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Nano-bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 92-117页

作者： Jing Zhao Zheng Chen Shanbiao liu Pin li Shiyi Yu Daishun ling Fangyuan li Institute of Pharmaceutics Hangzhou Institute of Innovative MedicineCollege of Pharmaceutical SciencesZhejiang UniversityHangzhouChina Frontiers Science center for Transformative Molecules School of Chemistry and Chemical EngineeringSchool of Biomedical EngineeringNational Center for Translational MedicineShanghai Jiao Tong UniversityShanghaiChina World Laureates Association(WLA)Laboratories ShanghaiChina Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province HangzhouChina Songjiang Institute and Songjiang Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina

Two-dimensional(2D)nanomaterials,known for their unique atomic arrangements and exceptional physicochemical properties,have garnered significant attention in biomedical applications,particularly in the realms of immunotherapy for tissue engineering and tumor *** applications necessitate a thorough assessment of the potential influence of 2D nanomaterials on immune ***,the mononuclear phagocyte system(MPS)cells,which play pivotal roles in both innate and adaptive immunity,are essential for maintaining organismal *** cells with phagocytic capability contribute to the prevention of foreign body invasion and the elimination of dead or senescent ***,MPS cells,including macrophages and dendritic cells,serve as vital bridges between innate and adaptive immune ***,understanding the nano-bio interactions between 2D nanomaterials and MPS cells is *** nano-bio interactions including cellular uptake,cytocompatibility,and immunological impact are invaluable forthe purposeful design of 2D ***,we provide an overview of the latest advancements in understanding the nano-bio interactions between 2D nanomaterials and MPS cells,and discuss the current challenges and future prospects of employing 2D nanomaterials in the field of nanomedicine.

关键词： 2D nanomaterials cellular uptake dendritic cells immunological impact macrophages mononuclear phagocyte system nano-bio interactions

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Effects of gallium surfactant on AlN thin films by microwave plasma chemical vapor deposition

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Journal of Semiconductors 2024年第9期45卷 53-60页

作者： Lu Wang Xulei Qin li Zhang Kun Xu Feng Yang Shaoqian Lu Yifei li Bosen liu Guohao Yu Zhongming Zeng Baoshun Zhang School of Physics Changchun University of Science and TechnologyChangchun 130013China Nanofabrication Facility Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

In this work, AlN films were grown using gallium (Ga) as surfactant on 4° off-axis 4H-SiC substrates via microwave plasma chemical vapor deposition (MPCVD). We have found that AlN growth rate can be greatly improved due to the catalytic effect of trimethyl-gallium (TMGa), but AlN crystal structure and composition are not affected. When the proportion of TMGa in gas phase was low, crystal quality of AlN can be improved and three-dimensional growth mode of AlN was enhanced with the increase of Ga source. When the proportion of TMGa in gas phase was high, two-dimensional growth mode of AlN was presented, with the increase of Ga source results in the deterioration of AlN crystal quality. Finally, employing a two-step growth approach, involving the initial growth of Ga-free AlN nucleation layer followed by Ga-assisted AlN growth, high quality of AlN film with flat surface was obtained and the full width at half maximum (FWHM) values of 415 nm AlN (002) and (102) planes were 465 and 597 arcsec.

关键词： AlN thin film MPCVD gallium surfactant nucleation layer laser

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A Mendelian randomisation,propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm

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Stroke & Vascular Neurology 2024年第3期9卷 202-211,I0104-I0109页

作者： Zhuohua Wen Xin Feng Xin Tong Chao Peng Anqi Xu Haiyan Fan Yiming Bi Wenchao liu Zhenjun li Shenquan Guo Fa Jin Ran li Yanchao liu Shixing Su Xin Zhang Xifeng li Xuying He Aihua liu Chuanzhi Duan Neurosurgery center Department of Cerebrovascular SurgeryEngineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular DiseaseZhujiang HospitalSouthern Medical UniversityGuangzhouChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina

Background and purpose Recent observational studies have reported that serum total homocysteine(tHcy)is associated with intracranial aneurysms(IAs).However,the causal effect of tHcy on IAs is *** leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA *** We performed a two-sample Mendelian randomisation(MR)using publicly available genome-wide association studies summary statistics to investigate the causal relationship between tHcy and IAs,following the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology-MR ***,a propensity score matching(PSM)analysis was conducted to evaluate the detailed effects of tHcy on risk of IA formation by utilizing real-world multicentre data,including 9902 patients with and without IAs(1:1 matched).Further interaction and subgroup analyses were performed to elucidate how tHcy affects risk of IA *** MR analyses indicated that genetically determined tHcy was causally associated with IA risk(OR,1.38,95%CI 1.07 to 1.79;p=0.018).This is consistent with the more conservative weighted median analysis(OR,1.41,95%CI 1.03 to 1.93;p=0.039).Further sensitivity analyses showed no evidence of horizontal pleiotropy or heterogeneity of single nucleotide polymorphisms in causal *** to the PSM study,we found that,compared with low tHcy(≤15μmol/L),moderate tHcy(>15-30μmol/L)(OR 2.13,95%CI 1.93 to 2.36)and high tHcy(>30μmol/L)(OR 3.66,95%CI 2.71 to 4.95)were associated with a higher IA risk(p trendcess risk due to interaction=1.65,95%CI 1.29 to 2.01).Conclusion Both large-scale genetic evidence and multicentre real-world data support a causal as

关键词： matching random centre

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Medium-and long-term sustainable supply approaches and strategies for essential and typical strategic resources in China

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Frontiers of Engineering Management 2024年第3期11卷 576-583页

作者： Ting YAO Zhen-Ying li Yue-Jun ZHANG School of Economics and Trade Hunan University of Technology and BusinessChangsha 410205China center for Resource and Environmental Management Hunan UniversityChangsha 410082China Business School Hunan UniversityChangsha 410082China

This paper examines sustainable supply strategies for essential and strategic resources in China,addressing both domestic requirements and global supply *** the context of intense global competition for resources and substantial internal demand,China’s significant role as a major consumer and global supplier is pivotal in the dynamics of the global supply *** study highlights China’s dependence on imports for essential resources and the critical need for resilient supply chains to enhance national security and promote environmental *** referencing international experiences and accounting for China’s specific circumstances,this study proposes strategic initiatives,including updating the strategic resource catalog,imposing export controls on key minerals,promoting resource conservation,and enhancing global *** strategies aim to reduce external dependencies and support global resource *** proposed framework can help policymakers ensure long-term resource security and manage resources more effectively in complex global landscapes.

关键词： resources sustainable supply supply chain security stability

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Coupling and coordinated evolution characteristics of regional economy-energy-carbon emission multiple systems:A case study of main China's Basin

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Journal of Environmental Sciences 2024年第6期140卷 204-218页

作者： Lu Chen Xin li Jingyi Zhao Xinyu Kang Lu liu Minxi Wang Wu Chen College of Management Science Chengdu University of TechnologyChengdu 610051China SDU life Cycle Engineering Department of Green TechnologyUniversity of Southern Denmark5230 OdenseDenmark

Comprehensive analysis of the Economy-Energy-Carbon Emission(EEce)system is beneficial for promoting sustainable social *** study analyzes the system development of major watersheds in China from 2010 to *** research fully considers the system’s internal and external inputs and outputs and proposes an evaluation index system for regional EEce coupling and coordinated ***,using the difference in system weight allocation to improve the coupling and coordination model,the study explores the dynamic system’s coupling and *** results show that(1)The development of the system structure is relatively stable,but the overall development status is not ideal;(2)The downstream of China’s main river basins has obvious economic advantages,while the energy system fluctuates *** efficiency of the carbon emission system will decrease in areas with rapid economic *** coupling and coordination level of the EEce system is better in the Yangtze River Basin than in the Yellow River Basin;(3)From the perspective of dynamic coordinated development,the main river basins have been divided into two states since 2012,but it is relatively stable *** dynamic coordination is often at a disadvantage in regions with rapid economic and energy development;(4)The coupling coordination degree of the two river basins has significant positive spatial *** provinces’significant spatial clustering characteristics of the coupling coordination degree are High-High ***-Low type provinces are mainly concentrated *** research process has certain reference significance for the collaborative governance of complex regional systems.

关键词： System structure Efficiency measure Coupling mechanism Dynamic coordination

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Facile formation of hierarchical magnesium silicate hydrate microspheres as an adsorbent for the textile dyes

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Particuology 2024年第10期93卷 99-110页

作者： Tin Kyawoo Naveed Karim Chao Jiang Saeed Ahmed Weiliang Tian Huiyu li Yongjun Feng State Key Laboratory of Chemical Resource Engineering Beijing Engineering Center for Hierarchical CatalystsBeijing University of Chemical TechnologyBeijing100029China Department of Chemistry The University of ChakwalChakwal48800Pakistan College of Chemistry and Chemical Engineering Tarim UniversityAlar843300China

Hierarchical porous magnesium silicate hydrate (MSH) microspheres composed of sheets are successfully developed under facile conditions using a hard template. The role of hexadecyltrimethylammonium bromide (CTAB) on the formation and adsorption behavior was also observed for the methyl orange and methylene blue. The formed MSH possesses a surface area of 453.24 m^(2)/g, an average pore size of 6.38 nm, and a pore volume of 0.75 cm^(3)/g without CTAB. Based on the role of CTAB and the change in the ratio of Mg/Si, the MSH retained its sphere-like structure with a variation in pore parameters. The formed MSH was used as an adsorbent to remove methylene blue and methyl orange. The pseudo-second-order kinetic and Langmuir Isotherm models are well-fitted, with a 256.4 mg/g removal capacity and 84.2 mg/g for methylene blue and methyl orange, respectively. The modified MSH with CTAB played a positive role for the methyl orange and a negative role for the methylene blue regarding removal performance.

关键词： Adsorption Hierarchical microspheres Magnesium silicate Methyl orange Methylene blue Surfacemodification

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Coseismic deformation and fault slip distribution of the 2023 M_(W)7.8 and M_(W)7.6 earthquakes in Türkiye

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Earthquake Science 2024年第3期37卷 263-276页

作者： Weikang li lijiang Zhao Kai Tan Xiaofei Lu Caihong Zhang Chengtao li Shuaishuai Han Institute of Seismology China Earthquake AdministrationWuhan 430071China Wuhan Gravitation and Solid Earth Tides National Observation and Research Station Wuhan 430071China School of Geological Engineering and Geomatics Chang'an UniversityXi'an 710054China

On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 that struck the nearby city of Elbistan 9 h *** study the characteristics of surface deformation caused by this event and the influence of fault rupture,this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system(GNSS)network.A maximum static coseismic displacement of 0.38 m for the M_(W)7.8 Kahramanmaras earthquake was observed at station ANTE,36 km from the epicenter,and a maximum dynamic coseismic displacement of 4.4 m for the M_(W)7.6 Elbistan earthquake was observed at station EKZ1,5 km from the *** rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a *** results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground,resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian *** maximum slip in the Pazarcik fault segment was 10.7 m,and rupture occurred at depths of 0–15 *** the Cardak fault region,the Elbistan earthquake caused significant ruptures at depths of 0–12 km,with the largest amount of slip reaching 11.6 *** Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars,and the area of increased Coulomb stress corresponded to the subsequent rupture region of the M_(W)7.6 ***,it is likely that the M_(W)7.8 earthquake triggered or promoted the M_(W)7.6 *** on the cumulative stress impact of the M_(W)7.8 and M_(W)7.6 events,the southwestern segment of the East Anatolian Fault,specifically the Amanos fault segment,experienced a Coulomb rupture stress change exc

关键词： 2023 Türkiye earthquake GNSS observation coseismic deformation field slip distribution

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Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi liu Zhe-Hao Wang Guan-Hua Xue lin Chen li-Hua Yuan Yi-Wen li Da-Gang Yu Jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

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Human brain organoid:trends,evolution,and remaining challenges

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Neural Regeneration Research 2024年第11期19卷 2387-2399页

作者： Minghui li Yuhan Yuan Zongkun Hou Shilei Hao liang Jin Bochu Wang Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqingChina Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)ChongqingChina School of Biology and Engineering/School of Basic Medical Sciences Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Advanced brain organoids provide promising platforms for deciphering the cellular and molecular processes of human neural development and *** various studies and reviews have described developments and advancements in brain organoids,few studies have comprehensively summarized and analyzed the global trends in this area of *** identify and further facilitate the development of cerebral organoids,we utilized bibliometrics and visualization methods to analyze the global trends and evolution of brain organoids in the last 10 ***,annual publications,countries/regions,organizations,journals,authors,co-citations,and keywords relating to brain organoids were *** hotspots in this field were also systematically ***,current applications for brain organoids in neuroscience,including human neural development,neural disorders,infectious diseases,regenerative medicine,drug discovery,and toxicity assessment studies,are comprehensively *** that end,several considerations regarding the current challenges in brain organoid research and future strategies to advance neuroscience will be presented to further promote their application in neurological research.

关键词： bibliometric analysis brain organoids cerebral organoids global trends neuroscience

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Implantable Electrochemical Microsensors for In Vivo Monitoring of Animal Physiological Information

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Nano-Micro Letters 2024年第3期16卷 183-211页

作者： Jin Zhou Shenghan Zhou Peidi Fan Xunjia li Yibin Ying Jianfeng Ping Yuxiang Pan Laboratory of Agricultural Information Intelligent Sensing College of Biosystems Engineering and Food ScienceZhejiang UniversityHangzhou 310058People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation center Zhejiang UniversityHangzhou 311200People’s Republic of China

In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human ***,implantable electrochemical microsensors have emerged as a prominent area of *** microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for *** have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional *** development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated *** review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for *** this,we proceeded to explore the various implantation technologies employed for electrochemical *** addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease ***,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.

关键词： Electrochemical microsensors Implantable sensors In vivo monitoring Animal physiological information

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