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U-Pb zircon geochronology of basaltic pyroclastic rocks from the basement beneath the Xisha Islands in the northwestern South China Sea and its geological significance

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Acta Oceanologica Sinica 2024年第2期43卷 83-93页

作者： Yu Zhang Kefu Yu shiying li Guangxi Laboratory on the Study of Coral Reefs in the South China Sea Guangxi UniversityNanning 530004China Coral Reef Research Center of China Guangxi UniversityNanning 530004China School of Marine Sciences Guangxi UniversityNanning 530004China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou 510301China

As one of the micro-blocks dispersed in the South China Sea(SCS), the basement of the Xisha Islands has rarely been drilled because of the thick overlying Cenozoic sediments, which has led to a confused understanding of the pre-Cenozoic basement of the Xisha Islands. Well CK-1, a kilometer-scale major scientific drill in the Xisha Islands in the northwestern SCS, penetrated thick reefal limestone(0–888.4 m) and the underlying basement rocks(888.4–901.4 m). In this study, we present the zircon U-Pb ages of basement basaltic pyroclastic rocks from Well CK-1 in the Xisha Islands of the northwestern SCS to investigate the basement nature of the Xisha microblock. The basement of Well CK-1 consists of basaltic pyroclastic rocks on the seamount. The zircon grains yielded apparent ages ranging from ca. 2 138.9 Ma to ca. 36 Ma. The old group of zircon grains from Well CK-1 was considered to be inherited zircons. Two Cenozoic zircons gave a weighted mean 206Pb/238U age of(36.3 ± 1.1) Ma,Mean Squared Weighted Deviations(MSWD) = 1.2, which may represent the maximum age of the volcano eruption. The Yanshanian inherited zircons(116.9–105.7 Ma and 146.1–130.2 Ma) from Well CK-1 are consistent with the zircons from Well XK-1, indicating that the basement of Chenhang Island may be similar to that of Well XK-1. We propose that the Xisha micro-block may have developed on a uniform Late Jurassic metamorphic crystalline basement, intruded by Cretaceous granitic magma.

关键词： South China Sea Xisha Islands basaltic pyroclastic rocks zircon

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Green Synthesis of Iron(Ⅱ,Ⅲ)-polyphenol Nanoparticles and Their Adsorption of Malachite Green

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 1025-1030页

作者：胡玉 ZHOU Fan ZHANG Nan PAN Xiaobin li shiying ZHANG Dong li li 张玲帆 Department of Chemistry and Environmental Engineering Hanjiang Normal UniversityShiyan 442000China Shiyan Hydrological and Water Resources Survey Bureau of Hubei Province Shiyan 442000China School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai 200237China

Three kinds of iron nanoparticles(FeNPs)were prepared via green route based on pomegranate(PG),green tea(GT),and mulberry(ML)extracts under ambient *** obtained materials were characterized by scanning electron microscopy(SEM),transmission electronic microscopy(TEM),X-ray energy-dispersive spectrometer(EDS),X-ray diffraction(XRD),fourier transform infrared spectroscopy(FTIR),and X-ray photoelectron spectroscopy(XPS)*** experimental results show that FeNPs were in the form of amorphous iron(Ⅱ,Ⅲ)-polyphenol complex with different dispersity and ***-Fe has the smallest size range of 25-35 nm,PG-Fe has a moderate size-distribution of 30-40 nm,while ML-Fe formed a tuberous net-type with a sheeting ***-Fe displays the highest removal efficiency of 90.2%in 20 min towards cationic dye of malachite green(16.6%by ML-Fe and 69.3%by GT-Fe),which is attributed to its highest polyphenol content,lowest zeta potential,as well as the most Fe^(2+)on the surface of *** removal mechanism was mainly induced by electrostatic adsorption based on pH and zeta potential tests.

关键词： iron nanoparticles pomegranate green tea mulberry adsorption

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Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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Chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang Kong Yanmei li Ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao shiying li Hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

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Transferrin receptor-targeted immunostimulant for photodynamic immunotherapy against metastatic tumors through β-catenin/CREB interruption

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ACTA PHARMACEUTICA SINICA B 2024年第9期14卷 4118-4133页

作者： Yan, Mengyi Chen, Xiayun li, Xiaotong liu, Qianqian Yu, Baixue Cen, Yi Zhang, Wei liu, Yibin li, Xinxuan Chen, Ying Wang, Tao li, shiying Guangzhou Med Univ Affiliated Hosp 5 Guangdong Prov Key Lab Mol Target & Clin Pharmacol NMPASch Pharmaceut Sci Guangzhou 511436 Peoples R China Guangzhou Med Univ Sch Pharmaceut Sci State Key Lab Resp Dis Guangzhou 511436 Peoples R China Southern Med Univ Zhujiang Hosp Dept Pulm & Crit Care Med Guangzhou 510280 Peoples R China Guangzhou Med Univ Dept Anesthesiol Clin Sch 2 Guangzhou 511436 Peoples R China Guangzhou Med Univ Affiliated Hosp 1 Guangzhou Inst Resp Hlth State Key Lab Resp DisGuangdong Key Lab Vasc Dis Guangzhou 510120 Peoples R China

The immunosuppressive phenotype of tumor cells extensively attenuates the immune activation effects of traditional treatments. In this work, a transferrin receptor (TfR) targeted immunostimulant (PTI) is fabricated for photodynamic immunotherapy against metastatic tumors by interrupting beta-catenin signal pathway. To synthesize PTI, the photosensitizer conjugated TfR targeting peptide moiety (PalmiticK(PpIX)-HAIYPRH) is unitized to encapsulate the transcription interrupter of ICG-001. On the one hand, the recognition of PTI and TfR can promote drug delivery into tumor cells to destruct primary tumors through photodynamic therapy and initiate an immunogenic cell death with the release of tumor-associated antigens. On the other hand, PTI will interrupt the binding between beta-catenin and cAMP response element-binding protein (CREB), regulating the gene transcription to downregulate programmed death ligand 1 (PD-L1) while upregulating C-C motif chemokine ligand 4 (CCL4). Furthermore, the elevated CCL4 can recruit the dendritic cells to present tumor-specific antigens and promote T cells activation and infiltration, and the downregulated PD-L1 can avoid the immune evasion of tumor cells and activate systemic anti-tumor immunity to eradicate lung metastasis. This work may inspire the development of antibody antibody-free strategy to activate systemic immune response in consideration of immunosuppressive conditions. (C) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. This is an open access article underthe CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Transferrin receptor beta-Catenin signal pathway Tumor targeting Photodynamic therapy Immunotherapy Immunogenic cell death Programmed death ligand 1 C- C motif chemokine ligand 4 CELLS PD-L1

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战略科学家共同体与智库科技期刊的共演模式研究

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中国科技期刊研究 2024年第8期35卷 1066-1073页

作者：张闳肆李诗颖中国工程院战略咨询中心清华大学能源与动力工程系四川大学公共管理学院

【目的】分析战略科学家共同体与智库科技期刊的共演过程，基于生态系统共演的视角提出加强智库科技期刊建设的对策建议。【方法】采用网络调研法、访谈法及单案例纵向研究法，对智库科技期刊与战略科学家共同体的共演过程阶段进行理论... 详细信息

【目的】分析战略科学家共同体与智库科技期刊的共演过程，基于生态系统共演的视角提出加强智库科技期刊建设的对策建议。【方法】采用网络调研法、访谈法及单案例纵向研究法，对智库科技期刊与战略科学家共同体的共演过程阶段进行理论分析；根据智库科技期刊不同发展阶段的资源动态，研究智库科技期刊与战略科学家共同体在共演过程中的资源交互。【结果】战略科学家共同体与智库科技期刊的共演是一个动态过程，在资源初建期、资源整合期和资源增益期的不同阶段相应产生资源联结与共建、资源协同与转化、资源涵养与增效等资源编排行为。【结论】应加强对智库科技期刊的科学家资源投入与整合，发挥战略科学家共同体促进智库科技期刊发展的功能，实现智库科技期刊发展与战略科学家职业成长的双向促进。

关键词：战略科学家智库智库科技期刊共演

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纳米抗氧化剂减轻心肌缺血再灌注损伤的研究进展

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中华心血管病杂志 2024年第6期52卷 729-734页

作者：付文佩邓诚李诗莹张丽谢明星杨亚利华中科技大学同济医学院附属协和医院超声医学科武汉430022

心肌缺血再灌注损伤是缺血心肌恢复血流灌注过程中心肌细胞进一步损伤、坏死和凋亡的现象,严重影响冠状动脉血流再通术患者预后。氧化应激是介导心肌缺血再灌注损伤发生发展的重要机制之一,使用抗氧化剂清除活性氧可有效缓解氧化应激、... 详细信息

心肌缺血再灌注损伤是缺血心肌恢复血流灌注过程中心肌细胞进一步损伤、坏死和凋亡的现象,严重影响冠状动脉血流再通术患者预后。氧化应激是介导心肌缺血再灌注损伤发生发展的重要机制之一,使用抗氧化剂清除活性氧可有效缓解氧化应激、减轻心肌缺血再灌注损伤。纳米抗氧化剂是一种新型抗氧化剂,相较于传统抗氧化剂,可改善治疗药物药代动力学和药效学性能,提高治疗效果,减少副作用,具有良好临床应用前景。该文就纳米抗氧化剂在心肌缺血再灌注损伤治疗中的最新研究进展进行综述。

关键词：心肌缺血心肌缺血再灌注损伤纳米抗氧化剂氧化应激活性氧

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射流清洗对微灌过滤器滤网清洗效果及损伤研究

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排灌机械工程学报 2024年第1期42卷 102-108页

作者：李诗莹叶含春王振华刘宁宁张金珠李淼石河子大学水利建筑工程学院新疆石河子832000 现代节水灌溉兵团重点实验室新疆石河子832000 兵团工业技术研究院新疆石河子832000

为探究射流清洗技术在农业微灌过滤器清洗过程中的应用,开展射流清洗试验研究,分析入射压力、喷嘴口径、喷嘴扩散角度等3个参数对微灌过滤器滤网清洗效果及表面损伤程度的影响规律.试验结果表明:清洗效果随入射压力、喷嘴口径、喷嘴扩... 详细信息

为探究射流清洗技术在农业微灌过滤器清洗过程中的应用,开展射流清洗试验研究,分析入射压力、喷嘴口径、喷嘴扩散角度等3个参数对微灌过滤器滤网清洗效果及表面损伤程度的影响规律.试验结果表明:清洗效果随入射压力、喷嘴口径、喷嘴扩散角度的增大而提升,但提升幅度不断减小;滤网表面损伤程度随入射压力、喷嘴口径的增大而增大,随喷嘴扩散角度的增大而减小,其幅度逐渐减小;通过方差分析可知,射流参数对清洗效果影响程度从大到小依次为喷嘴口径、入射压力、喷嘴扩散角度,对滤网表面损伤影响程度从大到小依次为喷嘴口径、喷嘴扩散角度、入射压力;通过TOPSIS综合评价得到最佳射流参数组合为入射压力0.3 MPa,喷嘴口径3 mm,喷嘴扩散角度80°.

关键词：微灌过滤器滤网射流清洗射流参数清洗效果基体损伤

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Unified Fast Suboptimal Fixed-IntervalWhite Noise Wiener Smoothing Algorithm^1）

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自动化学报 2004年第2期30卷 224-228页

作者： DENGZi-li XUYan shiying SUNShu-li InstituteofAppliedMathematicsandDepartmentofAutomation HeilongjiangUniversityHarbin150080

For the discrete stochastic control systems with correlated noises, using the Kalman fil-tering method, based on the CARMA innovation model, a unified optimal fixed-interval whitenoise recursive Wiener smoother is derived. It contains high degree polynomial matrices with coef-ficient matrices exponentially decaying to zero. Further, by the truncation method, the corre-sponding fast suboptimal fixed-interval white noise Wiener smoothing algorithm is presented,which obviously reduces the computational burden. The error formula of the smoother and theformula of selecting the truncated index are given. A simulation example for Bernoulli-Gaussianwhite noise shows the effectiveness of the proposed results.

关键词：线性离散随机控制系统 Wiener平滑器白噪声估值器 Wiener平滑算法

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光电氧化降解饮用水中有机污染物的效能

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环境工程学报 2024年第2期18卷 409-417页

作者：敖钰洁黄星星李世颖卢金锁西安建筑科技大学环境与市政工程学院西安710055 陕西省环境工程重点实验室西安710055 中国电力工程顾问集团华东电力设计院有限公司上海200000

针对地表水中普遍存在的有机污染物现状和常规水处理工艺无法去除有机污染物的问题,以紫外光电氧化技术为基础,提出了以“分质供水”为目标的末端深度水处理工艺。与单独电解和光解相比,电化学氧化与紫外耦合技术可以将布洛芬、阿特拉... 详细信息

针对地表水中普遍存在的有机污染物现状和常规水处理工艺无法去除有机污染物的问题,以紫外光电氧化技术为基础,提出了以“分质供水”为目标的末端深度水处理工艺。与单独电解和光解相比,电化学氧化与紫外耦合技术可以将布洛芬、阿特拉津、三氯乙酸、乐果的降解率在15 min内分别提高到92.5%、98.1%、71.0%和94.6%,并且能耗有所降低。电流和光强对光电氧化降解有机污染物有促进作用,但污染物初始质量浓度、Cl^(-)、HCO_(3)^(-)和天然有机物(HA)和污染物去除率呈反比关系。在此基础上,以布洛芬为污染物代表,测定了布洛芬的中间产物,并计算了降解中间体的毒性变化,发现光电氧化明显降低了布洛芬的毒性。

关键词：光电氧化饮用水处理有机污染物布洛芬毒性计算

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Looking at nerves,seeing the mind:Yu-Chuan Tsang as a modern Chinese physiological psychologist

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Protein & Cell 2021年第11期12卷 825-831页

作者： shiying li WEI CHEN SHENGJUN WEN Center for Brain Mindand EducationShaoxing UniversityShaoxing 312000China Department of Cognitive Neurology Hertie Institute for Clinical Brain ResearchUniversity of Tübingen72076 TübingenGermany

Yu-Chuan Tsang(臧玉洤,1901-1964),styled Botan(伯潭),was an outstanding Chinese physiological psychologist,a comparative neuroscientist,and a neuroanatomist(Fig.1).He was a member of the First Council of the Chinese Society for Anatomical Sciences,an executive member of the sec-ond,third,fourth and fifth councils,and the Chairman of the Third *** was one of the founders of neuroanatomy in modem China and the Beijing Medical College(now the Department of Medicine at Peking University).Neu-roanatomy is a discipline that consists of making observa-tions and making ***,there are different interdisciplinary subjects based on neuroscience,including cognitive science,neurobehavioral science,neuroengineer-ing,and ***'s academic career followed an opposite direction,starting from psychology and turning to neuroanatomy,where he made remarkable achievements.

关键词： anatomy turning Chuan

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