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Modeling CO_2 miscible flooding for enhanced oil recovery

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Petroleum Science 2012年第2期9卷 192-198页

作者： Ju Binshan Wu Yu-Shu Qin Jishun Fan Tailiang li zhiping School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Key Laboratory of Marine Reservoir Evolution and Hydrocarbon Accumulation Mechanism Ministry of EducationChinaUniversity of Geosciences(Beijing)Beijing 100083China Colorado School of Mines USA PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China

The injection of fuel-generated CO2 into oil reservoirs will lead to two benefits in both enhanced oil recovery （EOR） and the reduction in atmospheric emission of CO2. To get an insight into CO2 miscible flooding performance in oil reservoirs, a multi-compositional non-isothermal CO2 miscible flooding mathematical model is developed. The convection and diffusion of CO2-hydrocarbon mixtures in multiphase fluids in reservoirs, mass transfer between CO2 and crude, and formation damages caused by asphaltene precipitation are fully considered in the model. The governing equations are discretized in space using the integral finite difference method. The Newton-Raphson iterative technique was used to solve the nonlinear equation systems of mass and energy conservation. A numerical simulator, in which regular grids and irregular grids are optional, was developed for predicting CO2 miscible flooding processes. Two examples of one-dimensional （1D） regular and three-dimensional （3D） rectangle and polygonal grids are designed to demonstrate the functions of the simulator. Experimental data validate the developed simulator by comparison with 1D simulation results. The applications of the simulator indicate that it is feasible for predicting CO2 flooding in oil reservoirs for EOR.

关键词： Compositional simulator CO2 flooding mathematical model irregular grids

Theoretical method for calculating porosity and permeability under self-regulating effect

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International Journal of Mining Science and Technology 2013年第5期23卷 637-641页

作者： Lai Fengpeng li zhiping Wang Yining Yao Jingjie School of Energy Resources China University of Geosciences College of Petroleum Engineering China University of Petroleum

In order to study the effect of stress-sensitivity and matrix shrinkage on coalbed methane production,equivalent matrix particle model is proposed considering the process of adsorption and *** mathematical models for calculating porosity and permeability which considered matrix shrinkage by combining diameter model and desorption were *** calculations of porosity and permeability under self-regulating effect were obtained by combining traditional stress-sensitivity *** changes of porosity and permeability in different reservoirs were calculated and analyzed through a variety of basic *** results show that high coal rank reservoir has the biggest range ability of porosity and permeability under the same pressure difference conditions,followed by the middle rank and the low *** research observed the positive relationship between stress-sensitivity and declining period of porosity and permeability in low rank coal reservoir,and the inverse relationship between matrix shrinkage and declining period of porosity and *** stronger the matrix shrinkage is,the earlier declining period and rise period will occur.

关键词： Equivalent matrix Matrix shrinkage Stress-sensitivity Porosity Permeability

Preparation and luminescence characteristics of Sr_3SiO_5:Eu^(2+) phosphor for white LED

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Chinese Science Bulletin 2008年第7期53卷 974-977页

作者： li PanLai YANG zhiping WANG ZhiJun GUO Qinglin li Xu College of Physics Science and Technology Hebei University Baoding 071002 China

The Sr3SiO5:Eu2+ phosphor was synthesized by high temperature solid-state reaction. The emission spectrum of Sr3SiO5:Eu2+ shows two bands centered at 487 and 575 nm, which well agree with the theoretic values of emission spectrum. The excitation spectrum for 575 nm emission center has several excitation bands at 365, 418, 458 and 473 nm. And the results show that the emission spectrum of Sr3SiO5:Eu2+ is influenced by the Eu2+ concentration. The relative emission spectra of the white-emitting InGaN-based YAG:Ce3+ LED and Sr3SiO5:Eu2+ LED were investigated. The results show that the color development of InGaN-based Sr3SiO5:Eu2+ is better than that of InGaN-based YAG:Ce3+, and the CIE chromaticity of InGaN-based Sr3SiO5:Eu2+ is (x=0.348, y=0.326).

关键词：发光性无机发光材料白光二极管性状

在线课程混合教学模式构建——以无机化学实验为例

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广东化工 2024年第10期51卷 182-183页

作者：李岩郭文锋沙鸥李志平王静燕山大学环境与化学工程学院河北秦皇岛066004

无机化学实验是化学类相关专业开设的一门专业基础课,为了解决传统实验教学中存在的一些问题,如讲授时间过长,学生被动灌输内容,缺乏主观能动性,燕山大学进行了无机化学实验在线课程混合式教学实践。结果表明该模式充分利用线上线下资源... 详细信息

无机化学实验是化学类相关专业开设的一门专业基础课,为了解决传统实验教学中存在的一些问题,如讲授时间过长,学生被动灌输内容,缺乏主观能动性,燕山大学进行了无机化学实验在线课程混合式教学实践。结果表明该模式充分利用线上线下资源,提高了教学效率,激发了学生的学习兴趣,促进学生自主化学习,增强了教学效果,在提升实验技能的同时培养学生的创新意识和综合素质。

关键词：无机化学实验在线课程混合模式

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隐伏断层高密度电法响应特征与应用研究

河南科技 2024年第3期51卷 86-92页

作者：丁力闫亚景赵贵章李志萍李楠王展华北水利水电大学河南郑州450045 河南水利与环境职业学院河南郑州450008

【目的】为探究高密度电法不同装置类型对不同倾角断层的探测效果,开展了高密度电法温纳alpha、温纳beta、温纳gamma、偶极装置对不同倾角断层探测效果研究。【方法】通过参数设计建立了不同倾角断层模型,进行正演计算得出结果,并采用... 详细信息

【目的】为探究高密度电法不同装置类型对不同倾角断层的探测效果,开展了高密度电法温纳alpha、温纳beta、温纳gamma、偶极装置对不同倾角断层探测效果研究。【方法】通过参数设计建立了不同倾角断层模型,进行正演计算得出结果,并采用最小二乘法对不同倾角断层模型的正演结果进行反演成像。【结果】比较结果得出高密度电法对探测断层倾角的最优识别装置为温纳alpha,其识别结果与设置值的匹配度高达96.1%。【结论】在试验场地预埋断层并利用温纳alpha装置对其进行探测,结果验证了高密度电法温纳alpha装置对断层响应效果最优,可有效确定断层产状信息,且实测结果与数值模拟结果基本符合。

关键词：断层电阻率反演成像温纳alpha装置

基于Nrf2/Gpx4通路研究右美托咪定对缺血缺氧性脑损伤新生大鼠铁死亡及神经功能的影响

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河北医药 2024年第17期46卷 2586-2590页

作者：丁宁静李志平王海霞复旦大学附属华山医院麻醉科上海市200040 杭州医学院基础医学与法医学院

目的基于核因子E2相关因子2(Nrf2)/谷胱甘肽过氧化物酶4(Gpx4)信号通路,研究右美托咪定(DEX)对缺血缺氧性脑损伤(HIBD)新生大鼠铁死亡及神经功能的影响。方法构建HIBD新生大鼠模型,随机分为模型组、DEX(100μg/kg)组、DEX(100μg/kg)+... 详细信息

目的基于核因子E2相关因子2(Nrf2)/谷胱甘肽过氧化物酶4(Gpx4)信号通路,研究右美托咪定(DEX)对缺血缺氧性脑损伤(HIBD)新生大鼠铁死亡及神经功能的影响。方法构建HIBD新生大鼠模型,随机分为模型组、DEX(100μg/kg)组、DEX(100μg/kg)+抑制剂(Nrf2抑制剂鸦胆子苦醇2 mg/kg)组,每组12只,另取12只新生大鼠作为对照组。对照组和模型组腹腔注射相同体积的0.9%氯化钠溶液。大鼠神经功能缺损程度评分(NDS)评价大鼠神经功能;氨基酸自动分析仪检测海马组织中谷氨酸(Glu)和γ-氨基丁酸(GABA)水平;尼氏(Nissl)染色检测海马区神经元形态;酶联免疫吸附试验(EliSA)检测海马组织中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、神经元特异性烯醇化酶(NSE)含量;试剂盒检测海马组织丙二醛(MDA)、谷胱甘肽(GSH)、铁含量;蛋白免疫印迹检测海马组织中Nrf2、HO-1、Gpx4、胱氨酸/谷氨酸逆向转运蛋白(xCT)表达情况。结果与对照组比较,模型组海马区神经元形态异常,腹侧神经元轴突长短不一且排布不整齐,部分神经元呈背侧脱离趋势,NDS评分、海马组织中Glu、IL-6、TNF-α、NSE、MDA、铁含量升高(P<0.05),GABA、GSH含量及Nrf2、HO-1、Gpx4、xCT蛋白水平降低(P<0.05);与模型组比较,DEX组海马区神经元形态相对饱满,腹侧神经元轴突较整齐,NDS评分、海马组织中Glu、IL-6、TNF-α、NSE、MDA、铁含量降低(P<0.05),GABA、GSH含量及Nrf2、HO-1、Gpx4、xCT蛋白水平升高(P<0.05);Nrf2抑制剂可减轻DEX对HIBD新生大鼠神经损伤的改善作用(P<0.05)。结论DEX能够激活Nrf2/Gpx4通路,抑制铁死亡,改善HIBD新生大鼠神经损伤。

关键词：核因子E2相关因子2 谷胱甘肽过氧化物酶4 铁死亡右美托咪定缺血缺氧性脑损伤新生大鼠神经功能

Non-adiabatic flow characteristics of micro impeller

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Propulsion and Power Research 2014年第1期3卷 1-8页

作者： Qianwei Sun Qiushi li Ali Arshad zhiping li National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power EngineeringBeihang UniversityBeijing 100191China

Non-adiabatic working condition is one of the major causes of performance deterioration in micro gas turbine *** micro scale geometry,low Reynolds number operating condition and high surface to volume ratio all lead to severe heat *** paper first established a simple heat transfer model to determine appropriate non-adiabatic boundary condition for computational fluid dynamics(CFD)*** wall temperature is identified as a heat transfer boundary based on model analysis in combination with material selection for pre-design of the engine and verified by the experiment carried out on directed structure applied in the model.A series of numerical simulations with adiabatic and non-adiabatic boundary conditions is then carried out to study the flow characteristics of high speed,low Reynolds number micro *** physical nature for significant performance degradation related to flow behavior changes due to heat transfer effect is revealed by detailed analysis of typical flow features extracted from the comparative *** result established the basis for heat transfer modeling of micro impeller purposing implications for design modification in order to attain high efficiency and better performance.

关键词： Non-adiabatic Micro impeller Root separation Tip clearance flow Slip factor

A potentially serious adverse effect of GLP-1 receptor agonists

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2291-2293页

作者： Jinmiao Lu Hao liu Qingtong Zhou Ming-Wei Wang zhiping li Department of Pharmacy Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China School of Medicine Ningbo UniversityNingbo 31521lChina Research Center for Deepsea Bioresources Sanya 572025China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China

To the Editor:Glucagon-like peptide-1(GLP-1)is a small intestine-derived hormone^(1,2).Its peptidic analogs include exenatide,lixisenatide,dulaglutide,liraglutide,albiglutide,semaglutide,*** work as GLP-1 receptor ago... 详细信息

关键词： Glucagon-like peptide-1 receptor Agonist Clinical trial Adverse effect Constipation

通腑逐瘀方联合常规西药治疗腑实热结证急性胰腺炎临床研究

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新中医 2024年第10期56卷 81-85页

作者：李芝萍汪娅君张菊萍徐涛李俊华衢州市人民医院浙江衢州324000

目的:观察通腑逐瘀方辅助西药治疗腑实热结证急性胰腺炎的临床疗效。方法:选择98例急性胰腺炎患者,按随机数字表法分为联合组和对照组各49例。对照组给予常规西医治疗,联合组在对照组基础上联合通腑逐瘀方治疗。治疗7 d后,比较2组临床... 详细信息

目的:观察通腑逐瘀方辅助西药治疗腑实热结证急性胰腺炎的临床疗效。方法:选择98例急性胰腺炎患者,按随机数字表法分为联合组和对照组各49例。对照组给予常规西医治疗,联合组在对照组基础上联合通腑逐瘀方治疗。治疗7 d后,比较2组临床疗效、中医证候评分、临床症状恢复时间、炎症因子和肠黏膜屏障功能指标变化。结果:治疗后,联合组总有效率为93.88%,对照组为79.59%,2组比较,差异有统计学意义(P<0.05)。治疗后,联合组腹胀缓解时间、腹痛减轻时间、肠鸣音恢复时间、首次排气时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,2组主、次症中医证候评分及总分均较治疗前降低(P<0.05),且联合组主、次症评分及总分均低于对照组(P<0.05)。治疗后,2组白细胞计数(WBC)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平较治疗前降低(P<0.05),且联合组3项指标水平均低于对照组(P<0.05)。治疗后,2组二胺氧化酶(DAO)、D-乳酸、内毒素水平均较治疗前降低(P<0.05),且联合组3项指标水平均低于对照组(P<0.05)。结论:通腑逐瘀方联合常规西药治疗急性胰腺炎,可以进一步提高疗效,改善中医证候,加快临床症状康复,减轻炎症反应并改善肠黏膜屏障功能。

关键词：急性胰腺炎腑实热结证通腑逐瘀方炎症因子肠黏膜屏障功能