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SCHISTOSOMIASIS VACCINATION HISTORICAL DEVELOPMENT,PRESENT STATUS AND FUTURE PROSPECTS

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Chinese Medical Journal 1980年第5期93卷 297-312页

作者： HF Hsü sy li Hsü LK Eveland Professor Emeritus Department of Preventive Medicine and Environmental HealthCollege of MedicineUniversity of IowaIowa CityIowaUSA. Professor Department of Preventive Medicine and Environmental HealthCollege of MedicineUniversity of IowaIowa CityIowaUSA. Associate Professor Department of Microbiology and ImmunologyState University of New YorkBrooklynNew YorkUSA.

50 years of research on killed or live vaccinefor schistosomiasis without successful produc-tion of a human schistosomiasis vaccine arereviewed.

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EGFR expression as a predictive marker in esophageal squamous cell cancer:Review article

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东南大学学报（医学版） 2014年第4期33卷 540-544页

作者： TIWARI S GAUTAM M K li sy Department of Oncology Zhongda HospitalSoutheast University Department of Pediatrics Zhongda HospitalSoutheast University Department of Oncology Oncology HospitalHefei City

Esophageal cancer(EC)is a highly aggressive disease and 8thleading cause of death *** cell cancer is the main histological type in *** improvements in both surgical techniques and adjuvant/neoadjuvant radiotherapy and chemotherapy approaches have increased the survival of patients with the locoregional ***,most of the patients with EC have advanced disease either at diagnosis or at *** recent advances in the treatment,these patients still do *** expression of the epidermal growth factor receptor in esophageal cancer is associated with poor ***,very few researches have examined the role of epidermal growth factor receptor(EGFR)in prediction and therapeutic sensitivity to esophageal squamous cell cancer(ESCC).If pretherapeutic identification of esophageal squamous cell cancer which does not respond to chemoradiotherapy(CRT)can be done,it will help to improve the outcome of patients by selecting responders to *** this review we describe the predictive significance of EGFR expression in ESCC.

关键词： esophageal squamous cell cancer predictive marker chemoradiotherapy

Outbreak of mumps in a student population with high vaccination coverage in China:time for two dose vaccination

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Outbreak of mumps in a student population with high vaccinat...

Oligodendrocyte precursors-in vitro derivation from bone marrow stromal cells and use in remyelination therapy

安徽省2019年度流行病与卫生统计学学术年会

作者：秦伟 Wang Y Yang T Xu XK Meng XM Zhao CJ li sy Xie sy li KC Su H 六安市疾控中心

In 2016,an outbreak of mumps occurred in a primary school in China with a student population having high vaccination *** unmatched case-control study was performed to identify risk factors contributing to this outbreak,and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine(MuCV).A total of 97 cases were identified during the outbreak,and the overall attack rate was 8.2%.Among students with confirmed vaccination status,90% had received at least one dose of *** were more likely than non-cases to report taking the school bus during the epidemic period(adjusted OR = 2.3,95% CI:1.4-3.7).Vaccine effectiveness(VE) was higher for two-dose MuCV(76%,95% CI:49-89%) than for one-dose MuCV(59%,95% CI:36-74%).The protection afforded by both one-dose and two-dose MuCV waned over time,from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE,and from 90% to 25% over the same time period for two-dose *** found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV *** the VE of both two-dose and one-dose MuCV wanes over time,the overall VE for two-dose MuCV was superior than that of one-dose ***,a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China.

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Oligodendrocyte precursors-in vitro derivation from bone mar...

中国神经科学学会第十届全国学术会议

作者： Daisy KY Shum YP Tsui Rachel sy li Amy CY Lo YS Chan Department of Biochemistry The University of Hong Kong Department of Physiology The University of Hong Kong Department of Ophthalmology The University of Hong Kong

Myelin is crucial for survival of neurons and maintenance of neural network *** disorders are debilitating and are often associated with failure of resident oligodendrocyte precursor cells（OPCs） to differentiate into mature,myelinating *** of OPCs from a safe source that evades ethical issues offers a solution to remyelination *** therefore hypothesized that neural progenitor cells harboured at a pre-commitment stage among stromal cells of the adult bone marrow（BMSCs） can be directed to differentiate along the oligodendroglial *** started with adherent cultures of adult rat BMSCs ＞90%of which were positive for CD90,CD73 and STRO-1（stromal cell markers） but were negative for CD45（haematopoietic cell marker）.Only 10%of the BMSCs were *** to non-adherent culture fostered expansion of the nestin-positive neural progenitors（NPs） in sphere formation at the expense of stromal *** BM-NPs were maintained in adherent culture supplemented with glia-inducing factors,beta-Hereguhn,basic fibroblast growth factor and platelet-derived growth *** two weeks,cells positive for OPC markers- NG2,01ig2,PDGFRa and SoxlO,were *** cells could be expanded in culture for more than 3 months with no observable decline in marker ***-culture with dorsal root ganglion neurons induced maturation of the BM-OPCs into myelinating *** further transplanted BM-OPCs into the retina of adult rats and demonstrated that by 8 weeks,some of the BM-OPC extended,myelin basic protein-positive processes along the otherwise unmyelinated retinal *** results not only suppport our hypothesis,but also provide pointers to the adult bone marrow as a safe and accessible source for the derivation of OPCs towards transplantation therapy in demyelinating disorders.

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心理理论中的规则理论

中国组织工程研究与临床康复 2007年第39期11卷 7959-7961页

作者：李思雨李红黄恩亮西南大学教育科学院重庆市400715 西南大学心理学院西南大学中加联合儿童研究中心重庆市400715 重庆教育学院重庆市400067

目的:心理理论现有的规则理论是"认知复杂及控制理论"与"关系复杂理论",通过对这两个理论的比较、分析,意图对个体心理理论能力发展做深入探讨。资料来源:应用计算机检索Elsevier数据库和CNKI数据库1996/2005相关文章,检索词为"theroy o... 详细信息

目的:心理理论现有的规则理论是"认知复杂及控制理论"与"关系复杂理论",通过对这两个理论的比较、分析,意图对个体心理理论能力发展做深入探讨。资料来源:应用计算机检索Elsevier数据库和CNKI数据库1996/2005相关文章,检索词为"theroy of mind,rule,cognitivecomplexity,relational complexity,心理理论,规则"。资料选择:选择阐述"认知复杂及控制理论"与"关系复杂理论"的文章,排除重复文章。资料提炼:共检索到47篇关于心理理论的规则理论方面的文献,纳入33篇。资料综合:认知复杂及控制理论将执行上的失败归因于缺少对规则的反思,而不是归因于缺少对规则的意识;关系复杂理论通过概念组块和分段法降低加工负荷,它对变量进行压缩处理。关系复杂理论中的概念组块和认知复杂及控制理论中的反思来自于不同的方向,概念组块可以认为是来自通过组块对工作记忆负担的减轻,进而对复杂性程度的降低;而反思是个体本身对规则的再认识,这一过程又受到诸多因素的影响才能从多个简单规则整合成一个规则。关系复杂理论和认知复杂及控制理论都能够对心理理论任务进行解释,而真正非实验条件下的心理理论任务就需要更多的考量因素。结论:当面对多样性和层次性的心理理论任务时,这两个理论所作出的自上而下的"反思"与自下而上的"组块"有必要整合起来,形成解决任务的整合规则。

关键词：心理学认知模型规则

家庭行为阳性强化对精神分裂症患者的治疗作用

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中国组织工程研究与临床康复 2007年第34期11卷 6823-6826页

作者：李淑英吴汉荣常国胜华中科技大学同济医学院儿少卫生教研室郑州市第九人民医院精神科河南省郑州市450000

目的:了解家庭行为阳性强化对精神分裂症患者的治疗作用,为预防精神分裂症复发,改善其社会功能提供依据。A方法:选择2003-05/2005-05郑州市第九人民医院出院后的精神分裂症患者100例,其中实验组50例,对照组50例。实验组用药物治疗合并... 详细信息

目的:了解家庭行为阳性强化对精神分裂症患者的治疗作用,为预防精神分裂症复发,改善其社会功能提供依据。A方法:选择2003-05/2005-05郑州市第九人民医院出院后的精神分裂症患者100例,其中实验组50例,对照组50例。实验组用药物治疗合并阳性强化措施治疗,对照组只接受药物治疗。家庭阳性强化措施包括生活技能训练、社会能力训练、异常行为的纠正、适应工作能力的训练。分别于治疗前和治疗后半年、年、年末用阳性症状与阴性症状量表和社会功能缺陷筛选量表12进行精神病理学评定。结果:100例患者均进入结果分析。①阳性症状与阴性症状量表评分:治疗半年末实验组阳性症状与阴性症状量表总分低于对照组(P<0.05),治疗1年末实验组的阴性症状分、一般病理症状分和总分低于对照组(P<0.05、P<0.05、P<0.01)。治疗2年末实验组的阴性症状、一般病理症状、总分低于对照组(P均<0.01)。实验组阴性症状分治疗1年和2年末低于治疗前(P均<0.01),对照组阴性症状治疗2年末低于治疗前(P<0.05);实验组一般病理症状分治疗半年、1年、年末低于治疗前2(P<0.05、P<0.01、P<0.01),对照组一般病理症状分治疗1年、2年末低于治疗前(P<0.05,P<0.01);实验组总分治疗半年、1年、年末低于治疗前(P均<0.01),对照组总分治疗1年、年末低于治疗前(P<0.05,P<0.01)。②复发率:实验组22低于对照组(26%,52%,χ2=7.12,P<0.01)。③再就业率:实验组高于对照组(54%,28%,χ2=6.95,P<0.01)。④社会功能缺陷筛选量表评分:治疗1年和治疗2年末实验组与对照组比较差异有显著性(P均<0.01)。实验组治疗半年、年、年末与入12组前比较差异均有显著性(P均<0.01),对照组治疗2年末与入组前比较差异有显著性(P<0.01)。结论:家庭阳性强化疗法能改善精神分裂症患者的阴性症状,促进社会功能恢复,防止精神衰退,降低复发率,提高就业率,使患者能回归社会。

关键词：精神分裂症行为治疗家庭治疗

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery