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Expansion and improvement of ChinaMu by MuT-seq and chromosome-level assembly of the Mu-starter genome

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Journal of Integrative Plant Biology 2024年第4期66卷 645-659页

作者： Lei liang Yuancong Wang Yanbin Han Yicong Chen Mengfei li yibo Wu Zeyang Ma Han Zhao Rentao Song State Key Laboratory of Maize Bio-breeding Frontiers Science Center for Molecular Design BreedingJoint International Research Laboratory of Crop Molecular BreedingNational Maize Improvement CenterCollege of Agronomy and BiotechnologyChina Agricultural UniversityBeijing 100091China Institute of Crop Germplasm and Biotechnology Jiangsu Provincial Key Laboratory of AgrobiologyJiangsu Academy of Agricultural SciencesNanjing 210014China Sanya Institute of China Agricultural University Sanya 572025China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

ChinaMu is the largest sequence-indexed Mutator(Mu)transposon insertional library in maize(Zea mays).In this study,we made significant improvements to the size and quality of the ChinaMu *** developed a new Mu-tag isolation method Mu-Tn5-seq(MuT-seq).Compared to the previous method used by ChinaMu,MuT-seq recovered 1/3 more germinal insertions,while requiring only about 1/14 of the sequencing volume and 1/5 of the experimental *** MuT-seq,we identified 113,879 germinal insertions from 3,168 Mu-active F1 *** also assembled a high-quality genome for the Mu-active line Mu-starter,which harbors the initial active MuDR element and was used as the pollen donor for the mutation *** the Mu-starter genome,we recovered 33,662(15.6%)additional germinal insertions in 3,244(7.4%)genes in the Mu-starter *** Mu-starter genome also improved the assignment of 117,689(54.5%)germinal *** newly upgraded ChinaMu dataset currently contains 215,889 high-quality germinal *** insertions cover 32,224 pan-genes in the Mu-starter and B73Ref5 genomes,including 23,006(80.4%)core genes shared by the two *** a test model,we investigated Mu insertions in the pentatricopeptide repeat(PPR)superfamily,discovering insertions for 92%(449/487)of PPR genes in ChinaMu,demonstrating the usefulness of ChinaMu as a functional genomics resource for maize.

关键词： ChinaMu Mutator MuT-seq PPR gene Zea mays

Safety-Critical Trajectory Tracking for Mobile Robots With Guaranteed Performance

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2033-2035页

作者： Wentao Wu Di Wu yibo Zhang Shukang Chen Weidong Zhang Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China Department of Information and Communication Engineering Hainan UniversityHaikou 570288China

Dear Editor,This letter considers a collision-free trajectory tracking problem for performance-guaranteed mobile robots(MRs)subject to *** propose a safety-critical performance-guaranteed trajectory tracking method based on control barrier functions(CBFs).First,an auxiliary system is established to generate the non-negative signals for inflexible bounds such that the performance constraints are not violated when avoiding obstacles.

关键词： constraints bounds collision

Genome-wide Association Analyses Reveal the Genetic Basis of Stigma Exsertion in Rice

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Molecular Plant 2017年第4期10卷 634-644页

作者： Hao Zhou Pingbo li WeiboXie Saddam Hussain yibo li Duo Xia Hu Zhao Shengyuan Sun Junxiao Chen Hong Ye Jun Hou Da Zhao Guanjun Gao Qinglu Zhang Gongwei Wang Xingming lian Jinghua Xiao Sibin Yu Xianghua li Yuqing He National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070China

Stigma exsertion, a key determinant of the rice mating system, greatly contributes to the application of heterosis in rice. Although a few quantitative trait loci associated with stigma exsertion have been fine map- ped or cloned, the underlying genetic architecture remains unclear. We performed a genome-wide associ- ation study on stigma exsertion and related floral traits using 6.5 million SNPs characterized in 533 diverse accessions of Oryza sativa. We identified 23 genomic loci that are significantly associated with stigma exsertion and related traits, three of which are co-localized with three major grain size genes GS3, GW5, and GW2. Further analyses indicated that these three genes affected the stigma exsertion by controlling the size and shape of the spikelet and stigma. Combinations of GS3 and GW5 largely defined the levels of stigma exsertion and related traits. Selections of these two genes resulted in specific distributions of floral traits among subpopulations of O. sativa. The low stigma exsertion combination gw5GS3 existed in half of the cultivated rice varieties; therefore, introducing the GW5gs3 combination into male sterile lines is of high potential for improving the seed production of hybrid rice.

关键词： stigma exsertion GWAS hybrid seed production floral traits grain shape rice

A Review of Deep Learning-Based Vulnerability Detection Tools for Ethernet Smart Contracts

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 77-108页

作者： Huaiguang Wu yibo Peng Yaqiong He Jinlin Fan School of Computer Science and Technology Zhengzhou University of Light IndustryZhengzhou450001China

In recent years,the number of smart contracts deployed on blockchain has ***,the issue of vulnerability has caused incalculable *** to the irreversible and immutability of smart contracts,vulnerability detection has become particularly *** the popular use of neural network model,there has been a growing utilization of deep learning-based methods and tools for the identification of vulnerabilities within smart *** paper commences by providing a succinct overview of prevalent categories of vulnerabilities found in smart ***,it categorizes and presents an overview of contemporary deep learning-based tools developed for smart contract *** tools are categorized based on their open-source status,the data format and the type of feature extraction they *** we conduct a comprehensive comparative analysis of these tools,selecting representative tools for experimental validation and comparing them with traditional tools in terms of detection coverage and ***,Based on the insights gained from the experimental results and the current state of research in the field of smart contract vulnerability detection tools,we suppose to provide a reference standard for developers of contract vulnerability detection ***,forward-looking research directions are also proposed for deep learning-based smart contract vulnerability detection.

关键词： Smart contract vulnerability detection deep learning

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基于MARC平台的连续铸轧热力耦合分析

中国机械工程 2006年第9期17卷 915-918页

作者：李晓谦李毅波中南大学长沙410083

综合考虑辊套与铸轧板的弹塑性变形对温度场和应力场的影响,建立了铝带坯双辊连续铸轧过程的二维动态热力耦合计算模型;通过热模拟试验得出了纯铝高温流变本构关系和接触热阻计算模型;在MARC有限元分析软件平台上开发了粘塑性材料本构... 详细信息

综合考虑辊套与铸轧板的弹塑性变形对温度场和应力场的影响,建立了铝带坯双辊连续铸轧过程的二维动态热力耦合计算模型;通过热模拟试验得出了纯铝高温流变本构关系和接触热阻计算模型;在MARC有限元分析软件平台上开发了粘塑性材料本构用户子程序URPFLO.F和接触表面传热系数用户子程序UHTCON.F;采用更新的拉格朗日方法(UL法)进行分析,得出铝带坯连续铸轧过程温度场和应力场的分布。实例计算表明,所得结果与实测结果相吻合,模型和子程序能够很好地应用于连续铸轧过程的计算与研究。

关键词：连续铸轧热力耦合用户子程序有限元分析

Novel de novo TRPV4 mutation identified in a Chinese family with metatropic dysplasia inhibits chondrogenic differentiation

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Genes & Diseases 2024年第3期11卷 83-86页

作者： Ping Wei Weizhe Shi Tianying Nong Caixia Xian Xia li Zhaohui li Xin li Jianping Wu liyuan Shang Fulong Xu yibo Xu Hongwen Xu Mingwei Zhu Guangzhou Institute of Pediatrics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China Department of Pediatric Orthopedics Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhouGuangdong 510623China

Metatropicdysplasia(MD,MIM156530)is a rare congenital bone dysplasia primarily characterized by severe platyspondyly with long and wide vertebral bodies and dumbbell deformity of the tubular *** can be caused by heterozygous mutations in the gene encoding transient receptor potential vanilloid family member 4(TRPV4).We identifieda novel de novo mutation,c.2353T>C,in the TRPV4 gene,in a Chinese family with mild MD.

关键词： TRPV4 dysplasia congenital

O-glycosylation in viruses:A sweet tango

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mlife 2024年第1期3卷 57-73页

作者： Annan Ming Jianxin Zhao Yihan liu yibo Wang Xiaohui Wang Jing li Leiliang Zhang Shandong Provincial Hospital Affiliated to Shandong First Medical University JinanChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Bejing Key Laboratory of DNA Damage Response and College of life Sciences Capital Normal UniversityBeijingChina Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunChina School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefeiChina Bejing National Laboratory for Molecular Sciences BeijingChina

O-glycosylation is an ancient yet underappreciated protein posttranslational modification,on which many bacteria and viruses heavily rely to perform critical biological functions involved in numerous infectious diseases or even *** due to the innate complexity of O-glycosylation,research techniques have been limited to study its exact role in viral attachment and entry,assembly and exit,spreading in the host cells,and the innate and adaptive immunity of the ***,the advent of many newly developed methodologies(e.g.,mass spectrometry,chemical biology tools,and molecular dynamics simulations)has renewed and rekindled the interest in viral-related O-glycosylation in both viral proteins and host cells,which is further fueled by the COVID-19 *** this review,we summarize recent advances in viral-related O-glycosylation,with a particular emphasis on the mucin-type O-linkedα-N-acetylgalactosamine(O-GalNAc)on viral proteins and the intracellular O-linkedβ-N-acetylglucosamine(O-GlcNAc)modifications on host *** hope to provide valuable insights into the development of antiviral reagents or vaccines for better prevention or treatment of infectious diseases.

关键词： immune response O-GalNAc O-GlcNAc O-glycosylation virus

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粮食收购智能扦检系统的研究进展

粮食储藏 2024年第2期53卷 1-7,17页

作者：李月马浩然李艺博张军党王贵锦彭倍荣云陈戈董晓欢黄泽文刘育森中储粮成都储藏研究院有限公司 610091 中国储备粮管理集团有限公司成都分公司 610042 清华大学 100084 电子科技大学 611731 成都中储粮储备有限公司 610300 中央储备粮厦门直属库有限公司 361026 中央储备粮海口直属库有限公司 571152 中央储备粮长乐直属库有限公司 361026

当前我国涉粮企业和基层粮库普遍存在传统扦样检验自动化程度不高、劳动强度较大、检测效率较低等问题,如何利用创新技术手段提升粮食仓储“技防技控”水平,守好粮食收购入库第一关,对保障粮食安全具有重要意义。本文分析了目前粮食收... 详细信息

当前我国涉粮企业和基层粮库普遍存在传统扦样检验自动化程度不高、劳动强度较大、检测效率较低等问题,如何利用创新技术手段提升粮食仓储“技防技控”水平,守好粮食收购入库第一关,对保障粮食安全具有重要意义。本文分析了目前粮食收购环节中传统扦样和质量指标检验过程存在的问题,粮食收购智能扦检系统在粮库实际应用中的必要性,并从智能制造、信息技术、机器视觉、深度学习的创新应用等方面阐述了智能扦检流程和装备的研究进展,以期为智能化粮库建设中粮食收购智能扦检系统的研究应用提供参考。

关键词：粮食收购智能扦检技防技控

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论影视演员形体训练方法

北京电影学院学报 2008年第6期 47-50页

作者：李轶博中国戏曲学院导演系

形体训练是培养优秀影视演员的重要途径之一,本文论述了形体训练方法所包括规则的有定性的形体模仿、不规则形体模仿、影视表演领域的模仿。

关键词：影视演员形体训练模仿观察创造