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人尿酸盐转运子1基因多态性与中国汉族人群高尿酸血症相关性研究

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中华内科杂志 2010年第11期49卷 925-929页

作者：韩琳贾兆通李长贵青岛大学医学院附属医院痛风病实验室山东省代谢性疾病重点实验室 266003

目的研究人尿酸盐转运子1（hURAT1）基因多态性与原发性高尿酸血症的相关性.方法选择原发性高尿酸血症患者（病例组）215例,正常对照组323例.采用PCR方法分别扩增hURAT1基因第2、3、4外显子及外显子内含子交界处,分析该区域内多态性... 详细信息

目的研究人尿酸盐转运子1（hURAT1）基因多态性与原发性高尿酸血症的相关性.方法选择原发性高尿酸血症患者（病例组）215例,正常对照组323例.采用PCR方法分别扩增hURAT1基因第2、3、4外显子及外显子内含子交界处,分析该区域内多态性位点与原发性高尿酸血症的相关性.结果在中国汉族人群hURAT1基因中,共发现5个多态性位点.其中,在第3内含子区发现1个新的多态性位点11 G＞A.病例组AA＋AG基因型频率明显高于对照组（11.6%比3.7%,P=3.81×10-4）;突变型等位基因（A等位基因）频率明显高于对照组（6.0%比1.9%,P=2.66×10-5）.A等位基因构成的基因型AA＋AG基因型使高尿酸血症发病风险增加了3.41倍（OR=3.41,95% CI=1.67～6.95）.单倍型分析显示,包含第3内含子11 G＞A突变型A等位基因的单倍型在病例组中的频率显著高于对照组,与原发性高尿酸血症发病危险性密切相关（69.44%比30.56%,P＜0.001）.结论 hURAT1基因第3内含子11 G＞A多态性与中国汉族人群原发性高尿酸血症密切相关.

关键词：高尿酸血症多态性,单核苷酸人尿酸盐转运子1

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数据库中文件夹的整体存储与随机访问

计算机工程 2011年第5期37卷 41-43页

作者：李昌贵吕志平信息工程大学测绘学院郑州450052

当前的数据库系统不能提供对文件夹存取的直接支持。针对该问题,综合数据库二进制大对象(BLOB)技术、流技术和序列化技术,提出一种数据库中文件夹的整体存储和随机访问方法。将文件夹打包成连续的文件数据块和目录结构对象,序列化目录... 详细信息

当前的数据库系统不能提供对文件夹存取的直接支持。针对该问题,综合数据库二进制大对象(BLOB)技术、流技术和序列化技术,提出一种数据库中文件夹的整体存储和随机访问方法。将文件夹打包成连续的文件数据块和目录结构对象,序列化目录结构对象为目录结构数据块,保存文件数据块和目录结构数据块至数据库的BLOB列。访问数据库文件时,读取目录结构BLOB为目录结构数据块,通过反序列化将其恢复成目录结构对象。从目录结构对象中可选择欲访问的文件,确定其在文件数据BLOB中的位置和大小,读取其对应的数据,从而实现对数据库中文件夹的随机访问。

关键词：二进制大对象文件夹数据库整体存储随机访问

C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： Bai-Bei li Lei-Jie Chen Shi-liu Lu Biao Lei gui-lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of Immunology and Metabolism for liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

Synthesis of a High-Efficiency Demulsifier and Study on Optimal Demulsification Conditions

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 107-115页

作者： Zhu Shuai Zhang YingYu gui Xia College of Chemical Engineering Nanjing Tech University30 Puzhunan RoadNanjing 211816China

Oil and water separation has always been a top priority in the oil *** this study,a series of hyperbranched fluorinated polyamine-amine polymers(HFPA1-5)were synthesized directly using an improved“one-pot method.”The highly active fluorinated p-trifluoromethylaniline was used as the core raw material,while diethylenetriamine and methyl acrylate were used as the chain segment.A hyperbranched fluorine-containing polyamine-amine demulsifier(NHFPA6)was obtained through nano-grafting copolymerization of *** enhance the demulsification and dehydration performance,the copolymerized HFPA6 was modified and ***,the effects of the combination ratio,demulsifier concentration,demulsification time,and demulsification temperature on the demulsification effect were *** results revealed that a combination ratio of DE-401:NHFPA6=1:1,a demulsification temperature of 50℃,a demulsification time of 60 min,and a demulsifier concentration of 150 mg/L yielded a dehydration rate as high as 99.80%.A response surface optimization design of demulsification conditions was *** model verified that the optimal demulsification conditions were 50℃,300 mg/L,and 90 ***,considering the economic benefits of factories,it is more favorable to select demulsification conditions with a shorter time and lower concentration when the dehydration standard is ***,the demulsification conditions were selected as 50℃,150 mg/L,and 60 *** to existing demulsifiers,the demulsifier developed in this study exhibits a lower demulsification temperature and higher demulsification efficiency.

关键词： hyperbranched fluorinated polyamine-amine nano-SiO_(2)

In SAR-derived surface deformation characteristics and mining subsidence parameters in mountain coal mines

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Journal of Mountain Science 2024年第09期 3139-3156页

作者： JIANG Xiaowei SHI Wenbing liANG Feng gui Jingjing li Jiawei Key Laboratory of Karst Georesources and Environment Ministry of Education Guizhou University Mountain Geohazard Prevention R&D Center of guizhou Province College of Resources and Environmental Engineering Guizhou University

Mining-induced surface deformation disrupts ecological balance and impedes economic progress. This study employs SBAS-In SAR with 107-view of ascending and descending SAR data from Sentinel-1, spanning February 2017 to September 2020, to monitor surface deformation in the Fa'er Coal Mine, guizhou Province. Analysis on the surface deformation time series reveals the relationship between underground mining and surface shifts. Considering geological conditions, mining activities, duration, and ranges, the study determines surface movement parameters for the coal mine. It asserts that mining depth significantly influences surface movement parameters in mountainous mining areas. Increasing mining depth elevates the strike movement angle on the deeper side of the burial depth by 22.84°, while decreasing by 7.74° on the shallower side. Uphill movement angles decrease by 4.06°, while downhill movement angles increase by 15.71°. This emphasizes the technology's suitability for local mining design, which lays the groundwork for resource development, disaster prevention, and ecological protection in analogous contexts.

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Formation Characteristics of CO_(2) Hydrates in the Presence of Porous Media and NaCl

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 168-177页

作者： Han Jianchao Zhu Shuai gui Xia College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China

Hydrate-based CO_(2) sequestration is an effective method for reducing the greenhouse effect,and the presence of porous media and NaCl can impact the formation characteristics of *** study uses the constant volume temperature search method to investigate the effects of quartz sand particle size(0.006‒0.03 mm),water saturation(30%–90%),and NaCl concentration(1%‒9%)on the phase equilibrium and kinetics of CO_(2) hydrates within a temperature range of 273‒285 K and pressure range of 1.0‒3.5 *** results indicate that a decrease in quartz sand particle size or an increase in NaCl concentration shifts the hydrate phase equilibrium curve towards lower temperatures and higher pressures,making hydrate generation conditions more *** different particle size systems,there are no significant changes in the rate of CO_(2) hydrate formation or conversion *** highest hydrate conversion rate of 71.1%is observed in a 0.015 mm particle size *** increasing water saturation,both the generation rate and conversion rate of CO_(2) hydrates show a trend of first increasing and then ***,low concentrations of NaCl(1%–3%)are found to enhance the formation and conversion rates of CO_(2) ***,as NaCl concentration increases,the rate of CO_(2) hydrate formation and conversion rate decrease.

关键词： CO_(2)hydrate porous medium NaCl formation characteristics

Achieving High CO_(2)Photoreduction Activity by Conductive Crosslinks of Metal–Organic Framework

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CCS Chemistry 2024年第5期6卷 1211-1221页

作者： Ning li gui-Qi Lai Lai-Hon Chung Fei Yu Jun He Ya-Qian Lan Department School of Chemical Engineering and light Industry Guangdong University of TechnologyGuangzhouGuangdong 510006 School of Chemistry South China Normal UniversityGuangzhou 510006 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023

Fast photogenerated charge migration is crucial for the improvement of photocatalytic performance,but its deliberate modulation is *** work presents two Zr-based metal–organic framework catalysts,GDUT-8 and GDUT-8-Ox,for photocatalytic CO_(2)***,thiophene pendants in GDUT-8 were coupled covalently via Scholl reaction to give GDUT-8-Ox,a catalyst with at least two orders of magnitude(up to 6.1×10^(−3)S cm^(−1))enhanced conductivity and faster transport of photogenerated carriers during ***,from GDUT-8 to GDUT-8-Ox,stronger ligand-to-cluster charge transfer with pronounced light absorption extension was *** a result,GDUT-8-Ox exhibited the highest photocatalytic CO_(2)-to-HCOO−conversion rate(1725μmol g^(−1)h^(−1))to date,in the absence of photosensitizer,as well as turnover number,turnover frequency,and quantum efficiency much higher than *** work presents an unprecedented strategy to accelerate the photogenerated carrier transport of photocatalysts.

关键词： metal-organic framework Scholl reaction covalent crosslinks high conductivity CO_(2)photoreduction CO_(2)-to-HCOO−conversion

Sex differences in the association between the muscle quality index and the incidence of depression: A cross-sectional study

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World Journal of Psychiatry 2024年第9期14卷 1335-1345页

作者： gui-Ping Huang li-Ping Mai Zhi-Jie Zheng Xi-Pei Wang Guo-Dong He Institute of Medical Research Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Depression presents significant challenges to mental health *** phy-sical activity is highly beneficial to mental and physical health,relatively few stu-dies have conducted on the relationship between *** To investigate the association between muscle quality index(MQI)and incidence of *** The data used in this cross-sectional study were obtained from the 2011-2014 National Health and Nutritional Examination Survey,which included informa-tion on MQI,depression,and confounding *** logistic regre-ssion models were employed,while taking into account the complex multi-stage sampling design.A restricted cubic spline model was utilized to investigate the non-linear relationship between the MQI and ***,subgroup analyses were performed to identify influential *** The prevalence of depression in this population was 8.44%.With the adjusted model,the MQI was associated with depression in females(odds ratio=0.68,95%confidence interval:0.49-0.95)but not in males(odds ratio=1.08,95%confidence interval:0.77-1.52).Restricted cubic spline adjustment of all covariates showed a significant negative non-linear relationship between depression and the MQI in *** observed trend indicated an 80%decrease in the risk of depression for each unit increase in MQI,until a value of ***,when the MQI exceeded 2.2,the prevalence of depression increased by 20%for every unit increase in the *** analyses further confirmed that the MQI was negatively associated with *** The MQI was inversely correlated with depression in females but not males,suggesting that females with a higher MQI might decrease the risk of depression.

关键词： Sex differences Muscle quality index Depression National Health and Nutrition Examination Survey Population-based study

Grain boundary-induced drastic sensing performance enhancement of Fe2O3 gas sensors for acetone

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Rare Metals 2024年第9期43卷 4412-4424页

作者： Tian-Jun Hu Yi-Fan li Yu-Zhu Tian Ying Wang Ya-Ru Chen Jun-Ming Zhang Er-gui Luo Jian-Feng Jia Key Laboratory of Magnetic Molecules & Magnetic Information Materials Ministry of Education School of Chemical and Material ScienceShanxi Normal University

Exploring the structure-activity relationship between the performance of gas sensors and the structure of semiconductor metal oxide （SMO） nanomaterials is crucial for understanding and designing gas-sensing materials and overcoming the application limitations of SMO-based gas *** of a single SMO microstructure provides a promising solution to address this scientific problem due to its controllable *** this study,we control the grain boundary （GB） density of Fe2O3nanomaterials using a simple solvothermal *** have similar chemical compositions and crystal phases,providing an ideal platform for studying the influence of the GB density on the gas-sensing ***-sensing tests showed that the Fe2O3-1 sensor with medium GB density and the Fe2O3-2 sensor with high GB density had higher sensitivity and selectivity than the Fe2O3-0 sensors with low GB density before reaching the optimal operating ***,when the GB density increased,the response to acetone decreased slightly,whereas the optimal operating temperature *** work highlights the unique performance of the GB density in enhancing the gas sensitivity of a single SMO.

关键词： Charge transfer Gas sensors Grain boundary (GB) density Oxygen adsorption Semiconductor metal oxide (SMO)