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Hierarchical learning of gastric cancer molecular subtypes by integrating multi-modal DNA-level omics data and clinical stratification

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Quantitative Biology 2024年第2期12卷 182-196页

作者： Binyu Yang Siying liu Jiemin Xie Xi Tang Pan Guan Yifan Zhu Xuemei liu Yunhui Xiong Zuli Yang Weiyao li Yonghua Wang Wen chen Qingjiao li li c.Xia Department of Statistics and Financial Mathematics School of MathematicsSouth China University of TechnologyGuangzhouChina School of Physics and Optoelectronics South China University of TechnologyGuangzhouChina Department of Pathology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Laboratory Medicine the Eighth Affiliated HospitalSun Yat-sen UniversityShenzhenChina

Molecular subtyping of gastric cancer(Gc)aims to comprehend its genetic ***,the efficacy of current subtyping methods is hampered by their mixed use of molecular features,a lack of strategy optimization,and the limited availability of public Gc *** is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and *** on TcGA subtypes,we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping(HcG),which employs gene mutations,copy number aberrations,and methylation patterns as *** incorporating the closely related esophageal adenocarcinomas dataset,we expanded the TcGA Gc dataset for the training and testing of HcG(n=453).The optimization of HcG was achieved through three hierarchical strategies using Lasso-Logistic regression,evaluated by their overall the area under receiver operating characteristic curve(auROc),accuracy,F1 score,the area under precision-recall curve(auPRc)and their capability for clinical stratification using multivariate survival ***-specific DNA alteration biomarkers were discerned through difference tests based on HcG defined *** HcG classifier demonstrated superior performance in terms of overall auROc(0.95),accuracy(0.88),F1 score(0.87)and auPRc(0.86),significantly improving the clinical stratification of patients(overall p-value=0.032).Difference tests identified 25 subtype-specific DNA alterations,including a high mutation rate in the SYNE1,ITGB4,and cOL22A1 genes for the MSI subtype,and hypermethylation of ALS2cL,KIAA0406,and RPRD1B genes for the EBV *** is an accurate and robust classifier for DNA-based Gc molecular subtyping with highly predictive clinical stratification *** training and test datasets,along with the analysis programs of HcG,are accessible on the GitHub website(***/LabxScUT).

关键词： DNA alterations gastric cancer hierarchical classification molecular subtyping multi-omics

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Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang Sara chaothai Tsz chun Kwan John K.c.li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan li Amos M.T.Lee Jennifer H.Y.Lam Sau Man chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for Immunology and Infection c2i Hong KongChina

Background Optimising the immunogenicity of cOVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-cc versus ID-cc)and post-dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for ID-cc compared to IM-cc,whereas IgG avidity was *** ID-ccc,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),interferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 Immunity Intradermal Vaccine

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揭秘地质历史时期最大碳同位素负偏事件的本质

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中国科学：地球科学 2024年第3期54卷 902-906页

作者：李超王海洋成都理工大学油气藏地质及开发工程全国重点实验室成都610059 成都理工大学沉积地质研究院成都610059 成都理工大学自然资源部深时地理环境重建与应用重点实验室成都610059 成都理工大学沉积与生物地球化学国际研究中心成都610059 中国地质大学(武汉)生物地质与环境地质国家重点实验室武汉430074

碳循环通过大气-海洋的酸碱及氧化还原过程对地球表层化学环境起着关键控制作用,是地球表层环境演化的“发动机”.因而,弄清地球碳循环演化对于理解地球宜居性演化至关重要.作为地球宜居性演化过程中由前寒武纪向显生宙-现代地球系统转... 详细信息

碳循环通过大气-海洋的酸碱及氧化还原过程对地球表层化学环境起着关键控制作用,是地球表层环境演化的“发动机”.因而,弄清地球碳循环演化对于理解地球宜居性演化至关重要.作为地球宜居性演化过程中由前寒武纪向显生宙-现代地球系统转变的关键期,埃迪卡拉纪(635~539Ma)在全球范围内发生了地质历史上最大的一次沉积碳酸盐碳同位素组成(δ^(13)ccarb)的负偏事件。

关键词：地球表层氧化还原过程地质历史时期宜居性碳同位素碳循环 δ^(13)c 负偏

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关于通过生物力学与神经生物学联合途径探索神经血管耦合规律和脑疾病发病机理的探讨

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动力学与控制学报 2024年第1期22卷 97-98页

作者： Sunny c.li 谌小维重庆脑与智能科学中心重庆401336 中国人民解放军陆军军医大学重庆400038

随着我国人民生活方式的改变和人口老龄化进程加快,脑疾病的发病率逐年升高,严重危害国民健康,给患者及其家庭乃至社会带来沉重的经济负担.脑疾病伴随着血流动力学的改变,在以往的研究中,人们认为脑功能仅基于神经元活动和其网络连接.但... 详细信息

随着我国人民生活方式的改变和人口老龄化进程加快,脑疾病的发病率逐年升高,严重危害国民健康,给患者及其家庭乃至社会带来沉重的经济负担.脑疾病伴随着血流动力学的改变,在以往的研究中,人们认为脑功能仅基于神经元活动和其网络连接.但是,近二十年来的研究指出,胶质细胞和血管也紧密参与到脑活动及其调控中,而脑血管的病变更有可能直接与痴呆等神经退行性疾病相关.因此,迫切需要研究在不同尺度上和不同生理状态下血管与神经的相互调节关系.

关键词：神经血管国民健康神经退行性疾病脑疾病神经生物学神经元活动血流动力学生物力学

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STcF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.c.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.cai H.cai J.J.cao Q.H.cao X.cao Z.cao Q.chang K.T.chao D.Y.chen H.chen H.X.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.M.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.c.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich c.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge c.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.c.Gui A.Q.Guo F.K.Guo J.c.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou c.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.c.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.c.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev c.H.li c.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao c.X.lin D.X.lin X.S.lin B.J.liu c.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long c.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian c.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central china Normal University Wuhan 430079China central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STcF detector conceptual design

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中国碳酸盐岩地区岩溶无机碳汇格局及影响因素

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中国科学：地球科学 2024年第3期54卷 745-759页

作者：杜朝超白晓永李阳兵谭秋赵翠薇罗光杰吴路华陈飞李朝君冉晨张思蕊熊练宋丰姣肖碧琴李姿霖薛盈盈龙明康罗青张小芸李明会沈晓倩杨姝中国科学院地球化学研究所环境地球化学国家重点实验室贵阳550081 贵州师范大学地理与环境科学学院贵阳550001 中国科学院第四纪与全球变化卓越研究中心西安710061 贵州师范学院流域地理状态监测省级重点实验室贵阳550018 贵州大学资源与环境工程学院贵阳550025

碳酸盐岩化学风化碳汇降低了大气cO_(2)浓度上升和全球变暖的速率,然而,其碳汇通量(ccSF)的估算结果仍存在不确定性,并且气候变化和生态修复对ccSF的贡献率尚不清晰.为此,本文汇编了中国不同流域离子浓度站点数据,并采用经典热力学溶蚀... 详细信息

碳酸盐岩化学风化碳汇降低了大气cO_(2)浓度上升和全球变暖的速率,然而,其碳汇通量(ccSF)的估算结果仍存在不确定性,并且气候变化和生态修复对ccSF的贡献率尚不清晰.为此,本文汇编了中国不同流域离子浓度站点数据,并采用经典热力学溶蚀模型,重新评估了中国1991~2020年ccSF的潜力和时空格局,并定量分析了温度(MAT)、降水(MAP)、蒸散发(ET)、土壤水(SM)和归一化植被指数(NDVI)等因子对ccSF的贡献率.结果发现:(1)中国ccSF为22.76t cO_(2)km^(-2)a^(-1),高于全球平均水平(15.77t cO_(2)km^(-2)a^(-1));总量(ccS)为4772.67×10^(4)t cO_(2),以252.98×104km-2的碳酸盐岩面积贡献了全球14.91%的ccS.(2)中国ccSF由东南向西北逐渐减少,其中南方岩溶区、青藏岩溶区和北方岩溶区ccSF分别为33.14、12.93和7.27t cO_(2)km^(-2)a^(-1).(3)1991~2020年中国ccSF整体呈现增加趋势,增长速率为0.16t cO_(2)km^(-2)a^(-1).(4)MAP、MAT、ET、SM和NDVI对ccSF的贡献率分别为63.3%、3.02%、27.5%、3.1%和3.05%,其中降水增加是近30年ccSF上升的主要驱动因子,而蒸发作用的增强抵消了部分降水增加对ccSF的正贡献.总之,本文对中国长时间序列的碳酸盐岩化学风化碳汇量级、格局及影响因素进行系统的量化,这项工作对于国家和全球的碳中和能力诊断和差距分析具有很强的借鉴价值和参考意义.

关键词：碳酸盐岩碳汇格局影响因素热力学溶蚀模型

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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chinese Physics c 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.c.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.cai X.cai A.calcaterra G.F.cao N.cao S.A.cetin J.F.chang W.L.chang G.R.che G.chelkov c.chen c.H.chen chao chen G.chen H.S.chen M.L.chen S.J.chen S.L.chen S.M.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.choi X.chu G.cibinetto F.cossio J.J.cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich c.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici c.Q.Feng J.H.Feng Y.T.Feng K.Fischer M.Fritsch c.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge c.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong M.Y.Dong X.Dong M.c.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu c.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius c.H.Heinz Y.K.Heng c.Herold T.Holtmann P.c.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.c.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin M.Q.Jing X.M.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.c.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz c.li c.li c.H.li cheng li D.M.li F.li G.li H.li H.B.li H.J.li H.N.li Hui li J.R.li J.S.li K.li L.J.li L.K.li Lei li M.H.li P.R.li Q.M.li Q.X.li R.li S.X.li T.li W.D.li W.G.li X.li X.H.li X.L.li X.Y.li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia carnegie Mellon University PittsburghPennsylvania 15213USA central china Normal University Wuhan 430079China central South University Changsha 410083China china center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China chung-Ang University Seoul06974Republic of Korea cOMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan college Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the cP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the cKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis cP-even fraction

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO collaboration Zhen cao chuandong Gao cong li Ruo-Yu liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&computing center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Beijing 100049China TIANFU cosmic Ray Research center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of china Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(cygnus OB2)and a microquasar(cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： cosmic rays γ-rays Interstellar medium Star cluster

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Scaffold protein MAPK8IP2 expression is a robust prognostic factor in prostate cancer associated with AR signaling activity

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Asian Journal of Andrology 2023年第2期25卷 198-207页

作者： Jian Huang Wang liu Bi-Yun lin Jean c li Jane Lu Ben-Yi li center for Pathological Diagnosis and Research The Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001China Department of Urology The University of Kansas Medical CenterKansas CityKS 66160USA

Mitogen-activated protein kinase-8-interacting protein 2(MAPK8IP2)is a scaffold protein that modulates MAPK signal *** MAPK pathways were heavily implicated in prostate cancer progression,the regulation of MAPK8IP2 expression in prostate cancer is not yet *** assessed MAPK8IP2 gene expression in prostate cancer related to disease progression and patient survival ***8IP2 expression was analyzed using multiple genome-wide gene expression datasets derived from The cancer Genome Atlas(TcGA)RNA-sequence project and complementary DNA(cDNA)*** cox regressions and log-rank tests were used to analyze the overall survival outcome and progression-free ***8IP2 protein expression was evaluated using the immunohistochemistry *** quantitative PcR and Western blot methods analyzed androgen-stimulated MAPK8IP2 expression in LNcaP *** primary prostate cancer tissues,MAPK8IP2 mRNA expression levels were significantly higher than those in the case-matched benign prostatic *** MAPK8IP2 expression was strongly correlated with late tumor stages,lymph node invasion,residual tumors after surgery,higher Gleason scores,and preoperational serum prostate-specific antigen(PSA)***8IP2 upregulation was significantly associated with worse overall survival outcomes and progression-free *** castration-resistant prostate cancers,MAPK8IP2 expression strongly correlated with androgen receptor(AR)signaling *** cell culture-based experiments,MAPK8IP2 expression was stimulated by androgens in AR-positive prostate cancer ***,MAPK8IP2 expression was blocked by AR antagonists only in androgen-sensitive LNcaP but not castration-resistant c4-2B and 22RV1 *** results indicate that MAPK8IP2 is a robust prognostic factor and therapeutic biomarker for prostate *** potential role of MAPK8IP2 in the castration-resistant progression is under further investigation.

关键词： cell cycle regulation disease progression mitogen-activated protein kinase-8-interacting protein 2 patient survival prostate cancer

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Interface dominated deformation transition from inhomogeneous to apparent homogeneous mode in amorphous/amorphous nanolaminates

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Journal of Materials Science & Technology 2022年第4期99卷 178-183页

作者： Z.Q.chen M.c.li J.S.cao F.c.li S.W.Guo B.A.Sun H.B.Ke W.H.Wang Songshan Lake Materials Laboratory Dongguan 523808PR China Institute of Physics Chinese Academy of SciencesBeijing 100190PR China Institute of Materials Engineering Nanjing UniversityNantong 226019PR China School of Physics Science and Technology Xinjiang UniversityXinjiang 830046PR China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049PR China State Key Laboratory for Mechanical Behavior of Material Xi'an Jiaotong UniversityXi’an 710049PR China

The amorphous/amorphous nanolaminates(A/ANLs)have aroused great attentions owing to their tunable structure and enhanced mechanical ***,the plastic deformation mechanism of A/ANLs have yet been ***,we systematically examined the mechanical properties and deformation behavior of series of NiNb/ZrcuNi Al A/ANLs via nanoindentaion *** was found that both the amount and morphology of amorphous/amorphous interface(A/AIs)played crucial roles in the plastic deformation of A/*** and straighter A/AIs facilitated multiple shear banding deformation,of which the hardness increased with decreasing layer thickness,as the A/AIs hindered the propagation of shear bands(SBs).Whilst,more and wavier A/AIs promoted homogeneous deformation,of which the hardness stayed at a much lower value and was relatively irrelevant with the layer thickness,for the promoted activation of shear transformation zones by A/*** results provide guidance for modifying the mechanical properties of amorphous alloys with interface engineering design.

关键词： Amorphous alloys Nanolaminates Shear bands Hardness Interface

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