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Pancreaticoduodenal transplantation with portal venous and enteric drainage in rats

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World Journal of Gastroenterology 2000年第6期6卷 914-916页

作者： Gu YP Gu JY li js Nanjing Univ Nanjing Gen Hosp Sch Med Transplantat Ctr Nanjing 210002 Jiangsu Provinc Peoples R China

INTRODUCTIONThe use of combined pancreatic and renaltransplantation in patients with diabetes and end-stage renal failure has gained widespreadrecognition as an acceptable treatment *** method used for transplantation... 详细信息

关键词： pancreaticoduodenal transplantation kidney transplantation portal venous drainage enteric drainage postoperative complications rats

SOME CHARACTERISTICS OF liQUID METAL MENISCUS IN ELECTROMAGNETIC FIELD

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中国有色金属学会会刊：英文版 1995年第4期5卷 64-68页

作者： Shen, J li, js li, JG Fu, HZ Zeng, FC Cui, ZS NORTHWESTERN POLYTECH UNIV STATE KEY LAB SOLIDIFICAT PROCXIAN 710072PEOPLES R CHINA AVIAT IND CHINA DEPT SCI & TECHNOLBEIJING 100712PEOPLES R CHINA

ＳＯＭＥＣＨＡＲＡＣＴＥＲＩＳＴＩＣＳＯＦＬＩＱＵＩＤＭＥＴＡＬＭＥＮＩＳＣＵＳＩＮＥＬＥＣＴＲＯＭＡＧＮＥＴＩＣＦＩＥＬＤＳｈｅｎＪｕｎ；ＬｉＪｉｎｓｈａｎ；ＬｉＪｉａｎｇｕｏ；ＦｕＨｅｎｇｚｈｉ（ＳｔａｔｅＫｅｙ... 详细信息

ＳＯＭＥＣＨＡＲＡＣＴＥＲＩＳＴＩＣＳＯＦＬＩＱＵＩＤＭＥＴＡＬＭＥＮＩＳＣＵＳＩＮＥＬＥＣＴＲＯＭＡＧＮＥＴＩＣＦＩＥＬＤＳｈｅｎＪｕｎ；ＬｉＪｉｎｓｈａｎ；ＬｉＪｉａｎｇｕｏ；ＦｕＨｅｎｇｚｈｉ（ＳｔａｔｅＫｅｙＬａｂｏｒａｔｏｒｙｏｆＳｏｌｉｄ...

关键词： liquid metal meniscus electromagnetic cast unidirectional solidification

SYNTHESIS　AND　CHARACTERIZATION　OF　C_（60）NAr，THE　FIRST　AZIRIDINE　FULLERENE　DERIVATIVE

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Chinese Chemical Letters 1995年第7期6卷 569-572页

作者： Feng, J li, js Dong, GX Ji, GJ Acad Sinica Inst Chem Beijing 100080 Peoples R China

Fullerene deriwtives C60NAr 2 were opthesized by the reaction of fullerene C60 with pstituted Pbenyl andes in refluxing chlorobenzene. The structure of each product was elucidated on the basis of FD-MS. UV-Vis. IR. H... 详细信息

关键词： FIRST AZIRIDINE DERIVATIVE AND FULLERENE NAr OF SYNTHESIS THE

Evaluation of various solutions for small bowel graft preservation

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World Journal of Gastroenterology 1998年第2期4卷 48-51页

作者： li YS li js li N Jiang ZW Zhao YZ li NY liu FN

AIM To elucidate the effect of various solutions for small bowel graft preservation in pigs under hypothermic storage. METHODS The swine segmental small bowel graft was autotransplanted after it was preserved with lactated Ringer′s (LR), Euro Collins (EC), hyperosmolarity citrate adenine (HC A) and WMO 1 solutions for 10, 18 and 24 hours, respectively. The recipient survival rate, morphological structure, graft mucosal energy substances and Na + K + ATPase activity were studied, and graft absorption was estimated with D xylose absorption test. RESULTS The morphological study of the grafts preserved with LR or HC A solution for 10 hours or with EC and WMO 1 solution for 18 hours was normal 6 days after operation. Mucosal ATP, total adenine nucleotides (TAN) contents and Na + K + ATPase activity of the graft preserved with EC or WMO solution were higher than that of the graft preserved with LR or HC A solution. Serum level of D xylose was higher in EC and WMO 1 groups than in LR and HC A groups when the graft was preserved for 24 hours. CONCLUSIONS EC and WMO 1 solutions can preserve the swine small bowel up to 18 hours, which are superior to LR and HC A solutions.

关键词： intestine, small/transplantation organ preservation adenosine triphosphate intestine, small/transplatation Na(+) K(+) exchanging ATPase adenine nucleotides

Guideline on Chinese Medicine Rehabilitation for Idiopathic Pulmonary Fibrosis

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World Journal of Traditional Chinese Medicine 2023年第4期9卷 475-484页

作者： Jian-Sheng li Ming-Hang Wang Yang Xie 机构不祥

Foreword Note:Some of the elements of this document may be the subject of patent *** shall not be held responsible for identifying any or all such patent *** drafting organizations:Henan University of Chinese Medicine... 详细信息

关键词： Henan patent Medicine

lipopolysaccharide decreasing albumin expression in rat hepatocytes

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Hepatobiliary & Pancreatic Diseases International 2005年第3期4卷 410-415页

作者： Research Institute of General Surgery, Jinling Hospital, Nanjing 210002, China (Wang XY, li WQ, li N and li js) and Department of Orthopaedics, Zhongda Hospital, Nanjing 210009, China (Lu J) Research Institute of General Surgery Jinling Hospital Nanjing 210002 China. wxinying@***

The relations of the severity of hypoalbu-minemia to morbidity and mortality of patients with critical illness illustrate the need for better understanding of molecular mechanism of hypoalbuminemia. This study was undertaken to investigate the response of albumin synthesis to lipopolysaccharide(LPS)in rat hepatocytes in vitro in early acute phase of sepsis. METHODS:Hepatocytes were cultured at an initial cell density of 1.5×106 cells/well in 3 ml culture medium. There were two groups of samples which received either normal saline or 1 μg/L LPS randomly. Albumin mRNA in hepatocytes was assessed by reverse transcription-poly-merase chain reaction(RT-PCR) and albumin level in the supernatant was measured by EliSA at 0,2,8,12,24 hours after exposure. Meanwhile, the albumin precursor was evaluated at the same time points by flow cytometry. RESULTS:The quantitative changes of mRNA, albumin precursor and its protein were analogous. All of them tended to decline at 12 hours post-treatment and did not decrease significantly until 24 hours after LPS exposure. Meanwhile, albumin mRNA decreased about 30% and the levels of albumin precursor and albumin reduced approximately 50%. CONCLUSIONS: LPS can inhibit albumin synthesis in rat hepatocytes by prevention of albumin transcription. Moreover, the response of hepatic albumin synthesis to LPS changes with the stage of sepsis process. The results show that albumin metabolism in sepsis is a complicated process and further studies are required to understand the molecular mechanism of LPS-induced hypoalbuminemia in sepsis.

关键词： lipopolysaccharide hepatocyte albumin hypoalbuminemia signal transduction sepsis

Up-regulated intragraft gene expression, ICAM-1 and IL-2R molecules, and apoptotic epithelial cells during rejection of rat small intestine allografts

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Chinese Medical Journal 2001年第10期114卷 81-86,110页

作者：李元新李宁李幼生吴波黎介寿南京军区南京总医院普通外科研究所南京210002

Objective To investigate the kinetics and the magnitude of intragraft gene expression of interleukin-2(IL-2), interferon-gamma (IFN-y), perforin and granzyme B, and intragraft expression of interieukin-2receptor (IL-2R) and intercellular adhesion molecule-1 ( ICAM-1 ) during acute rejection episodes, and to analyze the changes in apoptosis in small intestinal allograft *** Heterotopic small intestine transplantation was performed with inbred rats F344/N (RT11) and Wistar/A (RT1-Ak, RT1-Ed). All recipients were divided into four groups: group 1 : Wistar, native control;group 2: Wistar→Wistar; group 3: F344→Wistar and group 4: F344→Wistar + cyclosporine A (6 mg·kg-1 ·d-1 I.M. ). The grafts were harvested on postoperative days (PODs) 3, 5 and 7. All samples were examined pathologically. Intragraft mRNA expression of IL-2, IFN-γ, perforin and granzyme B were detected with reverse transcriptase polymerase chain reaction (RT-PCR) and intragraft expression of IL-2R and ICAM-1 were stained using immunohistochemistry. We also analyzed the change in apoptosis rejection with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL).Results Mild acute rejection occurred on POD 3 in the ailograft group, moderate acute rejection on POD 5, and severe acute rejection on POD 7, while none of the isografts had histological evidence of acute rejection. Cyclosporine A could effectively control rejection. Gene expression was virtually negative in the native control. Only on POD 5 was IL-2 mRNA expression of ailografts significantly higher than that of isografts ( P ＜ 0.05). IFN-γ mRNA expression was significantly higher than that of the control groups ( P ＜0.01 ) on PODs 3, 5 and 7, and the level of perforin and granzyme B mRNA expression reached significantly higher levels than in the other two control groups on POD 5 and POD 7. Intragraft IL-2Rexpression of the allograft was significantly higher than that of the other three control groups. Only on

关键词： small intestine · transplantation · graft rejection · interleukin 2 · interleukin 2 receptor · interferon gamma · perforin · granzyme · intercellular adhesion molecular 1 · apoptosis

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胃肠道生理功能的再认识与肠衰竭

世界华人消化杂志 2005年第14期13卷 1650-1651页

作者：丁连安黎介寿青岛大学医学院附属医院普通外科山东省青岛市266003

胃肠道不仅具有消化吸收功能,还具有重要的屏障功能.后者包括四部分:机械屏障、生物屏障、免疫屏障、化学屏障.机体在遭受任何有害刺激作用下,都会对上述屏障产生影响,导致其发生改变:如超过了机体所能适应代偿的程度,胃肠道将会发生一... 详细信息

胃肠道不仅具有消化吸收功能,还具有重要的屏障功能.后者包括四部分:机械屏障、生物屏障、免疫屏障、化学屏障.机体在遭受任何有害刺激作用下,都会对上述屏障产生影响,导致其发生改变:如超过了机体所能适应代偿的程度,胃肠道将会发生一系列的病理生理变化,出现胃肠道功能障碍和全身症状.严重者,将发生严重的肠功能障碍一肠衰竭.因此,“胃肠道是外科应激反应的一个中心器官”.

关键词：肠衰竭胃肠道生理学肠屏障功能机械屏障生物屏障

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成体干细胞在中枢神经系统疾病修复中的效应

中国组织工程研究与临床康复 2007年第11期11卷 2144-2147页

作者：李建生刘敬霞河南中医学院老年医学研究所河南省郑州市450003 北京中医药大学 2004级北京市100029

目的:干细胞具有增殖能力和多向分化潜能,其成神经细胞特性为脑缺血神经细胞的保护及修复带来希望。文章回顾成体干细胞在中枢神经系统疾病修复中的研究和进展。资料来源:应用计算机检索Medline1997-01/2006-01期间的相关文章,检索词为"... 详细信息

目的:干细胞具有增殖能力和多向分化潜能,其成神经细胞特性为脑缺血神经细胞的保护及修复带来希望。文章回顾成体干细胞在中枢神经系统疾病修复中的研究和进展。资料来源:应用计算机检索Medline1997-01/2006-01期间的相关文章,检索词为"stem cells,cerebral ischemia",并限定文章语言种类为English。同时计算机检索中国期刊全文数据库1997-01/2006-01期间的相关文章,检索词为"干细胞,脑缺血",并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:①文章所述内容应涉及干细胞与脑缺血方面的研究。②选取有对照组的文章。③同一领域的研究选择近期发表或在权威杂志发表的文章。排除标准:重复研究的文章。资料提炼:共收集到187篇相关文献,86篇文献符合纳入标准,排除的101篇文献为内容陈旧或重复。符合纳入标准的86篇文献,涉及干细胞的分类以及干细胞在脑缺血损伤中的应用基础、途径、可能的作用机制等方面内容,选取其中的41篇作为文章参考文献。资料综合:干细胞是具有自我更新和多向分化潜能的细胞群体,可发育为某一器官或组织的特性为其在中枢神经系统疾病的保护与修复中的研究及应用奠定了基础。成体干细胞是多种组织中保留有未完全分化的原始细胞,具有横向分化特性,可分化为神经细胞,替代脑缺血损伤后丢失的神经元和神经胶质细胞,重建具有功能的神经环路;且成体干细胞可为梗死灶周围缺血半暗带组织提供营养支持,以及能促进内源性前体细胞的存活、迁移和分化,被认为是脑缺血最有希望的治疗。此外,成体干细胞可避免胚胎干细胞应用的伦理问题和免疫排斥障碍,是脑缺血损伤后神经保护和修复所需的理想干细胞供体。结论:干细胞的多向分化潜能为脑缺血损伤后的神经修复开辟了新的途径,其在脑缺血损伤后的神经细胞保护和修复以及功能重建的研究方面已取得相当进展,被认为具有广阔的应用前景,与之相关的问题均有待于进一步的研究。

关键词：干细胞脑缺血综述文献