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基于混合特征选择的中小学生近视影响因素及预测分析

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预防医学论坛 2024年第5期30卷 362-367页

作者：邢蒙李红梅张雪王铭李依霏西安市新城区疾病预防控制中心学校卫生科陕西710000 西安市新城区疾病预防控制中心传染病控制科

目的建立近视预测模型,分析西安市新城区中小学生近视影响因素,为制定学生近视防控策略以及干预措施的实施提供科学依据。方法基于2022年陕西省学生常见病监测项目,使用5 m标准对数视力表进行视力检查,并用台式电脑验光仪对学生眼睛... 详细信息

目的建立近视预测模型,分析西安市新城区中小学生近视影响因素,为制定学生近视防控策略以及干预措施的实施提供科学依据。方法基于2022年陕西省学生常见病监测项目,使用5 m标准对数视力表进行视力检查,并用台式电脑验光仪对学生眼睛进行屈光度检测。将参与视力筛查及填写调查问卷的2 511名学生纳入研究,分别使用支持向量机递归特征消除(SVM-RFE)、基于交叉验证的最小绝对收缩和选择算子回归(LASSOCV)、χ^(2)检验-SelectKBest、决策树-SelectFromModel、互信息法用于近视影响因素的筛选,将筛选出的变量分别纳入多因素logistic回归和5种分类预测模型,进行近视发生风险预测。结果共检出近视1 780名,近视率为70.89%(1 780/2 511),男生近视率为69.24%(833/1 203)、女生近视率为72.4%(947/1 203)。小学、初中、高中和职高学生近视率分别为54.69%(560/1 024)、78.96%(473/599)、84.12%(747/888)。所有变量在5种特征选择方法前15名中出现3次及以上的共17个。5种特征选择方法中,5种均选择了年龄、父母是否近视;4种选择了父母是否提醒注意读写姿势,读写时胸口离桌子边沿超过一拳,参加英语、数学、写作等文化类补习班时间。logistic回归结果显示,年龄(O R=1.329,95%CI:1.286~1.373,P<0.001)、父母近视情况(父母一方近视O R=1.808,95%C I:1.453~2.251,P<0.0001;父母均近视O R=3.566,95%CI:2.691~4.726,P<0.001)、父母提醒注意读写姿势(O R=1.349,95%CI:1.092~1.666,P=0.006)、课间休息时在户外活动(O R=0.774,95%CI:0.636~0.943,P=0.011)、看电视时眼睛距离电视显示屏超过3 m(经常或总是O R=0.792,95%CI:0.589~1.064,P=0.122;从不或者偶尔O R=1.099,95%CI:0.835~1.445,P=0.501)、平均每天放学后做作业读书时间(O R=1.342,95%CI:1.105~1.631,P=0.003)是近视发生的影响因素。5种模型预测结果显示,各模型变量筛选后性能均优于变量筛选前。变量筛选后的SVM-RBF取得了最优的分类性能[受试者工作特征曲线下面积(AUC)=0.73,准确度(accuracy)=0.72,f1值(f1-score)=0.74,精确度(precision)=0.78,召回值(recall)=0.72],其次为变量筛选后的SVM-POLY(AUC=0.73,accuracy=0.71,f1-score=0.73,precision=0.78,recall=0.71),说明并不是纳入的变量越多、模型的预测性能越好。结论学生近视率随着年龄、学段增长而快速增长,也与随着年级增长学生课业负担增加及使用手机等电子产品时间增加有关。

关键词：中小学生近视风险预测混合特征选择机器学习

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地区社会信任对企业ESG表现的影响研究

武汉商学院学报 2024年第2期38卷 67-74页

作者：谢帮生李梅红董丙瑞福建农林大学福建福州350002 宁德师范学院福建宁德352100

高质量发展仍是我国经济发展的核心内容,提升企业的ESG表现有助于推动该目标实现。文章以2011—2021年沪深A股上市公司为样本,研究地区社会信任对企业ESG表现的影响。研究表明,地区社会信任能够显著提升企业的ESG表现。异质性分析发现,... 详细信息

高质量发展仍是我国经济发展的核心内容,提升企业的ESG表现有助于推动该目标实现。文章以2011—2021年沪深A股上市公司为样本,研究地区社会信任对企业ESG表现的影响。研究表明,地区社会信任能够显著提升企业的ESG表现。异质性分析发现,当公司为民营企业,公司所在地的法律制度不完善或者分析师关注度低时,社会信任对ESG表现的促进作用更加明显。进一步分析发现,地区社会信任主要通过缓解企业融资约束和降低代理成本途径,来促进企业进行ESG实践。以上发现有助于理解地区社会信任影响微观企业的作用机理,也为企业ESG表现的提升和我国ESG的发展路径提供了理论支持和经验证据。

关键词：地区社会信任 ESG表现融资约束代理成本

In Vitro and In Vivo Effects and Safety Assessment of Corn Peptides on Alcohol Dehydrogenase Activities

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Chemical Research in Chinese Universities 2011年第5期27卷 820-826页

作者： li hong-mei WEN lian-kui li Shi-jun ZHANG Da-li liN Bai-song College of Food Science and Engineering .lilin Agricultural University Changchun 130118 P. R. China Departement of Cardiac Surgery China-Japan Union Hospital of Jilin University Changchun 130033 R R. China School of Environmental and Biological Engineering Jilin Institute Chemical Technology Jilin 132022 R R. China

The in vitro and in vivo effects of corn peptides（CPs） prepared from corn gluten meal by proteolysis with an alkaline protease and fractions of CPs from Sephadex G-15 and G-10 columns on activities of alcohol dehydroge-nase（ADH） were studied. The results show that CPs and fraction 3 of CPs from Sephadex G-10 column enhance in vitro ADH activity. Furthermore, the in vitro accelerating effect of the fraction 3 of CPs on ADH activity was superior to that of glutathione, which was also found even in the presence of ADH inhibitor, such as pyrazole. In the in vivo experiments, the animals were fed with different dosages of CPs and with a dose of Chinese distilled spirit orally, and sacrificed for the measurement of ADH activity. In vivo experimental results indicate that CPS enhanced hepatic ADH activities. To test the safety of CPs as health food, 30 d feeding test was performed. No obvious toxic effects were detected in treated Wistar rats.

关键词： Corn peptide Activity of alcohol dehydrogenase Activation effect Safety

结直肠癌患者血清miR-150-5p和miR-200b-3p水平及临床意义

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临床和实验医学杂志 2024年第10期23卷 1021-1025页

作者：宋淑莉王淑娇李红梅沧州市人民医院消化内科河北沧州061000

目的结直肠癌患者血清微小RNA(miR)-150-5p和miR-200b-3p水平及临床意义。方法回顾性选择2020年6月至2022年11月在沧州市人民医院就诊的结直肠癌患者116例为结直肠癌组,同时选取同期在本院治疗的结肠息肉患者60例作为结直肠良性肿瘤组,... 详细信息

目的结直肠癌患者血清微小RNA(miR)-150-5p和miR-200b-3p水平及临床意义。方法回顾性选择2020年6月至2022年11月在沧州市人民医院就诊的结直肠癌患者116例为结直肠癌组,同时选取同期在本院治疗的结肠息肉患者60例作为结直肠良性肿瘤组,选择同期在本院行健康体检者60名为对照组。采用实时荧光定量PCR(qRT-PCR)检测受试者血清miR-150-5p、miR-200b-3p水平;采用Pearson相关性分析对结直肠癌患者血清miR-150-5p与miR-200b-3p表达水平的相关性进行分析;分析结直肠癌患者血清miR-150-5p、miR-200b-3p水平与病理特征的关系;采用受试者操作特征(ROC)曲线分析血清miR-150-5p、miR-200b-3p表达水平对结直肠癌的诊断价值。结果结直肠癌组、结直肠良性肿瘤组血清miR-150-5p、miR-200b-3p水平均显著低于对照组,且结直肠癌组血清miR-150-5p、miR-200b-3p水平均显著低于结直肠良性肿瘤组,差异均有统计学意义(P<0.05)。Pearson相关性分析结果显示,结直肠癌患者血清miR-150-5p与miR-200b-3p表达水平呈正相关(r=0.562,P<0.05)。结直肠癌患者血清miR-150-5p、miR-200b-3p水平与分化程度、淋巴结转移、TNM分期、浸润深度有关(P<0.05),其中低分化、有淋巴结转移、TNM分期Ⅲ~Ⅳ期、浸润深度T 3~T 4的结直肠癌患者血清miR-150-5p、miR-200b-3p水平显著低于中高分化、无淋巴结转移、TNM分期Ⅰ~Ⅱ期、浸润深度T_(1)~T_(2)的患者(P<0.05)。血清miR-150-5p、miR-200b-3p单独及联合诊断结直肠癌的曲线下面积(AUC)分别为0.800、0.828、0.893,联合诊断AUC显著高于单独预测AUC(P<0.05)。结论结直肠癌患者血清miR-150-5p、miR-200b-3p水平降低,二者可作为诊断结直肠癌发生的辅助指标。

关键词：微RNAs 结直肠癌微小RNA-150-5p 微小RNA-200b-3p 临床意义

睡眠障碍与心血管疾病及其危险因素的关系的研究进展

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心血管康复医学杂志 2024年第4期33卷 499-502页

作者：安淇王咏丽张霞李红梅中国人民解放军总医院京北医疗区综合内科北京100094

睡眠障碍与心血管疾病之间存在密切联系。氧化应激、炎症、交感神经激活、血管内皮功能障碍、自主神经功能障碍及内分泌系统调节异常在睡眠障碍中扮演重要角色,而这些均是心血管疾病及其危险因素的诱因。睡眠障碍与糖尿病、高血压和心... 详细信息

睡眠障碍与心血管疾病之间存在密切联系。氧化应激、炎症、交感神经激活、血管内皮功能障碍、自主神经功能障碍及内分泌系统调节异常在睡眠障碍中扮演重要角色,而这些均是心血管疾病及其危险因素的诱因。睡眠障碍与糖尿病、高血压和心血管疾病的发展有关,心血管疾病也会加重睡眠障碍。本文就睡眠障碍和心血管疾病及其危险因素的关系和病理生理机制作一综述。

关键词：心血管疾病睡眠障碍危险因素

Study on PCR rapid molecular detection technique of Meloidogyne vitis

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Journal of Integrative Agriculture 2022年第11期21卷 3408-3416页

作者： YANG Yan-mei liU Pei li hong-mei PENG Huan DU Xia DONG Ye HU Xian-qi College of Plant Protection Yunnan Agricultural UniversityKunming 650201.P.R.China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201P.R.China Institute of Agricultural Environment&Resources Yunnan Academy of Agricultural SciencesKunming 650205P.R.China International College Yunnan Agricultural UniversityKunming 650201P.R.China State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Meloidogyne vitis is a new root-knot nematode parasitic on grape root in Yunnan Province,*** order to establish a rapid,reliable and specific molecular detection method for ***,the species-specific primers were designed with rDNA-ITS(ribosomal DNA internal transcribed spacer)gene fragment as the *** reaction system was optimized and the reliability,specificity and sensitivity of primer were testified,therefore,a rapid PCR detection method for *** was *** result showed that the optimal annealing temperature of the primers was 53℃,which was suitable for the detection of different life stages of *** test showed that the specific fragment size of 174 bp was obtained from ***,but other five non-target nematodes did not have any amplification bands,thus effectively distinguish *** and the other five species,and could specifically detect the *** from mixed *** test showed that this PCR technique could detect the DNA of a single second-stage juvenile(J_(2))and 10^(-4)***,this PCR technique could be used to detect directly *** from soil *** rapid,sensitive and specific PCR molecular detection technique could be used for the direct identification of a single J_(2)of *** and the detection of *** in mixed nematode populations and the detection of two J_(2)s or one male in 0.5 g soil samples,which will provide technical support for the investigation of the occurrence and damage of *** and the formulation of efficient green co ntrol strategies.

关键词： Meloidogyne vitis PCR rapid detection reliability specificity sensitivity

A Study on Anti-oxidative Activity of Soybean Peptideswith linoleic Acid Peroxidation Systems

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Chemical Research in Chinese Universities 2006年第2期22卷 205-208页

作者： XU li li hong-mei HUANG Yi-bing WANG Hua NIE Guang-jun ZHANG Xue-zhong Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education Jilin University Changchun 130021 P. R. China College of Food Engineering Jilin Agricultural University Changchun 130018 P. R. China China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China

Soybean bioactive peptides（SBPs） were prepared from the isolated soybean protein by proteolysis with an alkaline protease, alcalase, at 50℃ and pH = 8.0. The dependence of hydrolysis time on hydrolysis degree and molecular weight distribution were examined. The hydrolysate was fractionated on a Sephadex G-25 column and the anti-oxidative activities of the fractions were detected by the method of pyrogallol auto-oxidation. The average chain length of soybean peptides that have anti-oxidative activity was estimated to be about 7. The anti-oxidative properties of the soy- bean peptide were also studied by using linoleic acid peroxidation systems. The optimal condition of the peroxidation system was set up, Vc/Cu^2 ＋ as the inducer at pH = 7.4 and 25 ℃. In addition, soybean peptides show higher antioxidative activity compared with GSH.

关键词： Soybean bioactive peptides Anti-oxidative activity linoleic acid peroxidation system

A Multiple Functional Protein:the Herpes Simplex Virus Type 1 Tegument Protein VP22

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Virologica Sinica 2009年第3期24卷 153-161页

作者： mei-li li hong GUO Qiong DING Chun-fu ZHENG State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

The herpes simplex virus type 1 （HSV-1） VP22, is one of the most abundant HSV-I tegument proteins with an average stoichiometry of 2 400 copies per virion and conserved among alphaherpesvirinae. Many functions are attributed to VP22, including nuclear localization, chromatin binding, microtubule binding, induction ofmicrotubule reorganization, intercellular transport, interaction with cellular proteins, such as template activating VP16, pU factor I （TAF-I） and nonmuscle myosin II A （NMIIA）, and viral proteins including pUS9 and pUL46, glycoprotein E （gE） and gD. Recently, many novel functions perform tegument protein ed by the HSV-1 VP22 protein have been shown, including promotion of protein synthesis at late times in infection, accumulation of a subset of viral mRNAs at early times in infection and possible transcriptional regulation function .

关键词： Herpes simplex virus type 1 (HSV-1) VP22 Intercellular trafficking Protein interaction Tegument protein.

儿童青少年抗抑郁药超说明书用药情况及影响因素

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临床精神医学杂志 2024年第1期34卷 47-50页

作者：陈平李晓英李红梅姜秋波山东烟台市莱州荣军医院 261400

目的:了解精神病专科医院的儿童青少年抗抑郁药门诊使用现状、超说明书用药情况及影响因素。方法:采用自编临床用药情况调查表,通过门诊电子处方系统,调查近4年在某精神病专科医院门诊就诊的儿童青少年精神障碍患者的抗抑郁药使用现况,... 详细信息

目的:了解精神病专科医院的儿童青少年抗抑郁药门诊使用现状、超说明书用药情况及影响因素。方法:采用自编临床用药情况调查表,通过门诊电子处方系统,调查近4年在某精神病专科医院门诊就诊的儿童青少年精神障碍患者的抗抑郁药使用现况,并进行超说明书用药情况及影响因素分析。结果:儿童青少年的门诊抗抑郁药处方占门诊总抗抑郁药处方的2.0%,其中SSRIs的处方占比为84.7%,抗抑郁药使用频率前三位为艾司西酞普兰(41.5%)、氟伏沙明(20.8%)、舍曲林(18.0%);儿童青少年抗抑郁药超说明书用药处方占比为70.30%,是否超说明书用药在年龄、医生职称、疾病诊断、联合用药方面差异无统计学意义(P均<0.01);儿童青少年超说明书用药的影响因素有年龄、医师职称、疾病诊断和联合用药(分别Wald=13.728,Wald=13.332,Wald=18.224,Wald=13.484,P均<0.01)。结论:儿童青少年门诊抗抑郁药使用占门诊总抗抑郁药使用的比例较小,以SS-RIs类为主,超说明书用药现象较常见,受多种因素的影响。

关键词：儿童青少年抗抑郁药超说明书用药影响因素