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Large area^(3)He tube array detector with modular design for multi‑physics instrument at CSNS

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Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： lin Zhu Jian‑Rong Zhou Yuan‑Guang Xia liang Xiao Hong Luo Xiao‑Juan Zhou Wen‑Qin Yang Bei‑Ju Guan Xing‑Fen jiang Yan‑Feng Wang Hong Xu Hai‑Yun Teng li‑Xin Zeng Jia‑Jie li Lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑Xun Shen Jun Xu li‑jiang liao Xiao‑Zhuang Wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping Xu Zhi‑Duo li Song‑lin Wang Jian Zhuang Yu‑Bin Zhao Jun‑Rong Zhang Wen Yin Zhi‑Jia Sun Yuan‑Bo Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to facilitate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-Sheng li Qian-Jie Xu Wei Zhang Zhong-li liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling liao Xiao-li Pu Zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

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World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng liao Sha liao Yu-Jiao Gao Xi Wang li-Hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Physical-Layer Authentication via a Dynamic Scaling

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Chinese Journal of Electronics 2020年第4期29卷 651-659页

作者： li Min jiang Shaoquan liao Yongjian Institute of Information Security Mianyang Normal University School of Information and Software Engineering University of Electronic Science and Technology of China

Message authentication is a process that allows sender Alice to transmit a source state to receiver Bob such that the latter is assured of the *** study this problem in the physical-layer where the channel is degraded by a Rayleigh fading and a Gaussian *** propose an efficient construction for our *** idea is to amplify a basic codeword of the source state with a small but dynamic scaling *** scaling factor is asymptotically *** thus essentially incurs no power *** authentication is achieved through a statistical *** scheme is provably secure and performs better than the related existing ***,our error analysis allows it to be realized with very practical parameters.

关键词： Physical-layer authentication Information security Message authentication code

Hollow TiO_2 spheres with improved visible light photocatalytic activity synergistically enhanced by multi-stimulative: Morphology advantage,carbonate-doping and the induced Ti^(3+)

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Journal of Environmental Sciences 2018年第10期30卷 153-165页

作者： Guoliang li Chunyang liao Guibin jiang State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences

Great efforts have been devoted to improve the photocatalytic activity of TiO2 in the visible light region. Rational design of the external structure and adjustment of intrinsic electronic status by impurity doping are two main effective ways to achieve this purpose. A facile onepot synthetic approach was developed to prepare C-doped hollow TiO2 spheres, which simultaneously realized these advantages. The synthesized TiO2 exhibits a mesoporous hollow spherical structure composed of fine nanocrystals, leading to high specific surface area（~180 m^2/g） and versatile porous texture. Carbonate-doping was achieved by a postthermal treatment at a relatively low temperature（200°C）, which makes the absorption edge red-shifted to the visible region of the solar spectrum. Concomitantly, Ti^（3＋） induced by C-doping also functions in improving the visible-light photocatalytic activity by reducing the band gap. There exists a synergistic effect from multiple stimulatives to enhance the photocatalytic effect of the prepared TiO2 catalyst. It is not out of expectation that the asprepared C-doped hollow TiO2 spheres exhibits an improved photocatalytic activity under visible light irradiation in organic pollutant degradation.

关键词： Hollow TiO2 sphere Carbonate Ti^3+ Visible light Photo-degradation Synergistic enhancement

Subtidal variability in the Taiwan Strait induced by combined forcing of winter monsoon and topography

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Science China Earth Sciences 2018年第4期61卷 483-493页

作者： li li Xiaogang GUO Enhui liao Yuwu jiang Third Institute of Oceanography State Oceanic Administration State Key Laboratory of Marine Environmental Science Xiamen University College of Earth Ocean and EnvironmentUniversity of Delaware

As an important channel connecting the East and South China Seas, circulations in the Taiwan Strait are strongly influenced by the East Asian monsoon and the topography of the strait, especially the Taiwan Bank(TWB), which is a remarkable topographic feature located at the southern entrance to the strait. Based on a series of pressure gauges deployed roughly 40 km offshore along the western Strait, subtidal sea-level variability under the combined impact of winter monsoon and topography was studied. The analyses show significant along-strait coherences of subtidal sea levels and their coherences with the large-scale monsoon wind for periods from 2 to 14 days. It is suggested that these fluctuations are mainly forced waves driven by the large-scale winds. In addition to the normal cross-shore wind setup, a sea-level setup in the along-strait direction is confirmed, which is induced by the combined forcing of the fluctuating winter monsoon and the blocking of the TWB. A southward current surge driven by a northerly wind event will cause a rising sea level over the TWB inducing a southward alongshore slope anomaly to the north of the TWB and a reversed slope anomaly to the south The subtidal current through the channel to the west of the TWB is found to be influenced by the reversed slope anomalies generated via the along-shore setup.

关键词： Subtidal variabilities Along-strait sea level setup Taiwan Strait Taiwan Bank

Synthesis of CdSe quantum dots via paraffin liquid and oleic acid

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第1期9卷 133-136页

作者： Yu-feng liao Wen-jiang li Centre for Optical and Electromagnetic Research State Key Laboratory for Modern Optical Instrumentation Joint Research Center of Photonics of the Royal Institute of Technology （Sweden） and Zhejiang University Zhejiang University Hangzhou 310058 China

This paper reported an efficient and rapid method to produce highly monodispersed CdSe quantum dots (QDs), in which the traditional trioctylphosphine oxide (TOPO) was replaced by paraffin liquid as solvent and oleic acid as the reacting media. The experimental conditions and the properties of QDs had been studied in detail. The resulting samples were confirmed of uniform size distribution with transmission electronic microscopy (TEM), while UV-vis absorption and photoluminescence (PL) spectra clearly indicated that such synthesized QDs had good fluorescence properties.

关键词： CdSe Synthesis Quantum dots (QDs) Fluorescence