and immunotherapy for ***,the clinical significance of predictive biomarkers for chemo-immunotherapy in CCA remains *** is also worth exploring whether a combination of chemotherapeutic agents can increase the sensitivity of CCA *** SUMMARY This study reports a case of advanced iCCA in which clinical complete remission had been achieved using a programmed death 1(PD-1)inhibitor and paclitaxel without known predictive biomarkers,but with BRCA1,KRAS,and NTRK3 mutations after rapid progression to first-line chemotherapy,and has remained in clinical complete remission for more than two *** case suggests that chemo-immunotherapy is a potential therapeutic option for patients with iCCA and few known predictive biomarkers for immunotherapies as well as synergistic effect of the combination of paclitaxel and PD-1 monoclonal *** The combination of paclitaxel and PD-1 monoclonal antibodyr can be explored in patients with advanced iCCA.

关键词： Intrahepatic cholangiocarcinoma Programmed cell death protein-1 inhibitor Paclitaxel Chemo-immunotherapy Predictive biomarker Case report

Identification and functional prediction of long intergenic noncoding RNAs in fetal porcine longissimus dorsi muscle

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Journal of Integrative Agriculture 2021年第1期20卷 201-211页

作者： li cen-cen YU Shu-long REN Hai-feng WU Wei WANG Ya-ling HAN Qiu XU Hai-xia XU Yong-jie ZHANG Peng-peng College of life Sciences Xinyang Normal UniversityXinyang 464000P.R.China

Pigs are globally farmed animals which provide protein for human consumption in the form of skeletal muscle. To better understand the function of long intergenic noncoding RNAs(linc RNAs) in porcine skeletal muscle growth and development, we collected RNA-seq data from porcine longissimus dorsi muscle(LDM) during embryonic development. We identified a total of 739 linc RNA transcripts, which were distributed on all chromosomes except the chromosome Y, and analyzed their molecular characteristics. Compared to protein-coding genes, linc RNAs showed shorter transcripts, longer exons, fewer exons and higher tissue specificity. In addition, the abundance of linc RNAs in five embryonic development stages were analyzed and 45 differentially expressed linc RNAs were screened, three of which were highly expressed in LDM during porcine embryonic development. Finally, we predicted the potential target genes and functions of the linc RNAs, and identified 1 537 cis-target genes and 8 571 trans-target genes. Furthermore, we identified two key candidate linc RNAs involved in muscle development, XLOC_024652 and XLOC_001832, for post-trial validation. Our results provide a genome-wide resource of linc RNAs which are potentially involved in porcine embryonic skeletal muscle development and lay a foundation for the further study of their functions.

关键词： lincRNAs pig skeletal muscle embryo potential target genes

Stability of Boundary Feedback Control Based on Weighted Lyapunov Function in Networks of Open Channels

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自动化学报 2009年第1期35卷 97-102页

作者： cen li-Hui XI Yu-Geng Department of Automation Shanghai Jiao Tong University Shanghai 200240 P. R. China

Lyapunov 功能在串联为二条开的隧道的盒子基于熵的加权的和被构造，它被 Saint-Venant 方程描述。边界反馈控制器的一个班被介绍借助于 Lyapunov 设计途径在平衡点的一位邻居保证本地靠近环的 asymptotic 稳定性。

关键词： Saint-Venant方程熵 Lyapunov函数渐近稳定度边界反馈控制