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Interleukin-10 gene polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis

World Journal of Gastroenterology 2011年第34期17卷 3941-3947页

作者： Yong-Gang Wei, Fei liu, bo li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin YangYong-Gang Wei, Fei liu, bo li, Xi Chen, Yu Ma, Lv-Nan Yan, Tian-Fu Wen, Ming-Qing Xu, Wen-Tao Wang, Jia-Yin Yang, Department of liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Prov- ince, China Author contributions: Wei YG and liu F designed the study, collected and analyzed the data and wrote the manuscript li b collected and analyzed the data and wrote the manuscript Chen X and Ma Y collected and analyzed the data Yan LN analyzed the data and contributed to the discussion Wen TF and Xu MQ revised the manuscript Wang WT and Yang JY contributed to the discussion Wei YG and liu F contributed equally to this work. Department of liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China.

AIM: To assess the association between Interleu-kin-10 (IL-10) gene IL-10-1082 (G/A), IL-10-592(C/A), IL-10-819 (T/C) polymorphisms and hepatocellular carcinoma (HCC) ***: Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese biomedicine database. Summary odds ratios (ORs) and 95% conf idence intervals (95% CIs) for IL-10 polymorphisms and HCC were cal-culated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate. RESULTS: This meta analysis included seven eligiblestudies, which included 1012 HCC cases and 2308 controls. Overall, IL-10-1082 G/A polymorphism was not associated with the risk of HCC (AA vs AG + GG, OR = 1.11, 95% CI = 0.90-1.37). When stratifying for ethnicity, the results were similar (Asian, OR = 1.12, 95% CI = 0.87-1.44; non-Asian, OR = 1.10, 95% CI = 0.75-1.60). In the overall analysis, the IL-10 polymorphism at position -592 (C/A) was identified as a genetic risk factor for HCC among Asians; patients carrying the IL-10-592*C allele had an increased risk of HCC (OR = 1.29, 95% CI = 1.12-1.49). No association was observed between the IL-10-819 T/C polymorphism and HCC susceptibility (TT vs TC + CC, OR = 1.02, 95% CI = 0.79-1.32).CONCLUSION: This meta-analysis suggests that IL-10-592 A/C polymorphism may be associated with HCC among Asians. IL-10-1082 G/A and IL-10-819 T/C polymorphisms were not detected to be related to the risk for HCC.

关键词： Hepatocellular carcinoma Interleukin-10 Gene polymorphism Meta-analysis

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Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients

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World Journal of Gastroenterology 2008年第15期14卷 2434-2439页

作者： bin liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, beijing 100044, China Author contributions: liang b and Wang S contributed equally to this work liang b and Wang S designed the research liang b, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research liang b and Ye YJ analyzed the data liang b wrote the paper and revised the manuscript. Division of Surgical Oncology Peking University People's Hospital Beijing 100044 China.

AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO

关键词： Colorectal cancer Parenteral nutrition Omega-3 fatty acids Immunomodulation Abdominalsurgery

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A wearable real-time telemonitoring electrocardiogram device compared with traditional Holter monitoring

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The Journal of biomedical Research 2021年第3期35卷 238-246页

作者： Qin Shen Jianqing li Chang Cui Xingyao Wang Hongxiang Gao Chengyu liu Minglong Chen Department of Cardiology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China School of biomedical Engineering and Informatics Nanjing Medical UniversityNanjingJiangsu 211166China School of Instrument Science and Engineering Southeast UniversityNanjingJiangsu 210096China

Arrhythmias are very common in the healthy populations as well as patients with cardiovascular *** them,atrial fibrillation(AF)and malignant ventricular arrhythmias are usually associated with some clinical *** diagnosis of arrhythmias,particularly AF and ventricular arrhythmias,is very important for the treatment and prognosis of *** is a gold standard commonly recommended for noninvasive detection of paroxysmal ***,it has some shortcomings such as fixed detection timings,delayed report and inability of remote real-time *** deal with such problems,we designed and applied a new wearable 72-hour triple-lead H3-electrocardiogram(ECG)device with a remote cloud-based ECG platform and an expertsupporting *** this study,31 patients were recruited and 24-hour synchronous ECG data by H3-ECG and Holter were *** the H3-ECG group,ECG signals were transmitted using remote real-time modes,and confirmed reports were made by doctors in the remote expert-supporting system,while the traditional modes and detection systems were used in the Holter *** results showed no significant differences between the two groups in 24-hour total heart rate(HR),averaged HR,maximum HR,minimum HR,premature atrial complexes(PACs)and premature ventricular complexes(PVCs)(P>0.05).The sensitivity and specificity of capture and remote automatic cardiac events detection of PACs,PVCs,and AF by H3-ECG were 93%and 99%,98%and 99%,94%and 98%,***,the long-term limb triple-lead H3-ECG device can be utilized for domiciliary ECG self-monitoring and remote management of patients with common arrhythmia under medical supervision.

关键词： wearable ECG device Holter real-time remote ECG monitoring

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2012年彝良M_S5.7和M_S5.6级地震热辐射亮温异常分析

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地球物理学进展 2013年第5期28卷 2322-2327页

作者：解滔康春丽卢军马未宇中国地震台网中心北京100045

为分析与2012年彝良地震前有关的热红外异常现象,我们选取了99°E-109°E、23°N-33°N范围内从2010年11月1日至2012年10月31日为期两年由中国静止气象卫星FY-2E观测的热红外遥感亮温资料,对亮温资料进行阈值去云影响预处理,而后应用小... 详细信息

为分析与2012年彝良地震前有关的热红外异常现象,我们选取了99°E-109°E、23°N-33°N范围内从2010年11月1日至2012年10月31日为期两年由中国静止气象卫星FY-2E观测的热红外遥感亮温资料,对亮温资料进行阈值去云影响预处理,而后应用小波能谱分析方法对预处理后的资料进行分析,获得了亮温小波相对能谱信息.分析结果表明从2012年7月下旬开始在彝良MS5.7、MS5.6地震震中周围开始出现亮温相对能谱异常,之后异常区域逐渐扩大并向震中区域集中,并于8月中下旬在震中附近形成NE向沿活动断层条带状分布的异常区域,相对能谱最大异常幅度达8倍,随后异常区域和幅度逐渐减小,地震发生后数天异常消失.从像元(105.3°E,28.3°N)异常时间进程上可以看出此次异常是两年时间里亮温相对能谱最为突出的异常变化,因此认为这次沿彝良地震发震断裂带分布的亮温相对能谱增大现象可能是彝良地震引起的.

关键词：彝良地震热红外亮温小波能谱异常

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