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Synthesis of 6E-Geranylgeraniol-19-oic Acid

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Chemical Research in Chinese Universities 2003年第3期19卷 294-296页

作者： li shu hua PENG li Zeng li Wei dong li Yu lin National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou UniversityLanzhou 730000P.R.China

The present paper deals with the facile synthesis of 6 E geranylgeraniol 19 oic acid(1), a naturally occuring alicyclic diterpene acid, by a Horner Wadsworth Emmons olefination of two readily available fragments 7 and 3.

关键词： Horner Wadsworth Emmons reaction 6E-Geranylgeraniol-19-oic acid Synthesis

A new hydroxybenzoic acid glycosides from the plant of Trifolium lupinaster

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Chinese Chemical Letters 2010年第3期21卷 322-324页

作者： Wang, li Yan Xu, Qun li, shu hua Zhao, Bing Yang, Fei Qiqihar Univ Coll Chem & Chem Engn Qiqihar 161006 Peoples R China

A new 5-O-(β-D-glucopyranosyl)-6 -O-benzoyl-2,5-dihydroxybenzoic acid was isolated from the ethyl acetate extract from the whole plants of Trifolium lupinaster *** structure was determined and deduced on the basis of... 详细信息

关键词： Hydroxybenzoic acid glycosides Trifolium lupinaster Isolation

Stereoselective Palladium-catalyzed Cross-coupling of （2-Amido-l-phenylpropyl）zinc Compounds with Aryl Bromides

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Chemical Research in Chinese Universities 2013年第4期29卷 678-681页

作者： TANG Shi ZHOU Dong li shu-hua WANG Nai-xing College of Chemistry and Chemical Engineering Jishou University Jishou 416000 P. R. China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P R. China

A controllable diastereoselective C（sp2）-C（sp3） Negishi coupling reaction of secondary benzylic zinc reagents with aryl bromides to form medicinally important 2-arylphenylethylamines was *** the presence of Pd（OAc）2 and 2-dicyclohexylphosphino-2＇,6＇-dimethoxybiphenyl（S-phos）,open-chain（2-amido-1-phenylethyl）zinc reagent bearing a β-NHAc or NHCHO group undergoes coupling reaction to give syn-1-arylphenylethylamine mainly,whereas the zinc reagent bearing a sterically hindered β-amido group,for example NHCOC（CH3）2OTBS undergoes the coupling reaction to yield anti-1-arylphenylethylamines with a configuration *** addition,a working mechanism for the stereoselective Negishi cross-coupling was also proposed.

关键词： Palladium Stereoselective Negishi coupling Benzylic zinc 2-Arylphenylethylamine

Organic skeleton correspondence using part arrangements

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Applied Mathematics(A Journal of Chinese Universities) 2019年第3期34卷 326-339页

作者： li shu-hua liU Xiu-ping CAO Jun-jie WANG Shi-yao School of Mathematical Sciences Dalian University of Technology

Shape correspondence between semantically similar organic shapes with large shape variations is a difficult problem in shape *** part geometries are no longer similar,we claim that the challenge is to extract and compare prominent shape substructures,which are recurring part arrangements among semantically related *** main premise is that the challenge can be solved more efficiently on curve skeleton graphs of shapes,which provide a concise abstraction of shape geometry and *** of directly searching exponentially many skeleton subgraphs,our method extracts the intrinsic reflectional symmetry axis of the skeleton to guide the generation of subgraphs as part *** any two subgraphs from two skeletons,their orientations are aligned and their pose variations are normalized for ***,the matchings of all subgraph pairs are evaluated and accumulated to the skeletal feature node *** comparison results with the state-of-the-art work show that our method significantly improves the efficiency and accuracy of the semantic correspondence between a variety of shapes.

关键词： shape correspondence skeleton symmetry axis shape substructure

Inhibitory effects of Veratrum nigrum L. Var. ussurience Nakai alkaloids on the hypertrophy of cardiomyocytes from neonatal rat

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沈阳药科大学学报 2008年第S1期25卷 91-92页

作者： WANG li,li shu-yuan,li hua,ZHOU Qin(Dalian Medical University,Da lian 116044,China)

Objective To examine the effects of Veratrum nigrum *** Nakai alkaloids(VnA)on angiotensin Ⅱ(AngⅡ)-induced cardiomyocyte hypertrophy and to explore its possible *** The cadiocytes were induced by AngⅡ to set up myocardial hypertrophy model,the animals were divided into six groups according to the different treatments:control group,model group,positive control group,VnA group(low,middle and high dose).The cell protein content,the cell diameter and the expression of calcineurin(CaN)were measured respectively by BCA method,the micrometer and immunofluorescence *** VnA(middle and high dose)and Captopril inhibited significantly the increase in the protein content induced by AngⅡ(P<0.01).VnA and Captopril inhibited significantly the increase in the diameters induced by AngⅡ(P<0.01).By immunofluorescence analysis,the expression of calcineurin(CaN)was obviously increased in the AngⅡ-induced model *** decreased the expression of CaN *** VnA could inhibit the cardiomyocyte hypertrophy induced by AngⅡ significantly in a dose-dependent *** possible mechanism may be related to the inhibition of CaN expression.

关键词： Veratrum nigrum L. Var. ussurience Nakai alkaloids angiotensin Ⅱ cardiac hypertrophy calcineurin

FRACTALS OF HYBRID ORBITALS AND THEIR APPliCATIONS IN THE ENZYME MODELS

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Chinese Chemical Letters 1990年第3期1卷 257-260页

作者： Hou Qiang li shu hua CHEN hua Ming ZHAO Department of Chemistry.Sichuan University.Chengdu 610064

An enzyme is a kind of protein with catalytic activity and long chain,and its structure and shape are determined by the hybridized state of atomic *** fractal dimension(D_f)is closely related to the hybridization,e.g.D_f=2ln2/ln[2(1+α/(1-α))]for the spa type, where a denotes the fraction of the s orbital in the hybridized molecular *** relationship and the five fractal theorems introduced by the present paper play an important role in the investigations of the model of imitative enzyme.

关键词： FRACTALS OF HYBRID ORBITALS AND THEIR APPliCATIONS IN THE ENZYME MODELS Nature

Sensitized Luminescence of Rare Earths

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Chemical Research in Chinese Universities 1996年第1期12卷 10-15页

作者： SI Zhi-kun HU Jing-tian JIANG Wei and ZHU Gui-yun(Department of Chemistry, Shandong University, Jinan, 250100)li shu-hua(Department of Basic Courses, Shandong Institute of light Industry, jinan, 250100) SHANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA SHANDONG INST liGHT IND DEPT BASIC COURSESJINAN 250100PEOPLES R CHINA

The enhancement effect on the fluorescence intensities of an Eu3+ (or/and Sm3+ )-thenoyltrifluoroacetone (TTA )-dibenzo-18-crown-6 (18-C-6 ) system and Eu 3+ (or /and Sm3+ ) -benzoyltrifluoroacetone (BTA )-cetyltrimethylammonium bromide (CTMAB) system by dysprosium has been studied. In the presence of enhancing ions, the fluorescence intensities of the above systems were enhanced by a factor of about 40-150, respectively. The above systems were used for the determination of europlum or/and samarium in rare earths oxides and gave satisfactory results.

关键词： Sensitized luminescence Rare earths Fluorescence

The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

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中国园林 2007年第7期 28-29页

作者： XIE Jun-fei, li Yan-ming, li shu-hua

1 Preface In urban green space system, urban parks, with wide space, perfect facilities, low density of building, can provide excellent emergency shelter condition. Due to

关键词： The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

Outcomes of upper airway reconstructive surgery for obstructive sleep apnea syndrome based on polysomnography after nasopharyngeal tube insertion

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Chinese Medical Journal 2013年第24期126卷 4674-4678页

作者： li shu-hua WU Da-hai BAO Ji-min SHI Hong-jin Department of Otolaryngology-Head and Neck Surgery GeneralHospital of Shenyang Military Area Command Shenyang Liaoning110840 China Department of Otolaryngology-head and Neck Surgery Liaoning Jinqiu Hospital Shenyang Liaoning 110016 China

Background The most common obstruction sites for obstructive sleep apnea hypopnea syndrome （OSAHS） are the oropharynx and the glossopharyx. The diagnosis of glossopharyngeal airway obstruction is difficult. The study aimed to assess the effect of upper airway reconstructive surgery for OSAHS based on polysomnography （PSG） after nasopharyngeal tube insertion （NPT-PSG）, and to evaluate the clinical value of NPT-PSG in localizing the obstructive sites. Methods Seventy-nine OSAHS patients diagnosed with PSG were included in the study. PSG was repeated with a nasopharyngeal tube in place （NP＇r-PSG）. Results of the two PSGs were compared. A NPT-PSG apnea hypopnea index （AHI） greater than 15 times per hour was used as a threshold for glossopharyngeal surgery. The cause of glossopharyngeal airway obstruction was taken into consideration in planning glossopharyngeal surgery. Assessment of efficacy was followed-up. Results After NPT-PSG, patients＇ AHI significantly decreased and lowest oxygen saturation （LaSO2） significantly increased. Of the 79 patients, 47 were treated with uvulopalatopharyngoplasty （UPPP） alone and 32 with UPPP ＋ glossopharyngeal surgery. Thirty-two patients were considered cured, 33 markedly improved, and 14 failed. The overall surgery success rate was 82.3%. Conclusions NPT-PSG can be used as a diagnosis tool for localizing airway obstruction in OSAHS patients. Surgical treatment based on NPT-PSG results in good treatment efficacy.

关键词： obstructive sleep apnea hypopnea syndrome, nasopharyngeal tube, polysomnography surgery