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2022年吉林省食品中沙门氏菌耐药性及分子特征分析

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中国人兽共患病学报 2024年第2期40卷 104-110页

作者：孙景昱赵薇孙绩岩石奔李可维黄鑫吉林省疾病预防控制中心(吉林省公共卫生研究院) 长春130062 农安县人民医院长春130200

目的了解吉林省食品中沙门氏菌的分布情况和耐药基因特征,为防控食源性疾病提供科学依据。方法对2022年吉林省食品中61株沙门菌,采用微量肉汤稀释法进行25种抗生素耐药性试验。利用全基因组测序技术及生物信息学方法对菌株耐药基因进行... 详细信息

目的了解吉林省食品中沙门氏菌的分布情况和耐药基因特征,为防控食源性疾病提供科学依据。方法对2022年吉林省食品中61株沙门菌,采用微量肉汤稀释法进行25种抗生素耐药性试验。利用全基因组测序技术及生物信息学方法对菌株耐药基因进行分析。结果61株沙门菌分为19种血清型,优势血清型为肠炎沙门菌(52.46%,32/61)。耐药性分析结果显示,沙门菌对氨苄西林的耐药率最高(60.66%,37/61),多重耐药率达24.60%(15/61),无优势耐药谱。不同抗生素的耐药表型与耐药基因存在差异。结论吉林省食品中沙门氏菌的多重耐药比例较高,耐药谱模式复杂,耐药基因携带率较高,需加强耐药性监测,避免抗生素滥用。

关键词：沙门氏菌食品血清分型耐药基因全基因组测序

基于产业价值链视角的国产MCU产业发展研究

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中国集成电路 2024年第5期33卷 13-18,88页

作者：许林李克为孟健中科芯集成电路有限公司

微控制器(MCU)作为集成电路产业领域重要的核心控制芯片,其发展对中国电子信息产业实现自主可控具有重要意义。本文对MCU的产品种类、应用场景和产业价值链情况进行了概述,从技术和市场角度梳理并分析了国内外MCU产业发展现状,同时针对... 详细信息

微控制器(MCU)作为集成电路产业领域重要的核心控制芯片,其发展对中国电子信息产业实现自主可控具有重要意义。本文对MCU的产品种类、应用场景和产业价值链情况进行了概述,从技术和市场角度梳理并分析了国内外MCU产业发展现状,同时针对MCU产业发展过程中的问题提出改进措施和建议,为国产MCU产业高质量发展和电子信息产业自主可控体系建设提供参考和借鉴。

关键词：产业发展微控制器集成电路价值链

Deposition of Ti-Si-N coatings in deep blind-hole with pulsed dc power

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中国有色金属学会会刊：英文版 2004年第z1期14卷 260-263页

作者： MA Da-yan MA Sheng-li XU ke-wei State key Laboratory for Mechanical Behavior of Materials Xi''an Jiaotong University Xi''an 710049 China State Key Laboratory for Mechanical Behavior of MaterialsXi''an Jiaotong University Xi''an 710049 China State Key Laboratory for Mechanical Behavior of MaterialsXi''an Jiaotong University Xi''an 710049 China

Multiphase nanocomposite Ti-Si-N coatings deposited by pulsed dc plasma enhanced chemical vapor deposition technique on the surface of HSS substrate, which were bolted with deep blind-hole to simulate the complexshaped surface of various tools, were investigated. The micrographs show that the surface morphologies of the coatings become coarser with an increasing depth of the bottom holes. And the silicon content increases in Ti-Si-N coatings, which are composed of nanocrystalline TiN, nano-sized amorphous Si3N4, and occasionally amorphous or nanocrysralline TiSi2. The thickness of the coatings decreases with the increasing depth of holes, which may result from the changes of the composition in the coatings. The microhardness of the coatings increases firstly with the increasing depth of holes, reaches a maximum value of about HV5 700 at 10mm depth, and then decreases at larger depth.

关键词： nanocomposite pulsed dc PCVD Ti-Si-N deep blind-hole

Hepatic mucormycosis mimicking hilar cholangiocarcinoma:A case report and literature review

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World Journal of Gastroenterology 2010年第8期16卷 1039-1042页

作者： li, ke-wei Wen, Tian-Fu li, Gan-Di Sichuan Univ W China Hosp Div Liver Transplantat Chengdu 610041 Sichuan Prov Peoples R China Sichuan Univ W China Hosp Dept Pathol Chengdu 610041 Sichuan Prov Peoples R China

Mucormycosis is a rare but invasive opportunistic fungal infection associated with a high mortality rate,and normally occurs in immunocompromised patients. In this report,we describe an immunocompetent patient suffering from hepatic mucormycosis secondary to adrenal mucormycosis,which masquerades as hilar cholangiocarcinoma. After surgical procedure and treatment with amphotericin B and itraconazole,the patient recovered well and had a 2-year infection-free survival. To our knowledge,this special clinical manifestation of hepatic infection as well as adrenal mucormycosis has not been reported to date. Mean-while,this is the first case of an immunocompetent patient with both adrenal and hepatic mucormycosis who has been treated successfully.

关键词： Adrenal gland Hilar cholangiocarcinoma liver Mucormycosis

山东地区场地剪切波速经验外推模型及其适用性

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地震地质 2024年第4期46卷 934-954页

作者：李志恒谢俊举李柯苇温增平李小军王志才许洪泰赵晓芬张娜中国地震局地球物理研究所北京100081 山东省地震局济南250014 北京大学地球与空间科学学院北京100871 北京工业大学城市建设学部北京100124

场地剪切波速是进行场地分类和定量估计场地对地震动影响的重要参数,在工程抗震设防和震后震害快速评估等方面具有广泛应用。文中利用山东地区1336个工程场地的剪切波速剖面数据,分别基于常速度外推方法、速度梯度外推方法和条件独立方... 详细信息

场地剪切波速是进行场地分类和定量估计场地对地震动影响的重要参数,在工程抗震设防和震后震害快速评估等方面具有广泛应用。文中利用山东地区1336个工程场地的剪切波速剖面数据,分别基于常速度外推方法、速度梯度外推方法和条件独立方法建立了山东地区场地剪切波速V_(S20)和V_(S30)的经验外推模型。研究结果表明,常速度外推方法对较浅的钻孔进行波速外推时会产生明显的低估,且预测误差较大。速度梯度外推方法的拟合结果表现出明显的区域性特征,山东地区的V_(S30)预测结果与美国加州和北京平原地区的结果相比,总体上较为接近,但明显低于日本地区。综合考虑建立的3种区域外推模型的精度和预测误差,文中建议优先采用基于条件独立方法建立的山东地区的V_(S20)和V_(S30)经验外推模型,获得的波速外推结果可以较好地为山东地区场地分类提供依据。

关键词：场地分类外推模型平均剪切波速适用性 V_(S30)

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An approach to synthesis of(Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent(bis-(trichloromethyl)carbonate/DMF)

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Chinese Chemical Letters 2011年第12期22卷 1395-1398页

作者： Yi Yi Weng Jian Jun li wei ke Su key Laboratory of Pharmaceutical Engineering of Ministry of Education College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou 310014 China

A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.

关键词： Ring-opening Halogenation Vilsmeier reagent Bis-(trichloromethyl)carbonate (Z)-2-Chloro-1 3-diaryl-2-enones

N-cadherin knock-down decreases invasiveness of esophageal squamous cell carcinoma in vitro

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World Journal of Gastroenterology 2009年第6期15卷 697-704页

作者： ke li wei He Na lin Xin Wang Qing-Xia Fan Department of Oncology the First Affiliated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China

AIM： To examine the expressions of N-cadherin and E-cadherin in specimens of 62 normal esophageal epithela, 31 adjacent atypical hyperplastic epithelia and 62 esophageal squamous cell carcinomas （ESCCs）, and to investigate the roles of N-cadherin in the invasiveness of ESCC cell line EC9706 transfected by N-cadherin shRNA.METHODS： PV immunohistochemistry was used to detect the expression pattern of N-cadherin and E-cadherin in specimens of 62 normal esophageal epithelia, 31 adjacent atypical hyperplastic epithelia and 62 ESCCs. The invasiveness of ESCC line EC9706 was determined by transwell assay after EC9706 was transfected by N-cadherin shRNA.RESULTS： The positive rotes of N-cadherin decreased in the carcinoma, adjacent atypical hyperplastic and normal esophageal tissues （75.8%, 61.3% and 29.0%, P 〈 0.05）, respectively, while those of E-cadherin increased （40.3%, 71.0% and 95.2%, P 〈 0.05）. The increased expression of N-cadherin and decreased expression of E-cadherin were related to invasion, differentiation, and lymph node metastasis （P 〈 0.05）. The expression level of N-cadherin decreased in the N-cadherin knocked down cells, and the invasiveness of those cells decreased significantly as well. The number of cells which crossed the basement membrane filter decreased from 123.40 ± 8.23 to 49.60 ±6.80 （P 〈 0.05）.CONCLUSION： E-cadherin and N-cadherin expression is correlated with the invasion and aggravation of ESCC. The down-regulation of N-cadherin lowers the invasiveness of EC9706 cell line.

关键词： Esophageal squamous cell carcinoma RNAi N-cadherin EC9706

Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and liquid Chromatography-electrospray Ionization-mass Spectrometry Method

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Chinese Chemical Letters 2005年第12期16卷 1633-1636页

作者： Jian Xun ZHANG Chen Chen li Zheng CHEN Zhi Hua RAO Da wei WEN ke An li Hu wei liU College of Chemistry and Molecular Engineering Peking University Beijing 100871

Metabolism of four tobacco-specific N-nitrosamines （TSNAs）, N＇-nitrosonornicotine （NNN）, N＇-nitrosoanatabine （NAT）, N＇-nitrosoanabasine （NAB） and 4-（methyl nitrosamino）-1- （3-pyridyl）-1-butanone （NNK） was studied by solid-phase extraction （SPE） and liquid chromato- graphy-electrospray ionization-mass spectrometry （LC-ESI-MS）. SPE and LC-ESI-MS method was evaluated to be rapid, simple, sensitive and selective for analysis of TSNAs in rabbit serum. The doses of TSNAs administrated were 4.666 μg/kg and 11.665 μg/kg according to different levels in cigarettes. Metabolic curves of four TSNAs and 4-（methyl nitrosamino）-1-（3-pyridyl）- 1-butanone （NNAL）, the metabolite of NNK, were obtained.

关键词： Tobacco-specific N-nitrosamines metabolism liquid chromatography-electrosprayinterface-mass spectrometry

Steady-state multiscale CFD simulation of a circulating fl uidized bed riser

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PARTICUOLOGY 2024年第10期93卷 54-64页

作者： ke, Zhaojie Tian, Yujie li, Fei Lu, Bona Wang, wei Chinese Acad Sci Inst Proc Engn State Key Lab Mesosci & Engn Beijing 100190 Peoples R China Univ Chinese Acad Sci Sch Chem Engn Beijing 100049 Peoples R China

Compared to transient simulation, steady-state simulation of circulating fluidized bed risers is more efficient, but is also harder to perform due to the complex scale-dependency of dense gas-solid flows. In this work, steady-state computational fluid dynamics (CFD) simulation of a riser is performed using the steady energy-minimization multi-scale (EMMS) drag. It is found that the steady state corresponds to an extremely large scale of length and time, thus the grid size required in steady-state simulation is larger than that in transient one. The time-averaged two-fluid model (TFM) coupled with the steady-state EMMS/1M drag model enables a good prediction of the S-shaped, axial solids distribution and the choking transition, whereas the two-phase turbulence and solids stress models are important in predicting the radially core-annular distribution of solids. So far as we know, this is the first time that one can predict the choking transition in a steady-state CFD simulation. Further improvement may need an EMMS modeling of the time-averaged solid stresses. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Fluidization Drag force Steady state Simulation Mesoscale GAS-PARTICLE FLOW STRUCTURE-DEPENDENT ANALYSIS FILTERED 2-FLUID MODELS FLUIDIZED-BED NUMERICAL-SIMULATION SOliD FLOWS EULERIAN SIMULATION VERTICAL PIPE EMMS VAliDATION