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Transcriptomic analysis reveals the effects of maternal exposure to bisphenol AF on hypothalamic development in male neonatal mice

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Journal of Environmental Sciences 2024年第7期141卷 304-313页

作者： lin Lv Yuanyuan li Xuanyue Chen Zhanfen Qin State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Fragmented data suggest that bisphenol AF(BPAF),a chemical widely used in a variety of products,might have potential impacts on the ***,we employed male neonatal mice following maternal exposure to explore the effects of low-dose BPAF on hypothalamic development by *** found that maternal exposure to approximately 50μg/(kg·day)BPAF from postanal day(PND)0 to PND 15 altered the hypothalamic transcriptome,primarily involving the pathways and genes associated with extracellular matrix(ECM)and intercellular adhesion,neuroendocrine regulation,and neurological *** RNA analysis confirmed the changes in the expression levels of concerned ***,we further revealed that low-dose BPAF posed a stimulatory impact on pro-opiomelanocortin(POMC)neurons in the arcuate nucleus of the hypothalamus and induced the browning of inguinal white adipose *** findings indicate that developmental exposure to low-dose BPAF could interfere with hypothalamic development and thereby lead to alterations in the ***,5000μg/(kg·day)BPAF caused slighter,non-significant or even inverse alterations than the low dose of 50μg/(kg·day),displaying a dose-independent *** observations suggest that the the dose-independent effects of BPAF might be associated with oxidative stress and inflammatory responses caused by the high ***,our study highlights a risk of low-dose BPAF to human neuroendocrine regulation and metabolism.

关键词： Bisphenol AF Hypothalamus Transcriptomic alteration Pro-opiomelanocortin(POMC)neurons White adipose tissue browning

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Method for triangular fuzzy multiple attribute decision making based on two-dimensional density operator method

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Journal of Systems Engineering and Electronics 2024年第1期35卷 178-185页

作者： lin Youliang li Wu liU Gang HUANG Dong School of Economics and Management Hunan Institute of Science and TechnologyYueyang 414000China Hunan Vocational College for Nationalities Yueyang 414000China School of Information Science and Engineering Hunan Institute of Science and TechnologyYueyang 414000China

Aiming at the triangular fuzzy(TF)multi-attribute decision making(MADM)problem with a preference for the distribution density of attribute(DDA),a decision making method with TF number two-dimensional density(TFTD)operator is proposed based on the density operator theory for the decision maker(DM).Firstly,a simple TF vector clustering method is proposed,which considers the feature of TF number and the geometric distance of ***,the least deviation sum of squares method is used in the program model to obtain the density weight ***,two TFTD operators are defined,and the MADM method based on the TFTD operator is ***,a numerical example is given to illustrate the superiority of this method,which can not only solve the TF MADM problem with a preference for the DDA but also help the DM make an overall comparison.

关键词： fuzzy decision making clustering density operator multi-attribute decision making(MADM)

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Chlorajaponins A—Q,lindenane-Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities

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Chinese Journal of Chemistry 2024年第11期42卷 1247-1259页

作者： Wei-Jiao Feng Yue Gu Pei-Zhi Huang Hong-Ying yang Rui Zhang Yi-lin He Ting-Hong Lv ya li Kun Gao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu730000 China Research Institute Lanzhou Jiaotong UniversityLanzhouGansu730070 China

Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus *** 1 possesses an unprecedented 3/5/7/5/5/6/5/3 fused octacyclic scaffold,featuring a 6(5→4)-abeo-lindenane monomer,while 2 exhibits a 3/5/6/6/5/6/5/3 fused octacyclic *** structures were determined through a combination of spectroscopic analyses and X-ray *** 1,2,and 18 demonstrated significant inhibitory effects on lipid accumulation and effectively reduced the levels of triglycerides and total cholesterol,as well as the levels of aspartate aminotransferase and alanine aminotransferase in a HepG2 cell *** addition,compounds 1,2,and 18 significantly suppressed the protein expression of the fatty acid synthase(FASN)and the sterol regulatory element-binding protein 1(SREBP1).Moreover,the anti-inflammatory assay showed that compounds 19—22 and 25 inhibited the NO production induced by lipopolysaccharide in RAW 264.7 macrophages with IC50 values of 7.89±0.44,6.25±0.46,2.98±0.29,10.77±0.60,and 3.60±0.28μmol/L.

关键词： Chloranthus japonicus lindenane-type sesquiterpenoid dimers lipid-lowering activity Anti-inflammatory activity NMR spectroscopy Natural products X-ray diffraction

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Boosting Hydrogen Storage Performance of MgH_(2) by Oxygen Vacancy-Rich H-V_(2)O_(5) Nanosheet as an Excited H-Pump

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Nano-Micro Letters 2024年第8期16卷 398-416页

作者： li Ren Yinghui li Zi li Xi lin Chong Lu Wenjiang Ding Jianxin Zou National Engineering Research Center of light Alloys Net Forming&State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Engineering Research Center of Mg Materials and Applications&School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Instrumental Analysis Center of SJTU Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

MgH_(2) is a promising high-capacity solid-state hydrogen storage material,while its application is greatly hindered by the high desorption temperature and sluggish ***,intertwined 2D oxygen vacancy-rich V_(2)O_(5) nanosheets(H-V_(2)O_(5))are specifically designed and used as catalysts to improve the hydrogen storage properties of MgH_(2).The as-prepared MgH_(2)-H-V_(2)O_(5) composites exhibit low desorption temperatures(Tonset=185℃)with a hydrogen capacity of 6.54 wt%,fast kinetics(Ea=84.55±1.37 kJ mol^(-1) H_(2) for desorption),and long cycling ***,hydrogen absorption can be achieved at a temperature as low as 30℃ with a capacity of 2.38 wt%within 60 ***,the composites maintain a capacity retention rate of~99%after 100 cycles at 275℃.Experimental studies and theoretical calculations demonstrate that the in-situ formed VH_(2)/V catalysts,unique 2D structure of H-V_(2)O_(5) nanosheets,and abundant oxygen vacancies positively contribute to the improved hydrogen sorption ***,the existence of oxygen vacancies plays a double role,which could not only directly accelerate the hydrogen ab/de-sorption rate of MgH_(2),but also indirectly affect the activity of the catalytic phase VH_(2)/V,thereby further boosting the hydrogen storage performance of MgH_(2).This work highlights an oxygen vacancy excited“hydrogen pump”effect of VH_(2)/V on the hydrogen sorption of Mg/MgH_(2).The strategy developed here may pave a new way toward the development of oxygen vacancy-rich transition metal oxides catalyzed hydride systems.

关键词： Hydrogen storage MgH_(2) V_(2)O_(5)nanosheets Oxygen vacancies VH_(2)

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Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

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Journal of Geriatric Cardiology 2024年第4期21卷 407-420页

作者： Jian-Guo CUI Feng TIAN Yu-Hao MIAO Qin-Hua JIN ya-Jun SHI li li Meng-Jun SHEN Xiao-Ming XIE Shu-lin ZHANG Yun-Dai CHEN School of Medicine Nankai UniversityTianjinChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Joint Laboratory of Bioimaging Technology and Applications SAS-SIM-IT&MEDIShanghaiChina Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghaiChina

OBJECTIVE To evalu ate the role of resting magnetocardiography in identifying seve re coronary artery stenosis in patients with suspected coronary artery *** A total of 513 patients with angina symptoms were included and divided into two groups based on the extent of coronary artery disease determined by angiography:the non-severe coronary stenusis group(linical *** performance of the models was evaluated using receiver operating characteristic curves,accuracy,sensitivity,specificity,positive predictive value(PPV) and ne gative predictive value(NPV).Calibration plots and decision curve analysis were performed to investigate the clinical utility and performance of the models,*** In the severe coronary stenosis group,QR_MCTDd,S_MDp,and TT_(MA)C_(50) were significantly higher than those in the non-severe coronary stenosis group(10,46±10.66 vs,5.11±6.07,P <0.001;7.2±8.64 vs.4.68±6.95,P=0.003;0.32±57.29 vs.0.26±57.29,P <0.001).While,QR_MV_(amp),R_(MA),and T_(MA) in the severe coronary stenosis group were lower(0.23±0.16 vs.0.28±0.16,P<0.001;55.06±48.68 vs.59.24±53.01,P<0.001;51.67±39.32 vs. 60.45±51.33,P <0.001).Seven MFM parameters were integrated into the model,resulting in an area under the curve of 0.810(95% CI:0.765-0.855).The sensitivity,specificity,PPV,NPV,and accurecy were 71.7%,80.4%,93.3%,42.8 %,and 73.5%;*** combined model exhibited an area under the curve of 0.845(95% CI:0.798-0.892).The sensitivity,specificity,PPV,NPV,and accuracy were 84.3%,73.8%,92.6%,54.6%,and 82.1%;*** curves demonstrate d excellent agreement between the nomogram prediction and actual *** decision curve analysis showed that the c ombine d model provided greater net benefit compared to the magnetocardingraphy model.C

关键词： coronary stenosis specificity

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Advances in memristor based artificial neuron fabrication-materials,models,and applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 27-50页

作者： Jingyao Bian Zhiyong liu Ye Tao Zhongqiang Wang Xiaoning Zhao ya lin Haiyang Xu Yichun liu Key Laboratory for UV light-Emitting Materials and Technology(Northeast Normal University) Ministry of Education5268 Renmin StreetChangchunPeople’s Republic of China

Spiking neural network(SNN),widely known as the third-generation neural network,has been frequently investigated due to its excellent spatiotemporal information processing capability,high biological plausibility,and low energy consumption *** to the working mechanism of human brain,the SNN system transmits information through the spiking action of ***,artificial neurons are critical building blocks for constructing SNN in *** are drawing growing attention due to low consumption,high speed,and nonlinearity characteristics,which are recently introduced to mimic the functions of biological *** have proposed multifarious memristive materials including organic materials,inorganic materials,or even two-dimensional *** advantage of the unique electrical behavior of these materials,several neuron models are successfully implemented,such as Hodgkin–Huxley model,leaky integrate-and-fire model and integrate-and-fire *** this review,the recent reports of artificial neurons based on memristive devices are *** addition,we highlight the models and applications through combining artificial neuronal devices with sensors or other electronic ***,the future challenges and outlooks of memristor-based artificial neurons are discussed,and the development of hardware implementation of brain-like intelligence system based on SNN is also prospected.

关键词： artificial neuron memristor memristive materials neuron model micro-nano manufacturing spiking neural network

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Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil-water separation

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Nuclear Science and Techniques 2024年第9期35卷 103-114页

作者： Ying Sun Wen-Rui Wang Dan-Yi li Si-Yi Xu lin lin Man-li Lu Kai Fan Chen-yang Xing lin-Fan li Ji-Hao li Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Architecture and Materials Chongqing College of Electronic EngineeringChongqing 401331China Center for Stretchable Electronics and NanoSensors Key Laboratory of Optoelectronic Devices and Systems of Ministry of EducationCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

This paper presents a superhydrophobic melamine(ME)sponge(ME-g-PLMA)prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA)onto an ME sponge for efficient oil–water *** obtained ME-g-PLMA sponge had an excellent pore structure with superhydrophobic(water contact angle of 154°)and superoleophilic *** can absorb various types of oils up to 66–168 times its *** ME-g-PLMA sponge can continuously separate oil slicks in water by connecting a pump or separating oil underwater with a gravity-driven *** addition,it maintained its highly hydrophobic properties even after long-term immersion in different corrosive solutions and repeated oil *** modified ME-g-PLMA sponge exhibited excellent separation properties and potential for oil spill cleanup.

关键词： Radiation-induced graft polymerization Oil–water separation Sponge Superhydrophobic

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Numerical investigation on thermomechanical behavior of alumina–calcium hexaluminate refractories for purging plug

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Journal of Iron and Steel Research International 2024年第2期31卷 389-400页

作者： li-ping Pan ya-wei li Fang-guan Tan Yi-chen Chen yang-fan Xu Zhu He Bao-kuan li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina National-Provincial Joint Engineering Research Center of High Temperature Materials and lining Technology Wuhan University of Science and TechnologyWuhan430081HubeiChina

Alumina–spinel refractories used in slit-type purging plugs are susceptible to cross-sectional damage,resulting in a serious mismatch between their service life and that of ***–calcium hexaluminate refractories have gradually become the new trend in purging plug materials with the development of refining *** thermomechanical damage of slit-type purging plugs with alumina–calcium hexaluminate refractory was investigated by the thermo-solid coupling *** with the polynomial fitting and design of experiments methods,the influence of thermophysical parameters on temperature and thermal stress of alumina–calcium hexaluminate refractories for purging plugs was systematically *** results show that the maximum thermal stress of the purging plugs appears during the stages of steel transporting and stirring,and the vulnerable parts are located above Y=0.323 *** thermal conductivity and the coefficient of thermal expansion of the material are the most sensitive parameters to the temperature and thermal stress inside the structure,*** addition of more calcium hexaluminate can relieve the stress concentration and large deformation around the ***,when the content of calcium hexaluminate is 47 wt.%and in the form of aggregate-binder,the temperature and thermal stress distribution inside the refractory are optimal,which can effectively improve the service life of the slit-type purging plug.

关键词： Purging plug Thermomechanical damage Refractory Design of experiments method Stress

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Functional Optical Fiber Sensors Detecting Imperceptible Physical/Chemical Changes for Smart Batteries

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Nano-Micro Letters 2024年第8期16卷 268-308页

作者： Yiding li li Wang Youzhi Song Wenwei Wang Cheng lin Xiangming He Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084People’s Republic of China National Engineering Research Center of Electric Vehicles Beijing Institute of Technology(BIT)Beijing 100081People’s Republic of China Shenzhen Automotive Research Institute of BIT(Shenzhen Research Institute of National Engineering Research Center of Electric Vehicles) Shenzhen 518118People’s Republic of China

The battery technology progress has been a contradictory process in which performance improvement and hidden risks *** the battery is still a“black box”,thus requiring a deep understanding of its internal *** battery should“sense its internal physical/chemical conditions”,which puts strict requirements on embedded sensing *** paper summarizes the application of advanced optical fiber sensors in lithium-ion batteries and energy storage technologies that may be mass deployed,focuses on the insights of advanced optical fiber sensors into the processes of one-dimensional nano-micro-level battery material structural phase transition,electrolyte degradation,electrode-electrolyte interface dynamics to three-dimensional macro-safety *** paper contributes to understanding how to use optical fiber sensors to achieve“real”and“embedded”*** the inherent advantages of the advanced optical fiber sensor,it helps clarify the battery internal state and reaction mechanism,aiding in the establishment of more detailed *** advancements can promote the development of smart batteries,with significant importance lying in essentially promoting the improvement of system ***,with the help of smart batteries in the future,the importance of consistency can be weakened or even *** application of advanced optical fiber sensors helps comprehensively improve the battery quality,reliability,and life.

关键词： Smart battery Advanced embedded optical fiber sensor Battery internal physical/chemical state Quality-reliability-life characteristic

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Development of CONTHAC-3D and hydrogen distribution analysis of HPR1000

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Nuclear Science and Techniques 2024年第2期35卷 210-221页

作者： Hui Wang Jing-Jing li Yuan Chang Gong-lin li Ming Ding China Nuclear Power Engineering Co.LTD. Beijing 100084China Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin 100049China

An in-house code,CONTHAC-3D,was developed to calculate and analyze thermal-hydraulic phenomena in containments during severe ***-3D is a three-dimensional computational fluid dynamics code that can be applied to predict gas flow,diffusion,and steam condensation in a containment during a severe hypothetical accident,as well as to obtain an estimate of the local hydrogen concentration in various zones of the ***-3D was developed using multiple models to simulate the features of the proprietary systems and equipment of HPR1000 and ACP100,such as the passive cooling system,passive autocatalytic recombiners and the passive air cooling *** validate CONTHAC-3D,a GX6 test was performed at the Battelle Model Containment *** hydrogen concentration and temperature monitored by the GX6 test are accurately predicted by ***,the hydrogen distribution in the HPR1000 containment during a severe accident was *** results show that the hydrogen removal rates calculated using CONTHAC-3D for different types of PARs agree well with the theoretical values,with an error of less than 1%.As the accident progresses,the hydrogen concentration in the lower compartment becomes higher than that in the large space,which implies that the lower compartment has a higher hydrogen risk than the dome and large space at a later stage of the *** amount of hydrogen removed by the PARs placed on the floor of the compartment is small;therefore,raising the installation height of these recombiners appropriately is ***,we do not recommend installing all autocatalytic recombiners at high *** study findings in regard to the hydrogen distribution in the HPR1000 containment indicate that CONTHAC-3D can be applied to the study of hydrogen risk containment.

关键词： Hydrogen risk mitigation Pressurized water reactor HPR1000 Thermal hydraulic CONTHAC-3D

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