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Dietary copper improves intestinal structural integrity in juvenile grass carp (Ctenopharyngodon idella) probably related to its increased intestinal antioxidant capacity and apical junction complex

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ANIMAL NUTRITION 2024年第3期18卷 96-106页

作者： Ma, Rui Feng, lin Wu, Pei liu, Yang Ren, Hong-Mei Jin, Xiao-Wan li, shu-wei Tang, ling Zhou, Xiao-Qiu Jiang, wei-Dan Sichuan Agr Univ Anim Nutr Inst Chengdu 611130 Peoples R China Sichuan Agr Univ Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov Chengdu 611130 Peoples R China Minist Agr & Rural Affairs Minist Educ Key Lab Anim Dis Resistance Nutr Key Lab Sichuan Prov Chengdu 611130 Peoples R China Sichuan Animtech Feed Co Ltd Anim Nutr Inst Sichuan Acad Anim Sci Chengdu 610066 Peoples R China

This research evaluated the effects of copper (Cu) on intestinal antioxidant capacity and apical junctional complex (AJC) in juvenile grass carp. A total of 1080 healthy juvenile grass carp (11.16 +/- 0.01 g) were fed six diets including different dosages of Cu, namely 0, 2, 4, 6, 8 mg/kg (Cu citrate [CuCit] as Cu source) and 3 mg/kg (CuSO4 center dot 5H(2)O as Cu source). The trial lasted for 9 weeks. The findings revealed that dietary optimal Cu supplementation (2.2 to 4.1 mg/kg) promoted intestinal growth, including intestinal length, intestinal length index, intestinal weight, and intestinal somatic index (P ling pathway might be involved. Optimal Cu had no impact on glutathione peroxidase 1b (GPx1b) gene expression (P > 0.05). On the other hand, optimal Cu increased intestinal tight junction (TJ) proteins (except for claudin 15b) and adherens junction (AJ) proteins (E-cadherin, alpha-catenin, beta-catenin, nectin and afadin) mRNA levels (P ling pathway formed by the Ras homolog gene family, member A (RhoA), Rho-associated kinase (ROCK), and myosin light chain kinase (MLCK). Finally, based on serum indicator D-lactate and intestinal oxidative damage index (ROS), Cu requirement (CuCit as Cu source) for juvenile grass carp from initial weight to final weight (from 11 to 173 g) was determined to be 4.14 and 4.12 mg/kg diet, respectively. This work may provide a theoretical foundation for identifying putative Cu regulation pathways on fish intestinal he

关键词： Copper Ctenopharyngodon idella Structural integrity Intestine NF-KAPPA-B GROWTH-PERFORMANCE ENZYME-ACTIVITIES DIAMINE OXIDASE IMMUNE FUNCTION DEFICIENCY SUPPLEMENTATION REQUIREMENT NRF2 PHOSPHORUS

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Aflatoxin B1 decreased flesh flavor and inhibited muscle development in grass carp (Ctenopharyngodon idella)

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ANIMAL NUTRITION 2024年第3期18卷 27-38页

作者： He, Xiang-Ning Zeng, Zhen-Zhen Jiang, wei-Dan Wu, Pei liu, Yang Kuang, Sheng-Yao Tang, ling li, shu-wei Feng, lin Zhou, Xiao-Qiu Sichuan Agr Univ Anim Nutr Inst Chengdu 611130 Peoples R China Sichuan Agr Univ Fish Nutr & Safety Prod Univ Key Lab Sichuan Prov Chengdu 611130 Peoples R China Minist Agr & Rural Affairs Minist Educ Key Lab Anim Dis Resistance Nutr Key Lab Sichuan Prov Chengdu 611130 Peoples R China Sichuan Acad Anim Sci Anim Nutr Inst Chengdu 610066 Peoples R China

In nature, aflatoxins, especially aflatoxin B1 (AFB1), are the common mycotoxins, which cause serious health problems for humans and animals. This paper aimed to study the effects of AFB1 on flesh flavor and muscle development of grass carp (Ctenopharyngodon idella) and its mechanism. There were 1440 individual fish in total, with 6 treatments and each treatment replicated 3 times. The 6 treatments were fed a control diet with different doses of AFB1 (0.04, 29.48, 58.66, 85.94, 110.43 and 146.92 mu g/kg diet) for 60 d. AFB1 increased myofiber diameter, as well as decreased myofiber density of grass carp muscle (P ling pathway in grass carp muscle (P < 0.05). The mRNA and protein levels of myogenic regulatory factors were downregulated in grass carp muscle (P < 0.05). Furthermore, the activities of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) were increased (P < 0.05), and the protein levels of phosphorylate-38 mitogen-activated protein kinase (p-p38MAPK), phosphorylate-c-Jun N-terminal kinase, urokinase-type plasminogen activator (uPA), MMP-2 and MMP-9 were upregulated (P < 0.05), but collagen I, laminin beta 1 and fibronectin were downregulated (P < 0.05) with the dietary AFB1 increased in the muscle of grass carp. Based on the results of this study, we can draw the following conclusion: d

关键词： Aflatoxin B1 Flesh flavor Muscle development Grass carp PLASMINOGEN-ACTIVATOR ANTIOXIDANT CAPACITY MYOBLAST CELLS AMINO-ACID EXPRESSION RECEPTOR GROWTH SUPPLEMENTATION METABOliSM MECHANISMS

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Theoretical Studies on Structures and Properties of Endohedral Fullerenes Complexes: XH_n@C_(32)(X=F, O, N, C; n=1―4)

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Chemical Research in Chinese Universities 2008年第2期24卷 220-222页

作者： CHANG Ying-fei HONG Bo SUN li-li TANG shu-wei WANG Rong-shun Institute of Functional Material Chemistry Faculty of Chemistry Northeast Normal University Changchun 130024 P R. China

Theoretical studies on structures and properties of endohedral fullerene complexes formed by encapsulating small molecules of HF, H20, NH3, and CH4 in a C32 fullerene cage, were carried out by ab initio method. Current calculations reveal that these processes to encase them in fullerene are energetically unfavorable because of the small cavity size of C32. The red shift in the F-H stretching frequency indicates the potential existence of hydrogen bonding between the HF molecule and the carbon cage.

关键词： Endohedral fullerene C32 Ab initio Stretching frequency Hydrogen bonding

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A Semiparametric Additive-multiplicative Rates Model for the weighted Composite Endpoint of Recurrent and Terminal Events

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Acta Mathematica Sinica,English Series 2024年第4期40卷 985-999页

作者： Yi DENG Qiang XIONG shu wei li School of Economics and Statistics Guangzhou UniversityGuangzhou 510006P.R.China

Recurrent event data are commonly encountered in many scientific fields,including biomedical studies,clinical trials and epidemiological surveys,and many statistical methods have been proposed for their *** this paper,we consider to use a weighted composite endpoint of recurrent and terminal events,which is weighted by the severity of each event,to assess the overall effects of covariates on the two types of events.A flexible additive-multiplicative model incorporating both multiplicative and additive effects on the rate function is proposed to analyze such weighted composite event process,and more importantly,the dependence structure among the recurrent and terminal events is left *** the estimation,we construct the unbiased estimating equations by virtue of the inverse probability weighting technique,and the resulting estimators are shown to be consistent and asymptotically normal under some mild regularity *** evaluate the finite-sample performance of the proposed method via simulation studies and apply the proposed method to a set of real data arising from a bladder cancer study.

关键词： Additive-multiplicative rates model estimating equation recurrent events terminal event weighted composite endpoint

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Atomic Force Microscopy on the Ga_(0.16)In_(0.84)As_(0.80)Sb_(0.20)Epilayer Grown by Metalorganic Chemical Vapor Deposition

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Chinese Physics Letters 1998年第10期15卷 724-726页

作者： GAO Chun-xiao li shu-wei YANG Jie liU Bing-bing State Key Laboratory for Superhard Materials Jilin UniversityChangchun 130023 Changchun Institute of Physics Chinese Academy of SciencesChangchun 130021

The atomic force microscopy study was made on the quaternary Ga_(0.16)In_(0.84)As_(0.80)Sb_(0.20) epilayer prepared on GaSb substrate by metalorganic chemical vapor *** island-like defects were found on the substrate surface pretreated *** the growth process going,these island-like defects could be buried by the *** the initial stage,two-dimensional-growth-mode was *** the epilayer thickness reached 70nm,three-dimensional(3D)-growth-mode occurred and the perfect 3D islands were observed.

关键词： island mode buried

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高光泽水性双组分羟基丙烯酸清漆的研制

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现代涂料与涂装 2024年第4期27卷 8-10+13页

作者：李桂琴罗晖何智豪李树伟刘其平清远明宇材料科技有限公司

基于双组分羟基丙烯酸清漆在较高温度干燥过程中，漆膜出现橘皮收缩、缩孔等缺陷，研究了羟基丙烯酸分散体羟值、多异氰酸酯固化剂对漆膜性能的影响，分析了体系黏度的影响因素，优化配方组成和施工过程，结果如下：1）羟基丙烯酸分散... 详细信息

基于双组分羟基丙烯酸清漆在较高温度干燥过程中，漆膜出现橘皮收缩、缩孔等缺陷，研究了羟基丙烯酸分散体羟值、多异氰酸酯固化剂对漆膜性能的影响，分析了体系黏度的影响因素，优化配方组成和施工过程，结果如下：1）羟基丙烯酸分散体选择羟值3.9%;2)3种多异氰酸酯组分复配，以水相容性较高的组分包裹水容性较低的组分，提高漆膜外观，优化漆膜干燥速度；3)A组分溶剂选择乙二醇丁醚与丙二醇丁醚复配，B组分的稀释溶剂选择丙二醇二乙酸酯；4）施工过程预先将A组分与B组分搅拌均匀再加去离子水；5）制备得到干燥速度快、光泽高的水性双组分羟基丙烯酸清漆，漆膜各项性能满足要求。

关键词：双组分羟基丙烯酸清漆羟值多异氰酸酯复配光泽

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Experimental test of a new neutron threshold detector and its application

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Nuclear Science and Techniques 2002年第3期13卷 149-155页

作者： li Gui-Sheng, ZHANG Tian-Mei, SU You-Wu, li shu-wei(Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) Institute of Modern Physics the Chinese Academyo f Sciences Lanzhou 730000 Institute of Modern Physics the Chinese Academyo f Sciences Lznahou 730000

The possibility of using 209Bi as a new threshold detector to measurc high-energy neutrons was investigated for the first time. At the same time the experiment measured successfully the emitted neutron fiuence rate, energy spectrum and dose equivalent rate distributions in the heavy ion target area using a detector complex including 209Bi, 115In, 27A1, 19F and 12C samples.

关键词：阈探测器中子谱实验

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基于脱落细胞DNA倍体定量分析的口腔鳞状细胞癌筛查及效果评价

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临床口腔医学杂志 2024年第2期40卷 93-96页

作者：李淑薇李兴强辛颖张佳郭小梅赵倩齐红西安交通大学口腔医院、陕西省颅颌面精准医学研究重点实验室陕西西安710004 陕西省牙颌面疾病临床研究中心陕西西安710004 西安交通大学口腔医院病理科陕西西安710004 西安交通大学口腔医院头颈肿瘤外科陕西西安710004 西安交通大学口腔医院口腔黏膜病科陕西西安710004

目的:探究DNA倍体定量分析技术在口腔鳞状细胞癌筛查中的应用及效果评价。方法:2022年3月~2023年6月,对西安交通大学口腔医院门诊及住院107例患者,进行DNA倍体筛查及液基细胞学检查。DI>2.5的患者,为阳性患者,进行病理组织活检;DI2.5且... 详细信息

目的:探究DNA倍体定量分析技术在口腔鳞状细胞癌筛查中的应用及效果评价。方法:2022年3月~2023年6月,对西安交通大学口腔医院门诊及住院107例患者,进行DNA倍体筛查及液基细胞学检查。DI>2.5的患者,为阳性患者,进行病理组织活检;DI2.5且病理结果为恶性的患者共24例,DNA倍体诊断意见与病理报告结果相符,吻合率为100%;DI>2.5,病理结果未明确恶性的1例,为鳞状上皮乳头状增生,部分上皮中-重度不典型增生;D1<2.5,病理结果为良性的患者2例;病理结果为恶性的患者1例,显示有效检测细胞不足。口腔鳞状细胞癌共22例,21例DNA倍体诊断意见与病理报告结果相符,吻合率为95.45%。结论:对于口腔鳞状细胞癌,DNA倍体筛查结果与病理活检结果的吻合率较高,DNA倍体定量分析比传统的细胞学检查敏感,是一种较为可靠、客观的口腔癌无创筛查方法.

关键词： DNA倍体定量分析技术口腔鳞状细胞癌筛查

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Progress in preparation of AlN-reinforced magnesium matrix composites:A review

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China Foundry 2024年第1期21卷 1-10页

作者： Lu Chen shu-lin Lü Di-jia Zhao wei Guo Jian-yu li shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material,AlN has very good thermophysical and mechanical *** addition,AlN is an effective refining agent for Mg alloys because it has a lattice constant similar to that of ***,AlN is an ideal reinforcement for magnesium matrix composites(MMCs),and is attracting increasing *** review addresses the development of preparation technologies for AlN-reinforced Mg matrix *** mainstream preparation techniques include stir casting,melt infiltration,powder metallurgy,and in-situ *** addition,the advantages and disadvantages of these techniques are analyzed in depth,and it is pointed out that the next direction for the preparation of high-performance AlN-reinforced MMCs is less aluminization and multiple technologies integration.

关键词： AlN MMCs preparation thermophysical property mechanical property

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Transverse momentum balance of dijets in Xe+Xe collisions at the LHC

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Nuclear Science and Techniques 2024年第7期35卷 137-146页

作者： Yao li shu-Wan Shen Sa Wang Ben-wei Zhang Key Laboratory of Quark&Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan430079China College of Science China Three Gorges UniversityYichang443002China Center for Astronomy and Space Sciences and Institute of Modern Physics China Three Gorges UniversityYichang443002China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Guangdong Provincial Key Laboratory of Nuclear ScienceSouthern Nuclear Science Computing CenterSouth China Normal UniversityGuangzhou510006China

We present a theoretical study of the medium modifications of the p_(T)balance (x_(J)) of dijets in Xe+Xe collisions at■.The initial production of dijets was carried out using the POWHEG+PYTHIA8 prescription,which matches the next-toleading-order (NLO) QCD matrix elements with the parton shower (PS) *** SHELL model described the in-medium evolution of nucleus–nucleus collisions using a transport *** theoretical results of the dijet xJin the Xe+Xe collisions exhibit more imbalanced distributions than those in the p+p collisions,consistent with recently reported ATLAS *** utilizing the Interleaved Flavor Neutralisation,an infrared-and-collinear-safe jet flavor algorithm,to identify the flavor of the reconstructed jets,we classify dijets processes into three categories:gluon–gluon (gg),quark–gluon (qg),and quark–quark (qq),and investigated the respective medium modification patterns and fraction changes of the gg,qg,and qq components of the dijet sample in Xe+Xe *** is shown that the increased fraction of qg component at a small x_(J)contributes to the imbalance of the dijet;in particular,the q_(1)g_(2)(quark-jet-leading) dijets experience more significant asymmetric energy loss than the g_(1)q_(2)(gluon-jet-leading) dijets traversing the *** comparing the■of inclusive,■ dijets in Xe+Xe collisions,we observe■.Moreover,ρ_(Xe),P_(b),the ratios of the nuclear modification factors of dijets in Xe+Xe to those in Pb+Pb,were calculated,which indicates that the yield suppression of dijets in Pb+Pb is more pronounced than that in Xe+Xe owing to the larger radius of the lead nucleus.

关键词： Heavy-ion collisions Quark-gluon plasma Jet quenching Transverse momentum balance

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